WASHINGTON UNIVERSITY SCHOOL OF MEDICINE DEPARTMENT OF MEDICINE

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Areas of Clinical Research Interest

• Evaluation of the addition of EGFR inhibitors to induction chemotherapy in patients with SCCHN
• Evaluation of the molecular and metabolic effects of EGFR inhibitors in patients with SCCHN by sequential tumor biopsies and FDG-PET, respectively
• Evaluation of targeted agents and chemotherapy for the treatment of soft tissue sarcomas and bone sarcomas
• Evaluation of targeted agents in the treatment of metastatic medullary and differentiated thyroid cancers

Current Research Projects

• SCCHN
  • Determination of tumor SUV by FDG-PET/CT and phosphorylation status of tumor EGFR and downstream signaling molecules before and after cetuximab in patients with metastatic SCCHN
  • Determination of the primary tumor site response to each of three induction chemotherapy regimens (cisplatin and 5-fu given with either cetuximab, abraxane, or both) in patients with locally advanced SCCHN
  • Participation in cooperative group (RTOG, ECOG, SWOG), pharmaceutical, and multi-institutional investigator inititiated clinical trials in SCCHN: ECOG 1302, Paradigm, EPIC, AVIT, ARQ 501, Zactima, Imclone Lorhan Registry trials
• Sarcoma
  • Participation in cooperative group (Phase II Mayo Consortium, SWOG) and pharmaceutical clinical trials in sarcoma: STA-4783 (Synta), Sorafenib (SWOG), Glufosphamide (Threshold), CCI-779 (P2C)
• Thyroid Cancer
  • Participation in cooperative group (Phase II Mayo Consortium) and pharmaceutical clinical trials in thryroid cancer: 17-AAG (P2C), zactima

Education

1982	BS Biological Sciences (summa cum laude), Wright State University, Dayton, OH
1986	MD, Wright State University School of Medicine, Dayton, OH

Post-graduate Training

1986-1989	Internship & Residency, Internal Medicine, University of Texas Health Sciences Center, San Antonio, TX
1989-1990	Fellowship, Medical Oncology/Hematology, University of Texas Health Sciences Center, San Antonio, TX
1990-1992	Fellowship, Bone Marrow Transplantation, University of Texas Health Sciences Center, San Antonio, TX

Academic Appointments

1992-1994	Assistant Professor of Medicine, Saint Louis University Health Sciences Center, Division of Bone Marrow Transplantation, Oncology & Hematology, St. Louis, MO
1992-1994	Director, Allogeneic Bone Marrow Transplant Program, Medical Director, National Marrow Donor Program Transplant/Collection Center, Saint Louis University Health Sciences Center, Division of Bone Marrow Transplantation, Oncology & Hematology, St. Louis, MO
1995-2002	Assistant Professor of Medicine, Washington University School of Medicine, St. Louis, MO
1995-2004	Medical Director, National Marrow Donor Program Transplant and Collection Center, Washington University School of Medicine, Division of Oncology, St. Louis, MO
1998-2003	Supervisor, Data Management Section, Washington University School of Medicine, Division of Oncology, St. Louis, MO
2002-present	Associate Professor of Medicine, Washington University School of Medicine, St. Louis, MO

Committees

1993-1994	Working Group on Medical Records, Saint Louis University Medical Center
1993-1994	Southwest Oncology Group - Leukemia Committee
1995-1996	Mucositis Committee: Standards for Grading/Guidelines for Treatment, Barnes Hospital/Washington University School of Medicine
1995-2003	Bone Marrow Transplant Unit QA/QI Committee Barnes Hospital, Washington University School of Medicine
1996-2003	Barnard Cancer Center Physician's Advisory Board, Washington University School of Medicine
1996-2003	Protocol Review Committee, Division of BMT & Stem Cell Biology, Washington University School of Medicine
1997-2003	Protocol Quality Assurance Committee, Siteman Cancer Center, Washington University School of Medicine
1998-2003	Clinical Effectiveness Program - BMT Working Group, Barnes-Jewish Hospital & Washington University School of Medicine
2004-present	Head & Neck Cancer Focus Research Group, Siteman Cancer Center & Washington University School of Medicine

Board Certification

1990	American Board of Internal Medicine
1993	American Board of Internal Medicine (Medical Oncology)

Honors & Awards

1982	Montgomery County Medical Society Auxiliary Internal Medicine Scholarship
1982	Departmental Honors, Biological Sciences
1983	Miami Valley Family Practice Association Scholarship
1984	Montgomery County Medical Society Auxiliary Internal Medicine Scholarship
1984	Academy of Medicine Award, Wright State University School of Medicine
1985	Alpha Omega Alpha
1989	American Cancer Society Clinical Oncology Fellowship Recipient
1992	Recipient, American Society of Clinical Oncology Travel Grant
1995	Recipient, Dinah Kukes Grant, Phi Mu Foundation
2003, 2006	Best Doctors in America

Professional Societies

	American Society of Clinical Oncology
	International Society for Hematotherapy and Graft Engineering
	International Society for Experimental Hematology
	American Society of Hematology
	American Society for Blood and Marrow Transplantation
	American College of Physicians
	National Marrow Donor Program
	Texas Medical Association
	National Cancer Institute - Investigator #21461
	CALGB Investigator - Membership #4322
	National Comprehensive Cancer Network Bone Cancers Panel

Updated: July 14, 2008