Philip W. Majerus, M.D.

JBC Classics

Kresge N, Simoni RD, Hill RL
The Thrombin-induced Hydrolysis of Phosphatidylinositol: the Work of Philip W. Majerus.
J Biol Chem 2008 Mar 21;283(12):e7

Hofmann SL, Majerus PW. J Biol Chem 1982 Jun 10;257(11):6461-9
Wilson DB, Bross TE, Hofmann SL,, Majerus PW. J Biol Chem 1984 Oct 10;259(19):11718-24
Wilson DB, Neufeld EJ,, Majerus PW. J Biol Chem 1985 Jan 25;260(2):1046-51

Publications

Zou J, Marjanovic J, Kisseleva MV, Wilson M, Majerus PW
Type I phosphatidylinositol-4,5-bisphosphate 4-phosphatase regulates stress-induced apoptosis.
Proc Natl Acad Sci U S A 2007 Oct 23;104(43):16834-9

Majerus PW
A discrete signaling function for an inositol pyrophosphate.
Sci STKE 2007 Dec 11;2007(416):pe72

Chang SC, Majerus PW
Inositol polyphosphate multikinase regulates inositol 1,4,5,6-tetrakisphosphate.
Biochem Biophys Res Commun 2006 Jan 6;339(1):209-16

Ungewickell A, Hugge C, Kisseleva M, Chang SC, Zou J, Feng Y, Galyov EE, Wilson M, Majerus PW
The identification and characterization of two phosphatidylinositol-4,5-bisphosphate 4-phosphatases.
Proc Natl Acad Sci U S A 2005 Dec 27;102(52):18854-9

Verbsky J, Majerus PW
Increased levels of inositol hexakisphosphate (InsP6) protect HEK293 cells from tumor necrosis factor (alpha)- and Fas-induced apoptosis.
J Biol Chem 2005 Aug 12;280(32):29263-8

Verbsky J, Lavine K, Majerus PW
Disruption of the mouse inositol 1,3,4,5,6-pentakisphosphate 2-kinase gene, associated lethality, and tissue distribution of 2-kinase expression.
Proc Natl Acad Sci U S A 2005 Jun 14;102(24):8448-53

Miller GJ, Wilson MP, Majerus PW, Hurley JH
Specificity determinants in inositol polyphosphate synthesis: crystal structure of inositol 1,3,4-trisphosphate 5/6-kinase.
Mol Cell 2005 Apr 15;18(2):201-12

Ivetac I, Munday AD, Kisseleva MV, Zhang XM, Luff S, Tiganis T, Whisstock JC, Rowe T, Majerus PW, Mitchell CA
The type Ialpha inositol polyphosphate 4-phosphatase generates and terminates phosphoinositide 3-kinase signals on endosomes and the plasma membrane.
Mol Biol Cell 2005 May;16(5):2218-33

Majerus PW, Tollefsen DM
Blood coagulation and anticoagulant, thrombolytic, and antiplatelet drugs.
In "Goodman & Gilman's The Pharmacological Basis of Therapeutics, 11th Edition" (Brunton LL, Lazo JS, Parker KL, eds.), McGraw-Hill, New York, pp. 1467-1488 (2006)

Verbsky JW, Chang SC, Wilson MP, Mochizuki Y, Majerus PW
The pathway for the production of inositol hexakisphosphate in human cells.
J Biol Chem 2005 Jan 21;280(3):1911-20

Insel PA, Kornfeld S, Majerus PW, Marks AR, Marks PA, Relman AS, Scharschmidt BF, Stossel TP, Varki AP, Weiss SJ, Wilson JD
Blasts from the past.
J Clin Invest 2004 Oct;114(8):1017-33

Ungewickell A, Ward ME, Ungewickell E, Majerus PW
The inositol polyphosphate 5-phosphatase Ocrl associates with endosomes that are partially coated with clathrin.
Proc Natl Acad Sci U S A 2004 Sep 14;101(37):13501-6

Rayala HJ, Kendirgi F, Barry DM, Majerus PW, Wente SR
The mRNA export factor human Gle1 interacts with the nuclear pore complex protein Nup155.
Mol Cell Proteomics 2004 Feb;3(2):145-55

Sun Y, Mochizuki Y, Majerus PW
Inositol 1,3,4-trisphosphate 5/6-kinase inhibits tumor necrosis factor-induced apoptosis.
J Biol Chem 2003 Oct 31;278(44):43645-53

Mochizuki Y, Majerus PW
Characterization of myotubularin-related protein 7 and its binding partner, myotubularin-related protein 9.
Proc Natl Acad Sci U S A 2003 Aug 19;100(17):9768-73

Nandurkar HH, Layton M, Laporte J, Selan C, Corcoran L, Caldwell KK, Mochizuki Y, Majerus PW, Mitchell CA
Identification of myotubularin as the lipid phosphatase catalytic subunit associated with the 3-phosphatase adapter protein, 3-PAP.
Proc Natl Acad Sci U S A 2003 Jul 22;100(15):8660-5

Sun Y, Wilson MP, Majerus PW
Inositol 1,3,4-trisphosphate 5/6-kinase associates with the COP9 signalosome by binding to CSN1.
J Biol Chem 2002 Nov 29;277(48):45759-64

Chang SC, Miller AL, Feng Y, Wente SR, Majerus PW
The human homolog of the rat inositol phosphate multikinase is an inositol 1,3,4,6-tetrakisphosphate 5-kinase.
J Biol Chem 2002 Nov 15;277(46):43836-43

Verbsky JW, Wilson MP, Kisseleva MV, Majerus PW, Wente SR
The synthesis of inositol hexakisphosphate. Characterization of human inositol 1,3,4,5,6-pentakisphosphate 2-kinase.
J Biol Chem 2002 Aug 30;277(35):31857-62

Kisseleva MV, Cao L, Majerus PW
Phosphoinositide-specific inositol polyphosphate 5-phosphatase IV inhibits Akt/protein kinase B phosphorylation and leads to apoptotic cell death.
J Biol Chem 2002 Feb 22;277(8):6266-72

Nandurkar HH, Caldwell KK, Whisstock JC, Layton MJ, Gaudet EA, Norris FA, Majerus PW, Mitchell CA
Characterization of an adapter subunit to a phosphatidylinositol (3)P 3-phosphatase: identification of a myotubularin-related protein lacking catalytic activity.
Proc Natl Acad Sci U S A 2001 Aug 14;98(17):9499-504

Wilson MP, Sun Y, Cao L, Majerus PW
Inositol 1,3,4-trisphosphate 5/6-kinase is a protein kinase that phosphorylates the transcription factors c-Jun and ATF-2.
J Biol Chem 2001 Nov 2;276(44):40998-1004

Feng Y, Wente SR, Majerus PW
Overexpression of the inositol phosphatase SopB in human 293 cells stimulates cellular chloride influx and inhibits nuclear mRNA export.
Proc Natl Acad Sci U S A 2001 Jan 30;98(3):875-9

Vyas P, Norris FA, Joseph R, Majerus PW, Orkin SH
Inositol polyphosphate 4-phosphatase type I regulates cell growth downstream of transcription factor GATA-1.
Proc Natl Acad Sci U S A 2000 Dec 5;97(25):13696-701

Field J, Wilson MP, Mai Z, Majerus PW, Samuelson J
An Entamoeba histolytica inositol 1,3,4-trisphosphate 5/6-kinase has a novel 3-kinase activity.
Mol Biochem Parasitol 2000 Apr 30;108(1):119-23

Kisseleva MV, Wilson MP, Majerus PW
The isolation and characterization of a cDNA encoding phospholipid-specific inositol polyphosphate 5-phosphatase.
J Biol Chem 2000 Jun 30;275(26):20110-6

