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Song X, Lasanajak Y, Olson LJ, Boonen M, Dahms NM, Kornfeld S, Cummings RD, Smith DF
Glycan microarray analysis of P-type lectins reveals distinct phospho-mannose glycan recognition.
J Biol Chem 2009 Sep 28; [Epub ahead of print]
Boonen M, Vogel P, Platt KA, Dahms N, Kornfeld S Mice lacking mannose 6-phosphate uncovering enzyme activity have a milder phenotype than mice deficient for N-acetylglucosamine-1-phosphotransferase activity.
Mol Biol Cell 2009 Oct;20(20):4381-9
Muslin AJ, Kornfeld S, Polonsky KS
The physician scientist training program in internal medicine at Washington University School of Medicine.
Acad Med 2009 Apr;84(4):468-71
Varki A, Kornfeld S P-type Lectins.
In: Varki A, Cummings RD, Esko JD, Freeze HH, Stanley P, Bertozzi CR, Hart GW, Etzler ME (Eds), Essentials of Glycobiology (2nd ed), 425-437. Cold Spring Harbor: Cold Spring Harbor Laboratory Press, 2009
Vogel P, Payne BJ, Read R, Lee WS, Gelfman CM, Kornfeld S Comparative pathology of murine mucolipidosis types II and IIIC.
Vet Pathol 2009 Mar;46(2):313-24
Lee I, Drake MT, Traub LM, Kornfeld S Cargo-sorting signals promote polymerization of adaptor protein-1 in an Arf-1.GTP-independent manner.
Arch Biochem Biophys 2008 Nov 1;479(1):63-8
Doray B, Knisely JM, Wartman L, Bu G, Kornfeld S Identification of acidic dileucine signals in LRP9 that interact with both GGAs and AP-1/AP-2.
Traffic 2008 Sep;9(9):1551-62
Lee I, Doray B, Govero J, Kornfeld S Binding of cargo sorting signals to AP-1 enhances its association with ADP ribosylation factor 1-GTP.
J Cell Biol 2008 Feb 11;180(3):467-72
Gelfman CM, Vogel P, Issa TM, Turner CA, Lee WS, Kornfeld S, Rice DS
Mice lacking alpha/beta subunits of GlcNAc-1-phosphotransferase exhibit growth retardation, retinal degeneration, and secretory cell lesions.
Invest Ophthalmol Vis Sci 2007 Nov;48(11):5221-8
Lee WS, Payne BJ, Gelfman CM, Vogel P, Kornfeld S Murine UDP-GlcNAc:lysosomal enzyme N-acetylglucosamine-1-phosphotransferase lacking the gamma-subunit retains substantial activity toward acid hydrolases.
J Biol Chem 2007 Sep 14;282(37):27198-203
Doray B, Lee I, Knisely J, Bu G, Kornfeld S The gamma/sigma1 and alpha/sigma2 hemicomplexes of clathrin adaptors AP-1 and AP-2 harbor the dileucine recognition site.
Mol Biol Cell 2007 May;18(5):1887-96
Steet R, Chung S, Lee WS, Pine CW, Do H, Kornfeld S Selective action of the iminosugar isofagomine, a pharmacological chaperone for mutant forms of acid-beta-glucosidase.
Biochem Pharmacol 2007 May 1;73(9):1376-83
Steet RA, Chung S, Wustman B, Powe A, Do H, Kornfeld SA The iminosugar isofagomine increases the activity of N370S mutant acid beta-glucosidase in Gaucher fibroblasts by several mechanisms.
Proc Natl Acad Sci U S A 2006 Sep 12;103(37):13813-8
Steet RA, Hullin R, Kudo M, Martinelli M, Bosshard NU, Schaffner T, Kornfeld S, Steinmann B
A splicing mutation in the alpha/beta GlcNAc-1-phosphotransferase gene results in an adult onset form of mucolipidosis III associated with sensory neuropathy and cardiomyopathy.
Am J Med Genet A 2005 Feb 1;132(4):369-75
Insel PA, Kornfeld S, Majerus PW, Marks AR, Marks PA, Relman AS, Scharschmidt BF, Stossel TP, Varki AP, Weiss SJ, Wilson JD
Blasts from the past.
J Clin Invest 2004 Oct;114(8):1017-33
Sullivan B, Kornfeld SA, Frieden C, Goldberg DE
The Washington University Medical Scientist Training Program.
Mo Med 2004 Sep-Oct;101(5):491-5
Wu X, Steet RA, Bohorov O, Bakker J, Newell J, Krieger M, Spaapen L, Kornfeld S, Freeze HH
Mutation of the COG complex subunit gene COG7 causes a lethal congenital disorder.
Nat Med 2004 May;10(5):518-23
Bai H, Doray B, Kornfeld S GGA1 interacts with the adaptor protein AP-1 through a WNSF sequence in its hinge region.
J Biol Chem 2004 Apr 23;279(17):17411-7
Ghosh P, Kornfeld S Phosphorylation-induced conformational changes regulate GGAs 1 and 3 function at the trans-Golgi network.
J Biol Chem 2003 Apr 18;278(16):14543-9
Ghosh P, Kornfeld S AP-1 binding to sorting signals and release from clathrin-coated vesicles is regulated by phosphorylation.
J Cell Biol 2003 Mar 3;160(5):699-708
Doray B, Ghosh P, Griffith J, Geuze HJ, Kornfeld S Cooperation of GGAs and AP-1 in packaging MPRs at the trans-Golgi network.
Science 2002 Sep 6;297(5587):1700-3
Do H, Lee WS, Ghosh P, Hollowell T, Canfield W, Kornfeld S Human mannose 6-phosphate uncovering enzyme is synthesized as a pro-enzyme that is activated by the endoprotease furin.
