Gregory D. Longmore, M.D.

Guinto JB, Arur S, Schultz SA, Kisseleva M, Longmore GD, Wolff T
CK2, a canonical Wnt signaling kinase, interacts with Strabismus and Disheveled to regulate non-canonical Wnt signaling in the Drosophila retina.
Development, in revision

Epple H, Cremasco V, Zhang K, Mao D, Longmore GD, Faccio R
Phospholipase Cgamma2 modulates integrin signaling in the osteoclast by affecting the localization and activation of Src kinase.
Mol Cell Biol 2008 Jun;28(11):3610-22

Hou Z, Peng H, Ayyanathan K, Yan KP, Langer EM, Longmore GD, Rauscher FJ 3rd
The LIM protein AJUBA recruits protein arginine methyltransferase 5 to mediate SNAIL-dependent transcriptional repression.
Mol Cell Biol 2008 May;28(10):3198-207

Langer EM, Feng Y, Zhaoyuan H, Rauscher FJ 3rd, Kroll KL, Longmore GD
Ajuba LIM proteins are snail/slug corepressors required for neural crest development in Xenopus.
Dev Cell 2008 Mar;14(3):424-36

Lu L, Feng Y, Hucker WJ, Oswald SJ, Longmore GD, Yin FC
Actin stress fiber pre-extension in human aortic endothelial cells.
Cell Motil Cytoskeleton 2008 Apr;65(4):281-94

Giurisato E, Cella M, Takai T, Kurosaki T, Feng Y, Longmore GD, Colonna M, Shaw AS
Phosphatidylinositol 3-kinase activation is required to form the NKG2D immunological synapse.
Mol Cell Biol 2007 Dec;27(24):8583-99

Wacker BK, Alford SK, Scott EA, Das Thakur M, Longmore GD, Elbert DL
Endothelial cell migration on RGD-peptide-containing PEG hydrogels in the presence of sphingosine 1-phosphate.
Biophys J 2008 Jan 1;94(1):273-85

Ayyanathan K, Peng H, Hou Z, Fredericks WJ, Goyal RK, Langer EM, Longmore GD, Rauscher FJ 3rd
The Ajuba LIM domain protein is a corepressor for SNAG domain mediated repression and participates in nucleocytoplasmic Shuttling.
Cancer Res 2007 Oct 1;67(19):9097-106

Longmore GD
Do cancer cells express functional erythropoietin receptors?
N Engl J Med 2007 Jun 14;356(24):2447

Feng Y, Zhao H, Luderer HF, Epple H, Faccio R, Ross FP, Teitelbaum SL, Longmore GD
The LIM protein, Limd1, regulates AP-1 activation through an interaction with Traf6 to influence osteoclast development.
J Biol Chem 2007 Jan 5;282(1):39-48

Longmore GD
A unique role for Stat5 in recovery from acute anemia.
J Clin Invest 2006 Mar;116(3):626-8

Jones KB, Anderson DW, Longmore GD
Effects of recombinant hematopoietins on blood-loss anemia in mice.
Iowa Orthop J 2005;25:129-34

Feng Y, Longmore GD
The LIM protein Ajuba influences interleukin-1-induced NF-kappaB activation by affecting the assembly and activity of the protein kinase Czeta/p62/TRAF6 signaling complex.
Mol Cell Biol 2005 May;25(10):4010-22

Kisseleva M, Feng Y, Ward M, Song C, Anderson RA, Longmore GD
The LIM protein Ajuba regulates phosphatidylinositol 4,5-bisphosphate levels in migrating cells through an interaction with and activation of PIPKI alpha.
Mol Cell Biol 2005 May;25(10):3956-66

Pratt SJ, Epple H, Ward M, Feng Y, Braga VM, Longmore GD
The LIM protein Ajuba influences p130Cas localization and Rac1 activity during cell migration.
J Cell Biol 2005 Feb 28;168(5):813-24

