A. Craig Lockhart, M.D.
- Associate Professor
- Department of Medicine
- Oncology Division
- Medical Oncology Section
- Oncology Division
- Department of Medicine
- Clinical interests
- GI cancers
- Research interests
- Phase I studies
- Genomics
Research
My clinical interests are in the areas of early phase oncology drug development and cancers of the gastrointestinal (GI) tract. I am a member of the Developmental Therapeutics program for the Siteman Cancer Center where we aim to assist in the development of novel anticancer therapies by conducting Phase I clinical trials. I have an interest in incorporating genomics into these studies to eventually personalize cancer treatment. As a member of the GI oncology clinical team, I have a particular interest in cancers of the upper GI tract. In this regard, I design and conduct clinical trials for patients with esophageal, gastroesophageal junction and gastric cancers. With an aim towards personalized cancer care, we try to incorporate genomics or other correlative studies into these clinical trials.
Pharmacokinetics of SR271425
From: Lockhart AC, Calvo E, Tolcher AW, Rowinsky EK, Shackleton G, Morrison JG, Rafi R, VerMeulen W, Rothenberg ML
A phase I dose-escalation study of SR271425, an intravenously dosed thioxanthone analog, administered weekly in patients with refractory solid tumors.
Am J Clin Oncol 2009 Feb;32(1):9-14
Biographical Sketch
Education
| 1989 | BA, Rice University, Houston, TX |
| 1993 | MD, University of Texas Southwestern Medical School, Dallas, TX |
| 2001 | MHS, Duke University, Durham, NC |
Post-graduate Training
| 1993-1994 | Intern, Barnes Hospital at Washington University, St. Louis, MO |
| 1994-1997 | Internal Medicine Resident, Barnes Hospital at Washington University, St. Louis, MO |
| 1997-2001 | Hematology/Oncology Fellow, Duke University Medical Center, Durham, NC |
| 1999-2001 | Fellow in Clinical Pharmacology, GlaxoSmithKline |
Academic Appointments
| 2001-2008 | Assistant Professor of Medicine, Vanderbilt University Medical Center, Nashville, TN |
| 2008-present | Associate Professor of Medicine, Washington University School of Medicine, St. Louis, MO |
| Director, Developmental Therapeutics Program |
Board Certification
| 1996 | Internal Medicine (ABIM) |
| 2000 | Medical Oncology (ABIM) |
Honors & Awards
| 1999 | American Association for Cancer Research Minority Scholar in Cancer Research |
| 2000 | American Association for Cancer Research Minority Scholar in Cancer Research |
| 2000 | Excellence in Teaching Award, Duke University Physician Assistants Program |
| 2003-2004 | Vanderbilt Physician-Scientist Development Award, Vanderbilt University |
Professional Organizations
| American Association for Cancer Research | |
| American Society of Clinical Oncology | |
| Cancer and Leukemia Group B | |
| American College of Surgeons Oncology Group |
Academic Committees
| 2005 | ASCO Scientific Committee, Experimental Therapeutics: Molecularly Targeted Agents |
| 2007-present | ACOSOG Medical Oncology Committee, Core Group Member |
| 2008-2009 | ASCO Scientific Committee, Non-colorectal GI |
| 2009 | Ontario Institute of Cancer Research, Grant Review Committee |
- Updated: May 22, 2009