J Biol Chem 2002 Aug 16;277(33):29737-44
Doray B, Bruns K, Ghosh P, Kornfeld S Interaction of the cation-dependent mannose 6-phosphate receptor with GGA proteins.
J Biol Chem 2002 May 24;277(21):18477-82
Lee WS, Rohrer J, Kornfeld R, Kornfeld S Multiple signals regulate trafficking of the mannose 6-phosphate-uncovering enzyme.
J Biol Chem 2002 Feb 1;277(5):3544-51
Zhu Y, Doray B, Poussu A, Lehto VP, Kornfeld S Binding of GGA2 to the lysosomal enzyme sorting motif of the mannose 6-phosphate receptor.
Science 2001 Jun 1;292(5522):1716-8
Doray B, Kornfeld S gamma Subunit of the ap-1 adaptor complex binds clathrIn: implications for cooperative binding in coated vesicle assembly.
Mol Biol Cell 2001 Jul;12(7):1925-35
Kornfeld S, Sly WS
I-cell disease and pseudo-Hurler polydystrophy: Disorders of lysosomal enzyme phosphorylation and localization.
In C.R. Scriver, A.L. Beaudet, W.S. Sly, and D. Valle (Eds), The Metabolic Basis of Inherited Disease (8th ed), Vol. III, 3469-3482. New York: McGraw Hill, 2001
Zhu Y, Drake MT, Kornfeld S Adaptor protein 1-dependent clathrin coat assembly on synthetic liposomes and Golgi membranes.
Methods Enzymol 2001;329:379-87
Drake MT, Zhu Y, Kornfeld S The assembly of AP-3 adaptor complex-containing clathrin-coated vesicles on synthetic liposomes.
Mol Biol Cell 2000 Nov;11(11):3723-36
Nishikawa A, Nanda A, Gregory W, Frenz J, Kornfeld S Identification of amino acids that modulate mannose phosphorylation of mouse DNase I, a secretory glycoprotein [In Process Citation]
J Biol Chem 1999 Jul 2;274(27):19309-15
Zhu Y, Traub LM, Kornfeld S High-affinity binding of the AP-1 adaptor complex to trans-golgi network membranes devoid of mannose 6-phosphate receptors.
Mol Biol Cell 1999 Mar;10(3):537-49
York SJ, Arneson LS, Gregory WT, Dahms NM, Kornfeld S The rate of internalization of the mannose 6-phosphate/insulin-like growth factor II receptor is enhanced by multivalent ligand binding.
J Biol Chem 1999 Jan 8;274(2):1164-71
Zhu Y, Traub LM, Kornfeld S ADP-ribosylation factor 1 transiently activates high-affinity adaptor protein complex AP-1 binding sites on Golgi membranes.
Mol Biol Cell 1998 Jun;9(6):1323-37
Nykjaer A, Christensen EI, Vorum H, Hager H, Petersen CM, Roigaard H, Min HY, Vilhardt F, Moller LB, Kornfeld S, Gliemann J
Mannose 6-phosphate/insulin-like growth factor-II receptor targets the urokinase receptor to lysosomes via a novel binding interaction.
J Cell Biol 1998 May 4;141(3):815-28
Kornfeld S Diseases of abnormal protein glycosylation: An emerging area.
J Clin Invest 1998;101:1293-1295
Kundra R, Kornfeld S Wortmannin retards the movement of the mannose 6-phosphate/insulin-like growth factor II receptor and its ligand out of endosomes.
J Biol Chem 1998 Feb 13;273(7):3848-53
Schweizer A, Kornfeld S, Rohrer J
Proper sorting of the cation-dependent mannose 6-phosphate receptor in endosomes depends on a pair of aromatic amino acids in its cytoplasmic tail.
Proc Natl Acad Sci U S A 1997 Dec 23;94(26):14471-6
Liang JO, Sung TC, Morris AJ, Frohman MA, Kornfeld S Different domains of mammalian ADP-ribosylation factor 1 mediate interaction with selected target proteins.
J Biol Chem 1997 Dec 26;272(52):33001-8
Nishikawa A, Gregory W, Frenz J, Cacia J, Kornfeld S The phosphorylation of bovine DNase I Asn-linked oligosaccharides is dependent on specific lysine and arginine residues.
J Biol Chem 1997 Aug 1;272(31):19408-12
Liang JO, Kornfeld S Comparative activity of ADP-ribosylation factor family members in the early steps of coated vesicle formation on rat liver Golgi membranes [published erratum appears in J Biol Chem 1998 Jan 23;273(4):2488]
J Biol Chem 1997 Feb 14;272(7):4141-8
Traub LM, Bannykh SI, Rodel JE, Aridor M, Balch WE, Kornfeld S AP-2-containing clathrin coats assemble on mature lysosomes.
J Cell Biol 1996 Dec;135(6 Pt 2):1801-14
Glickman JN, Morton PA, Slot JW, Kornfeld S, Geuze HJ
The biogenesis of the MHC class II compartment in human I-cell disease B lymphoblasts.
J Cell Biol 1996 Mar;132(5):769-85
Schweizer A, Kornfeld S, Rohrer J
Cysteine34 of the cytoplasmic tail of the cation-dependent mannose 6- phosphate receptor is reversibly palmitoylated and required for normal trafficking and lysosomal enzyme sorting.
J Cell Biol 1996 Feb;132(4):577-84
Rohrer J, Schweizer A, Russell D, Kornfeld S The targeting of Lamp1 to lysosomes is dependent on the spacing of its cytoplasmic tail tyrosine sorting motif relative to the membrane.
J Cell Biol 1996 Feb;132(4):565-76
Dustin ML, McCourt DW, Kornfeld S A mannose 6-phosphate-containing N-linked glycopeptide derived from lysosomal acid lipase is bound to MHC class II in B lymphoblastoid cell lines.
