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News & Notes

Evan Sadler appointed chief of the Hematology Division

Evan Sadler has been appointed chief of the Hematology Division effective July 1, 2009. He succeeds Stuart Kornfeld and Phil Majerus, who became co-directors of the division in 1973. Evan was recently elected vice-president of the American Society of Hematology and will serve as president in 2011. ASH 11/3/08 | In an interview with ScienceWatch.com, Evan discussed the classification of von Willebrand disease. Science Watch 9/09

Estrogen therapy for advanced breast cancer

Matthew Ellis and collaborators have found that treatment with low-dose oral estradiol benefits about 30 percent of patients with hormone receptor-positive, aromatase inhibitor-resistant breast cancer. Record 8/27/09 | JAMA 8/19/09

New protocols for atypical adult hemolytic uremic syndrome

Clinical trials of eculizumab for patients with atypical hemolytic uremic syndrome are now open for enrollment. Patients do not need to have a known complement pathway mutation to qualify (mutation analysis will be done in conjunction with each study). Please contact Lukas Wartman or Elaine Majerus for more information.

Neural tube defects linked to inositol metabolism

Monita Wilson and co-workers found neural tube defects in embryos from female mice genetically modified to have low levels of ITPK1, an enzyme involved in the metabolism of inositol. The finding suggests that inositol depletion is linked to these birth defects. PNAS 6/16/09 | News Release 5/25/09

Faculty members elected to the AAP and ASCI in 2009

Congratulations to Dan Link on his election to the Association of American Physicians and to Mike Tomasson on his election to the American Society for Clinical Investigation.

Whole-genome sequencing of AML

A team led by Tim Ley used whole-genome sequencing to identify 10 acquired mutations in a patient with AML. Two were previously described mutations that are thought to contribute to tumor progression, and 8 were new mutations, the functions of which are not yet known. Sequencing of another patient with AML was recently completed. Tim received the 2008 ASH Mentor Award for his commitment to trainees and his advocacy of scientific education. Nature 11/6/08 | NY Times 11/6/08 | Outlook Spring/09 | Record 8/13/09 | NEJM 9/10/09