Timothy J. Ley, M.D.

Bredemeyer AJ, Townsend RR, Ley TJ
Use of protease proteomics to discover granzyme B substrates.
Immunol Res 2005;32(1-3):143-54

Ley TJ
Retrospective: Stanley Joel Korsmeyer (1950-2005).
Science 2005 May 6;308(5723):803-4

Wilson RK, Ley TJ, Cole FS, Milbrandt JD, Clifton S, Fulton L, Fewell G, Minx P, Sun H, McLellan M, Pohl C, Mardis ER
Mutational profiling in the human genome.
Cold Spring Harb Symp Quant Biol 2003;68:23-9

Ley TJ
1998 ASCI Presidential Address.
J Clin Invest 2003 Dec;112(12):S9-11

Grossman WJ, Revell PA, Lu ZH, Johnson H, Bredemeyer AJ, Ley TJ
The orphan granzymes of humans and mice.
Curr Opin Immunol 2003 Oct;15(5):544-52 [Erratum: Curr Opin Immunol 2003 Dec;15(6):731]

Russell JH, Ley TJ
Lymphocyte-mediated cytotoxicity.
Annu Rev Immunol 2002;20:323-70

Pollock JL, Westervelt P, Walter MJ, Lane AA, Ley TJ
Mouse models of acute promyelocytic leukemia.
Curr Opin Hematol 2001 Jul;8(4):206-11

Westervelt P, Ley TJ
Seed versus soil: the importance of the target cell for transgenic models of human leukemias.
Blood 1999 Apr 1;93(7):2143-8

Shresta S, Pham CT, Thomas DA, Graubert TA, Ley TJ
How do cytotoxic lymphocytes kill their targets?
Curr Opin Immunol 1998 Oct;10(5):581-7

Ley TJ, Hug B, Fiering S, Epner E, Bender MA, Groudine M
Reduced beta-globin gene expression in adult mice containing deletions of locus control region 5' HS-2 or 5' HS-3.
Ann N Y Acad Sci 1998 Jun 30;850:45-53

Pham CT, Ley TJ
The role of granzyme B cluster proteases in cell-mediated cytotoxicity.
Semin Immunol 1997 Apr;9(2):127-33

Graubert TA, Ley TJ
How do lymphocytes kill tumor cells?
Clin Cancer Res 1996 May;2(5):785-9

Grisolano JL, Ley TJ
Regulation of azurophil granule-associated serine protease genes during myelopoiesis.
Curr Opin Hematol 1996 Jan;3(1):55-62

Shresta S, Heusel JW, Macivor DM, Wesselschmidt RL, Russell JH, Ley TJ
Granzyme B plays a critical role in cytotoxic lymphocyte-induced apoptosis.
Immunol Rev 1995 Aug;146:211-21

Welgus HG, Senior RM, Parks WC, Kahn AJ, Ley TJ, Shapiro SD, Campbell EJ
Neutral proteinase expression by human mononuclear phagocytes: a prominent role of cellular differentiation.
Matrix Suppl 1992;1:363-7

Moon AM, Ley TJ
Conservation of the primary structure, organization, and function of the human and mouse b-globin locus control regions.
In: 7th Hemoglobin Switching Conference Proceedings, Johns Hopkins University Press, Baltimore, MD, pp. 138-152, 1991

Ley TJ
The pharmacology of hemoglobin switching: of mice and men.
Blood 1991 Mar 15;77(6):1146-52

Ulrich MJ, Moon AM, Ley TJ
Function of transfected globin promoters and the globin locus activator in K562 erythroleukemia cells.
Ann N Y Acad Sci 1990;612:207-14

Lin HJ, Bodine DM, Rutherford TR, Anagnou NP, McDonagh KT, Ley TJ, Nienhuis AW
Regulatory regions flanking the human fetal gamma-globin genes.
Ann N Y Acad Sci 1989;565:13-22