Kunz J, Wilson MP, Kisseleva M, Hurley JH, Majerus PW, Anderson RA
The activation loop of phosphatidylinositol phosphate kinases determines signaling specificity.
Mol Cell 2000 Jan;5(1):1-11

Ungewickell AJ, Majerus PW
Increased levels of plasma lysosomal enzymes in patients with Lowe syndrome.
Proc Natl Acad Sci U S A 1999 Nov 9;96(23):13342-4

Munday AD, Norris FA, Caldwell KK, Brown S, Majerus PW, Mitchell CA
The inositol polyphosphate 4-phosphatase forms a complex with phosphatidylinositol 3-kinase in human platelet cytosol.
Proc Natl Acad Sci U S A 1999 Mar 30;96(7):3640-5

Majerus PW, Kisseleva MV, Norris FA
The role of phosphatases in inositol signaling reactions.
J Biol Chem 1999 Apr 16;274(16):10669-72

Damen JE, Liu L, Ware MD, Ermolaeva M, Majerus PW, Krystal G
Multiple forms of the SH2-containing inositol phosphatase, SHIP, are generated by C-terminal truncation.
Blood 1998 Aug 15;92(4):1199-205

Norris FA, Wilson MP, Wallis TS, Galyov EE, Majerus PW
SopB, a protein required for virulence of Salmonella dublin, is an inositol phosphate phosphatase [see comments]
Proc Natl Acad Sci U S A 1998 Nov 24;95(24):14057-9

Roach TI, Slater SE, White LS, Zhang X, Majerus PW, Brown EJ, Thomas ML
The protein tyrosine phosphatase SHP-1 regulates integrin-mediated adhesion of macrophages.
Curr Biol 1998 Sep 10;8(18):1035-8

Zhang X, Hartz PA, Philip E, Racusen LC, Majerus PW
Cell lines from kidney proximal tubules of a patient with Lowe syndrome lack OCRL inositol polyphosphate 5-phosphatase and accumulate phosphatidylinositol 4,5-bisphosphate.
J Biol Chem 1998 Jan 16;273(3):1574-82

Zhang X, Majerus PW
Phosphatidylinositol signalling reactions.
Semin Cell Dev Biol 1998 Apr;9(2):153-60

Majerus PW
Prostaglandins: critical roles in pregnancy and colon cancer.
Curr Biol 1998 Jan 29;8(3):R87-9

Damen JE, Liu L, Wakao H, Miyajima A, Rosten P, Jefferson AB, Majerus PW, Krosl J, Humphries RK, Krystal G
The role of erythropoietin receptor tyrosine phosphorylation in erythropoietin-induced proliferation.
Leukemia 1997 Apr;11 Suppl 3:423-5

Norris FA, Atkins RC, Majerus PW
The cDNA cloning and characterization of inositol polyphosphate 4- phosphatase type II. Evidence for conserved alternative splicing in the 4-phosphatase family.
J Biol Chem 1997 Sep 19;272(38):23859-64

Zhang X, Loijens JC, Boronenkov IV, Parker GJ, Norris FA, Chen J, Thum O, Prestwich GD, Majerus PW, Anderson RA
Phosphatidylinositol-4-phosphate 5-kinase isozymes catalyze the synthesis of 3-phosphate-containing phosphatidylinositol signaling molecules.
J Biol Chem 1997 Jul 11;272(28):17756-61

Norris FA, Atkins RC, Majerus PW
Inositol polyphosphate 4-phosphatase is inactivated by calpain-mediated proteolysis in stimulated human platelets.
J Biol Chem 1997 Apr 25;272(17):10987-9

Wilson MP, Majerus PW
Characterization of a cDNA encoding Arabidopsis thaliana inositol 1,3,4- trisphosphate 5/6-kinase.
Biochem Biophys Res Commun 1997 Mar 27;232(3):678-81

Jefferson AB, Auethavekiat V, Pot DA, Williams LT, Majerus PW
Signaling inositol polyphosphate-5-phosphatase. Characterization of activity and effect of GRB2 association.
J Biol Chem 1997 Feb 28;272(9):5983-8

Auethavekiat V, Abrams CS, Majerus PW
Phosphorylation of platelet pleckstrin activates inositol polyphosphate 5-phosphatase I.
J Biol Chem 1997 Jan 17;272(3):1786-90

Liu L, Jefferson AB, Zhang X, Norris FA, Majerus PW, Krystal G
A novel phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase associates with the interleukin-3 receptor.
J Biol Chem 1996 Nov 22;271(47):29729-33

Osborne MA, Zenner G, Lubinus M, Zhang X, Songyang Z, Cantley LC, Majerus P, Burn P, Kochan JP
The inositol 5'-phosphatase SHIP binds to immunoreceptor signaling motifs and responds to high affinity IgE receptor aggregation.
J Biol Chem 1996 Nov 15;271(46):29271-8

Majerus PW
Inositols do it all.
Genes Dev 1996 May 1;10(9):1051-3

Gu M, Meng K, Majerus PW
The effect of overexpression of the protein tyrosine phosphatase PTPMEG on cell growth and on colony formation in soft agar in COS-7 cells.
Proc Natl Acad Sci U S A 1996 Nov 12;93(23):12980-5

Wilson MP, Majerus PW
Isolation of inositol 1,3,4-trisphosphate 5/6-kinase, cDNA cloning and expression of the recombinant enzyme.
J Biol Chem 1996 May 17;271(20):11904-10

Gu M, Majerus PW
The properties of the protein tyrosine phosphatase PTPMEG.
J Biol Chem 1996 Nov 1;271(44):27751-9

Jefferson AB, Majerus PW
Mutation of the conserved domains of two inositol polyphosphate 5- phosphatases.
Biochemistry 1996 Jun 18;35(24):7890-4

Damen JE, Liu L, Rosten P, Humphries RK, Jefferson AB, Majerus PW, Krystal G
The 145-kDa protein induced to associate with Shc by multiple cytokines is an inositol tetraphosphate and phosphatidylinositol 3,4,5- triphosphate 5-phosphatase.
Proc Natl Acad Sci U S A 1996 Feb 20;93(4):1689-93

Kavanaugh WM, Pot DA, Chin SM, Deuter-Reinhard M, Jefferson AB, Norris FA, Masiarz FR, Cousens LS, Majerus PW, Williams LT
Multiple forms of an inositol polyphosphate 5-phosphatase form signaling complexes with Shc and Grb2.
Curr Biol 1996 Apr 1;6(4):438-45

Norris FA, Auethavekiat V, Majerus PW
The isolation and characterization of cDNA encoding human and rat brain inositol polyphosphate 4-phosphatase.
J Biol Chem 1995 Jul 7;270(27):16128-33

Zhang X, Jefferson AB, Auethavekiat V, Majerus PW
The protein deficient in Lowe syndrome is a phosphatidylinositol-4,5- bisphosphate 5-phosphatase.
Proc Natl Acad Sci U S A 1995 May 23;92(11):4853-6

York JD, Ponder JW, Majerus PW
Definition of a metal-dependent/Li(+)-inhibited phosphomonoesterase protein family based upon a conserved three-dimensional core structure.
Proc Natl Acad Sci U S A 1995 May 23;92(11):5149-53

Jefferson AB, Majerus PW
Properties of type II inositol polyphosphate 5-phosphatase.
J Biol Chem 1995 Apr 21;270(16):9370-7

Norris FA, Ungewickell E, Majerus PW
Inositol hexakisphosphate binds to clathrin assembly protein 3 (AP- 3/AP180) and inhibits clathrin cage assembly in vitro.
J Biol Chem 1995 Jan 6;270(1):214-7