J Immunol 1996 Mar 1;156(5):1841-7
Rohrer J, Schweizer A, Johnson KF, Kornfeld S A determinant in the cytoplasmic tail of the cation-dependent mannose 6- phosphate receptor prevents trafficking to lysosomes.
J Cell Biol 1995 Sep;130(6):1297-306
Kornfeld S, Sly WS
I-cell disease and pseudo-Hurler polydystrophy: Disorders of lysosomal enzyme phosphorylation and localization.
In CR Scriver, AL Beaudet, WS Sly, and D Valle (Eds.), The Metabolic Basis of Inherited Disease (7th ed), pp. 2495-2508. 1995. New York: McGraw Hill
Traub LM, Kornfeld S, Ungewickell E
Different domains of the AP-1 adaptor complex are required for Golgi membrane binding and clathrin recruitment.
J Biol Chem 1995 Mar 3;270(9):4933-42
Dustin ML, Baranski TJ, Sampath D, Kornfeld S A novel mutagenesis strategy identifies distantly spaced amino acid sequences that are required for the phosphorylation of both the oligosaccharides of procathepsin D by N-acetylglucosamine 1- phosphotransferase.
J Biol Chem 1995 Jan 6;270(1):170-9
Brunetti CR, Burke RL, Kornfeld S, Gregory W, Masiarz FR, Dingwell KS, Johnson DC
Herpes simplex virus glycoprotein D acquires mannose 6-phosphate residues and binds to mannose 6-phosphate receptors.
J Biol Chem 1994 Jun 24;269(25):17067-74
Schweizer A, Rohrer J, Hauri HP, Kornfeld S Retention of p63 in an ER-Golgi intermediate compartment depends on the presence of all three of its domains and on its ability to form oligomers.
J Cell Biol 1994 Jul;126(1):25-39
Glickman JN, Kornfeld S Mannose 6-phosphate-independent targeting of lysosomal enzymes in I- cell disease B lymphoblasts.
J Cell Biol 1993 Oct;123(1):99-108
Cantor AB, Kornfeld S Phosphorylation of Asn-linked oligosaccharides located at novel sites on the lysosomal enzyme cathepsin D.
J Biol Chem 1992 Nov 15;267(32):23357-63
Cantor AB, Baranski TJ, Kornfeld S Lysosomal enzyme phosphorylation. II. Protein recognition determinants in either lobe of procathepsin D are sufficient for phosphorylation of both the amino and carboxyl lobe oligosaccharides.
J Biol Chem 1992 Nov 15;267(32):23349-56
Baranski TJ, Cantor AB, Kornfeld S Lysosomal enzyme phosphorylation. I. Protein recognition determinants in both lobes of procathepsin D mediate its interaction with UDP- GlcNAc:lysosomal enzyme N-acetylglucosamine-1-phosphotransferase.
J Biol Chem 1992 Nov 15;267(32):23342-8
Johnson KF, Kornfeld S The cytoplasmic tail of the mannose 6-phosphate/insulin-like growth factor-II receptor has two signals for lysosomal enzyme sorting in the Golgi.
J Cell Biol 1992 Oct;119(2):249-57
Johnson KF, Kornfeld S A His-Leu-Leu sequence near the carboxyl terminus of the cytoplasmic domain of the cation-dependent mannose 6-phosphate receptor is necessary for the lysosomal enzyme sorting function.
J Biol Chem 1992 Aug 25;267(24):17110-5
Cantor AB, Kornfeld S A method for [3H]mannose labeling of Asn-linked oligosaccharides on recombinant glycoproteins synthesized in Xenopus oocytes.
Anal Biochem 1992 Sep;205(2):220-6
Ketcham CM, Kornfeld S Characterization of UDP-N-acetylglucosamine:glycoprotein N- acetylglucosamine-1-phosphotransferase from Acanthamoeba castellanii.
J Biol Chem 1992 Jun 5;267(16):11654-9
Ketcham CM, Kornfeld S Purification of UDP-N-acetylglucosamine:glycoprotein N- acetylglucosamine-1-phosphotransferase from Acanthamoeba castellanii and identification of a subunit of the enzyme.
J Biol Chem 1992 Jun 5;267(16):11645-53
Jadot M, Canfield WM, Gregory W, Kornfeld S Characterization of the signal for rapid internalization of the bovine mannose 6-phosphate/insulin-like growth factor-II receptor.
J Biol Chem 1992 Jun 5;267(16):11069-77
Kornfeld S Structure and function of the mannose 6-phosphate/insulinlike growth factor II receptors.
Annu Rev Biochem 1992;61:307-30
Baranski TJ, Koelsch G, Hartsuck JA, Kornfeld S Mapping and molecular modeling of a recognition domain for lysosomal enzyme targeting.
J Biol Chem 1991 Dec 5;266(34):23365-72
Westlund B, Dahms NM, Kornfeld S The bovine mannose 6-phosphate/insulin-like growth factor II receptor. Localization of mannose 6-phosphate binding sites to domains 1-3 and 7- 11 of the extracytoplasmic region.
J Biol Chem 1991 Dec 5;266(34):23233-9
Canfield WM, Johnson KF, Ye RD, Gregory W, Kornfeld S Localization of the signal for rapid internalization of the bovine cation-independent mannose 6-phosphate/insulin-like growth factor-II receptor to amino acids 24-29 of the cytoplasmic tail.
J Biol Chem 1991 Mar 25;266(9):5682-8
Johnson KF, Chan W, Kornfeld S Cation-dependent mannose 6-phosphate receptor contains two internalization signals in its cytoplasmic domain [published erratum appears in Proc Natl Acad Sci U S A 1991 Feb 15;88(4):1591]
Proc Natl Acad Sci U S A 1990 Dec;87(24):10010-4
Baranski TJ, Faust PL, Kornfeld S Generation of a lysosomal enzyme targeting signal in the secretory protein pepsinogen.