Hadland BK, Huppert SS, Kanungo J, Xue Y, Jiang R, Gridley T, Conlon RA, Cheng AM, Kopan R, Longmore GD
A requirement for Notch1 distinguishes 2 phases of definitive hematopoiesis during development.
Blood 2004 Nov 15;104(10):3097-105

Young AP, Longmore GD
Differential regulation of apoptotic genes by Rb in human versus mouse cells.
Oncogene 2004 Apr 8;23(15):2587-99

Young AP, Longmore GD
Differences in stability of repressor complexes at promoters underlie distinct roles for Rb family members.
Oncogene 2004 Jan 22;23(3):814-23

Young AP, Longmore GD
Ras protects Rb family null fibroblasts from cell death: a role for AP-1.
J Biol Chem 2004 Mar 19;279(12):10931-8

Young AP, Nagarajan R, Longmore GD
Mechanisms of transcriptional regulation by Rb-E2F segregate by biological pathway.
Oncogene 2003 Oct 16;22(46):7209-17

Marie H, Pratt SJ, Betson M, Epple H, Kittler JT, Meek L, Moss SJ, Troyanovsky S, Attwell D, Longmore GD, Braga VM
The LIM protein Ajuba is recruited to cadherin-dependent cell junctions through an association with alpha-catenin.
J Biol Chem 2003 Jan 10;278(2):1220-8

Marie H, Billups D, Bedford FK, Dumoulin A, Goyal RK, Longmore GD, Moss SJ, Attwell D
The amino terminus of the glial glutamate transporter GLT-1 interacts with the LIM protein Ajuba.
Mol Cell Neurosci 2002 Feb;19(2):152-64

Afrikanova I, Yeh E, Bartos D, Watowich SS, Longmore GD
Oncogene cooperativity in Friend erythroleukemia: erythropoietin receptor activation by the env gene of SFFV leads to transcriptional upregulation of PU.1, independent of SFFV proviral insertion.
Oncogene 2002 Feb 14;21(8):1272-84

Hadland BK, Manley NR, Su D, Longmore GD, Moore CL, Wolfe MS, Schroeter EH, Kopan R
Gamma -secretase inhibitors repress thymocyte development.
Proc Natl Acad Sci U S A 2001 Jun 19;98(13):7487-91

Watowich SS, Mikami A, Busche RA, Xie X, Pharr PN, Longmore GD
Erythropoietin receptors that signal through Stat5 or Stat3 support fetal liver and adult erythropoiesis: lack of specificity of stat signals during red blood cell development.
J Interferon Cytokine Res 2000 Dec;20(12):1065-70

Pharr PN, Hofbauer A, Worthington RE, Longmore GD
Residual erythroid progenitors in W/W mice respond to erythropoietin in the absence of steel factor signals.
Int J Hematol 2000 Aug;72(2):178-85

Kanungo J, Pratt SJ, Marie H, Longmore GD
Ajuba, a cytosolic LIM protein, shuttles into the nucleus and affects embryonal cell proliferation and fate decisions.
Mol Biol Cell 2000 Oct;11(10):3299-313

Wooten DK, Xie X, Bartos D, Busche RA, Longmore GD, Watowich SS
Cytokine signaling through Stat3 activates integrins, promotes adhesion, and induces growth arrest in the myeloid cell line 32D.
J Biol Chem 2000 Aug 25;275(34):26566-75

Beckman DL, Lin LL, Quinones ME, Longmore GD
Activation of the erythropoietin receptor is not required for internalization of bound erythropoietin.
Blood 1999 Oct 15;94(8):2667-75

Goyal RK, Longmore GD
Abnormalities of cytokine receptor signalling contributing to diseases of red blood cell production.
Ann Med 1999 Jun;31(3):208-16

Gaffen SL, Lai SY, Longmore GD, Liu KD, Goldsmith MA
Genetic evidence for an additional factor required for erythropoietin-induced signal transduction.
Blood 1999 Jul 1;94(1):74-86

