Katherine Parker Ponder, M.D.

Publications

• Metcalf JA, Ma X, Linders B, Wu S, Schambach A, Ohlemiller KK, Kovacs A, Bigg M, He L, Tollefsen DM, Ponder KP
  A self-inactivating gamma-retroviral vector reduces manifestations of mucopolysaccharidosis I in mice.
  Mol Ther 2009 Oct 20; [Epub ahead of print]
• Metcalf JA, Zhang Y, Hilton MJ, Long F, Ponder KP
  Mechanism of shortened bones in mucopolysaccharidosis VII.
  Mol Genet Metab 2009 Jul;97(3):202-11
• Tittiger ME, Ma X, Xu L, Ponder K
  Neonatal intravenous injection of a gamma retroviral vector has a low incidence of tumor induction in mice.
  Hum Gene Ther 2008;11:1217-23
• Sleeper MM, Haskins ME, Ponder KP
  Gene therapy for cardiovascular manifestations of lysosomal storage diseases.
  Heart and Metabolism 2008;41:21-4
• Ponder KP
  Immune response hinders therapy for lysosomal storage diseases.
  J Clin Invest 2008 Aug;118(8):2686-9
• Herati RS, Knox VW, O'Donnell P, D'Angelo M, Haskins ME, Ponder KP
  Radiographic evaluation of bones and joints in mucopolysaccharidosis I and VII dogs after neonatal gene therapy.
  Mol Genet Metab 2008 Nov;95(3):142-51
• Sleeper MM, Kusiak CM, Shofer FS, O'Donnell P, Bryan C, Ponder KP, Haskins ME
  Clinical characterization of cardiovascular abnormalities associated with feline mucopolysaccharidosis I and VI.
  J Inherit Metab Dis 2008 Jun;31(3):424-31
• Herati RS, Ma X, Tittiger M, Ohlemiller KK, Kovacs A, Ponder KP
  Improved retroviral vector design results in sustained expression after adult gene therapy in mucopolysaccharidosis I mice.
  J Gene Med 2008 Sep;10(9):972-82
• Ma X, Tittiger M, Knutsen RH, Kovacs A, Schaller L, Mecham RP, Ponder KP
  Upregulation of elastase proteins results in aortic dilatation in mucopolysaccharidosis I mice.
  Mol Genet Metab 2008 Jul;94(3):298-304
• Ponder KP, Srivastava A
  Walk a mile in the moccasins of people with haemophilia.
  Haemophilia 2008 May;14(3):618-20
• Ponder KP
  Immunology of neonatal gene transfer.
  Curr Gene Ther 2007 Oct;7(5):403-10
• Xu L, Mei M, Ma X, Ponder KP
  High expression reduces an antibody response after neonatal gene therapy with B domain-deleted human factor VIII in mice.
  J Thromb Haemost 2007 Sep;5(9):1805-12
• Ponder KP, Haskins ME
  Gene therapy for mucopolysaccharidosis.
  Expert Opin Biol Ther 2007 Sep;7(9):1333-45
• Traas AM, Wang P, Ma X, Tittiger M, Schaller L, O'donnell P, Sleeper MM, Vite C, Herati R, Aguirre GD, Haskins M, Ponder KP
  Correction of clinical manifestations of canine mucopolysaccharidosis I with neonatal retroviral vector gene therapy.
  Mol Ther 2007 Aug;15(8):1423-31
• Ma X, Liu Y, Tittiger M, Hennig A, Kovacs A, Popelka S, Wang B, Herati R, Bigg M, Ponder KP
  Improvements in mucopolysaccharidosis I mice after adult retroviral vector-mediated gene therapy with immunomodulation.
  Mol Ther 2007 May;15(5):889-902
• Ponder KP
  Gene transfer to the liver.
  In: Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics (Dunn M, Jorde L, Little P, Subramaniam S, eds.), John Wiley & Sons, Inc., 2007
• Xu L, Mei M, Haskins ME, Nichols TC, O'donnell P, Cullen K, Dillow A, Bellinger D, Ponder KP
  Immune response after neonatal transfer of a human factor IX-expressing retroviral vector in dogs, cats, and mice.
  Thromb Res 2007;120(2):269-80
• Chung S, Ma X, Liu Y, Lee D, Tittiger M, Ponder KP
  Effect of neonatal administration of a retroviral vector expressing alpha-L-iduronidase upon lysosomal storage in brain and other organs in mucopolysaccharidosis I mice.
  Mol Genet Metab 2007 Feb;90(2):181-92
• Spitzer D, Wu X, Ma X, Xu L, Ponder KP, Atkinson JP
  Cutting edge: treatment of complement regulatory protein deficiency by retroviral in vivo gene therapy.