York JD, Ponder JW, Chen ZW, Mathews FS, Majerus PW
Crystal structure of inositol polyphosphate 1-phosphatase at 2.3-A resolution.
Biochemistry 1994 Nov 15;33(45):13164-71

York JD, Saffitz JE, Majerus PW
Inositol polyphosphate 1-phosphatase is present in the nucleus and inhibits DNA synthesis.
J Biol Chem 1994 Aug 5;269(31):19992-9

Majerus PW
Human genetics. Bad blood by mutation [news; comment]
Nature 1994 May 5;369(6475):14-5

Norris FA, Majerus PW
Hydrolysis of phosphatidylinositol 3,4-bisphosphate by inositol polyphosphate 4-phosphatase isolated by affinity elution chromatography.
J Biol Chem 1994 Mar 25;269(12):8716-20

York JD, Majerus PW
Nuclear phosphatidylinositols decrease during S-phase of the cell cycle in HeLa cells [published erratum appears in J Biol Chem 1994 Dec 9;269(49):31322]
J Biol Chem 1994 Mar 18;269(11):7847-50

York JD, Chen ZW, Ponder JW, Chauhan AK, Mathews FS, Majerus PW
Crystallization and initial X-ray crystallographic characterization of recombinant bovine inositol polyphosphate 1-phosphatase produced in Spodoptera frugiperda cells.
J Mol Biol 1994 Feb 18;236(2):584-9

Majerus PW
Platelets.
In G. Stamatoyannopoulos, A.W. Nienhuis, P.W. Majerus and H. Varmus (Eds.), Molecular Basis of Blood Diseases, 2nd ed.  Philadelphia: W.B. Saunders Company (1994)

York JD, Veile RA, Donis-Keller H, Majerus PW
Cloning, heterologous expression, and chromosomal localization of human inositol polyphosphate 1-phosphatase.
Proc Natl Acad Sci U S A 1993 Jun 15;90(12):5833-7

Miletich JP, Prescott SM, White R, Majerus PW, Bovill EG
Inherited predisposition to thrombosis.
Cell 1993 Feb 26;72(4):477-80

Ross TS, Wang FP, Majerus PW
Mammalian cells that express Bacillus cereus phosphatidylinositol- specific phospholipase C have increased levels of inositol cyclic 1:2- phosphate, inositol 1-phosphate, and inositol 2-phosphate.
J Biol Chem 1992 Oct 5;267(28):19919-23

Ross TS, Majerus PW
Identification of a phosphodiesterase that converts inositol cyclic 1:2- phosphate to inositol 2-phosphate.
J Biol Chem 1992 Oct 5;267(28):19924-8

Gu M, Warshawsky I, Majerus PW
Cloning and expression of a cytosolic megakaryocyte protein-tyrosine- phosphatase with sequence homology to retinaldehyde-binding protein and yeast SEC14p.
Proc Natl Acad Sci U S A 1992 Apr 1;89(7):2980-4

Majerus PW
Inositol phosphate biochemistry.
Annu Rev Biochem 1992;61:225-50

Majerus PW
The George M. Kober Lecture: molecular mechanisms of intracellular signal transduction.
Trans Assoc Am Physicians 1991;104:clxviii-clxxx

Bejcek BE, Hoffman RM, Lipps D, Li DY, Mitchell CA, Majerus PW, Deuel TF
The v-sis oncogene product but not platelet-derived growth factor (PDGF) A homodimers activate PDGF alpha and beta receptors intracellularly and initiate cellular transformation.
J Biol Chem 1992 Feb 15;267(5):3289-93

Neuwald AF, York JD, Majerus PW
Diverse proteins homologous to inositol monophosphatase.
FEBS Lett 1991 Dec 2;294(1-2):16-8

Walsh JP, Caldwell KK, Majerus PW
Formation of phosphatidylinositol 3-phosphate by isomerization from phosphatidylinositol 4-phosphate.
Proc Natl Acad Sci U S A 1991 Oct 15;88(20):9184-7

Ross TS, Jefferson AB, Mitchell CA, Majerus PW
Cloning and expression of human 75-kDa inositol polyphosphate-5- phosphatase.
J Biol Chem 1991 Oct 25;266(30):20283-9

Caldwell KK, Lips DL, Bansal VS, Majerus PW
Isolation and characterization of two 3-phosphatases that hydrolyze both phosphatidylinositol 3-phosphate and inositol 1,3-bisphosphate.
J Biol Chem 1991 Sep 25;266(27):18378-86

Gu MX, York JD, Warshawsky I, Majerus PW
Identification, cloning, and expression of a cytosolic megakaryocyte protein-tyrosine-phosphatase with sequence homology to cytoskeletal protein 4.1.
Proc Natl Acad Sci U S A 1991 Jul 1;88(13):5867-71

Cunningham TW, Majerus PW
Pathway for the formation of D-3 phosphate containing inositol phospholipids in PDGF stimulated NIH 3T3 fibroblasts.
Biochem Biophys Res Commun 1991 Mar 15;175(2):568-76

Ross TS, Whiteley B, Graham RA, Majerus PW
Cyclic hydrolase-transfected 3T3 cells have low levels of inositol 1,2- cyclic phosphate and reach confluence at low density.
J Biol Chem 1991 May 15;266(14):9086-92

Ross TS, Majerus PW
Inositol-1,2-cyclic-phosphate 2-inositolphosphohydrolase. Substrate specificity and regulation of activity by phospholipids, metal ion chelators, and inositol 2-phosphate.
J Biol Chem 1991 Jan 15;266(2):851-6

Majerus PW, Broze GJ Jr, Miletich JP, Tollefsen DM
Anticoagulant, thrombolytic and antiplatelet drugs.
The pharmacologic basis of theropeutics.  A. Gilman, ed., pp. 1311-1331.  New York: Pergamon Press (1990)

Majerus PW, Bansal VS, Lips DL, Ross TA, Mitchell CA, Caldwell KK, Cunningham TW
The phosphatidylinositol pathway of platelets and vascular cells.
Ann N Y Acad Sci 1991;614:44-50

York JD, Majerus PW
Isolation and heterologous expression of a cDNA encoding bovine inositol polyphosphate 1-phosphatase.
Proc Natl Acad Sci U S A 1990 Dec;87(24):9548-52

Mitchell CA, Jefferson AB, Bejeck BE, Brugge JS, Deuel TF, Majerus PW
Thrombin-stimulated immunoprecipitation of phosphatidylinositol 3- kinase from human platelets.
Proc Natl Acad Sci U S A 1990 Dec;87(23):9396-400

Majerus PW, Ross TS, Cunningham TW, Caldwell KK, Jefferson AB, Bansal VS
Recent insights in phosphatidylinositol signaling.
Cell 1990 Nov 2;63(3):459-65

Bansal VS, Majerus PW
Phosphatidylinositol-derived precursors and signals.
Annu Rev Cell Biol 1990;6:41-67

Ross TS, Tait JF, Majerus PW
Identity of inositol 1,2-cyclic phosphate 2-phosphohydrolase with lipocortin III.
Science 1990 May 4;248(4955):605-7

Cunningham TW, Lips DL, Bansal VS, Caldwell KK, Mitchell CA, Majerus PW
Pathway for the formation of D-3 phosphate containing inositol phospholipids in intact human platelets.
J Biol Chem 1990 Dec 15;265(35):21676-83

Bansal VS, Caldwell KK, Majerus PW
The isolation and characterization of inositol polyphosphate 4- phosphatase.
J Biol Chem 1990 Jan 25;265(3):1806-11

Dittman WA, Majerus PW
Structure and function of thrombomodulin: a natural anticoagulant.
Blood 1990 Jan 15;75(2):329-36