Cell 1990 Oct 19;63(2):281-91
Kornfeld S Role of Mannose 6-Phosphate Receptors in Lysosomal Enzyme Targeting.
In: Proceedings of the Robert A. Welch Foundation Conference on Chemical Research. XXXIII. Membrane Proteins: Targeting and Transduction, 143-155, 1990
Messner DJ, Griffiths G, Kornfeld S Isolation and characterization of membranes from bovine liver which are highly enriched in mannose 6-phosphate receptors.
J Cell Biol 1989 Jun;108(6):2149-62
Lobel P, Fujimoto K, Ye RD, Griffiths G, Kornfeld S Mutations in the cytoplasmic domain of the 275 kd mannose 6-phosphate receptor differentially alter lysosomal enzyme sorting and endocytosis.
Cell 1989 Jun 2;57(5):787-96
Dahms NM, Kornfeld S The cation-dependent mannose 6-phosphate receptor. Structural requirements for mannose 6-phosphate binding and oligomerization.
J Biol Chem 1989 Jul 5;264(19):11458-67
Canfield WM, Kornfeld S The chicken liver cation-independent mannose 6-phosphate receptor lacks the high affinity binding site for insulin-like growth factor II.
J Biol Chem 1989 May 5;264(13):7100-3
Tong PY, Kornfeld S Ligand interactions of the cation-dependent mannose 6-phosphate receptor. Comparison with the cation-independent mannose 6-phosphate receptor.
J Biol Chem 1989 May 15;264(14):7970-5
Tong PY, Gregory W, Kornfeld S Ligand interactions of the cation-independent mannose 6-phosphate receptor. The stoichiometry of mannose 6-phosphate binding.
J Biol Chem 1989 May 15;264(14):7962-9
Faust PL, Kornfeld S Expression of the yeast aspartyl protease, proteinase A. Phosphorylation and binding to the mannose 6-phosphate receptor are altered by addition of cathepsin D sequences.
J Biol Chem 1989 Jan 5;264(1):479-88
Griffiths G, Hoflack B, Simons K, Mellman I, Kornfeld S The mannose 6-phosphate receptor and the biogenesis of lysosomes.
Cell 1988 Feb 12;52(3):329-41
Tong PY, Tollefsen SE, Kornfeld S The cation-independent mannose 6-phosphate receptor binds insulin-like growth factor II.
J Biol Chem 1988 Feb 25;263(6):2585-8
Lobel P, Dahms NM, Kornfeld S Cloning and sequence analysis of the cation-independent mannose 6- phosphate receptor.
J Biol Chem 1988 Feb 15;263(5):2563-70
Duncan JR, Kornfeld S Intracellular movement of two mannose 6-phosphate receptors: return to the Golgi apparatus.
J Cell Biol 1988 Mar;106(3):617-28
Faust PL, Wall DA, Perara E, Lingappa VR, Kornfeld S Expression of human cathepsin D in Xenopus oocytes: phosphorylation and intracellular targeting.
J Cell Biol 1987 Nov;105(5):1937-45
Dahms NM, Lobel P, Breitmeyer J, Chirgwin JM, Kornfeld S 46 kd mannose 6-phosphate receptor: cloning, expression, and homology to the 215 kd mannose 6-phosphate receptor.
Cell 1987 Jul 17;50(2):181-92
Lobel P, Dahms NM, Breitmeyer J, Chirgwin JM, Kornfeld S Cloning of the bovine 215-kDa cation-independent mannose 6-phosphate receptor [published erratum appears in Proc Natl Acad Sci U S A 1987 Nov;84(21):7523]
Proc Natl Acad Sci U S A 1987 Apr;84(8):2233-7
Couso R, van Halbeek H, Reinhold V, Kornfeld S The high mannose oligosaccharides of Dictyostelium discoideum glycoproteins contain a novel intersecting N-acetylglucosamine residue.
J Biol Chem 1987 Apr 5;262(10):4521-7
Hoflack B, Fujimoto K, Kornfeld S The interaction of phosphorylated oligosaccharides and lysosomal enzymes with bovine liver cation-dependent mannose 6-phosphate receptor.
J Biol Chem 1987 Jan 5;262(1):123-9
Couso R, Lang L, Roberts RM, Kornfeld S Phosphorylation of the oligosaccharide of uteroferrin by UDP- GlcNAc:glycoprotein N-acetylglucosamine-1-phosphotransferases from rat liver, Acanthamoeba castellani, and Dictyostelium discoideum requires alpha 1,2-linked mannose residues.
J Biol Chem 1986 May 15;261(14):6326-31
Lang L, Couso R, Kornfeld S Glycoprotein phosphorylation in simple eucaryotic organisms. Identification of UDP-GlcNAc:glycoprotein N-acetylglucosamine-1- phosphotransferase activity and analysis of substrate specificity.
J Biol Chem 1986 May 15;261(14):6320-5
Elhammer A, Kornfeld S Purification and characterization of UDP-N-acetylgalactosamine: polypeptide N-acetylgalactosaminyltransferase from bovine colostrum and murine lymphoma BW5147 cells.
J Biol Chem 1986 Apr 25;261(12):5249-55
Davis CG, Elhammer A, Russell DW, Schneider WJ, Kornfeld S, Brown MS, Goldstein JL
Deletion of clustered O-linked carbohydrates does not impair function of low density lipoprotein receptor in transfected fibroblasts.
J Biol Chem 1986 Feb 25;261(6):2828-38
Lang L, Takahashi T, Tang J, Kornfeld S Lysosomal enzyme phosphorylation in human fibroblasts. Kinetic parameters offer a biochemical rationale for two distinct defects in the uridine diphospho-N-acetylglucosamine:lysosomal enzyme precursor N- acetylglucosamine-1-phosphotransferase.
