Advancing Knowledge
Training Leaders
Pioneering Treatments
Advancing Knowledge
Training Leaders
Pioneering Treatments
  • ASH Recognizes John DiPersio for Outstanding Mentorship

    The American Society of Hematology (ASH) will honor Grover C. Bagby Jr., MD, and John F. DiPersio, MD, PhD, with 2014 Mentor Awards at the 56th ASH Annual Meeting and Exposition in San Francisco for their sustained, outstanding commitment to the training and career development of early-career hematologists. ASH Press Release 7/22/14

  • Stephen Oh named Doris Duke-Damon Runyon Clinical Investigator

    Steve Oh is one of seven new Damon Runyon Clinical Investigators. The recipients of this prestigious three-year award are outstanding early career physician-scientists conducting patient-oriented cancer research at major research centers under the mentorship of the nation's leading scientists and clinicians. Each will receive $450,000 to support the development of his/her cancer research program. Dr. Oh aims to investigate the cellular abnormalities that underlie myeloproliferative neoplasms. Damon Runyon Cancer Research Foundation 6/23/14

  • Lung cancer study hints at new treatments

    Ramaswamy Govindan and collaborators in The Cancer Genome Atlas Research Network have discovered mutations in the RTK/RAS/RAF signaling pathway that are present in about 75% of patients with adenocarcinoma of the lung. The new findings may expand treatments for this disease, because drugs targeting some of these genetic changes already are available or are in clinical trials. WU Record 7/9/14

  • Some aggressive cancers may respond to anti-inflammatory drugs

    Jason Weber's laboratory has found that triple-negative breast cancer cells lacking the tumor suppressor proteins p53 and ARF turn on a JAK-dependent pathway involved in the innate immune response to viral infection. This antiviral response may create a local environment of inflammation that supports more aggressive tumors. The study suggests that some patients may benefit from JAK inhibitors, a class of anti-inflammatory drugs currently prescribed for rheumatoid arthritis. Cell Reports 2014;7:514 | WU Record 6/26/14

  • New center aims to use immune system to fight cancer, other diseases

    A laboratory within the Center for Human Immunology and Immunotherapy Programs (CHiiPs) will monitor changes in the immune system during clinical trials of new immunotherapies. The centerpiece of the laboratory, directed by Steve Oh, is a state-of-the-art instrument known as a time-of-flight mass cytometer that simultaneously can detect more than 50 different structures either on the cell surface or inside the cell. WU Record 4/17/14

  • Journal honors breast cancer researcher

    The Journal of Biological Chemistry has recognized Ron Bose and his colleagues for their work describing the combined structure of two proteins (HER2 and HER3) that, when bound together, drive growth of many breast cancers. This work was chosen as JBC's best signal transduction article of 2013. JBC 2013;288:25254 | WU Record 3/27/14

  • Surprising culprit found in cell recycling defect

    Members of Stuart Kornfeld's laboratory have identified an unusual cause of the lysosomal storage disorder called mucolipidosis III. They found that a phosphotransferase, which is responsible for adding the targeting signal to lysosomal enzymes, seems to lack a mechanism that keeps it properly localized in the Golgi apparatus. PNAS 2014;111:3532 | WU Record 3/12/14

  • Study shows 1 in 5 women with ovarian cancer has inherited predisposition

    A new study by Li Ding and colleagues estimates that about 20% of women with ovarian cancer have inherited genetic mutations associated with increased risk, even though most of these women do not have strong family histories of the disease. The research is the first large-scale analysis of the combined contributions of inherited and acquired mutations in a major cancer type. Nat Commun 2014;5:3156 | WU Record 2/22/14

  • Lee Ratner named Wolff Professor of Oncology

    Lee Ratner's primary research interest focuses on retroviruses, including the human T-cell leukemia virus type 1, which causes a specific form of lymphoma, and the human immunodeficiency virus (HIV) associated with AIDS. His studies have been applied to developing novel therapeutic approaches for these viral infections. WU Record 11/7/13

  • Evan Sadler elected to the Institute of Medicine

    Evan Sadler, chief of the Division of Hematology, has been elected to the Institute of Medicine of the National Academy of Sciences, one of the highest honors medical scientists in the United States can receive. The Institute of Medicine serves as a national resource for independent analysis and recommendations on issues related to medicine, biomedical sciences and health. WU Record 10/21/13

  • Genetic errors identified in 12 major cancer types

    Li Ding and co-workers have identified 127 repeatedly mutated genes that appear to drive the development and progression of a range of tumors. For example, a gene mutated in 25 percent of leukemia cases also was found in tumors of the breast, rectum, head and neck, kidney, lung, ovary and uterus. The discovery sets the stage for devising new diagnostic tools and more personalized cancer treatments. Nature 2013;502:333 | WU Record 10/16/13

  • Database of disease genes shows potential drug therapies

    Obi Griffith and his twin brother Malachi, working with colleagues at The Genome Institute, have created an online database that matches genes linked to cancer and other diseases with drugs that target those genes. The database includes more than 14,000 drug-gene interactions involving 2,600 genes and 6,300 drugs. Another 6,700 genes are in the database because they potentially could be targeted with future drugs. Nat Methods 2013 Oct 13 | WU Record 10/13/13