Ley TJ
Thalassemia.
In: Conn's Current Therapy (R.E. Rakel, ed.). W.B. Saunders Co., Philadelphia, PA, pp. 311-315, 1989

Ley TJ
Thalassemia.
In: Conn's Current Therapy (R.E. Rakel, ed.). W. B. Saunders Co., Philadelphia, PA, pp. 307-312, 1988

Bodine DM, Ley TJ
A transient assay system to study gamma globin gene expression in K562 cells.
Prog Clin Biol Res 1987;251:189-200

Cheah MS, Ley TJ, Tronick SR, Robbins KC
Induction of fgr proto-oncogene mRNA in B lymphocytes as a consequence of Epstein-Barr virus infection.
Curr Top Microbiol Immunol 1986;132:237-45

Dean A, Wu YJ, Ley T, Fordis CM, Schechter AN
Augmentation of hemoglobin synthesis by S-phase specific drugs in the K562 cell line.
Prog Clin Biol Res 1985;191:205-16

Dover GJ, Humphries RK, Young N, Ley T, Boyer S, Charache S, Nienhuis A
Pharmacologic manipulation of fetal hemoglobin synthesis.
Prog Clin Biol Res 1985;191:447-54

Nienhuis AW, Ley TJ, Humphries RK, Young NS, Dover G
Pharmacological manipulation of fetal hemoglobin synthesis in patients with severe beta-thalassemia.
Ann N Y Acad Sci 1985;445:198-211

Ley TJ, Nienhuis AW
Induction of hemoglobin F synthesis in patients with beta thalassemia.
Annu Rev Med 1985;36:485-98

Ley TJ, Nienhuis AW
Prospects for therapeutic manipulation of human gene function.
In: Principles and Techniques of Human Research and Therapeutics, Vol. II (F.G. McMahon and T.J. Ley, eds.). Futura, Mt. Kisco, NY, pp. 59-85, 1985

Nienhuis AW, Anagnou NP, Ley TJ
Advances in thalassemia research.
Blood 1984 Apr;63(4):738-58

Ley TJ, Nienhuis AW
Chelation therapy for transfusion-dependent adults [letter]
N Engl J Med 1983 Jun 9;308(23):1422-3

Ley TJ, Anagnou NP, Young NS, Nienhuis AW, DeSimone J, Heller P
5-azacytidine for beta thalassaemia? [letter]
Lancet 1983 Feb 26;1(8322):467

Humphries RK, Ley T, Goldsmith ME, Kantor JA, Cline AC, Nienhuis AW
"Silent" nucleotide substitution in codon 24 of a beta+ thalassemia globin gene activates splice site in coding sequence RNA.
Prog Clin Biol Res 1983;134:123-6

Anderson WF, Chiang YL, Sanders-Haigh L, Ley TJ
Globin gene expression in somatic cell hybrids.
Prog Clin Biol Res 1983;134:39-52

Dean A, Ley TJ, Humphries RK, Fordis CM Jr, Schechter AN
Abundance and structure of globin mRNA in K562 human leukemia cells.
Prog Clin Biol Res 1983;134:323-34

Ley TJ, Anagnou NP, Noguchi CT, Schechter AN, DeSimone J, Heller P, Nienhuis AW
DNA methylation and globin gene expression in patients treated with 5- azacytidine.
Prog Clin Biol Res 1983;134:457-74

Nienhuis AW, Ley TJ, Humphries RK
Expression of human normal and thalassemic globin genes.
In: Proceedings of the Regulation of Hemoglobin Biosynthesis (E. Goldwasser, ed.). Elsevier, North Holland, pp. 385-389, 1983

Nienhuis AW, Ley T, Pepe G, Tam J, Kantor J
Molecular defects in beta-thalassemia.
Birth Defects Orig Artic Ser 1982;18(7):69-79

Ley TJ, Griffith P, Nienhuis AW
Transfusion haemosiderosis and chelation therapy.
Clin Haematol 1982 Jun;11(2):437-64