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Ellis MJ, Lin L, Crowder R, Tao Y, Hoog J, Snider J, Davies S, Deschryver K, Evans DB, Steinseifer J, Bandaru R, Liu W, Gardner H, Semiglazov V, Watson M, Hunt K, Olson J, Baselga J
Phosphatidyl-inositol-3-kinase alpha catalytic subunit mutation and response to neoadjuvant endocrine therapy for estrogen receptor positive breast cancer.
Breast Cancer Res Treat 2009 Oct 21; [Epub ahead of print]
Tebbit CL, Zhai J, Untch BR, Ellis MJ, Dressman HK, Bentley RC, Baker JA, Marcom PK, Nevins JR, Marks JR, Olson JA Jr
Novel tumor sampling strategies to enable microarray gene expression signatures in breast cancer: a study to determine feasibility and reproducibility in the context of clinical care.
Breast Cancer Res Treat 2009 Feb 18; [Epub ahead of print]
Robertson JF, Llombart-Cussac A, Rolski J, Feltl D, Dewar J, Macpherson E, Lindemann J, Ellis MJ Activity of fulvestrant 500 mg versus anastrozole 1 mg as first-line treatment for advanced breast cancer: results from the FIRST study.
J Clin Oncol 2009 Sep 20;27(27):4530-5
Ellis MJ, Miller WR, Tao Y, Evans DB, Chaudri Ross HA, Miki Y, Suzuki T, Sasano H
Aromatase expression and outcomes in the P024 neoadjuvant endocrine therapy trial.
Breast Cancer Res Treat 2009 Jul;116(2):371-8
Ellis MJ, Gao F, Dehdashti F, Jeffe DB, Marcom PK, Carey LA, Dickler MN, Silverman P, Fleming GF, Kommareddy A, Jamalabadi-Majidi S, Crowder R, Siegel BA
Lower-dose vs high-dose oral estradiol therapy of hormone receptor-positive, aromatase inhibitor-resistant advanced breast cancer: a phase 2 randomized study.
JAMA 2009 Aug 19;302(7):774-80
Graveel CR, DeGroot JD, Su Y, Koeman J, Dykema K, Leung S, Snider J, Davies SR, Swiatek PJ, Cottingham S, Watson MA, Ellis MJ, Sigler RE, Furge KA, Vande Woude GF
Met induces diverse mammary carcinomas in mice and is associated with human basal breast cancer.
Proc Natl Acad Sci U S A 2009 Aug 4;106(31):12909-14
Harris LN, Broadwater G, Abu-Khalaf M, Cowan D, Thor AD, Budman D, Cirrincione CT, Berry DA, Winer EP, Hudis CA, Hayes DF, Friedman P, Ellis M, Dressler L
Topoisomerase II{alpha} amplification does not predict benefit from dose-intense cyclophosphamide, doxorubicin, and fluorouracil therapy in HER2-amplified early breast cancer: results of CALGB 8541/150013.
J Clin Oncol 2009 Jul 20;27(21):3430-6
Cheang MC, Chia SK, Voduc D, Gao D, Leung S, Snider J, Watson M, Davies S, Bernard PS, Parker JS, Perou CM, Ellis MJ, Nielsen TO
Ki67 index, HER2 status, and prognosis of patients with luminal B breast cancer.
J Natl Cancer Inst 2009 May 20;101(10):736-50
Olson JA Jr, Budd GT, Carey LA, Harris LA, Esserman LJ, Fleming GF, Marcom PK, Leight GS Jr, Giuntoli T, Commean P, Bae K, Luo J, Ellis MJ Improved surgical outcomes for breast cancer patients receiving neoadjuvant aromatase inhibitor therapy: results from a multicenter phase II trial.
J Am Coll Surg 2009 May;208(5):906-14
Fracasso PM, Picus J, Wildi JD, Goodner SA, Creekmore AN, Gao F, Govindan R, Ellis MJ, Tan BR, Linette GP, Fu CJ, Pentikis HS, Zumbrun SC, Egorin MJ, Bellet RE
Phase 1 and pharmacokinetic study of weekly docosahexaenoic acid-paclitaxel, Taxoprexin, in resistant solid tumor malignancies.