  J Immunol 2006 Oct 15;177(8):4953-6
• Ponder KP
  Bringing home the bacon for hemophilia.
  Blood 2006;107:3817
• Ponder KP
  Gene therapy for hemophilia.
  Curr Opin Hematol 2006 Sep;13(5):301-7
• Kulkarni R, Ponder KP, James AH, Soucie JM, Koerper M, Hoots WK, Lusher JM
  Unresolved issues in diagnosis and management of inherited bleeding disorders in the perinatal period: a White Paper of the Perinatal Task Force of the Medical and Scientific Advisory Council of the National Hemophilia Foundation, USA.
  Haemophilia 2006 May;12(3):205-11
• Ponder KP
  Gene therapy goes to the dogs.
  Blood 2006;107:3018-3019
• Ponder KP, Wang B, Wang P, Ma X, Herati R, Wang B, Cullen K, O'Donnell P, Ellinwood NM, Traas A, Primeau TM, Haskins ME
  Mucopolysaccharidosis I cats mount a cytotoxic T lymphocyte response after neonatal gene therapy that can be blocked with CTLA4-Ig.
  Mol Ther 2006 Jul;14(1):5-13
• Wang B, O'Malley TM, Xu L, Vite C, Wang P, O'Donnell PA, Ellinwood NM, Haskins ME, Ponder KP
  Expression in blood cells may contribute to biochemical and pathological improvements after neonatal intravenous gene therapy for mucopolysaccharidosis VII in dogs.
  Mol Genet Metab 2006 Jan;87(1):8-21
• Wang B, Gao C, Ponder KP
  C/EBPbeta contributes to hepatocyte growth factor-induced replication of rodent hepatocytes.
  J Hepatol 2005 Aug;43(2):294-302
• Ponder KP
  An ounce of prevention potentiates a pound of cure for hemophilia A.
  Blood 2005;105:2620
• Xu L, Nichols TC, Sarkar R, McCorquodale S, Bellinger DA, Ponder KP
  Absence of a desmopressin response after therapeutic expression of factor VIII in hemophilia A dogs with liver-directed neonatal gene therapy.
  Proc Natl Acad Sci U S A 2005 Apr 26;102(17):6080-5
• Ponder KP
  A more clinically relevant mouse model of hemophilia B.
  Blood 2004;104:1594
• Liu Y, Xu L, Hennig AK, Kovacs A, Fu A, Chung S, Lee D, Wang B, Herati RS, Mosinger Ogilvie J, Cai SR, Ponder KP
  Liver-directed neonatal gene therapy prevents cardiac, bone, ear, and eye disease in mucopolysaccharidosis I mice.
  Mol Ther 2005 Jan;11(1):35-47
• Ponder KP
  Gene Therapy for Hemophilia B.
  In: Textbook of Hemophilia (Lee CA, Berntorp EE, Hoots WK, eds.), Blackwell Publishing, Malden, MA, pp. 220-225, 2005
• Xu L, O'Malley T, Sands MS, Wang B, Meyerrose T, Haskins ME, Ponder KP
  In vivo transduction of hematopoietic stem cells after neonatal intravenous injection of an amphotropic retroviral vector in mice.
  Mol Ther 2004 Jul;10(1):37-44
• Mango RL, Xu L, Sands MS, Vogler C, Seiler G, Schwarz T, Haskins ME, Ponder KP
  Neonatal retroviral vector-mediated hepatic gene therapy reduces bone, joint, and cartilage disease in mucopolysaccharidosis VII mice and dogs.
  Mol Genet Metab 2004 May;82(1):4-19
• Sleeper MM, Fornasari B, Ellinwood NM, Weil MA, Melniczek J, O'Malley TM, Sammarco CD, Xu L, Ponder KP, Haskins ME
  Gene therapy ameliorates cardiovascular disease in dogs with mucopolysaccharidosis VII.
  Circulation 2004 Aug 17;110(7):815-20
• Zhang J, Xu L, Haskins ME, Ponder KP
  Neonatal gene transfer with a retroviral vector results in tolerance to human factor IX in mice and dogs.
  Blood 2004 Jan 1;103(1):143-51
• Ponder KP
  Novel therapies for hemophilia A.
  Blood 2003;102:3857-8
• Xu L, Gao C, Sands MS, Cai SR, Nichols TC, Bellinger DA, Raymer RA, McCorquodale S, Ponder KP
  Neonatal or hepatocyte growth factor-potentiated adult gene therapy with a retroviral vector results in therapeutic levels of canine factor IX for hemophilia B.