Goyal RK, Lin P, Kanungo J, Payne AS, Muslin AJ, Longmore GD
Ajuba, a novel LIM protein, interacts with Grb2, augments mitogen-activated protein kinase activity in fibroblasts, and promotes meiotic maturation of Xenopus oocytes in a Grb2- and Ras-dependent manner.
Mol Cell Biol 1999 Jun;19(6):4379-89

Watowich SS, Liu KD, Xie X, Lai SY, Mikami A, Longmore GD, Goldsmith MA
Oligomerization and scaffolding functions of the erythropoietin receptor cytoplasmic tail.
J Biol Chem 1999 Feb 26;274(9):5415-21

Goldsmith MA, Mikami A, You Y, Liu KD, Thomas L, Pharr P, Longmore GD
Absence of cytokine receptor-dependent specificity in red blood cell differentiation in vivo.
Proc Natl Acad Sci U S A 1998 Jun 9;95(12):7006-11

Zamorano J, Wang HY, Wang R, Shi Y, Longmore GD, Keegan AD
Regulation of cell growth by IL-2: role of STAT5 in protection from apoptosis but not in cell cycle progression.
J Immunol 1998 Apr 1;160(7):3502-12

Longmore GD, You Y, Molden J, Liu KD, Mikami A, Lai SY, Pharr P, Goldsmith MA
Redundant and selective roles for erythropoietin receptor tyrosines in erythropoiesis in vivo.
Blood 1998 Feb 1;91(3):870-8

Tarr K, Watowich SS, Longmore GD
Cell surface organization of the erythropoietin receptor complex differs depending on its mode of activation.
J Biol Chem 1997 Apr 4;272(14):9099-107

Lai SY, Xu W, Gaffen SL, Liu KD, Longmore GD, Greene WC, Goldsmith MA
The molecular role of the common gamma c subunit in signal transduction reveals functional asymmetry within multimeric cytokine receptor complexes.
Proc Natl Acad Sci U S A 1996 Jan 9;93(1):231-5

Goldsmith MA, Lai SY, Xu W, Amaral MC, Kuczek ES, Parent LJ, Mills GB, Tarr KL, Longmore GD, Greene WC
Growth signal transduction by the human interleukin-2 receptor requires cytoplasmic tyrosines of the beta chain and non-tyrosine residues of the gamma c chain.
J Biol Chem 1995 Sep 15;270(37):21729-37

McArthur GA, Longmore GD, Klingler K, Johnson GR
Lineage-restricted recruitment of immature hematopoietic progenitor cells in response to Epo after normal hematopoietic cell transfection with EpoR.
Exp Hematol 1995 Jul;23(7):645-54

Tanner JW, Chen W, Young RL, Longmore GD, Shaw AS
The conserved box 1 motif of cytokine receptors is required for association with JAK kinases.
J Biol Chem 1995 Mar 24;270(12):6523-30

Pharr PN, Ogawa M, Hofbauer A, Longmore GD
Expression of an activated erythropoietin or a colony-stimulating factor 1 receptor by pluripotent progenitors enhances colony formation but does not induce differentiation.
Proc Natl Acad Sci U S A 1994 Aug 2;91(16):7482-6

Longmore GD, Pharr PN, Lodish HF
A constitutively activated erythropoietin receptor stimulates proliferation and contributes to transformation of multipotent, committed nonerythroid and erythroid progenitor cells.
Mol Cell Biol 1994 Apr;14(4):2266-77

Longmore GD, Watowich SS, Hilton DJ, Lodish HF
The erythropoietin receptor: its role in hematopoiesis and myeloproliferative diseases.
J Cell Biol 1993 Dec;123(6 Pt 1):1305-8

Longmore GD, Pharr P, Neumann D, Lodish HF
Both megakaryocytopoiesis and erythropoiesis are induced in mice infected with a retrovirus expressing an oncogenic erythropoietin receptor.
Blood 1993 Oct 15;82(8):2386-95

Longmore G, Watowich S, Pharr P, Neumann D, Lodish H
Activation of the erythropoietin receptor and leukemia induction in mice.
Leukemia 1993 Aug;7 Suppl 2:S113-6