J Clin Invest 1985 Dec;76(6):2191-5
Hoflack B, Kornfeld S Purification and characterization of a cation-dependent mannose 6- phosphate receptor from murine P388D1 macrophages and bovine liver.
J Biol Chem 1985 Oct 5;260(22):12008-14
Hoflack B, Kornfeld S Lysosomal enzyme binding to mouse P388D1 macrophage membranes lacking the 215-kDa mannose 6-phosphate receptor: evidence for the existence of a second mannose 6-phosphate receptor.
Proc Natl Acad Sci U S A 1985 Jul;82(13):4428-32
Lang L, Reitman M, Tang J, Roberts RM, Kornfeld S Lysosomal enzyme phosphorylation. Recognition of a protein-dependent determinant allows specific phosphorylation of oligosaccharides present on lysosomal enzymes.
J Biol Chem 1984 Dec 10;259(23):14663-71
Gabel CA, Costello CE, Reinhold VN, Kurz L, Kornfeld S Identification of methylphosphomannosyl residues as components of the high mannose oligosaccharides of Dictyostelium discoideum glycoproteins.
J Biol Chem 1984 Nov 25;259(22):13762-9
Conzelmann A, Kornfeld S A murine cytotoxic T lymphocyte cell line resistant to Vicia villosa lectin is deficient in UDP-GalNAc:beta-galactose beta 1,4-N- acetylgalactosaminyltransferase.
J Biol Chem 1984 Oct 25;259(20):12536-42
Conzelmann A, Kornfeld S Beta-linked N-acetylgalactosamine residues present at the nonreducing termini of O-linked oligosaccharides of a cloned murine cytotoxic T lymphocyte line are absent in a Vicia villosa lectin-resistant mutant cell line.
J Biol Chem 1984 Oct 25;259(20):12528-35
Reitman ML, Lang L, Kornfeld S UDP-N-acetylglucosamine: lysosomal enzyme N-acetylglucosamine-1- phosphotransferase.
Methods Enzymol 1984;107:163-72
Cummings RD, Kornfeld S The distribution of repeating [Gal beta 1,4GlcNAc beta 1,3] sequences in asparagine-linked oligosaccharides of the mouse lymphoma cell lines BW5147 and PHAR 2.1.
J Biol Chem 1984 May 25;259(10):6253-60
Elhammer A, Kornfeld S Two enzymes involved in the synthesis of O-linked oligosaccharides are localized on membranes of different densities in mouse lymphoma BW5147 cells.
J Cell Biol 1984 Jul;99(1 Pt 1):327-31
Gabel CA, Kornfeld S Targeting of beta-glucuronidase to lysosomes in mannose 6-phosphate receptor-deficient MOPC 315 cells.
J Cell Biol 1984 Jul;99(1 Pt 1):296-305
Lang L, Kornfeld S A simplified procedure for synthesizing large quantities of highly purified uridine [beta-32P]diphospho-N-acetylglucosamine.
Anal Biochem 1984 Jul;140(1):264-9
Goldberg DE, Gabel CA, Kornfeld S Processing of lysosomal enzyme oligosaccharide units.
In: Lysosomes in Biology and Pathology, 7, JT Dingle, RT Dean and W Sly (eds.)., Elsevier Science Publishers, 45-62, 1984
Goldberg DE, Gabel CA, Kornfeld S Studies of the biosynthesis of the mannose 6-phosphate receptor in receptor-positive and -deficient cell lines.
J Cell Biol 1983 Dec;97(6):1700-6
Cummings RD, Kornfeld S, Schneider WJ, Hobgood KK, Tolleshaug H, Brown MS, Goldstein JL
Biosynthesis of N- and O-linked oligosaccharides of the low density lipoprotein receptor.
J Biol Chem 1983 Dec 25;258(24):15261-73
Freeze HH, Yeh R, Miller AL, Kornfeld S The mod A mutant of Dictyostelium discoideum is missing the alpha 1,3- glucosidase involved in asparagine-linked oligosaccharide processing.
J Biol Chem 1983 Dec 25;258(24):14880-4
Freeze HH, Yeh R, Miller AL, Kornfeld S Structural analysis of the asparagine-linked oligosaccharides from three lysosomal enzymes of Dictyostelium discoideum. Evidence for an unusual acid-stable phosphodiester.
J Biol Chem 1983 Dec 25;258(24):14874-9
Varki A, Sherman W, Kornfeld S Demonstration of the enzymatic mechanisms of alpha-N-acetyl-D- glucosamine-1-phosphodiester N-acetylglucosaminidase (formerly called alpha-N-acetylglucosaminylphosphodiesterase) and lysosomal alpha-N- acetylglucosaminidase.
Arch Biochem Biophys 1983 Apr 1;222(1):145-9
Goldberg DE, Kornfeld S Evidence for extensive subcellular organization of asparagine-linked oligosaccharide processing and lysosomal enzyme phosphorylation.
J Biol Chem 1983 Mar 10;258(5):3159-65
Varki A, Kornfeld S The spectrum of anionic oligosaccharides released by endo-beta-N- acetylglucosaminidase H from glycoproteins. Structural studies and interactions with the phosphomannosyl receptor.
J Biol Chem 1983 Mar 10;258(5):2808-18
Gabel CA, Goldberg DE, Kornfeld S Identification and characterization of cells deficient in the mannose 6- phosphate receptor: evidence for an alternate pathway for lysosomal enzyme targeting.
Proc Natl Acad Sci U S A 1983 Feb;80(3):775-9
Rearick JI, Kulczycki A Jr, Kornfeld S Structural studies of oligosaccharides of rat IgE and reexamination of the high-mannose oligosaccharide of human IgE.