  Blood 2003 May 15;101(10):3924-32
• Ponder KP
  Should gene therapy be used for newborns with hemophilia?
  Mol Ther 2003 Jan;7(1):7-8
• Xu L, Mango RL, Sands MS, Haskins ME, Ellinwood NM, Ponder KP
  Evaluation of pathological manifestations of disease in mucopolysaccharidosis vii mice after neonatal hepatic gene therapy.
  Mol Ther 2002 Dec;6(6):745-58
• Ponder KP, Melniczek JR, Xu L, Weil MA, O'Malley TM, O'Donnell PA, Knox VW, Aguirre GD, Mazrier H, Ellinwood NM, Sleeper M, Maguire AM, Volk SW, Mango RL, Zweigle J, Wolfe JH, Haskins ME
  Therapeutic neonatal hepatic gene therapy in mucopolysaccharidosis VII dogs.
  Proc Natl Acad Sci U S A 2002 Oct 1;99(20):13102-7
• Ponder KP
  Gene therapy for hemophilia B in dogs: finally prevention of bleeding, but concerns about inhibitors remain.
  Blood 2002;99:2635-6
• Xu L, Haskins ME, Melniczek JR, Gao C, Weil MA, O'Malley TM, O'Donnell PA, Mazrier H, Ellinwood NM, Zweigle J, Wolfe JH, Ponder KP
  Transduction of hepatocytes after neonatal delivery of a Moloney murine leukemia virus based retroviral vector results in long-term expression of beta-glucuronidase in mucopolysaccharidosis VII dogs.
  Mol Ther 2002 Feb;5(2):141-53
• Wang B, Cai SR, Gao C, Sladek FM, Ponder KP
  Lipopolysaccharide results in a marked decrease in hepatocyte nuclear factor 4 alpha in rat liver.
  Hepatology 2001 Nov;34(5):979-89
• Gao C, Kennedy S, Ponder KP
  Lipopolysaccharide potentiates the effect of hepatocyte growth factor upon replication in lung, thyroid, spleen, and colon in rats in vivo.
  Mol Ther 2001 Apr;3(4):462-75
• Xu L, Daly T, Gao C, Flotte TR, Song S, Byrne BJ, Sands MS, Ponder KP
  CMV-beta-actin promoter directs higher expression from an adeno-associated viral vector in the liver than the cytomegalovirus or elongation factor 1 alpha promoter and results in therapeutic levels of human factor X in mice.
  Hum Gene Ther 2001 Mar 20;12(5):563-73
• Gao C, Sands MS, Haskins ME, Ponder KP
  Delivery of a retroviral vector expressing human beta-glucuronidase to the liver and spleen decreases lysosomal storage in mucopolysaccharidosis VII mice.
  Mol Ther 2000 Sep;2(3):233-44
• Flye MW, Ponder KP
  Gene therapy for primary and metastatic cancer to the liver.
  Asian J Surg 2000;23:64-79
• Ponder KP
  The vectors of gene therapy.
  In An Introduction to Molecular Medicine and Gene Therapy, ed. by Kresina T.F., John Wiley and Sons, Inc., 2001
• Cai SR, Motoyama K, Shen KJ, Kennedy SC, Flye MW, Ponder KP
  Lovastatin decreases mortality and improves liver functions in fulminant hepatic failure from 90% partial hepatectomy in rats.
  J Hepatol 2000 Jan;32(1):67-77
• Ponder KP
  Systemic gene therapy for cardiovascular disease.
  Trends Cardiovasc Med 1999 Aug;9(6):158-62
• Gao C, Jokerst R, Gondipalli P, Cai SR, Kennedy S, Flye MW, Ponder KP
  Lipopolysaccharide potentiates the effect of hepatocyte growth factor on hepatocyte replication in rats by augmenting AP-1 activity.
  Hepatology 1999 Dec;30(6):1405-16
• Gao C, Jokerst R, Gondipalli P, Cai SR, Kennedy S, Ponder KP
  Intramuscular injection of an adenoviral vector expressing hepatocyte growth factor facilitates hepatic transduction with a retroviral vector in mice.
  Hum Gene Ther 1999 Apr 10;10(6):911-22
• Duncan JR, Hicks ME, Cai SR, Brunt EM, Ponder KP
  Embolization of portal vein branches induces hepatocyte replication in swine: a potential step in hepatic gene therapy.
  Radiology 1999 Feb;210(2):467-77
• Flye MW, Ponder KP
  Gene therapy for liver cancer.
