Daniel C. Link, M.D.

Christopher MJ, Link DC
Granulocyte Colony-Stimulating Factor Induces Osteoblast Apoptosis and Inhibits Osteoblast Differentiation.
J Bone Miner Res 2008 Jul 2; [Epub ahead of print]

Capoccia BJ, Gregory AD, Link DC
Recruitment of the inflammatory subset of monocytes to sites of ischemia induces angiogenesis in a monocyte chemoattractant protein-1-dependent fashion.
J Leukoc Biol 2008 Jun 11; [Epub ahead of print]

Rosova I, Dao M, Capoccia B, Link D, Nolta JA
Hypoxic Preconditioning Results in Increased Motility and Improved Therapeutic Potential of Human Mesenchymal Stem Cells.
Stem Cells 2008 May 29; [Epub ahead of print]

Devine SM, Vij R, Rettig M, Todt L, McGlauchlen K, Fisher N, Devine H, Link DC, Calandra G, Bridger G, Westervelt P, Dipersio JF
Rapid mobilization of functional donor hematopoietic cells without G-CSF using plerixafor, an antagonist of the CXCR4/SDF-1 interaction.
Blood 2008 Aug 15;112(4):990-8

Hunter MG, McLemore M, Link DC, Loveland M, Copelan A, Avalos BR
Divergent pathways in COS-7 cells mediate defective internalization and intracellular routing of truncated G-CSFR forms in SCN/AML.
PLoS ONE 2008 Jun 18;3(6):e2452

Xiang Z, Zhao Y, Mitaksov V, Fremont DH, Kasai Y, Molitoris A, Ries RE, Miner TL, McLellan MD, Dipersio JF, Link DC, Payton JE, Graubert TA, Watson M, Shannon W, Heath SE, Naggarajan R, Mardis ER, Wilson RK, Ley TJ, Tomasson MH
Identification of somatic JAK1 mutations in patients with acute myeloid leukemia.
Blood 2008 May 1;111(9):4809-12

Tomasson MH, Xiang Z, Walgren R, Zhao Y, Kasai Y, Miner T, Ries RE, Lubman O, Fremont D, McLellan MD, Payton JE, Westervelt P, Dipersio JF, Link DC, Walter MJ, Graubert TA, Watson M, Baty J, Heath S, Shannon WD, Nagarajan R, Bloomfield CD, Mardis ER, Wilson RK, Ley TJ
Somatic mutations and germline sequence variants in the expressed tyrosine kinase genes of patients with de novo acute myeloid leukemia.
Blood 2008 May 1;111(9):4797-808

Liu F, Kunter G, Krem MM, Eades WC, Cain JA, Tomasson MH, Hennighausen L, Link DC
Csf3r mutations in mice confer a strong clonal HSC advantage via activation of Stat5.
J Clin Invest 2008 Mar;118(3):946-55

Rosenberg PS, Alter BP, Link DC, Stein S, Rodger E, Bolyard AA, Aprikyan AA, Bonilla MA, Dror Y, Kannourakis G, Newburger PE, Boxer LA, Dale DC
Neutrophil elastase mutations and risk of leukaemia in severe congenital neutropenia.
Br J Haematol 2008 Jan;140(2):210-3

Grenda DS, Murakami M, Ghatak J, Xia J, Boxer LA, Dale D, Dinauer MC, Link DC
Mutations of the ELA2 gene found in patients with severe congenital neutropenia induce the unfolded protein response and cellular apoptosis.
Blood 2007 Dec 15;110(13):4179-87

Rawls AS, Gregory AD, Woloszynek JR, Liu F, Link DC
Lentiviral-mediated RNAi inhibition of Sbds in murine hematopoietic progenitors impairs their hematopoietic potential.
Blood 2007 Oct 1;110(7):2414-22

Link DC, Kunter G, Kasai Y, Zhao Y, Miner T, McLellan MD, Ries RE, Kapur D, Nagarajan R, Dale DC, Bolyard AA, Boxer LA, Welte K, Zeidler C, Donadieu J, Bellanne-Chantelot C, Vardiman JW, Caligiuri MA, Bloomfield CD, DiPersio JF, Tomasson MH, Graubert TA, Westervelt P, Watson M, Shannon W, Baty J, Mardis ER, Wilson RK, Ley TJ
Distinct patterns of mutations occurring in de novo AML versus AML arising in the setting of severe congenital neutropenia.
Blood 2007 Sep 1;110(5):1648-55

Schuster DP, Brody SL, Zhou Z, Bernstein M, Arch R, Link D, Mueckler M
Regulation of lipopolysaccharide-induced increases in neutrophil glucose uptake.
Am J Physiol Lung Cell Mol Physiol 2007 Apr;292(4):L845-51

Gregory AD, Hogue LA, Ferkol TW, Link DC
Regulation of systemic and local neutrophil responses by G-CSF during pulmonary Pseudomonas aeruginosa infection.
Blood 2007 Apr 15;109(8):3235-43