Deckmyn H, Whiteley BJ, Majerus PW
Phosphatidylinositol phospholipase C.
In L. Birnbaumer and R. Iyengar (eds.), G-Proteins.  Academic Press, 429-452 (1990)

McEver RP, Majerus PW
Inherited disorders of platelets.
In R. Scriver, A.L. Beaudet, W.S. Sly, and D. Valle (eds.), The Metabolic Basis of Inherited Disease, 6th edition.  New York: McGraw Hill  (1989)

Lips DL, Majerus PW
The discovery of a 3-phosphomonoesterase that hydrolyzes phosphatidylinositol 3-phosphate in NIH 3T3 cells.
J Biol Chem 1989 Nov 25;264(33):19911-5

Dittman WA, Kumada T, Majerus PW
Transcription of thrombomodulin mRNA in mouse hemangioma cells is increased by cycloheximide and thrombin.
Proc Natl Acad Sci U S A 1989 Sep;86(18):7179-82

Lips DL, Majerus PW, Gorga FR, Young AT, Benjamin TL
Phosphatidylinositol 3-phosphate is present in normal and transformed fibroblasts and is resistant to hydrolysis by bovine brain phospholipase C II.
J Biol Chem 1989 May 25;264(15):8759-63

Mitchell CA, Connolly TM, Majerus PW
Identification and isolation of a 75-kDa inositol polyphosphate-5- phosphatase from human platelets.
J Biol Chem 1989 May 25;264(15):8873-7

Dittman WA, Majerus PW
Sequence of a cDNA for mouse thrombomodulin and comparison of the predicted mouse and human amino acid sequences.
Nucleic Acids Res 1989 Jan 25;17(2):802

Ishii H, Nakano M, Tsubouchi J, Kazama M, Majerus PW
[Distribution of thrombomodulin in human tissues and characterization of thrombomodulin in plasma]
Nippon Ketsueki Gakkai Zasshi 1988 Nov;51(7):1228-33

Dittman WA, Kumada T, Sadler JE, Majerus PW
The structure and function of mouse thrombomodulin. Phorbol myristate acetate stimulates degradation and synthesis of thrombomodulin without affecting mRNA levels in hemangioma cells.
J Biol Chem 1988 Oct 25;263(30):15815-22

Inhorn RC, Majerus PW
Properties of inositol polyphosphate 1-phosphatase.
J Biol Chem 1988 Oct 5;263(28):14559-65

Majerus PW, Connolly TM, Bansal VS, Inhorn RC, Ross TS, Lips DL
Inositol phosphates: synthesis and degradation.
J Biol Chem 1988 Mar 5;263(7):3051-4

Kumada T, Dittman WA, Majerus PW
A role for thrombomodulin in the pathogenesis of thrombin-induced thromboembolism in mice.
Blood 1988 Mar;71(3):728-33

Lips DL, Bross TE, Majerus PW
Isolation of 1-monomethylphosphoinositol 4,5-bisphosphate [a product of methanolysis of inositol 1,2-(cyclic)-4,5-trisphosphate] from Swiss mouse 3T3 cells.
Proc Natl Acad Sci U S A 1988 Jan;85(1):88-92

Majerus PW, Connolly TM, Bansal VS, Inhorn RC, Deckmyn H
The metabolism of inositol phosphates.
Cellular and Molecular Aspects of Inflammation, pp. 445-459.  Philadelphia: Smith Kline and French Laboratories Research Symposium (1988)

Inhorn RC, Majerus PW
Inositol polyphosphate 1-phosphatase from calf brain. Purification and inhibition by Li+, Ca2+, and Mn2+.
J Biol Chem 1987 Nov 25;262(33):15946-52

Yonezawa S, Maruyama I, Sakae K, Igata A, Majerus PW, Sato E
Thrombomodulin as a marker for vascular tumors. Comparative study with factor VIII and Ulex europaeus I lectin.
Am J Clin Pathol 1987 Oct;88(4):405-11

Wen DZ, Dittman WA, Ye RD, Deaven LL, Majerus PW, Sadler JE
Human thrombomodulin: complete cDNA sequence and chromosome localization of the gene.
Biochemistry 1987 Jul 14;26(14):4350-7

Bansal VS, Inhorn RC, Majerus PW
The metabolism of inositol 1,3,4-trisphosphate to inositol 1,3- bisphosphate.
J Biol Chem 1987 Jul 15;262(20):9444-7

Majerus PW
Platelets: Disorders and role in hemostasis.
In P. Leder, PW Majerus, A.W. Nienhuis, G. Stamatoyannopoulos (eds.), Molecular Basis of Blood Diseases, pp. 689-721.  Philadelphia: W.B. Saunders Company (1987)

Laposata M, Kaiser SL, Reich EL, Majerus PW
Eicosadiynoic acid: a non-toxic inhibitor of multiple enzymatic steps in the production of icosanoids from arachidonic acid.
Prostaglandins 1987 Apr;33(4):603-15

Inhorn RC, Bansal VS, Majerus PW
Pathway for inositol 1,3,4-trisphosphate and 1,4-bisphosphate metabolism.
Proc Natl Acad Sci U S A 1987 Apr;84(8):2170-4

Auchus RJ, Kaiser SL, Majerus PW
Synthesis of inositol 1,2-(cyclic)-4,5-trisphosphate.
Proc Natl Acad Sci U S A 1987 Mar;84(5):1206-9

Laposata M, Majerus PW
Measurement of icosanoid precursor uptake and release by intact cells.
Methods Enzymol 1987;141:350-5

Majerus PW, Wilson DB, Connolly TM, Bross TE, Neufeld EJ
Phosphoinositide turnover provides a link in stimulus-response coupling.
In R. Bradshaw & S. Prentis (eds.), Oncogenes and Growth Factors, pp. 269-274.  Cambridge, U.K.: Elsevier Publications (1987)

Connolly TM, Bansal VS, Bross TE, Irvine RF, Majerus PW
The metabolism of tris- and tetraphosphates of inositol by 5- phosphomonoesterase and 3-kinase enzymes.
J Biol Chem 1987 Feb 15;262(5):2146-9

Maruyama I, Majerus PW
Protein C inhibits endocytosis of thrombin-thrombomodulin complexes in A549 lung cancer cells and human umbilical vein endothelial cells.
Blood 1987 May;69(5):1481-4

Wilson DB, Connolly TM, Ross TS, Ishii H, Bross TE, Deckmyn H, Brass LF, Majerus PW
Phosphoinositide metabolism in human platelets.
Adv Prostaglandin Thromboxane Leukot Res 1987;17A:558-62

Salem HH, Esmon NL, Esmon CT, Majerus PW
Complex interaction between factor Va-light chain and thrombomodulin in the regulation of protein C activation.
Ann N Y Acad Sci 1986;485:221-7

Majerus PW, Connolly TM, Deckmyn H, Ross TS, Bross TE, Ishii H, Bansal VS, Wilson DB
The metabolism of phosphoinositide-derived messenger molecules.
Science 1986 Dec 19;234(4783):1519-26

Deckmyn H, Tu SM, Majerus PW
Guanine nucleotides stimulate soluble phosphoinositide-specific phospholipase C in the absence of membranes.
J Biol Chem 1986 Dec 15;261(35):16553-8

Connolly TM, Lawing WJ Jr, Majerus PW
Protein kinase C phosphorylates human platelet inositol trisphosphate 5'-phosphomonoesterase, increasing the phosphatase activity.
Cell 1986 Sep 12;46(6):951-8