Arch Biochem Biophys 1983 Jan;220(1):95-105
Cummings RD, Trowbridge IS, Kornfeld S A mouse lymphoma cell line resistant to the leukoagglutinating lectin from Phaseolus vulgaris is deficient in UDP-GlcNAc: alpha-D-mannoside beta 1,6 N-acetylglucosaminyltransferase.
J Biol Chem 1982 Nov 25;257(22):13421-7
Gabel CA, Goldberg DE, Kornfeld S Lysosomal enzyme oligosaccharide phosphorylation in mouse lymphoma cells: specificity and kinetics of binding to the mannose 6-phosphate receptor in vivo.
J Cell Biol 1982 Nov;95(2 Pt 1):536-42
Cummings RD, Kornfeld S Fractionation of asparagine-linked oligosaccharides by serial lectin- Agarose affinity chromatography. A rapid, sensitive, and specific technique.
J Biol Chem 1982 Oct 10;257(19):11235-40
Cummings RD, Kornfeld S Characterization of the structural determinants required for the high affinity interaction of asparagine-linked oligosaccharides with immobilized Phaseolus vulgaris leukoagglutinating and erythroagglutinating lectins.
J Biol Chem 1982 Oct 10;257(19):11230-4
Gabel CA, Kornfeld S Lysosomal enzyme phosphorylation in mouse lymphoma cell lines with altered asparagine-linked oligosaccharides.
J Biol Chem 1982 Sep 25;257(18):10605-12
Reitman ML, Trowbridge IS, Kornfeld S A lectin-resistant mouse lymphoma cell line is deficient in glucosidase II, a glycoprotein-processing enzyme.
J Biol Chem 1982 Sep 10;257(17):10357-63
Kornfeld S, Reitman ML, Varki A, Goldberg D, Gabel CA
Steps in the phosphorylation of the high mannose oligosaccharides of lysosomal enzymes.
Ciba Found Symp 1982;(92):138-56
Varki A, Reitman ML, Vannier A, Kornfeld S, Grubb JH, Sly WS
Demonstration of the heterozygous state for I-cell disease and pseudo- Hurler polydystrophy by assay of N-acetylglucosaminylphosphotransferase in white blood cells and fibroblasts.
Am J Hum Genet 1982 Sep;34(5):717-29
Kornfeld S Oligosaccharide processing during glycoprotein biosynthesis.
In: The Glycoconjugates, Vol. III, M Horowitz (ed.) Academic Press, 3-23, 1982
Varki AP, Reitman ML, Kornfeld S Identification of a variant of mucolipidosis III (pseudo-Hurler polydystrophy): a catalytically active N- acetylglucosaminylphosphotransferase that fails to phosphorylate lysosomal enzymes.
Proc Natl Acad Sci U S A 1981 Dec;78(12):7773-7
Rearick JI, Chapman A, Kornfeld S Glucose starvation alters lipid-linked oligosaccharide biosynthesis in Chinese hamster ovary cells.
J Biol Chem 1981 Jun 25;256(12):6255-61
Reitman ML, Varki A, Kornfeld S Fibroblasts from patients with I-cell disease and pseudo-Hurler polydystrophy are deficient in uridine 5'-diphosphate-N- acetylglucosamine: glycoprotein N-acetylglucosaminylphosphotransferase activity.
J Clin Invest 1981 May;67(5):1574-9
Reitman ML, Kornfeld S UDP-N-acetylglucosamine:glycoprotein N-acetylglucosamine-1- phosphotransferase. Proposed enzyme for the phosphorylation of the high mannose oligosaccharide units of lysosomal enzymes.
J Biol Chem 1981 May 10;256(9):4275-81
Rearick JI, Fujimoto K, Kornfeld S Identification of the mannosyl donors involved in the synthesis of lipid-linked oligosaccharides.
J Biol Chem 1981 Apr 25;256(8):3762-9
Gibson R, Kornfeld S, Schlesinger S
The effect of oligosaccharide chains of different sizes on the maturation and physical properties of the G protein of vesicular stomatitis virus.
J Biol Chem 1981 Jan 10;256(1):456-62
Gibson R, Kornfeld S, Schlesinger S
A Role of oligosaccharides in glycoprotein biosynthesis.
TIBS 1980;5:290-293
Reitman ML, Trowbridge IS, Kornfeld S Mouse lymphoma cell lines resistant to pea lectin are defective in fucose metabolism.
J Biol Chem 1980 Oct 25;255(20):9900-6
Varki A, Kornfeld S An autosomal dominant gene regulates the extent of 9-O-acetylation of murine erythrocyte sialic acids. A probable explanation for the variation in capacity to activate the human alternate complement pathway.
J Exp Med 1980 Sep 1;152(3):532-44
Varki A, Kornfeld S Identification of a rat liver alpha-N-acetylglucosaminyl phosphodiesterase capable of removing "blocking" alpha-N- acetylglucosamine residues from phosphorylated high mannose oligosaccharides of lysosomal enzymes.
J Biol Chem 1980 Sep 25;255(18):8398-401
Roos MH, Shreffler DC, Kornfeld S Role of glycosylation in the proteolytic processing and secretion of the 4th component of complement (Ss protein) of the mouse.
J Immunol 1980 Oct;125(4):1869-71
Tabas I, Kornfeld S Biosynthetic intermediates of beta-glucuronidase contain high mannose oligosaccharides with blocked phosphate residues.
J Biol Chem 1980 Jul 25;255(14):6633-9
Roos MH, Kornfeld S, Shreffler DC
Characterization of the oligosaccharide units of the fourth component of complement (Ss protein) synthesized by murine macrophages.
