Timothy A. Graubert, M.D.

Funk RK, Maxwell TJ, Izumi M, Edwin D, Kreisel F, Ley TJ, Cheverud JM, Graubert TA
Quantitative trait loci associated with susceptibility to therapy-related acute murine promyelocytic leukemia in hCG-PML/RARA transgenic mice.
Blood 2008 Jun 13; [Epub ahead of print]

Cahan P, Godfrey LE, Eis PS, Richmond TA, Selzer RR, Brent M, McLeod HL, Ley TJ, Graubert TA
wuHMM: a robust algorithm to detect DNA copy number variation using long oligonucleotide microarray data.
Nucleic Acids Res 2008 Apr;36(7):e41

Tomasson MH, Xiang Z, Walgren R, Zhao Y, Kasai Y, Miner T, Ries RE, Lubman O, Fremont D, McLellan MD, Payton JE, Westervelt P, Dipersio JF, Link DC, Walter MJ, Graubert TA, Watson M, Baty J, Heath S, Shannon WD, Nagarajan R, Bloomfield CD, Mardis ER, Wilson RK, Ley TJ
Somatic mutations and germline sequence variants in the expressed tyrosine kinase genes of patients with de novo acute myeloid leukemia.
Blood 2008 May 1;111(9):4797-808

Xiang Z, Zhao Y, Mitaksov V, Fremont DH, Kasai Y, Molitoris A, Ries RE, Miner TL, McLellan MD, Dipersio JF, Link DC, Payton JE, Graubert TA, Watson M, Shannon W, Heath SE, Naggarajan R, Mardis ER, Wilson RK, Ley TJ, Tomasson MH
Identification of somatic JAK1 mutations in patients with acute myeloid leukemia.
Blood 2008 May 1;111(9):4809-12

Fong T, Trinkaus K, Adkins D, Vij R, Devine SM, Tomasson M, Goodnough LT, Lopez S, Graubert T, Shenoy S, Dipersio JF, Khoury HJ
A Randomized Double-Blind Trial of Hydroxychloroquine for the Prevention of Chronic Graft-versus-Host Disease after Allogeneic Peripheral Blood Stem Cell Transplantation.
Biol Blood Marrow Transplant 2007 Oct;13(10):1201-6

Graubert TA, Cahan P, Edwin D, Selzer RR, Richmond TA, Eis PS, Shannon WD, Li X, McLeod HL, Cheverud JM, Ley TJ
A High-Resolution Map of Segmental DNA Copy Number Variation in the Mouse Genome.
PLoS Genet 2007 Jan 5;3(1):e3

Hake CR, Graubert TA, Fenske TS
Does autologous transplantation directly increase the risk of secondary leukemia in lymphoma patients?
Bone Marrow Transplant 2007 Jan;39(2):59-70

Knoche E, McLeod HL, Graubert TA
Pharmacogenetics of alkylator-associated acute myeloid leukemia.
Pharmacogenomics 2006 Jul;7(5):719-29

Fenske TS, McMahon C, Edwin D, Jarvis JC, Cheverud JM, Minn M, Mathews V, Bogue MA, Province MA, McLeod HL, Graubert TA
Identification of candidate alkylator-induced cancer susceptibility genes by whole genome scanning in mice.
Cancer Res 2006 May 15;66(10):5029-38

Devine SM, Brown RA, Mathews V, Trinkaus K, Khoury H, Adkins D, Vij R, Sempek D, Graubert T, Tomasson M, Goodnough LT, DiPersio JF
Reduced risk of acute GVHD following mobilization of HLA-identical sibling donors with GM-CSF alone.
Bone Marrow Transplant 2005 Sep;36(6):531-8

Mitchell PO, Mills T, O'Connor RS, Graubert T, Dzierzak E, Pavlath GK
Sca-1 negatively regulates proliferation and differentiation of muscle cells.
Dev Biol 2005 Jul 1;283(1):240-52

Bradfute SB, Graubert TA, Goodell MA
Roles of Sca-1 in hematopoietic stem/progenitor cell function.
Exp Hematol 2005 Jul;33(7):836-43

Fenske TS, Pengue G, Mathews V, Hanson PT, Hamm SE, Riaz N, Graubert TA
Stem cell expression of the AML1/ETO fusion protein induces a myeloproliferative disorder in mice.
Proc Natl Acad Sci U S A 2004 Oct 19;101(42):15184-9