Ishii H, Connolly TM, Bross TE, Majerus PW
Inositol cyclic triphosphate [inositol 1,2-(cyclic)-4,5-triphosphate] is formed upon thrombin stimulation of human platelets.
Proc Natl Acad Sci U S A 1986 Sep;83(17):6397-401

Ross TS, Majerus PW
Isolation of D-myo-inositol 1:2-cyclic phosphate 2- inositolphosphohydrolase from human placenta.
J Biol Chem 1986 Aug 25;261(24):11119-23

Ishii H, Salem HH, Bell CE, Laposata EA, Majerus PW
Thrombomodulin, an endothelial anticoagulant protein, is absent from the human brain.
Blood 1986 Feb;67(2):362-5

Connolly TM, Wilson DB, Bross TE, Majerus PW
Isolation and characterization of the inositol cyclic phosphate products of phosphoinositide cleavage by phospholipase C. Metabolism in cell-free extracts.
J Biol Chem 1986 Jan 5;261(1):122-6

Majerus PW
The production of phosphoinositide-derived messenger molecules.
Harvey Lect 1986-87;82:145-55

Majerus PW, Connolly TM, Ross TS, Ishii H, Deckmyn H
The role of phosphoinositides in cell physiology.
Symp Fundam Cancer Res 1986;39:157-63

Ishii H, Majerus PW
Thrombomodulin is present in human plasma and urine.
J Clin Invest 1985 Dec;76(6):2178-81

Maruyama I, Majerus PW
The turnover of thrombin-thrombomodulin complex in cultured human umbilical vein endothelial cells and A549 lung cancer cells. Endocytosis and degradation of thrombin.
J Biol Chem 1985 Dec 15;260(29):15432-8

Wilson DB, Connolly TM, Bross TE, Majerus PW, Sherman WR, Tyler AN, Rubin LJ, Brown JE
Isolation and characterization of the inositol cyclic phosphate products of polyphosphoinositide cleavage by phospholipase C. Physiological effects in permeabilized platelets and Limulus photoreceptor cells.
J Biol Chem 1985 Nov 5;260(25):13496-501

Laposata M, Reich EL, Majerus PW
Arachidonoyl-CoA synthetase. Separation from nonspecific acyl-CoA synthetase and distribution in various cells and tissues.
J Biol Chem 1985 Sep 15;260(20):11016-20

Auchus RJ, Wilson DB, Covey DF, Majerus PW
The 5-hydroxyl of myo-inositol is essential for uptake into HSDM1C1 mouse fibrosarcoma cells.
Biochem Biophys Res Commun 1985 Aug 15;130(3):1139-46

Neufeld EJ, Majerus PW, Krueger CM, Saffitz JE
Uptake and subcellular distribution of [3H]arachidonic acid in murine fibrosarcoma cells measured by electron microscope autoradiography.
J Cell Biol 1985 Aug;101(2):573-81

Majerus PW, Wilson DB, Connolly TM, Bross TE, Neufeld EJ
Phosphoinositide turnover provides a link in stimulus-response coupling.
Trends Biochem Sci 1985;10:168-171

Majerus PW, Wilson DB, Connolly TM, Bross TE, Neufeld EJ
Pathways of phosphoinositide metabolism in human platelets.
Adv Prostaglandin Thromboxane Leukot Res 1985;15:109-12

Wilson DB, Bross TE, Sherman WR, Berger RA, Majerus PW
Inositol cyclic phosphates are produced by cleavage of phosphatidylphosphoinositols (polyphosphoinositides) with purified sheep seminal vesicle phospholipase C enzymes.
Proc Natl Acad Sci U S A 1985 Jun;82(12):4013-7

Connolly TM, Bross TE, Majerus PW
Isolation of a phosphomonoesterase from human platelets that specifically hydrolyzes the 5-phosphate of inositol 1,4,5-trisphosphate.
J Biol Chem 1985 Jul 5;260(13):7868-74

Maruyama I, Bell CE, Majerus PW
Thrombomodulin is found on endothelium of arteries, veins, capillaries, and lymphatics, and on syncytiotrophoblast of human placenta.
J Cell Biol 1985 Aug;101(2):363-71

Wilson DB, Neufeld EJ, Majerus PW
Phosphoinositide interconversion in thrombin-stimulated human platelets.
J Biol Chem 1985 Jan 25;260(2):1046-51

Maruyama I, Salem HH, Ishii H, Majerus PW
Human thrombomodulin is not an efficient inhibitor of the procoagulant activity of thrombin.
J Clin Invest 1985 Mar;75(3):987-91

Majerus PW, Neufeld EJ, Laposata M
Mechanisms for eicosanoid precursor uptake and release by a tissue culture cell line.
In J.E. Bleasdale, Eichberg, J., and G. Hauser (eds.), Inositol and Phosphoinositides: Metabolism and Regulation, pp. 443-457.  Clifton, NJ: Humana Press (1985)

Majerus PW, Neufeld EJ, Wilson DB
Production of phosphoinositide-derived messengers.
Cell 1984 Jul;37(3):701-3

Wilson DB, Bross TE, Hofmann SL, Majerus PW
Hydrolysis of polyphosphoinositides by purified sheep seminal vesicle phospholipase C enzymes.
J Biol Chem 1984 Oct 10;259(19):11718-24

Salem HH, Maruyama I, Ishii H, Majerus PW
Isolation and characterization of thrombomodulin from human placenta.
J Biol Chem 1984 Oct 10;259(19):12246-51

Maruyama I, Salem HH, Majerus PW
Coagulation factor Va binds to human umbilical vein endothelial cells and accelerates protein C activation.
J Clin Invest 1984 Jul;74(1):224-30

Salem HH, Esmon NL, Esmon CT, Majerus PW
Effects of thrombomodulin and coagulation Factor Va-light chain on protein C activation in vitro.
J Clin Invest 1984 Apr;73(4):968-72

Neufeld EJ, Sprecher H, Evans RW, Majerus PW
Fatty acid structural requirements for activity of arachidonoyl-CoA synthetase.
J Lipid Res 1984 Mar;25(3):288-93

Neufeld EJ, Bross TE, Majerus PW
A mutant HSDM1C1 fibrosarcoma line selected for defective eicosanoid precursor uptake lacks arachidonate-specific acyl-CoA synthetase.
J Biol Chem 1984 Feb 10;259(3):1986-92

Wilson DB, Salem HH, Mruk JS, Maruyama I, Majerus PW
Biosynthesis of coagulation Factor V by a human hepatocellular carcinoma cell line.
J Clin Invest 1984 Mar;73(3):654-8

Majerus PW
Arachidonate metabolism in vascular disorders.
J Clin Invest 1983 Nov;72(5):1521-5

Bross TE, Prescott SM, Majerus PW
RHC 80267 does not inhibit the diglyceride lipase pathway in intact platelets.
Biochem Biophys Res Commun 1983 Oct 14;116(1):68-74

Majerus PW
Antithrombotic therapy: Current achievements and future directions.
Drug Therapy 1983;13:51-52

Salem HH, Broze GJ, Miletich JP, Majerus PW
The light chain of factor Va contains the activity of factor Va that accelerates protein C activation by thrombin.
J Biol Chem 1983 Jul 25;258(14):8531-4

Neufeld EJ, Wilson DB, Sprecher H, Majerus PW
High affinity esterification of eicosanoid precursor fatty acids by platelets.
J Clin Invest 1983 Jul;72(1):214-20

Salem HH, Broze GJ, Miletich JP, Majerus PW
Human coagulation factor Va is a cofactor for the activation of protein C.
Proc Natl Acad Sci U S A 1983 Mar;80(6):1584-8

Neufeld EJ, Majerus PW
Arachidonate release and phosphatidic acid turnover in stimulated human platelets.
J Biol Chem 1983 Feb 25;258(4):2461-7