J Immunol 1980 Jun;124(6):2860-3
Chapman A, Fujimoto K, Kornfeld S The primary glycosylation defect in class E Thy-1-negative mutant mouse lymphoma cells is an inability to synthesize dolichol-P-mannose.
J Biol Chem 1980 May 25;255(10):4441-6
Kornfeld R, Kornfeld S Structure of glycoproteins and their oligosaccharide units.
In: The Biochemistry of Glycoproteins and Proteoglycans, WJ Lennarz (ed.) Plenum Press, 1-34, 1980
Michael JM, Kornfeld S Partial purification and characterization of the glucosidases involved in the processing of asparagine-linked oligosaccharides.
Arch Biochem Biophys 1980 Jan;199(1):249-58
Kornfeld S, Kornfeld R
Use of lectins in the study of mammalian glycoproteins.
In: The Glycoconjugates, 2, M.I. Horowitz and W. Pigman (eds.) Academic Press, 437-447, 1979
Tabas I, Kornfeld S Purification and characterization of a rat liver Golgi alpha- mannosidase capable of processing asparagine-linked oligosaccharides.
J Biol Chem 1979 Nov 25;254(22):11655-63
Kornfeld S, Gregory W, Chapman A
Class E Thy-1 negative mouse lymphoma cells utilize an alternate pathway of oligosaccharide processing to synthesize complex-type oligosaccharides.
J Biol Chem 1979 Nov 25;254(22):11649-54
Li E, Kornfeld S Structural studies of the major high mannose oligosaccharide units from Chinese hamster ovary cell glycoproteins.
J Biol Chem 1979 Mar 10;254(5):1600-5
Chapman A, Li E, Kornfeld S The biosynthesis of the major lipid-linked oligosaccharide of Chinese hamster ovary cells occurs by the ordered addition of mannose residues.
J Biol Chem 1979 Oct 25;254(20):10243-9
Gibson R, Schlesinger S, Kornfeld S The nonglycosylated glycoprotein of vesicular stomatitis virus is temperature-sensitive and undergoes intracellular aggregation at elevated temperatures.
J Biol Chem 1979 May 10;254(9):3600-7
Chapman A, Trowbridge IS, Hyman R, Kornfeld S Structure of the lipid-linked oligosaccharides that accumulate in class E Thy-1-negative mutant lymphomas.
Cell 1979 Jul;17(3):509-15
Li E, Kornfeld S Biosynthesis of lipid-linked oligosaccharides. Isolation and structure of a second lipid-linked oligosaccharide in Chinese hamster ovary cells.
J Biol Chem 1979 Apr 25;254(8):2754-8
Briles EB, Gregory W, Fletcher P, Kornfeld S Vertebrate lectins, Comparison of properties of beta-galactoside- binding lectins from tissues of calf and chicken.
J Cell Biol 1979 Jun;81(3):528-37
Gottlieb C, Kornfeld S, Schlesinger S
Restricted replication of two alphaviruses in ricin-resistant mouse L cells with altered glycosyltransferase activities.
J Virol 1979 Jan;29(1):344-51
Tabas I, Kornfeld S The synthesis of complex-type oligosaccharides. III. Identification of an alpha-D-mannosidase activity involved in a late stage of processing of complex-type oligosaccharides.
J Biol Chem 1978 Nov 10;253(21):7779-86
Kornfeld S, Li E, Tabas I
The synthesis of complex-type oligosaccharides. II. Characterization of the processing intermediates in the synthesis of the complex oligosaccharide units of the vesicular stomatitis virus G protein.
J Biol Chem 1978 Nov 10;253(21):7771-8
Li E, Tabas I, Kornfeld S The synthesis of complex-type oligosaccharides. I. Structure of the lipid-linked oligosaccharide precursor of the complex-type oligosaccharides of the vesicular stomatitis virus G protein.
J Biol Chem 1978 Nov 10;253(21):7762-70
Briles EB, Kornfeld S Lectin-resistant cell surface variants of eukaryotic cells.
TIBS 1978;3:223-228
Hickman S, Kornfeld S Effect of tunicamycin on IgM, IgA, and IgG secretion by mouse plasmacytoma cells.
J Immunol 1978 Sep;121(3):990-6
Li E, Kornfeld S Structure of the altered oligosaccharide present in glycoproteins from a clone of Chinese hamster ovary cells deficient in N- acetylglucosaminyltransferase activity.
J Biol Chem 1978 Sep 25;253(18):6426-31
Gibson R, Leavitt R, Kornfeld S, Schlesinger S
Synthesis and infectivity of vesicular stomatitis virus containing nonglycosylated G protein.
Cell 1978 Apr;13(4):671-9
Tabas I, Schlesinger S, Kornfeld S Processing of high mannose oligosaccharides to form complex type oligosaccharides on the newly synthesized polypeptides of the vesicular stomatitis virus G protein and the IgG heavy chain.
J Biol Chem 1978 Feb 10;253(3):716-22
Leavitt R, Schlesinger S, Kornfeld S Impaired intracellular migration and altered solubility of nonglycosylated glycoproteins of vesicular stomatitis virus and Sindbis virus.
J Biol Chem 1977 Dec 25;252(24):9018-23
Shearer WT, Gottlieb C, Kornfeld S Humoral immunostimulation. VII. Sialic acid masks antigenic sites on an antibody-selected bariant cell line.
J Immunol 1977 Aug;119(2):614-7
Li E, Kornfeld S Effect of wheat germ agglutinin on membrane transport.
Biochim Biophys Acta 1997;469:202-210
Hickman S, Kulczycki A Jr, Lynch RG, Kornfeld S Studies of the mechanism of tunicamycin in hibition of IgA and IgE secretion by plasma cells.
J Biol Chem 1977 Jun 25;252(12):4402-8
Leavitt R, Schlesinger S, Kornfeld S Tunicamycin inhibits glycosylation and multiplication of Sindbis and vesicular stomatitis viruses.