Cancer Chemother Pharmacol 2009 Feb;63(3):451-8
Wong KK, Fracasso PM, Bukowski RM, Lynch TJ, Munster PN, Shapiro GI, Janne PA, Eder JP, Naughton MJ, Ellis MJ, Jones SF, Mekhail T, Zacharchuk C, Vermette J, Abbas R, Quinn S, Powell C, Burris HA
A phase I study with neratinib (HKI-272), an irreversible pan ErbB receptor tyrosine kinase inhibitor, in patients with solid tumors.
Clin Cancer Res 2009 Apr 1;15(7):2552-8
Parker JS, Mullins M, Cheang MC, Leung S, Voduc D, Vickery T, Davies S, Fauron C, He X, Hu Z, Quackenbush JF, Stijleman IJ, Palazzo J, Marron JS, Nobel AB, Mardis E, Nielsen TO, Ellis MJ, Perou CM, Bernard PS
Supervised risk predictor of breast cancer based on intrinsic subtypes.
J Clin Oncol 2009 Mar 10;27(8):1160-7
Dehdashti F, Mortimer JE, Trinkaus K, Naughton MJ, Ellis M, Katzenellenbogen JA, Welch MJ, Siegel BA
PET-based estradiol challenge as a predictive biomarker of response to endocrine therapy in women with estrogen-receptor-positive breast cancer.
Breast Cancer Res Treat 2009 Feb;113(3):509-17
Crowder RJ, Phommaly C, Tao Y, Hoog J, Luo J, Perou CM, Parker JS, Miller MA, Huntsman DG, Lin L, Snider J, Davies SR, Olson JA Jr, Watson MA, Saporita A, Weber JD, Ellis MJ PIK3CA and PIK3CB inhibition produce synthetic lethality when combined with estrogen deprivation in estrogen receptor-positive breast cancer.
Cancer Res 2009 May 1;69(9):3955-62
Wolff AC, Berry D, Carey LA, Colleoni M, Dowsett M, Ellis M, Garber JE, Mankoff D, Paik S, Pusztai L, Smith ML, Zujewski J
Research issues affecting preoperative systemic therapy for operable breast cancer.
J Clin Oncol 2008 Feb 10;26(5):806-13
Leyland-Jones BR, Ambrosone CB, Bartlett J, Ellis MJ, Enos RA, Raji A, Pins MR, Zujewski JA, Hewitt SM, Forbes JF, Abramovitz M, Braga S, Cardoso F, Harbeck N, Denkert C, Jewell SD
Recommendations for collection and handling of specimens from group breast cancer clinical trials.
J Clin Oncol 2008 Dec 1;26(34):5638-44
Ellis MJ, Tao Y, Luo J, A'Hern R, Evans DB, Bhatnagar AS, Chaudri Ross HA, von Kameke A, Miller WR, Smith I, Eiermann W, Dowsett M
Outcome prediction for estrogen receptor-positive breast cancer based on postneoadjuvant endocrine therapy tumor characteristics.
J Natl Cancer Inst 2008 Oct 1;100(19):1380-8
Brown LA, Hoog J, Chin SF, Tao Y, Zayed AA, Chin K, Teschendorff AE, Quackenbush JF, Marioni JC, Leung S, Perou CM, Neilsen TO, Ellis M, Gray JW, Bernard PS, Huntsman DG, Caldas C
ESR1 gene amplification in breast cancer: a common phenomenon?
Nat Genet 2008 Jul;40(7):806-7; author reply 810-2
Mullins M, Perreard L, Quackenbush JF, Gauthier N, Bayer S, Ellis M, Parker J, Perou CM, Szabo A, Bernard PS
Agreement in breast cancer classification between microarray and quantitative reverse transcription PCR from fresh-frozen and formalin-fixed, paraffin-embedded tissues.
Clin Chem 2007 Jul;53(7):1273-9
Marcom PK, Isaacs C, Harris L, Wong ZW, Kommarreddy A, Novielli N, Mann G, Tao Y, Ellis MJ The combination of letrozole and trastuzumab as first or second-line biological therapy produces durable responses in a subset of HER2 positive and ER positive advanced breast cancers.
Breast Cancer Res Treat 2007 Mar;102(1):43-9
Hayes DF, Thor AD, Dressler LG, Weaver D, Edgerton S, Cowan D, Broadwater G, Goldstein LJ, Martino S, Ingle JN, Henderson IC, Norton L, Winer EP, Hudis CA, Ellis MJ, Berry DA
HER2 and response to paclitaxel in node-positive breast cancer.
