Lee Ratner, M.D., Ph.D.
- Professor
- Department of Medicine
- Oncology Division
- Medical Oncology Section
- Molecular Oncology Section
- Oncology Division
- Department of Molecular Microbiology
- Department of Pathology & Immunology
- Department of Medicine
- Clinical interests
- AIDS
- Oncology
- Research interests
- Human retrovirology (HIV and HTLV)
Research
My laboratory is studying human retrovirus infections. In particular, we are examining the leukemogenic determinants of human T cell leukemia virus and the molecular details of human immunodefiency virus replication. My clinical research focuses on the treatment of human retrovirus-associated malignancies.
My laboratory is involved in a molecular dissection of virus-cell interactions. We focus on two retroviurses: Human T-Cell Leukemia Virus Type 1 (HTLV-1) which causes a specific form of lymphoma, and Human Immunodeficiency Viruses (HIV) Types 1 and 2. Our studies of HTLV-1 are concerned with analysis of the mechanisms of leukemogenesis through studies of: transforming determinants in an infectious immortalizing HTLV-1 proviral clone; transgenic models utilizing the HTLV-1 trans-activator protein, which results in a lymphoproliferative malignancy; and identification and characterization of the receptor for the virus.
Our studies of HIV-1 focus on two distinct questions: 1) How does viral protein X (Vpx) enhance virus replication in quiescent cells? 2) How does the viral envelope interact with the receptor (CD4) and coreceptor (CXCR4 or CCR5) to allow virus entry? For these studies, we utilize infectious molecular clones of HIV-1 and HIV-2, cell culture and animal studies, small molecule and siRNA inhibitors, as well as viral and cellular cofactor mutants.
Information from these studies has been applied to developing novel therapeutic approaches for HTLV-1 and HIV-1 infections.
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Luminol-BLI of spontaneous LGL tumors in Gzmb:Tax mice
(a) H&E staining of a large tumor from the tail of a Gzmb:Tax mouse, showing that the majority of the cell mass is made of neutrophils.
From: Gross S, Gammon ST, Moss BL, Rauch D, Harding J, Heinecke JW, Ratner L, Piwnica-Worms D
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Biographical Sketch
Education
| 1973 | BA/MA (Chemistry), Harvard University, Cambridge, MA |
| 1979 | MD/PhD (Molecular Biochemistry and Biophysics), Yale University, New Haven, CT |
Post-graduate Training
| 1979-1982 | Intern and Resident in Internal Medicine, Washington University, Barnes Hospital, St. Louis, MO |
| 1982-1983 | Medical Staff Fellow, Pediatric and Medical Oncology Branches, National Cancer Institute, National Institutes of Health, Bethesda, MD |
| 1983-1985 | Research Staff Fellow (Laboratory of Drs Flossie Wong-Staal and Robert Gallo), National Cancer Institute, National Institutes of Health, Bethesda, MD |
Academic Positions & Employment
| 1985-1990 | Assistant Professor of Medicine, Washington University, St. Louis, MO |
| 1986-1990 | Assistant Professor of Molecular Microbiology, Washington University, St. Louis, MO |
| 1990-1993 | Associate Professor of Medicine and Molecular Microbiology, Washington University, St. Louis, MO |
| 1993-present | Professor of Medicine and Molecular Microbiology, Washington University, St. Louis, MO |
| 1995-present | Professor of Pathology, Washington University, St. Louis, MO |
| 2003-present | Director of Molecular Oncology |
University Committees
| 1989-1992 | Washington University Medical School Communicable Disease Council |
| 1989-1992 | Washington University AIDS Committee |
| 1991-1996 | Washington University Biosafety Committee |
| 1992-1993 | Washington University Animal Biosafety Committee |
| 1993-1998 | Steering Committee for Molecular Genetics Graduate Program |
| 2002-present | Director, Cancer Biology Educational Program |
| 2002-present | Director, Oncology Fellowship Protocol Committee |
| 2005-present | Siteman Cancer Center Scientific Leadership Committee |
| 2007-present | Washington University School of Medicine Admissions Committee |
| 2008-present | Co-Director, Siteman Cancer Center Clinical and Translational Research Program |
National and International Committees
| 1987-1990 | Chairman, AIDS Clinical Trials Group Basic Research Committee |
| 1990-1995 | Member, AIDS Clinical Trials Group Core Oncology Committee |
| 1987-1995 | Scientific Advisory Board, American Foundation for AIDS Research |
| 1988-1989 | Protocol Chairman, AIDS ITP Study, ACTG 087 |
| 1991-1996 | AIDS Related Research Virology Study Section ARRC, DRG, NIH 1991-1996, Member 1994-1996, Chairman |
| 1995-1996 | Macrophage Culture SWAT Team, AIDS Clinical Trials Group |
| 2000-2003 | Co-Chair and Chair, Laboratory Working Group, AIDS Malignancy Consortium |
| 2005-present | European Union Virus-Associated Malignancies Grant Reviews |
| 2007-present | Veterans Administration Merit Grant Reviews in Infectious Diseases |
Editorial Responsibilities
| 1987-1992 | AIDS Targeted Information Newsletter |
| 1987-present | AIDS Research & Human Retroviruses |
| 1988-present | Journal of the Acquired Immune Deficiency Syndrome |
| 1989-present | Virology |
| 1993-present | AIDS |
| 1995-present | Journal of Virology |
Professional Societies
| 1983 | American Federation for Clinical Research |
| 1983 | American Society for Microbiology |
| 1983 | American Association for the Advancement of Sciences |
| 1986 | American Association of Cancer Reseerach |
| 1987 | American Society of Hematology |
| 1987 | American Society of Clinical Oncology |
| 1988 | International AIDS Society |
| 1990 | American Society for Clinical Investigation |
| 1990 | American Society for Virology |
| 1992 | International Society for Antiviral Research |
| 1993 | International Society for Human Retrovirology |
| 1995 | American College of Physicians, Fellow |
| 1997 | Association of American Physicians |
| 1997 | American Foundation for AIDS Research, Scientific Advisory Board |
Board Certification
| 1982 | Internal Medicine |
| 1985 | Medical Oncology |
Honors & Awards
| 1985 | American Federation for Clinical Research Trainee Award |
| 1985 | Coleman/Fannie Mae Candies Foundation Fellowship Award |
| 1985 | John A & George L Hartford Foundation Fellowship Award |
| 1986 | American Society of Clinical Oncology Young Investigator Award |
| 1990 | American Cancer Society Faculty Research Award |
| 2001 | Lifetime Achievement Award for Studies of Human T Cell Leukemia Viruses, International Conference on Human Retrovirology, Dublin |
- Updated: May 26, 2009