Yuan W, Payton JE, Holt MS, Link DC, Watson MA, DiPersio JF, Ley TJ
Commonly dysregulated genes in murine APL cells.
Blood 2007 Feb 1;109(3):961-70

Panopoulos AD, Zhang L, Snow JW, Jones DM, Smith AM, El Kasmi KC, Liu F, Goldsmith MA, Link DC, Murray PJ, Watowich SS
STAT3 governs distinct pathways in emergency granulopoiesis and mature neutrophils.
Blood 2006 Dec 1;108(12):3682-90

Shepherd RM, Capoccia BJ, Devine SM, Dipersio J, Trinkaus KM, Ingram D, Link DC
Angiogenic cells can be rapidly mobilized and efficiently harvested from the blood following treatment with AMD3100.
Blood 2006 Dec 1;108(12):3662-7

Capoccia BJ, Shepherd RM, Link DC
G-CSF and AMD3100 mobilize monocytes into the blood that stimulate angiogenesis in vivo through a paracrine mechanism.
Blood 2006 Oct 1;108(7):2438-45

Mermel CH, McLemore ML, Liu F, Pereira S, Woloszynek J, Lowell CA, Link DC
Src family kinases are important negative regulators of G-CSF-dependent granulopoiesis.
Blood 2006 Oct 15;108(8):2562-8

Guven H, Shepherd RM, Bach RG, Capoccia BJ, Link DC
The number of endothelial progenitor cell colonies in the blood is increased in patients with angiographically significant coronary artery disease.
J Am Coll Cardiol 2006 Oct 17;48(8):1579-87

Khanna-Gupta A, Sun H, Zibello T, Lozovatsky L, Ghosh PK, Link DC, McLemore ML, Berliner N
p120 nucleolar-proliferating antigen is a direct target of G-CSF signaling during myeloid differentiation.
J Leukoc Biol 2006 May;79(5):1011-21

Gamero AM, Potla R, Wegrzyn J, Szelag M, Edling AE, Shimoda K, Link DC, Dulak J, Baker DP, Tanabe Y, Grayson JM, Larner AC
Activation of Tyk2 and Stat3 is required for the apoptotic actions of interferon-beta in primary pro-B cells.
J Biol Chem 2006 Jun 16;281(24):16238-44

Semerad CL, Christopher MJ, Liu F, Short B, Simmons PJ, Winkler I, Levesque JP, Chappel J, Ross FP, Link DC
G-CSF potently inhibits osteoblast activity and CXCL12 mRNA expression in the bone marrow.
Blood 2005 Nov 1;106(9):3020-7

Woloszynek JR, Rothbaum RJ, Rawls AS, Minx PJ, Wilson RK, Mason PJ, Bessler M, Link DC
Mutations of the SBDS gene are present in most patients with Shwachman-Diamond syndrome.
Blood 2004 Dec 1;104(12):3588-90

Han B, Unsinger J, Liu F, Link DC, Bessler M
G-CSF induced progenitor mobilization in mice with PIGA- blood cells.
Hematol J 2004;5(4):347-52

Levesque JP, Liu F, Simmons PJ, Betsuyaku T, Senior RM, Pham C, Link DC
Characterization of hematopoietic progenitor mobilization in protease-deficient mice.
Blood 2004 Jul 1;104(1):65-72

Zhang Y, Woodward VK, Shelton JM, Richardson JA, Zhou XJ, Link D, Kielar ML, Jeyarajah DR, Lu CY
Ischemia-reperfusion induces G-CSF gene expression by renal medullary thick ascending limb cells in vivo and in vitro.
Am J Physiol Renal Physiol 2004 Jun;286(6):F1193-201

Ley TJ, Minx PJ, Walter MJ, Ries RE, Sun H, McLellan M, DiPersio JF, Link DC, Tomasson MH, Graubert TA, McLeod H, Khoury H, Watson M, Shannon W, Trinkaus K, Heath S, Vardiman JW, Caligiuri MA, Bloomfield CD, Milbrandt JD, Mardis ER, Wilson RK
A pilot study of high-throughput, sequence-based mutational profiling of primary human acute myeloid leukemia cell genomes.
Proc Natl Acad Sci U S A 2003 Nov 25;100(24):14275-80

Watters JW, Kloss EF, Link DC, Graubert TA, McLeod HL
A mouse-based strategy for cyclophosphamide pharmacogenomic discovery.
J Appl Physiol 2003 Oct;95(4):1352-60

Richards MK, Liu F, Iwasaki H, Akashi K, Link DC
Pivotal role of granulocyte colony-stimulating factor in the development of progenitors in the common myeloid pathway.
Blood 2003 Nov 15;102(10):3562-8

Semerad CL, Liu F, Gregory AD, Stumpf K, Link DC
G-CSF is an essential regulator of neutrophil trafficking from the bone marrow to the blood.
Immunity 2002 Oct;17(4):413-23

Grenda DS, Johnson SE, Mayer JR, McLemore ML, Benson KF, Horwitz M, Link DC
Mice expressing a neutrophil elastase mutation derived from patients with severe congenital neutropenia have normal granulopoiesis.
Blood 2002 Nov 1;100(9):3221-8