N Engl J Med 2007 Oct 11;357(15):1496-506
Ellis MJ, Crowder R
"PIKing" the winner for phosphatidylinositol 3-kinase inhibitors in ErbB2-positive breast cancer: let's not "PTENed" it's easy!
Clin Cancer Res 2007 Oct 1;13(19):5661-2
Hu Z, Fan C, Oh DS, Marron JS, He X, Qaqish BF, Livasy C, Carey LA, Reynolds E, Dressler L, Nobel A, Parker J, Ewend MG, Sawyer LR, Wu J, Liu Y, Nanda R, Tretiakova M, Ruiz Orrico A, Dreher D, Palazzo JP, Perreard L, Nelson E, Mone M, Hansen H, Mullins M, Quackenbush JF, Ellis MJ, Olopade OI, Bernard PS, Perou CM
The molecular portraits of breast tumors are conserved across microarray platforms.
BMC Genomics 2006 Apr 27;7:96
Hayes DF, Cristofanilli M, Budd GT, Ellis MJ, Stopeck A, Miller MC, Matera J, Allard WJ, Doyle GV, Terstappen LW
Circulating tumor cells at each follow-up time point during therapy of metastatic breast cancer patients predict progression-free and overall survival.
Clin Cancer Res 2006 Jul 15;12(14 Pt 1):4218-24
Harris LN, Broadwater G, Lin NU, Miron A, Schnitt SJ, Cowan D, Lara J, Bleiweiss I, Berry D, Ellis M, Hayes DF, Winer EP, Dressler L
Molecular subtypes of breast cancer in relation to paclitaxel response and outcomes in women with metastatic disease: results from CALGB 9342.
Breast Cancer Res 2006;8(6):R66
Ellis MJ, Tao Y, Young O, White S, Proia AD, Murray J, Renshaw L, Faratian D, Thomas J, Dowsett M, Krause A, Evans DB, Miller WR, Dixon JM
Estrogen-independent proliferation is present in estrogen-receptor HER2-positive primary breast cancer after neoadjuvant letrozole.
J Clin Oncol 2006 Jul 1;24(19):3019-25
Budd GT, Cristofanilli M, Ellis MJ, Stopeck A, Borden E, Miller MC, Matera J, Repollet M, Doyle GV, Terstappen LW, Hayes DF
Circulating tumor cells versus imaging--predicting overall survival in metastatic breast cancer.
Clin Cancer Res 2006 Nov 1;12(21):6403-9
Spector NL, Xia W, Burris H 3rd, Hurwitz H, Dees EC, Dowlati A, O'Neil B, Overmoyer B, Marcom PK, Blackwell KL, Smith DA, Koch KM, Stead A, Mangum S, Ellis MJ, Liu L, Man AK, Bremer TM, Harris J, Bacus S
Study of the biologic effects of lapatinib, a reversible inhibitor of ErbB1 and ErbB2 tyrosine kinases, on tumor growth and survival pathways in patients with advanced malignancies.
J Clin Oncol 2005 Apr 10;23(11):2502-12
Crowder RJ, Ellis MJ Treating breast cancer through novel inhibitors of the phosphatidylinositol 3'-kinase pathway.
Breast Cancer Res 2005;7(5):212-4
Cristofanilli M, Hayes DF, Budd GT, Ellis MJ, Stopeck A, Reuben JM, Doyle GV, Matera J, Allard WJ, Miller MC, Fritsche HA, Hortobagyi GN, Terstappen LW
Circulating tumor cells: a novel prognostic factor for newly diagnosed metastatic breast cancer.
J Clin Oncol 2005 Mar 1;23(7):1420-30
Burris HA 3rd, Hurwitz HI, Dees EC, Dowlati A, Blackwell KL, O'Neil B, Marcom PK, Ellis MJ, Overmoyer B, Jones SF, Harris JL, Smith DA, Koch KM, Stead A, Mangum S, Spector NL
Phase I safety, pharmacokinetics, and clinical activity study of lapatinib (GW572016), a reversible dual inhibitor of epidermal growth factor receptor tyrosine kinases, in heavily pretreated patients with metastatic carcinomas.
J Clin Oncol 2005 Aug 10;23(23):5305-13
Wong ZW, Phillips SJ, Ellis MJ Dramatic response of choroidal metastases from breast cancer to a combination of trastuzumab and vinorelbine.
Breast J 2004 Jan-Feb;10(1):54-6
Wong ZW, Ellis MJ First-line endocrine treatment of breast cancer: aromatase inhibitor or antioestrogen?