J Virol 1977 Jan;21(1):375-85
Briles EB, Li E, Kornfeld S Isolation of wheat germ agglutinin-resistant clones of Chinese hamster ovary cells deficient in membrane sialic acid and galactose.
J Biol Chem 1977 Feb 10;252(3):1107-16
Gottlieb C, Kornfeld S Isolation and characterization of two mouse L cell lines resistant to the toxic lectin ricin.
J Biol Chem 1976 Dec 25;251(24):7761-8
de Waard A, Hickman S, Kornfeld S Isolation and properties of beta-galactoside binding lectins of calf heart and lung.
J Biol Chem 1976 Dec 10;251(23):7581-7
Minnich V, Smith ME, Thompson D, Kornfeld S Detection of mutagenic activity in human urine using mutant strains of Salmonella typhimurium.
Cancer 1976 Sep;38(3):1253-8
Emerson WA, Kornfeld S Characterization of the oligosaccharide units of the bovine erythrocyte membrane glycoprotein.
Biochemistry 1976 Apr 20;15(8):1697-703
Schlesinger S, Gottlieb C, Feil P, Gelb N, Kornfeld S Growth of enveloped RNA viruses in a line of chinese hamster ovary cells with deficient N-acetylglucosaminyltransferase activity.
J Virol 1975 Jan;17(1):239-46
Ewart RB, Kornfeld S, Kipnis DM
Effect of lectins on hormone release from isolated rat islets of langerhans.
Diabetes 1975 Aug;24(8):705-14
Gottlieb C, Baenziger J, Kornfeld S Deficient uridine diphosphate-N-acetylglucosamine:glycoprotein N- acetylglucosaminyltransferase activity in a clone of Chinese hamster ovary cells with altered surface glycoproteins.
J Biol Chem 1975 May 10;250(9):3303-9
Triche TJ, Tillack TW, Kornfeld S Localization of the binding sites for the Ricinus communis, Agaricus bisporus and wheat germ lectins on human erythrocyte membranes.
Biochim Biophys Acta 1975 Jul 18;394(4):540-9
Baenziger J, Kornfeld S Structure of the carbohydrate units of IgA1 immunoglobulin. II. Structure of the O-glycosidically linked oligosaccharide units.
J Biol Chem 1974 Nov 25;249(22):7270-81
Baenziger J, Kornfeld S Structure of the carbohydrate units of IgA1 immunoglobulin. I. Composition, glycopeptide isolation, and structure of the asparagine- linked oligosaccharide units.
J Biol Chem 1974 Nov 25;249(22):7260-9
Kornfeld S, Adair W, Gottlieb C, Kornfeld R
Membrane glycoproteins as plant lectin receptors.
In: Biology and Chemistry of Eucaryotic Cell Surfaces, Miami Winter Symposium. EYC Lee and E. Smith (eds.), Academic Press, 291-311, 1974
Adair W, Kornfeld S Isolation of the receptors for wheat germ agglutinin and the Ricinus communis lectins from human erythrocytes using affinity chromatography.
J Biol Chem 1974;249:4696-4704
Kornfeld S, Eider W, Gregory W
Inhibition of protein and DNA synthesis in human lymphocytes by the Ricinus communis agglutinins.
In: Lymphocyte Recognition and Effector Mechanisms, Lindahl-Kiessling and D. Osoba (eds.), Academic Press, 515-519, 1974
Baenziger J, Kornfeld S, Kochwa S
Structure of the carbohydrate units of IgE immunoglobulin. II. Sequence of the sialic acid-containing glycopeptides.
J Biol Chem 1974 Mar 25;249(6):1897-903
Baenziger J, Kornfeld S, Kochwa S
Structure of the carbohydrate units of IgE immunoglobulin. I. Over-all composition, glycopeptide isolation, and structure of the high mannose oligosaccharide unit.
J Biol Chem 1974 Mar 25;249(6):1889-96
Kornfeld S, Eider W, Gregory W
Inhibition of protein and DNA synthesis in mammalian cells by the Ricinus communis agglutins.
In: Control of Proliferation in Animal Cells, B Clarkson and R Baserga (eds.) Cold Spring Harbor Laboratory Publisher, 435-445, 1974
Kornfeld R, Gregory W, Kornfeld S Red Kidney Bean Phyto- hemagglutinin.
Methods Enzymol 1972;28:344-349
Leseney AM, Bourrillon R, Kornfeld S The nature of the erythrocyte receptor site for Robinia pseudoaccacia phytohemagglutinin.
Arch Biochem Biophys 1972 Dec;153(2):831-6
Boldt S, Skinner AM, Kornfeld S Studies of two subpopulations of human lymphocytes differing in responsiveness to concanavalin A.
J Clin Invest 1972 Dec;51(12):3225-34
Rogers JC, Boldt D, Kornfeld S, Skinner A, Valeri CR
Excretion of deoxyribonucleic acid by lymphocytes stimulated with phytohemagglutinin or antigen.
Proc Natl Acad Sci U S A 1972 Jul;69(7):1685-9
Kornfeld S, Kornfeld R
The structure of phytohemagglutinin receptor sites.
In: Glycoproteins of Blood Cells and Plasma, GA Jamieson and TJ Greenwalt (eds.) J.B. Lippincott, Philadelphia, p. 50, 1971
Kornfeld S, Rogers J, Gregory W
The nature of the cell surface receptor site for Lens culinaris phytohemagglutinin.
J Biol Chem 1971 Nov;246(21):6581-6
Mendelsohn J, Skinner A, Kornfeld S The rapid induction by phytohemagglutinin of increased alpha- aminoisobutyric acid uptake by lymphocytes.
J Clin Invest 1971 Apr;50(4):818-26