Prescott SM, Majerus PW
Characterization of 1,2-diacylglycerol hydrolysis in human platelets. Demonstration of an arachidonoyl-monoacylglycerol intermediate.
J Biol Chem 1983 Jan 25;258(2):764-9

Majerus PW, Prescott SM, Hofmann SL, Neufeld EJ, Wilson DB
Uptake and release of arachidonate by platelets.
Adv Prostaglandin Thromboxane Leukot Res 1983;11:45-52

Prescott SM, Majerus PW
Drugs for the prevention of cardiovascular disease.
In Kaplan (ed.), Preventive Cardiology, pp. 147-160.  Philadelphia: W.B. Saunders (1983)

Laposata M, Prescott SM, Bross TE, Majerus PW
Development and characterization of a tissue culture cell line with essential fatty acid deficiency.
Proc Natl Acad Sci U S A 1982 Dec;79(24):7654-8

Hofmann SL, Majerus PW
Modulation of phosphatidylinositol-specific phospholipase C activity by phospholipid interactions, diglycerides, and calcium ions.
J Biol Chem 1982 Dec 10;257(23):14359-64

Kane WH, Mruk JS, Majerus PW
Activation of coagulation factor V by a platelet protease.
J Clin Invest 1982 Nov;70(5):1092-100

Majerus PW
Fraud in medical research. Presidential address delivered before the 74th annual meeting of the American Society for Clinical Investigation, Washington, DC, 8 May 1982.
J Clin Invest 1982 Jul;70(1):213-7

Hofmann SL, Majerus PW
Identification and properties of two distinct phosphatidylinositol- specific phospholipase C enzymes from sheep seminal vesicular glands.
J Biol Chem 1982 Jun 10;257(11):6461-9

Wilson DB, Prescott SM, Majerus PW
Discovery of an arachidonoyl coenzyme A synthetase in human platelets.
J Biol Chem 1982 Apr 10;257(7):3510-5

Hofmann SL, Prescott SM, Majerus PW
The effects of mepacrine and p-bromophenacyl bromide on arachidonic acid release in human platelets.
Arch Biochem Biophys 1982 Apr 15;215(1):237-44

Majerus PW, Prescott SM
Characterization and assay of diacylglycerol lipase from human platelets.
Methods Enzymol 1982;86:11-7

Prescott SM, Majerus PW
Platelet and vascular effects of aspirin.
Primary Cardiology 1982;8:58-65

McEver RP, Baenziger JU, Majerus PW
Isolation and structural characterization of the polypeptide subunits of membrane glycoprotein IIb-IIIa from human platelets.
Blood 1982 Jan;59(1):80-5

McEver RP, Majerus PW
Inherited disorders of platelets.
In Stanbury (ed.), Metabolic Basis of Inherited Disease, 5th edition, pp. 1561-1572.  New York: McGraw-Hill(1982)

Kane WH, Majerus PW
The interaction of human coagulation factor Va with platelets.
J Biol Chem 1982 Apr 10;257(7):3963-9

Miletich JP, Broze GJ, Majerus PW
Purification of human coagulation factors II, IX and X using sulfated dextran beads.
Methods Enzymol 1981;80:221-228

Broze GJ, Majerus PW
Human factor VII.
Methods Enzymol 1981;80:228-237

Kane WH, Majerus PW
Purification and characterization of human coagulation factor V.
J Biol Chem 1981 Jan 25;256(2):1002-7

Prescott SM, Majerus PW
The fatty acid composition of phosphatidylinositol from thrombin- stimulated human platelets.
J Biol Chem 1981 Jan 25;256(2):579-82

McEver RP, Baenziger NL, Majerus PW
Isolation and quantitation of the platelet membrane glycoprotein deficient in thrombasthenia using a monoclonal hybridoma antibody.
J Clin Invest 1980 Dec;66(6):1311-8

Majerus PW, Stanford N
Prevention of thrombosis by inhibition of prostaglandin synthesis.
In P. Ramwell (ed.), Prostaglandin Synthetase Inhibitors, pp. 209-219.  New York: A.R. Liss, Inc. (1980)

Bell RL, Baenziger NL, Majerus PW
Bradykinin-stimulated release of arachidonate from phosphatidyl inositol in mouse fibrosarcoma cells.
Prostaglandins 1980 Aug;20(2):269-74

Miletich JP, Broze GJ Jr, Majerus PW
The synthesis of sulfated dextran beads for isolation of human plasma coagulation factors II, IX, and X.
Anal Biochem 1980 Jul 1;105(2):304-10

Bell RL, Majerus PW
Thrombin-induced hydrolysis of phosphatidylinositol in human platelets.
J Biol Chem 1980 Mar 10;255(5):1790-2

Broze GJ Jr, Majerus PW
Purification and properties of human coagulation factor VII.
J Biol Chem 1980 Feb 25;255(4):1242-7

Kane WH, Lindhout MJ, Jackson CM, Majerus PW
Factor Va-dependent binding of factor Xa to human platelets.
J Biol Chem 1980 Feb 10;255(3):1170-4

Baenziger NL, Becherer PR, Dillender M, Majerus PW
Prostacyclin production in cultured human vascular endothelial cells, smooth muscle cells, and skin fibrobalsts.
In Mann and Taylor (eds.), The Regulation of coagulation, pp. 479-485.  New York: Elsevier North Holland, Inc. (1980)

Majerus PW, Bell RL, Stanford N, Kennerly DA
Diglyceride lipase: A pathway for arachidonate release from human platelets.
In Mann and Taylor (eds.), The Regulation of Coagulation, pp. 461-470.  New York: Elsevier North Holland, Inc. (1980)

Majerus PW, Miletich JP, Kane WH, Hofmann SL, Stanford N, Jackson CM
The formation of thrombin on the platelet surface.
In Mann and Taylor (eds.) The Regulation of Coagulation, pp. 215-224.  New York: Elsevier North Holland, Inc. (1980)

Morita T, Kane WH, Majerus PW, Jackson CM
Enzymatic properties of activated factor X from the g-carboxyglutamic acid containing domain has been removed.
In Mann and Taylor (eds.), The Regulation of Coagulation, pp. 187-188.  New York: Elsevier North Holland, Inc. (1980)

Bell RL, Stanford N, Kennerly DA, Majerus PW
Diglyceride lipase: a pathway for arachidonate release from human platelets.
Adv Prostaglandin Thromboxane Res 1980;6:219-24

Rotoli B, Majerus PW
Plasma antithrombins and thrombin binding to platelets in plasma.
Haematologica 1979 Oct;64(5):537-51

Miletich JP, Kane WH, Hofmann SL, Stanford N, Majerus PW
Deficiency of factor Xa-factor Va binding sites on the platelets of a patient with a bleeding disorder.
Blood 1979 Nov;54(5):1015-22

Harter HR, Burch JW, Majerus PW, Stanford N, Delmez JA, Anderson CB, Weerts CA
Prevention of thrombosis in patients on hemodialysis by low-dose aspirin.
N Engl J Med 1979 Sep 13;301(11):577-9

Bell RL, Kennerly DA, Stanford N, Majerus PW
Diglyceride lipase: a pathway for arachidonate release from human platelets.
Proc Natl Acad Sci U S A 1979 Jul;76(7):3238-41

Burch JW, Majerus PW
The role of prostaglandins in platelet function.
Semin Hematol 1979 Jul;16(3):196-207

Shuman MA, Majerus PW, Tollefsen DM
Thrombin generation during hemostasis.
Proceedings of First Florence Conference on Hemostasis and Thrombosis.  Academic Press, pp. 91-101 (1979)