McLemore ML, Grewal S, Liu F, Archambault A, Poursine-Laurent J, Haug J, Link DC
STAT-3 activation is required for normal G-CSF-dependent proliferation and granulocytic differentiation.
Immunity 2001 Feb;14(2):193-204

Liu F, Poursine-Laurent J, Link DC
Expression of the G-CSF receptor on hematopoietic progenitor cells is not required for their mobilization by G-CSF.
Blood 2000 May 15;95(10):3025-31

Semerad CL, Poursine-Laurent J, Liu F, Link DC
A role for G-CSF receptor signaling in the regulation of hematopoietic cell function but not lineage commitment or differentiation.
Immunity 1999 Aug;11(2):153-61

Betsuyaku T, Liu F, Senior RM, Haug JS, Brown EJ, Jones SL, Matsushima K, Link DC
A functional granulocyte colony-stimulating factor receptor is required for normal chemoattractant-induced neutrophil activation.
J Clin Invest 1999 Mar;103(6):825-32

Zhang P, Iwama A, Datta MW, Darlington GJ, Link DC, Tenen DG
Upregulation of interleukin 6 and granulocyte colony-stimulating factor receptors by transcription factor CCAAT enhancer binding protein alpha (C/EBP alpha) is critical for granulopoiesis.
J Exp Med 1998 Sep 21;188(6):1173-84

McLemore ML, Poursine-Laurent J, Link DC
Increased granulocyte colony-stimulating factor responsiveness but normal resting granulopoiesis in mice carrying a targeted granulocyte colony-stimulating factor receptor mutation derived from a patient with severe congenital neutropenia.
J Clin Invest 1998 Aug 1;102(3):483-92

Jacob J, Haug JS, Raptis S, Link DC
Specific signals generated by the cytoplasmic domain of the granulocyte colony-stimulating factor (G-CSF) receptor are not required for G-CSF- dependent granulocytic differentiation.
Blood 1998 Jul 15;92(2):353-61

Liu F, Poursine-Laurent J, Wu HY, Link DC
Interleukin-6 and the granulocyte colony-stimulating factor receptor are major independent regulators of granulopoiesis in vivo but are not required for lineage commitment or terminal differentiation.
Blood 1997 Oct 1;90(7):2583-90

Liu F, Poursine-Laurent J, Link DC
The granulocyte colony-stimulating factor receptor is required for the mobilization of murine hematopoietic progenitors into peripheral blood by cyclophosphamide or interleukin-8 but not flt-3 ligand.
Blood 1997 Oct 1;90(7):2522-8

Liu F, Wu HY, Wesselschmidt R, Kornaga T, Link DC
Impaired production and increased apoptosis of neutrophils in granulocyte colony-stimulating factor receptor-deficient mice.
Immunity 1996 Nov;5(5):491-501

Rodel JE, Link DC
Suppression of apoptosis during cytokine deprivation of 32D cells is not sufficient to induce complete granulocytic differentiation.
Blood 1996 Feb 1;87(3):858-64

Zhou MJ, Lublin DM, Link DC, Brown EJ
Distinct tyrosine kinase activation and Triton X-100 insolubility upon Fc gamma RII or Fc gamma RIIIB ligation in human polymorphonuclear leukocytes. Implications for immune complex activation of the respiratory burst.
J Biol Chem 1995 Jun 2;270(22):13553-60

Link DC, Zutter M
The proto-oncogene c-fgr is expressed in normal mantle zone B lymphocytes and is developmentally regulated during myelomonocytic differentiation in vivo.
Blood 1995 Jan 15;85(2):472-9

Shenoy-Scaria AM, Dietzen DJ, Kwong J, Link DC, Lublin DM
Cysteine3 of Src family protein tyrosine kinase determines palmitoylation and localization in caveolae.
J Cell Biol 1994 Jul;126(2):353-63

Link DC, Gutkind SJ, Robbins KC, Ley TJ
Characterization of the 5' untranslated region of the human c-fgr gene and identification of the major myelomonocytic c-fgr promoter.
Oncogene 1992 May;7(5):877-84

Perkins SL, Link DC, Kling S, Ley TJ, Teitelbaum SL
1,25-Dihydroxyvitamin D3 induces monocytic differentiation of the PLB- 985 leukemic line and promotes c-fgr mRNA expression.
J Leukoc Biol 1991 Nov;50(5):427-33

Gutkind JS, Link DC, Katamine S, Lacal P, Miki T, Ley TJ, Robbins KC
A novel c-fgr exon utilized in Epstein-Barr virus-infected B lymphocytes but not in normal monocytes.
Mol Cell Biol 1991 Mar;11(3):1500-7

Link DC, Hill EA
Secondary alpha-deuterium isotope effects on reactions of the grignard reagent from 1-bromopentane-1, 1-d2.
Organometallics 1982;1:1510-150

Link DC, Donndelinger P, Hill EA
Gem-dimethyl effect in a grignard reagent cyclization-cleavage rearrangement.
J Org Chem 1981;46:1177-1182