WASHINGTON UNIVERSITY SCHOOL OF MEDICINE DEPARTMENT OF MEDICINE

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My general interests are in GI and GU malignancies. Specifically, I have focused on prostate and pancreatic cancers. In prostate cancer, I have been looking at alternative hormonal therapies, and also developing chemotherapy for hormone refractory disease. We have successfully conducted a trial showing the utility of Mitoxantrone and Taxotere in treating this cancer. In addition, we have looked at multiple other newer compounds, including monoclonal antibodies, viral and other biological therapies. For pancreatic malignancies, we have helped to establish the activity of Gemcitabine in this cancer, and are looking at ways to increase its activity by coming up with a unique combination of Gemcitabine and radiation therapy. We are also running one of the few clinical trials in the country for gallbladder and cholangiocarcinomas, and have thereby become a national referral center for these cancers. Finally, with our colleagues in radation oncology, we have established the utility of combined radiation therapy and chemotherapy in downstaging rectal cancers safely and effectively.

Education

1975-1979	University of Illinois, Urbana, IL BA Honors Biology, Summa Cum Laude BS Electrical Engineering, Highest Honors Selected Honors: Phi Beta Kappa, Tau Beta Pi, Bronze Tablet Scholar
1979-1984	Harvard Medical School, Boston, MA MD, Magna Cum Laude Participant in Harvard-MIT program in Health Sciences and Technology Thesis: The Immune System of a Naturally Occurring Hematopoietic Chimeric Primate: Saguinus oedipus

Post-graduate Training

1984-1985	Medicine Internship, Duke University Medical Center, Durham, NC
1985-1987	Resident in Internal Medicine, Duke University Medical Center, Durham, NC
1987-1991	Fellow in Hematology-Oncology, Cancer Research Institute, University of California, San Francisco, CA

Fellowships

1982-1983	Karin Grunebaum Cancer Research Foundation Fellow
1989-1991	American Cancer Society Physician Training Award

Academic Positions

1991-1999	Assistant Professor, Department of Medicine, Division  of Hematology-Oncology, Washington University , St. Louis, MO
1991-1994	Director, Washington University Hematology Laboratory
1999-present	Associate Professor, Department of Medicine, Division of Oncology, Washington University, St. Louis, MO

Committee Appointments

1991-present	Barnes Hospital Cancer Committee (Co-chair Data Services Subcommittee)
1992-1998	Therapeutic Nutrition Committee of Barnes Hospital
1994-present	Prostate Committee, Cadre Member, CALGB
1994-present	Co-chair, GI Committee, Hoosier Oncology Group
1996-present	Protocol Review and Monitoring Committee, Washington University Cancer Center (Co-chair since 2002)
1997-1998	GI Committee, Cadre Member, CALGB
2006-present	Director, Hematology-Oncology Fellowship Program, Washington University

Professional Societies

	American Association for the Advancement of Science
	American Association for Cancer Research
	American College of Physicians
	American Federation for Clinical Research
	American Medical Association
	American Society of Hematology
	American Society of Internal Medicine
	American Society of Clinical Oncology
	American Urological Association
	Cancer and Leukemia Group B       Cadre Member - Prostate Committee       Cadre Member - GI Committee
	Hoosier Oncology Group       Co-Chair - GI Committee

Board Certification

1987	Diplomate of American Board of Internal Medicine
1989	Board Certified in Oncology
1990	Board Certified in Hematology

Updated: July 2, 2008