Baenziger NL, Becherer PR, Majerus PW
Characterization of prostacyclin synthesis in cultured human arterial smooth muscle cells, venous endothelial cells and skin fibroblasts.
Cell 1979 Apr;16(4):967-74

Baenziger NL, Majerus PW
The mechanism of action of antiplatelet drugs.
In J.H. Joist and L.A. Sherman (eds.) Venous and Arterial Thrombosis. Pathogenesis, Diagnosis, Prevention, and Treatment.  New York: Grune and Stratton, pp. 327-338 (1979)

Rotoli B, Miletich JP, Majerus PW
The relation of conductivity to the binding of thrombin to human platelets.
Thromb Res 1978 Dec;13(6):1103-9

Burch JW, Baenziger NL, Stanford N, Majerus PW
Sensitivity of fatty acid cyclooxygenase from human aorta to acetylation by aspirin.
Proc Natl Acad Sci U S A 1978 Oct;75(10):5181-4

Miletich JP, Majerus DW, Majerus PW
Patients with congenital factor V deficiency have decreased factor Xa binding sites on their platelets.
J Clin Invest 1978 Oct;62(4):824-31

Miletich JP, Jackson CM, Majerus PW
Properties of the factor Xa binding site on human platelets.
J Biol Chem 1978 Oct 10;253(19):6908-16

Majerus PW
Bleeding disorders secondary to platelet abnormalities.
In H.F. Conn (ed.).  Philadelphia: W.B. Saunders, pp. 288-290 (1978)

Burch JW, Stanford N, Majerus PW
Inhibition of platelet prostaglandin synthetase by oral aspirin.
J Clin Invest 1978 Feb;61(2):314-9

Majerus PW, Miletich JP
Relationships between platelets and coagulation factors in hemostasis.
Annu Rev Med 1978;29:41-9

Miletich JP, Jackson CM, Majerus PW
Interaction of coagulation factor Xa with human platelets.
Proc Natl Acad Sci U S A 1977 Sep;74(9):4033-6
 

Roth GJ, Stanford N, Jacobs JW, Majerus PW
Acetylation of prostaglandin synthetase by aspirin. Purification and properties of the acetylated protein from sheep vesicular gland.
Biochemistry 1977 Sep 20;16(19):4244-8

Baenziger NL, Dillender MJ, Majerus PW
Cultured human skin fibroblasts and arterial cells produce a labile platelet-inhibitory prostaglandin.
Biochem Biophys Res Commun 1977 Sep 9;78(1):294-301

Majerus PW, Stanford N
Comparative effects of aspirin and diflunisal on prostaglandin synthetase from human platelets and sheep seminal vesicles.
Br J Clin Pharmacol 1977 Feb;4 Suppl 1:15S-18S

Stanford N, Roth GJ, Shen TY, Majerus PW
Lack of covalent modification of prostaglandin synthetase (cyclo- oxygenase) by indomethacin.
Prostaglandins 1977 Apr;13(4):669-75

Minkes M, Stanford N, Chi MM, Roth GJ, Raz A, Needleman P, Majerus PW
Cyclic adenosine 3',5'-monophosphate inhibits the availability of arachidonate to prostaglandin synthetase in human platelet suspensions.
J Clin Invest 1977 Mar;59(3):449-54

Roth GJ, Majerus PW
Acetylation of prostaglandin synthetase by aspirin.
In M. Silver (ed.) Prostaglandins in Hematology, Spectrum Publications, pp. 345-360 (1977)

Shuman MA, Majerus PW
The measurement of thrombin in clotting blood by radioimmunoassay.
J Clin Invest 1976 Nov;58(5):1249-58

Majerus PW, Tollefsen DM, Shuman MA
The interaction of platelets with thrombin.
In J.L. Gordon (ed.) Platelets in Biology and Pathology.  ASP Biological Press, pp. 241-260 (1976)

Tollefsen DM, Majerus PW
Evidence for a single class of thrombin-binding sites of human platelets.
Biochemistry 1976 May 18;15(10):2144-9

Majerus PW
Editorial: Why aspirin?
Circulation 1976 Sep;54(3):357-9

Rome LH, Lands WE, Roth GJ, Majerus PW
Aspirin as a quantitative acetylating reagent for the fatty acid oxygenase that forms prostaglandins.
Prostaglandins 1976 Jan;11(1):23-30

Shuman MA, Tollefsen DM, Majerus PW
The binding of human and bovine thrombin to human platelets.
Blood 1976 Jan;47(1):43-54

Tollefsen DM, Jackson CM, Majerus PW
Binding of the products of prothrombin activation to human platelets.
J Clin Invest 1975 Jul;56(1):241-5

Shuman MA, Majerus PW
The perturbation of thrombin binding to human platelets by anions.
J Clin Invest 1975 Oct;56(4):945-50

Roth GJ, Stanford N, Majerus PW
Acetylation of prostaglandin synthase by aspirin.
Proc Natl Acad Sci U S A 1975 Aug;72(8):3073-6

Lyons RM, Stanford N, Majerus PW
Thrombin-induced protein phosphorylation in human platelets.
J Clin Invest 1975 Oct;56(4):924-36

Roth GJ, Majerus PW
The mechanism of the effect of aspirin on human platelets. I. Acetylation of a particulate fraction protein.
J Clin Invest 1975 Sep;56(3):624-32

Lyons RM, Chaplin H, Tillack TW, Majerus PW
Gamma heavy chain disease: rapid, sustained response to cyclophosphamide and prednisone.
Blood 1975 Jul;46(1):1-9

Tollefsen DM, Majerus PW
Inhibition of human platelet aggregation by monovalent antifibrinogen antibody fragments.
J Clin Invest 1975 Jun;55(6):1259-68

Baenziger NL, Majerus PW
Isolation of human platelets and platelet surface membranes.
Methods Enzymol 1974;31(Pt A):149-55

Allen RH, Burger RL, Mehlman CS, Majerus PW
Use of vitamin B 12 in affinity chromatography.
Methods Enzymol 1974;34:305-14

Minnich V, Smith ME, Rajanasathit C, Majerus PW
Erythrocyte glutathione synthesis in the neonate.
Biol Neonate 1974;24(1):128-33

Tollefsen DM, Feagler JR, Majerus PW
The binding of thrombin to the surface of human platelets.
J Biol Chem 1974 Apr 25;249(8):2646-51

Feagler JR, Tillack TW, Chaplin DD, Majerus PW
The effects of thrombin on phytohemagglutinin receptor sites in human platelets.
J Cell Biol 1974 Mar;60(3):541-53

Tollefsen DM, Feagler JR, Majerus PW
Induction of the platelet release reaction by phytohemagglutinin.
J Clin Invest 1974 Jan;53(1):211-8

Jacobs RA, Majerus PW
The regulation of fatty acid synthesis in human skin fibroblasts. Inhibition of fatty acid synthesis by free fatty acids.
J Biol Chem 1973 Dec 25;248(24):8392-401

Jacobs RA, Sly WS, Majerus PW
The regulation of fatty acid biosynthesis in human skin fibroblasts.
J Biol Chem 1973 Feb 25;248(4):1268-76

Johnson FL, Lerner KG, Siegel M, Feagler JR, Majerus PW, Hartmann JR, Thomas ED
Association of androgenic-anabolic steroid therapy with development of hepatocellular carcinoma.
Lancet 1972 Dec 16;2(7790):1273-6

Allen RH, Majerus PW
Isolation of vitamin B12-binding proteins using affinity chromatography. 3. Purification and properties of human plasma transcobalamin II.
J Biol Chem 1972 Dec 10;247(23):7709-17

