WASHINGTON UNIVERSITY SCHOOL OF MEDICINE DEPARTMENT OF MEDICINE

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My research focus is on the clinical treatment of patients with non-malignant hematologic disease. In particular, we have provided comprehensive care to a large cohort of adult patients with sickle cell disease as part of a funded Adult Hemoglobinopathy Treatment Center and have participated in several investigator-initiated and sponsored studies. For the treatment of sickle cell disease, one current focus is in further understanding the issues in transitioning from pediatric to adult care. Another focus is in the understanding and treatment of iron overload disorders with oral iron chelators. In addition to iron overload, I also have a longstanding interest in the diagnosis and treatment of iron deficiency anemia including the use of IV iron agents.

The second major clinical focus is the treatment of immune-mediated hematologic disease, most notably including ITP and TTP, with both newer regimens of immunosuppression as well as small molecules. We have participated in several clinical trials evaluating new approaches to the treatment of these diseases.

Lastly, my focus has been on the diagnosis and treatment of bleeding and thromboembolic disorders, including the participation in several multicenter studies for the treatment of venous thromboembolism. We have also recently established a Comprehensive Hemophilia Treatment Center including a multidisciplinary approach and are expanding our role in the hemophilia community.

 

Education

1973-1977	B.S., University of Notre Dame, Notre Dame, IN
1977-1981	M.D., St. Louis University School of Medicine, St. Louis, MO

Post-graduate Training

1981-1984	Resident in Internal Medicine, Department of Medicine, University of Illinois School of Medicine, Chicago, IL
1984-1986	Fellow in Hematology, Department of Internal Medicine, University of Washington School of Medicine, Seattle, WA
1986-1990	Post-doctoral Research Fellow, Division of Hematology-Oncology, Washington University School of Medicine, St. Louis, MO

Academic Positions

1990-1998	Assistant Professor, Division of Laboratory Medicine, Washington University School of Medicine, St. Louis, MO
1994-present	Medical Director, Wohl Hematology Laboratory
1996-present	Associate Member, Alvin J. Siteman Cancer Center
1998-present	Associate Professor of Medicine and Pathology & Immunology, Washington University School of Medicine, St. Louis, MO

Appointments & Committees

1990-present	Barnes-Jewish Hospital Medical Staff
2000-present	Medical Staff Association, Barnes-Jewish Hospital
2005-2007	Vice Chair of the Executive Committee of the Faculty Council, Washington University School of Medicine
2007-present	Transfusion Committee, Barnes-Jewish Hospital
2010-present	Associate Director, Hematology-Oncology Fellowship Program

Board Certification

1984	Diplomate of the American Board of Internal Medicine
1987	Diplomate of the American Board in Medical Oncology
1988	Diplomate of the American Board in Hematology

Honors & Awards

1987-1989	Fellow of the American Heart Association, Missouri Affiliate
1990	European Patent Number 90870188.1 “Modified Heparin Cofactor II”; Inventors: DM Tollefsen, VM Derechin, MA Blinder
1992	U.S. Patent Number 5,102,995 “DNA Encoding Modified Heparin Cofactor II”; Inventors: DM Tollefsen, VM Derechin, MA Blinder
1992	U.S. Patent Number 5,118,793 “Modified Heparin Cofactor II ”; Inventors: DM Tollefsen, VM Derechin, and MA Blinder
1995	Outstanding Teacher for the 1994-95 Academic Year, Department of Internal Medicine, Washington University School of Medicine
1999	Dr. Neville Grant Award for Clinical Excellence
2001-2011	Listed in Best Doctors in America
2001-2011	Listed in Castle Connolly America’s Top Doctors
2004-present	Missouri Genetic Disease Advisory Committee, Appointed by Governor Bob Holden; Reappointed by Governor Matt Blunt 2006; Reappointed by Governor Jay Nixon 2010
2008-present	Chairman, Sickle Cell Anemia Standing Committee, State of Missouri, Department of Health and Senior Services

Professional Societies

1992	American Society of Hematology
1993	American College of Physicians, Member
1995	Academy of Clinical Laboratory Physicians and Scientists

Consulting Relationships & Board Memberships

2008-2011	Data and Safety Monitoring Board, National Institute of Neurologic Disorders and Stroke Desferoxamine in Intracranial Hemorrhage Trial
2011-present	Chairman, Safety Monitoring Committee, National Heart, Lung and Blood Institute (NHLBI), Safety to Reduce Iron Deficiency (STRIDE) Study
2011-present	Panel Member, NCCN Guidelines - Cancer and Chemotherapy-Induced Anemia

• Updated: February 25, 2013
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