Br J Cancer 2004 Jan 12;90(1):20-5
Stearns V, Coop A, Singh B, Gallagher A, Yamauchi H, Lieberman R, Pennanen M, Trock B, Hayes DF, Ellis MJ A pilot surrogate end point biomarker trial of perillyl alcohol in breast neoplasia.
Clin Cancer Res 2004 Nov 15;10(22):7583-91
Ellis MJ Importance of correlative science in advancing hormonal therapy and a new clinical paradigm for neoadjuvant therapy.
Ann Surg Oncol 2004 Jan;11(1 Suppl):9S-17S
Dougherty MK, Schumaker LM, Jordan VC, Welshons WV, Curran EM, Ellis MJ, El-Ashry D
Estrogen receptor expression and sensitivity to paclitaxel in breast cancer.
Cancer Biol Ther 2004 May;3(5):460-7
Cristofanilli M, Budd GT, Ellis MJ, Stopeck A, Matera J, Miller MC, Reuben JM, Doyle GV, Allard WJ, Terstappen LW, Hayes DF
Circulating tumor cells, disease progression, and survival in metastatic breast cancer.
N Engl J Med 2004 Aug 19;351(8):781-91
Come SE, Buzdar AU, Arteaga CL, Bissell MJ, Brown MA, Ellis MJ, Goss PE, Green JE, Ingle JN, Lee AV, Medina D, Nicholson RI, Santen RJ, Schiff R, Hart CS
Proceedings of the Third International Conference on Recent Advances and Future Directions in Endocrine Manipulation of Breast Cancer: conference summary statement.
Clin Cancer Res 2004 Jan 1;10(1 Pt 2):327S-330S
Stearns V, Singh B, Tsangaris T, Crawford JG, Novielli A, Ellis MJ, Isaacs C, Pennanen M, Tibery C, Farhad A, Slack R, Hayes DF
A prospective randomized pilot study to evaluate predictors of response in serial core biopsies to single agent neoadjuvant doxorubicin or paclitaxel for patients with locally advanced breast cancer.
Clin Cancer Res 2003 Jan;9(1):124-33
Schneider SM, Ellis M, Coombs WT, Shonkwiler EL, Folsom LC
Virtual reality intervention for older women with breast cancer.
Cyberpsychol Behav 2003 Jun;6(3):301-7
Robertson JF, Osborne CK, Howell A, Jones SE, Mauriac L, Ellis M, Kleeberg UR, Come SE, Vergote I, Gertler S, Buzdar A, Webster A, Morris C
Fulvestrant versus anastrozole for the treatment of advanced breast carcinoma in postmenopausal women: a prospective combined analysis of two multicenter trials.
Cancer 2003 Jul 15;98(2):229-38
Ellis MJ, Rosen E, Dressman H, Marks J
Neoadjuvant comparisons of aromatase inhibitors and tamoxifen: pretreatment determinants of response and on-treatment effect.
J Steroid Biochem Mol Biol 2003 Sep;86(3-5):301-7
Ellis MJ, Coop A, Singh B, Tao Y, Llombart-Cussac A, Janicke F, Mauriac L, Quebe-Fehling E, Chaudri-Ross HA, Evans DB, Miller WR
Letrozole inhibits tumor proliferation more effectively than tamoxifen independent of HER1/2 expression status.
Cancer Res 2003 Oct 1;63(19):6523-31
Osborne CK, Pippen J, Jones SE, Parker LM, Ellis M, Come S, Gertler SZ, May JT, Burton G, Dimery I, Webster A, Morris C, Elledge R, Buzdar A
Double-blind, randomized trial comparing the efficacy and tolerability of fulvestrant versus anastrozole in postmenopausal women with advanced breast cancer progressing on prior endocrine therapy: results of a North American trial.
J Clin Oncol 2002 Aug 15;20(16):3386-95
Ellis M, Davis N, Coop A, Liu M, Schumaker L, Lee RY, Srikanchana R, Russell CG, Singh B, Miller WR, Stearns V, Pennanen M, Tsangaris T, Gallagher A, Liu A, Zwart A, Hayes DF, Lippman ME, Wang Y, Clarke R
Development and validation of a method for using breast core needle biopsies for gene expression microarray analyses.