  • Discovery helps show how breast cancer spreads

    Working in mouse models of breast cancer and breast tumor samples from patients, Greg Longmore and his colleagues showed that a protein on the surface of tumor cells, called DDR2, binds to collagen and activates a multistep pathway that encourages tumor cells to spread. This finding may explain why women with dense breasts are at increased risk for invasive breast cancer. Nature Cell Biology 2013;15:677-87 | WU Record 5/5/13

  • Distinct niches in bone marrow nurture blood stem cells

    In research that one day could improve the success of stem cell transplants and chemotherapy, Dan Link and co-workers have found that distinct niches exist in bone marrow to nurture different types of blood stem cells. The new findings, in mice, suggest that it may be possible to therapeutically target support cells in a particular niche. Nature 2013;495:227-30 | WU Record 2/24/13

  • Doctors turn to genetics to search for cancer's Achilles' heel

    To develop more effective treatments for cancer, doctors are zeroing in on the disease's genetic drivers. Listen to John DiPersio and Merck's Gary Gilliland discuss how this may revolutionize the future of cancer treatment. NPR Science Friday 1/11/13

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  • Sep
    17
    Wed

    Fellows' Tumor Board

    12:00 PM

    8841 CSRB

    Tom Regenbogen (Presenter): "Locally Advanced Esophageal Cancer"

    Andrea Wang-Gillam (Faculty Mentor): "Locally Advanced Esophageal Cancer"

  • Sep
    18
    Thu

    Hematology Lecture Series

    12:00 PM

    14th Floor NW Tower

    Morey Blinder: "Iron Deficiency Anemia"

  • Sep
    19
    Fri

    Hematology-Oncology Grand Rounds

    8:00 AM

    8841 CSRB

    Jeff Ward: "TBA"

    Peter Riedell: "B-Cell Receptor Signaling in Lymphoid Malignancies"

  • Sep
    19
    Fri

    Friday Noon Conference

    12:00 PM

    14th Floor NW Tower

    Steve Sorscher: "Colon Cancer"

  • Sep
    19
    Fri

    Philip Majerus Symposium

    1:00 PM

    EPNEC Auditorium

    1:00 PM
    Evan Sadler, MD, PhD: Introduction
    1:30 PM
    P. Roy Vagelos, MD (Regeneron): "Phil, Science, and Medicine"
    2:15 PM
    Sandra Hofmann, MD, PhD (UT Southwestern): "Molecular Basis of Infantile Batten Disease"
    3:15 PM
    Stephen M. Prescott, MD (Oklahoma Medical Research Foundation): "TBA"
    4:00 PM
    John York, PhD (Vanderbilt University): "Insights into Inositol Phosphate Cellular Signaling Pathways"

  • Sep
    22
    Mon

    Hematology Case Conference

    12:00 PM

    8841 CSRB

  • Sep
    23
    Tue

    Translational Oncology Group

    12:00 PM

    14th Floor NW Tower

  • Sep
    24
    Wed

    Fellows' Journal Club (Colon Cancer)

    12:00 PM

    8841 CSRB

    Jeff Ward (Fellow Presenter)

    Kevin Chen (Fellow Presenter)

  • Sep
    25
    Thu

    Genomics Tumor Board

    4:00 PM

    Erlanger Auditorium

  • Sep
    26
    Fri

    Hematology-Oncology Grand Rounds

    8:00 AM

    8841 CSRB

    Jesse Keller

    Brian Hess

  • Sep
    26
    Fri

    Paul Calabresi Career Development & Clinical Oncology Symposium

    8:00 AM

    EPNEC Auditorium

    8:45 AM
    Ramaswamy Govindan, MD: Welcome and Overview
    9:00 AM
    Timothy J. Ley, MD: "Keynote Address: Physician-Scientist Shortage and its Impact on Research"
    9:45-10:45 AM
    Oral Presentations: Work in Progress
    11:00 AM-noon
    Oral Presentations: Educational Session
    1:00-1:30 PM
    Panel Discussion on Career Development
    1:30-1:50 PM
    Scholar Experience Speaker (K12 Alumnus)
    1:50-2:00 PM
    John DiPersio, MD, PhD: Closing Remarks

  • Sep
    26
    Fri

    Work-in-Progress

    4:00 PM

    8841 CSRB

    Daniel Fisher (Stephen Oh lab)

    Garima Gupta Tyagi (Evan Sadler lab)

  • Nov
    21
    Fri

    Sixth Annual Fellows' Research Symposium

    1:00 PM

    Holden Auditorium

    1:00-1:45 PM

    Poster Presentations

    1:45-3:30 PM

    Oral presentations

Featured Video

Lukas Wartman

In treatment for leukemia, glimpses of the future

By Gina Kolata
ST. LOUIS - Genetics researchers at Washington University, one of the world's leading centers for work on the human genome, were devastated. Dr. Lukas Wartman, a young, talented and beloved colleague, had the very cancer he had devoted his career to studying.... New York Times 7/7/12

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