WASHINGTON UNIVERSITY SCHOOL OF MEDICINE DEPARTMENT OF MEDICINE

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Hematopoiesis, the process by which all blood cells are formed, is a tightly regulated process that is disrupted in a number of blood diseases, including leukemias. The main interest of our laboratory is to define the mechanisms that regulate normal and leukemic hematopoiesis. Current projects include the following:

Characterization of the pathogenesis of congenital neutropenia syndromes.
These syndromes are characterized by neutropenia at birth and are associated with a marked propensity to develop leukemia. Studies to define the molecular mechanisms of disease pathogenesis and leukemogenesis are underway.

Identification of the mechanisms regulating the trafficking of neutrophils and hematopoietic stem cells from the bone marrow to blood.
Neutrophils are released from the bone marrow in a regulated fashion to maintain homeostatic levels in the blood and to rapidly increase neutrophil numbers in the blood in response to stress, such as infection. We are characterizing the molecular mechanisms regulating neutrophil and stem cell release from the bone marrow to blood.

Characterization of leukemic stem cells.
A major emphasis in current cancer research is the identification of cancer stem cells and the molecular pathways that mediate their inherent resistance to chemotherapy. We have developed a novel mouse model to study leukemic stem cells. Studies are underway to understand how leukemic stem cells gain clonal dominance in the bone marrow.

Regulation of stem cell niches in the bone marrow by G-CSF. Treatment of G-CSF leads to a marked suppression of osteoblasts in the bone marrow, leading to the mobilization of stem cells into the blood. In contrast, the vascular niche appears to be unaffected.

Education

1981	BS, University of Wisconsin-Milwaukee, Milwaukee, WI
1985	MD, University of Wisconsin-Madison, Madison, WI

Post-graduate Training

1984	Medical Research, NCI summer training award, NIH, Baltimore, MD
1985-1986	Intern in Medicine, Barnes Hospital, St. Louis, MO
1986-1988	Assistant Resident in Medicine, Barnes Hospital, St. Louis, MO
1988-1992	Hematology-Oncology Fellow, Washington University Medical Center, St. Louis, MO

Academic Positions

1993-1996	Instructor, Department of Medicine, Washington University Medical School, St. Louis, MO
1996-2003	Assistant Professor, Departments of Medicine and Pathology & Immunology, Washington University Medical School, St. Louis, MO
2003-2008	Associate Professor, Department of Medicine, Washington University Medical School, St. Louis, MO
2008-present	Professor, Departments of Medicine and Pathology & Immunology, Washington University Medical School, St. Louis, MO

Current Appointments & Committees

	Co-program leader, Hematopoietic Development and Malignancy Program, Siteman Cancer Center
	Co-leader, Translational Oncology Program at Washington University
	Member, Basic Science Leadership Committee, Siteman Cancer Center
	Markey Pathway Admissions and Steering Committee, Washington University
	MA/MD Program Admissions and Steering Committee, Washington University
	Summer Scholars Program in Biology and Biomedical Research Admissions Committee, Washington University

Board Certification

1989	Internal Medicines
1990	Hematology

Honors & Awards

1981	Kurt H. Vanselow Undergraduate Research Scholarship; University of Wisconsin-Milwaukee, Milwaukee, WI
1981	The American Institute of Chemists' Student Award; University of Wisconsin-Milwaukee, Milwaukee, WI
1981	Phi Beta Kappa; University of Wisconsin-Milwauikee, Milwuakee, WI
1981-1984	Outstanding Achievement Award by Promotion's Committee; University of Wisconsin-Madison Medical School, Madison, WI
1982	Academic Excellence Award (top 2% of class); University of Wisconsin-Madison Medical School, Madison, WI
1984	Alpha Omega Alpha; University of Wisconsin-Madison Medical School, Madison, WI
1984	NCI Summer Training Award; National Institutes of Health, Bethesda, MD
1993	McDonnell Scholar in Molecular Oncology; Washington University Medical Center, St. Louis, MO
1998	28th Mallinckrodt Scholar, Edward Mallinckrodt, Jr. Foundation
2000	Election to American Society of Clinical Investigation
2005	Medical Advisory Board of the Severe Congenital Neutropenia International Registry
2009	Election to the Association of American Physicians

Editorial Responsibilities

2002	Editorial Board, Experimental Hematology
2002	Editorial Board, Blood

Professional Societies

	Alpha Omega Alpha
	American Society of Hematology
	American Society of Clinical Investigation
	Association of American Physicians
	International Society for Experimental Hematology

• Updated: July 7, 2009
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