Allen RH, Majerus PW
Isolation of vitamin B12-binding proteins using affinity chromatography. II. Purification and properties of a human granulocyte vitamine B12-binding protein.
J Biol Chem 1972 Dec 10;247(23):7702-8

Allen RH, Majerus PW
Isolation of vitamin B12-binding proteins using affinity chromatography. I. Preparation and properties of vitamin B12-sepharose.
J Biol Chem 1972 Dec 10;247(23):7695-701

Majerus PW, Brodie GN
The binding of phytohemagglutinins to human platelet plasma membranes.
J Biol Chem 1972 Jul 10;247(13):4253-7

Baenziger NL, Brodie GN, Majerus PW
Isolation and properties of a thrombin-sensitive protein of human platelets.
J Biol Chem 1972 May 10;247(9):2723-31

Brodie GN, Baenziger NL, Chase LR, Majerus PW
The effects of thrombin on adenyl cyclase activity and a membrane protein from human platelets.
J Clin Invest 1972 Jan;51(1):81-8

Majerus PW
Bleeding disorders secondary to platelet abnormalities.
In H.F. Conn (ed.) Current Therapy, pp. 260-262.  Philadelphia: W.B. Saunders (1972)

Majerus PW, Brauner MJ, Smith MB, Minnich V
Glutathione synthesis in human erythrocytes. II. Purification and properties of the enzymes of glutathione biosynthesis.
J Clin Invest 1971 Aug;50(8):1637-43

Keller JW, Majerus PW, Finke EH
An unusual type of spiculated erythrocyte in metastatic liver disease and hemolytic anemia. Report of a case.
Ann Intern Med 1971 May;74(5):732-7

Baenziger NL, Brodie GN, Majerus PW
A thrombin-sensitive protein of human platelet membranes.
Proc Natl Acad Sci U S A 1971 Jan;68(1):240-3

Majerus PW, Baenziger NL, Brodie GN
Lipid metabolism in human platelets.
Ser Haematol 1971;4(1):59-74

Minnich V, Smith MB, Brauner MJ, Majerus PW
Glutathione biosynthesis in human erythrocytes. I. Identification of the enzymes of glutathione synthesis in hemolysates.
J Clin Invest 1971 Mar;50(3):507-13

Mohler DN, Majerus PW, Minnich V, Hess CE, Garrick MD
Glutathione synthetase deficiency as a cause of hereditary hemolytic disease.
N Engl J Med 1970 Dec 3;283(23):1253-7

Jacobs R, Kilburn E, Majerus PW
Acetyl coenzyme A carboxylase. The effects of biotin deficiency on enzyme in rat liver and adipose tissue.
J Biol Chem 1970 Dec 10;245(23):6462-7

Majerus PW, Kilburn E
Acetyl coenzyme A carboxylase. The roles of synthesis and degradation in regulation of enzyme levels in rat liver.
J Biol Chem 1969 Nov 25;244(22):6254-62

Lewis N, Majerus PW
Lipid metabolism in human platelets. II. De novo phospholipid synthesis and the effect of thrombin on the pattern of synthesis.
J Clin Invest 1969 Nov;48(11):2114-23

Majerus PW, Smith MB, Clamon GH
Lipid metabolism in human platelets. I. Evidence for a complete fatty acid synthesizing system.
J Clin Invest 1969 Jan;48(1):156-64

Vagelos PR, Alberts AW, Majerus PW
Beta-ketoacyl acyl carrier protein reductase.
Methods Enzymol 1969;14:60-63

Majerus PW, Alberts AW, Vagelos PR
Beta-hydroxyacyl ACP dehydrase from Escherichia coli.
Methods Enzymol 1969;14:64-66

Alberts AW, Majerus PW, Vagelos PR
Beta-ketoacyl acyl carrier protein synthetase.
Methods Enzymol 1969;14:57-60

Alberts AW, Majerus PW, Vagelos PR
Acetyl CoA-acyl carrier protein transacylase.
Methods Enzymol 1969;14:53-56

Alberts AW, Majerus PW, Vagelos PR
Malonyl CoA-acyl carrier protein transacylase.
Methods Enzymol 1969;14:50-53

Majerus PW, Alberts AW, Vagelos PR
Acyl carrier protein from Escherichia coli.
Methods Enzymol 1969;14:43-49

Vagelos PR, Jacobs RH, Smith MB, Majerus PW
Mechanism of saturated fatty acid biosynthesis in Escherichia coli.
Methods Enzymol 1969;14:39-43

Majerus PW, Jacobs R, Smith MB, Morris HP
The regulation of fatty acid biosynthesis in rat hepatomas.
J Biol Chem 1968 Jul 10;243(13):3588-95

Majerus PW
Acyl carrier protein: effects of acetylation and tryptic hydrolysis on function in fatty acid synthesis.
Science 1968 Jan 26;159(813):428-30

Majerus PW, Alberts AW, Vagelos PR
The preparation of the acyl carrier protein from Escherichia coli.
Biochemical Preparations, Vol. 12, 56-65 (1968)

Majerus PW, Lastra R
Fatty acid biosynthesis in human leukocytes.
J Clin Invest 1967 Oct;46(10):1596-602

Majerus PW
Acyl carrier protein. Structural requirements for function in fatty acid biosynthesis.
J Biol Chem 1967 May 25;242(10):2325-32

Majerus PW, Vagelos PR
Fatty acid biosynthesis and the role of the acyl carrier protein.
Adv Lipid Res 1967;5:1-33

Vagelos PR, Majerus PW, Alberts AW, Larrabee AR, Ailhaud GP
Structure and function of the acyl carrier protein.
Fed Proc 1966 Sep-Oct;25(5):1485-94

Rudney H, Stewart PR, Majerus PW, Vagelos PR
The biosynthesis of beta-hydroxy-beta-methylglutaryl coenzyme A in yeast. V. The role of acyl carrier protein.
J Biol Chem 1966 Mar 10;241(5):1226-8

Vagelos PR, Alberts AW, Majerus PW
The mechanism of fatty acid biosynthesis and the involvement of an acyl carrier protein.
Ann N Y Acad Sci 1965 Oct 8;131(1):177-88

Majerus PW, Alberts AW, Vagelos PR
Acyl carrier protein. VII. The primary structure of the substrate- binding site.
J Biol Chem 1965 Dec;240(12):4723-6

Alberts AW, Majerus PW, Vagelos PR
Acyl carrier protein. VI. Purification and properties of beta-ketoacyl carrier protein synthetase.
Biochemistry 1965;4:2265-2274

Majerus PW, Alberts AW, Vagelos PR
Acyl carrier protein.  IV. The identification of 4'-phosphopantetheine as the prosthetic group of the acyl carrier protein.
Proc Natl Acad Sci USA 1965;53:410-417

Majerus PW, Alberts AW, Vagelos PR
Acyl carrier protein.  III. An enoyl-hydrase specific for acyl carrier protein thioesters.
J Biol Chem 1965;240:618-621

Alberts AW, Majerus PW, Talamo B, Vagelos PR
Acyl carrier protein.  II. Intermediary reactions of fatty acid synthesis.
Biochemistry 1964;3:1563-1571

Majerus PW, Alberts AW, Vagelos PR
The acyl carrier protein of fatty acid synthesis.  I. Purification, physical properties and substrate binding site.
Proc Natl Acad Sci USA 1964;51:1231-1238

Majerus PW, Guze SB, Delong WB, Robins E
Psychologic factors and psychiatric disease in hyperemesis gravidarum: A followup study of 69 vomiters and 66 controls.
Am J Psych 1960;117:421-428

Guze SB, Delong WB, Majerus PW, Robins E
Association of clinical psychiatric disease with hyperemesis gravidarum.
N Eng J Med 1959;261:1363-1368