Mathews V, Hanson PT, Ford E, Fujita J, Polonsky KS, Graubert TA
Recruitment of bone marrow-derived endothelial cells to sites of pancreatic beta-cell injury.
Diabetes 2004 Jan;53(1):91-8

Hidalgo JD, Krone R, Rich MW, Blum K, Adkins D, Fan MY, Brown R, Devine S, Graubert T, Blum W, Tomasson M, Goodnough LT, Vij R, DiPersio J, Khoury H
Supraventricular tachyarrhythmias after hematopoietic stem cell transplantation: incidence, risk factors and outcomes.
Bone Marrow Transplant 2004 Oct;34(7):615-9

Ley TJ, Minx PJ, Walter MJ, Ries RE, Sun H, McLellan M, DiPersio JF, Link DC, Tomasson MH, Graubert TA, McLeod H, Khoury H, Watson M, Shannon W, Trinkaus K, Heath S, Vardiman JW, Caligiuri MA, Bloomfield CD, Milbrandt JD, Mardis ER, Wilson RK
A pilot study of high-throughput, sequence-based mutational profiling of primary human acute myeloid leukemia cell genomes.
Proc Natl Acad Sci U S A 2003 Nov 25;100(24):14275-80

Chohan R, Vij R, Adkins D, Blum W, Brown R, Tomasson M, Devine S, Graubert T, Goodnough LT, DiPersio JF, Khoury H
Long-term outcomes of allogeneic stem cell transplant recipients after calcineurin inhibitor-induced neurotoxicity.
Br J Haematol 2003 Oct;123(1):110-3

Watters JW, Kloss EF, Link DC, Graubert TA, McLeod HL
A mouse-based strategy for cyclophosphamide pharmacogenomic discovery.
J Appl Physiol 2003 Oct;95(4):1352-60

Hanson P, Mathews V, Marrus SH, Graubert TA
Enhanced green fluorescent protein targeted to the Sca-1 (Ly-6A) locus in transgenic mice results in efficient marking of hematopoietic stem cells in vivo.
Exp Hematol 2003 Feb;31(2):159-67

Welm BE, Tepera SB, Venezia T, Graubert TA, Rosen JM, Goodell MA
Sca-1(pos) cells in the mouse mammary gland represent an enriched progenitor cell population.
Dev Biol 2002 May 1;245(1):42-56

Patterson JM, Johnson MH, Zimonjic DB, Graubert TA
Characterization of Ly-6M, a novel member of the Ly-6 family of hematopoietic proteins.
Blood 2000 May 15;95(10):3125-32

Shresta S, Graubert TA, Thomas DA, Raptis SZ, Ley TJ
Granzyme A initiates an alternative pathway for granule-mediated apoptosis.
Immunity 1999 May;10(5):595-605

Graubert TA, Hug BA, Wesselschmidt R, Hsieh CL, Ryan TM, Townes TM, Ley TJ
Stochastic, stage-specific mechanisms account for the variegation of a human globin transgene.
Nucleic Acids Res 1998 Jun 15;26(12):2849-58

Graubert TA, DiPersio JF, Russell JH, Ley TJ
Perforin/granzyme-dependent and independent mechanisms are both important for the development of graft-versus-host disease after murine bone marrow transplantation.
J Clin Invest 1997 Aug 15;100(4):904-11

Graubert TA, Russell JH, Ley TJ
The role of granzyme B in murine models of acute graft-versus-host disease and graft rejection.
Blood 1996 Feb 15;87(4):1232-7

Berliner N, Hsing A, Graubert T, Sigurdsson F, Zain M, Bruno E, Hoffman R
Granulocyte colony-stimulating factor induction of normal human bone marrow progenitors results in neutrophil-specific gene expression.
Blood 1995 Feb 1;85(3):799-803

Strair RK, Medina DJ, Nelson CJ, Graubert TA, Mellors JW
Recombinant retroviral systems for the analysis of drug resistant HIV.
Nucleic Acids Res 1993 Oct 11;21(20):4836-42

Graubert T, Johnston J, Berliner N
Cloning and expression of the cDNA encoding mouse neutrophil gelatinase: demonstration of coordinate secondary granule protein gene expression during terminal neutrophil maturation.
Blood 1993 Nov 15;82(10):3192-7