Longmore GD
Erythropoietin receptor mutations and Olympic glory.
Nat Genet 1993 Jun;4(2):108-10

Youssoufian H, Longmore G, Neumann D, Yoshimura A, Lodish HF
Structure, function, and activation of the erythropoietin receptor.
Blood 1993 May 1;81(9):2223-36

Pharr PN, Hankins D, Hofbauer A, Lodish HF, Longmore GD
Expression of a constitutively active erythropoietin receptor in primary hematopoietic progenitors abrogates erythropoietin dependence and enhances erythroid colony-forming unit, erythroid burst-forming unit, and granulocyte/macrophage progenitor growth.
Proc Natl Acad Sci U S A 1993 Feb 1;90(3):938-42

Yoshimura A, Zimmers T, Neumann D, Longmore G, Yoshimura Y, Lodish HF
Mutations in the Trp-Ser-X-Trp-Ser motif of the erythropoietin receptor abolish processing, ligand binding, and activation of the receptor.
J Biol Chem 1992 Jun 5;267(16):11619-25

Watowich SS, Yoshimura A, Longmore GD, Hilton DJ, Yoshimura Y, Lodish HF
Homodimerization and constitutive activation of the erythropoietin receptor.
Proc Natl Acad Sci U S A 1992 Mar 15;89(6):2140-4

Lodish HF, Hilton D, Longmore G, Watowich SS, Yoshimura A
The erythropoietin receptor: dimerization, activation, and tumorigenesis.
Cold Spring Harb Symp Quant Biol 1992;57:95-106

Longmore GD, Pharr P, Lodish HF
Mutation in murine erythropoietin receptor induces erythropoietin-independent erythroid proliferation in vitro, polycythemia in vivo.
Leukemia 1992;6 Suppl 3:130S-134S

Baliga BS, Isoyama K, Longmore G, Yang YM, Shah AK, Mankad VN
A simple method for hemoglobin measurement in cell culture system.
Blood Cells 1992;18(2):187-93; discussion 194-5

Longmore GD, Lodish HF
An activating mutation in the murine erythropoietin receptor induces erythroleukemia in mice: a cytokine receptor superfamily oncogene.
Cell 1991 Dec 20;67(6):1089-102

Yoshimura A, Longmore G, Lodish HF
Point mutation in the exoplasmic domain of the erythropoietin receptor resulting in hormone-independent activation and tumorigenicity.
Nature 1990 Dec 13;348(6302):647-9

Longmore G, Guinan EC, Weinstein HJ, Gelber RD, Rappeport JM, Antin JH
Bone marrow transplantation for myelodysplasia and secondary acute nonlymphoblastic leukemia.
J Clin Oncol 1990 Oct;8(10):1707-14

Hubbard SC, Kranz DM, Longmore GD, Sitkovsky MV, Eisen HN
Glycosylation of the T-cell antigen-specific receptor and its potential role in lectin-mediated cytotoxicity.
Proc Natl Acad Sci U S A 1986 Mar;83(6):1852-6

Longmore GD, Schachter H
Product-identification and substrate-specificity studies of the GDP-L-fucose:2-acetamido-2-deoxy-beta-D-glucoside (FUC goes to Asn-linked GlcNAc) 6-alpha-L-fucosyltransferase in a Golgi-rich fraction from porcine liver.
Carbohydr Res 1982 Mar 1;100:365-92

Williams D, Longmore G, Matta KL, Schachter H
Mucin synthesis. II. Substrate specificity and product identification studies on canine submaxillary gland UDP-GlcNAc:Gal beta 1-3GalNAc(GlcNAc leads to GalNAc) beta 6-N-acetylglucosaminyltransferase.
J Biol Chem 1980 Dec 10;255(23):11253-61

Narasimhan S, Harpaz N, Longmore G, Carver JP, Grey AA, Schachter H
Control of glycoprotein synthesis. The purification by preparative high voltage paper electrophoresis in borate of glycopeptides containing high mannose and complex oligosaccharide chains linked to asparagine.
J Biol Chem 1980 May 25;255(10):4876-84