Clin Cancer Res 2002 May;8(5):1155-66
Ellis MJ, Coop A, Singh B, Mauriac L, Llombert-Cussac A, Janicke F, Miller WR, Evans DB, Dugan M, Brady C, Quebe-Fehling E, Borgs M
Letrozole is more effective neoadjuvant endocrine therapy than tamoxifen for ErbB-1- and/or ErbB-2-positive, estrogen receptor-positive primary breast cancer: evidence from a phase III randomized trial.
J Clin Oncol 2001 Sep 15;19(18):3808-16
Eiermann W, Paepke S, Appfelstaedt J, Llombart-Cussac A, Eremin J, Vinholes J, Mauriac L, Ellis M, Lassus M, Chaudri-Ross HA, Dugan M, Borgs M
Preoperative treatment of postmenopausal breast cancer patients with letrozole: A randomized double-blind multicenter study.
Ann Oncol 2001 Nov;12(11):1527-32
Dressman MA, Walz TM, Lavedan C, Barnes L, Buchholtz S, Kwon I, Ellis MJ, Polymeropoulos MH
Genes that co-cluster with estrogen receptor alpha in microarray analysis of breast biopsies.
Pharmacogenomics J 2001;1(2):135-41
Buzdar AU, Come SE, Brodie A, Ellis M, Goss PE, Ingle JN, Johnston SR, Lee AV, Osborne CK, Vogel VG, Hart CS
Proceedings of the First International Conference on Recent Advances and Future Directions in Endocrine Therapy for Breast Cancer: summary consensus statement.
Clin Cancer Res 2001 Dec;7(12 Suppl):4335s-4337s; discussion 4411s-4412s
DaCosta SA, Schumaker LM, Ellis MJ Mannose 6-phosphate/insulin-like growth factor 2 receptor, a bona fide tumor suppressor gene or just a promising candidate?
J Mammary Gland Biol Neoplasia 2000 Jan;5(1):85-94
Srivastava RK, Lee YN, Noguchi K, Park YG, Ellis MJ, Jeong JS, Kim SN, Cho-Chung YS
The RIIbeta regulatory subunit of protein kinase A binds to cAMP response element: an alternative cAMP signaling pathway.
Proc Natl Acad Sci U S A 1998 Jun 9;95(12):6687-92
Oates AJ, Schumaker LM, Jenkins SB, Pearce AA, DaCosta SA, Arun B, Ellis MJ The mannose 6-phosphate/insulin-like growth factor 2 receptor (M6P/IGF2R), a putative breast tumor suppressor gene.
Breast Cancer Res Treat 1998 Feb;47(3):269-81
Ellis MJ, Jenkins S, Hanfelt J, Redington ME, Taylor M, Leek R, Siddle K, Harris A
Insulin-like growth factors in human breast cancer.
Breast Cancer Res Treat 1998;52(1-3):175-84
Ellis MJ, Leav BA, Yang Z, Rasmussen A, Pearce A, Zweibel JA, Lippman ME, Cullen KJ
Affinity for the insulin-like growth factor-II (IGF-II) receptor inhibits autocrine IGF-II activity in MCF-7 breast cancer cells.
Mol Endocrinol 1996 Mar;10(3):286-97
Ellis MJ, Lindon AC, Flint KJ, Jones NC, Goodbourn S
Activating transcription factor-1 is a specific antagonist of the cyclic adenosine 3'.5'-monophosphate (cAMP) response element-binding protein-1-mediated response to cAMP.
Mol Endocrinol 1995 Feb;9(2):255-65
Ellis MJ, Hurst HC, Goodbourn S
A novel cyclic AMP response element-binding protein-1 (CREB-1) splice product may down-regulate CREB-1 activity.
J Mol Endocrinol 1995 Apr;14(2):191-8
Ellis MJ, Singer C, Hornby A, Rasmussen A, Cullen KJ
Insulin-like growth factor mediated stromal-epithelial interactions in human breast cancer.
Breast Cancer Res Treat 1994;31(2-3):249-61
Masson N, Ellis M, Goodbourn S, Lee KA
Cyclic AMP response element-binding protein and the catalytic subunit of protein kinase A are present in F9 embryonal carcinoma cells but are unable to activate the somatostatin promoter.
Mol Cell Biol 1992 Mar;12(3):1096-106
Cullen KJ, Allison A, Martire I, Ellis M, Singer C
Insulin-like growth factor expression in breast cancer epithelium and stroma.
Breast Cancer Res Treat 1992;22(1):21-9