  In Liver Metastasis Biology, Diagnosis, and Treatment, ed. by O.J. Garden, J. G. Geraghty, and D.M. Ngorney, Springer Verlag, 1998
• Cai SR, Kennedy SC, Bowling WM, Flye MW, Ponder KP
  Therapeutic levels of human protein C in rats after retroviral vector- mediated hepatic gene therapy.
  J Clin Invest 1998 Jun 15;101(12):2831-41
• Ponder KP, Duncan JR, and Hicks ME
  Gene therapy for hepatic and vascular disorders.
  J Vasc Interven Radiol 1997;8:142-6
• Le M, Okuyama T, Cai SR, Kennedy SC, Bowling WM, Flye MW, Ponder KP
  Therapeutic levels of functional human factor X in rats after retroviral-mediated hepatic gene therapy.
  Blood 1997 Feb 15;89(4):1254-9
• Bowling WM, Kennedy SC, Cai SR, Duncan JR, Gao C, Flye MW, Ponder KP
  Portal branch occlusion safely facilitates in vivo retroviral vector transduction of rat liver.
  Hum Gene Ther 1996 Nov 10;7(17):2113-21
• Pearline RV, Lin YZ, Shen KJ, Brunt EM, Bowling WM, Hafenrichter DG, Kennedy S, Flye MW, Ponder KP
  Alterations in enzymatic functions in hepatocytes and hepatocellular carcinomas from Ras-transduced livers resemble the effects of insulin.
  Hepatology 1996 Oct;24(4):838-48
• Ponder KP
  Analysis of liver development, regeneration, and carcinogenesis by genetic marking studies.
  FASEB J 1996 May;10(7):673-82
• Okuyama T, Huber RM, Bowling W, Pearline R, Kennedy SC, Flye MW, Ponder KP
  Liver-directed gene therapy: a retroviral vector with a complete LTR and the ApoE enhancer-alpha 1-antitrypsin promoter dramatically increases expression of human alpha 1-antitrypsin in vivo.
  Hum Gene Ther 1996 Mar 20;7(5):637-45
• Wu X, Holschen J, Kennedy SC, Ponder KP
  Retroviral vector sequences may interact with some internal promoters and influence expression.
  Hum Gene Ther 1996 Jan 20;7(2):159-71
• Ponder KP
  Gene delivery for systemic expression.
  In Gene Transfer in Cardiovascular Biology, ed. by KL March, Kluwar Academic Publishers, Boston, 1997
• Lin YZ, Brunt EM, Bowling W, Hafenrichter DG, Kennedy SC, Flye MW, Ponder KP
  Ras-transduced diethylnitrosamine-treated hepatocytes develop into cancers of mixed phenotype in vivo.
  Cancer Res 1995 Nov 15;55(22):5242-50
• Kennedy S, Rettinger S, Flye MW, Ponder KP
  Experiments in transgenic mice show that hepatocytes are the source for postnatal liver growth and do not stream.
  Hepatology 1995 Jul;22(1):160-8
• Hafenrichter DG, Ponder KP, Rettinger SD, Kennedy SC, Flye MW
  Optimization of liver-directed retroviral gene delivery.
  Transplant Proc 1994 Dec;26(6):3379-80
• Hafenrichter DG, Wu X, Rettinger SD, Kennedy SC, Flye MW, Ponder KP
  Quantitative evaluation of liver-specific promoters from retroviral vectors after in vivo transduction of hepatocytes.
  Blood 1994 Nov 15;84(10):3394-404
• Hafenrichter DG, Ponder KP, Rettinger SD, Kennedy SC, Wu X, Saylors RS, Flye MW
  Liver-directed gene therapy: evaluation of liver specific promoter elements.
  J Surg Res 1994 Jun;56(6):510-7
• Rettinger SD, Kennedy SC, Wu X, Saylors RL, Hafenrichter DG, Flye MW, Ponder KP
  Liver-directed gene therapy: quantitative evaluation of promoter elements by using in vivo retroviral transduction.
  Proc Natl Acad Sci U S A 1994 Feb 15;91(4):1460-4
• Rettinger SD, Ponder KP, Saylors RL, Kennedy SC, Hafenrichter DG, Flye MW
  In vivo hepatocyte transduction with retrovirus during in-flow occlusion.
  J Surg Res 1993 May;54(5):418-25
• Kay MA, Ponder KP, Woo SL
  Human gene therapy: present and future.
  Breast Cancer Res Treat 1992;21(2):83-93
• Kay MA, Baley P, Rothenberg S, Leland F, Fleming L, Ponder KP, Liu T, Finegold M, Darlington G, Pokorny W, et al
  Expression of human alpha 1-antitrypsin in dogs after autologous transplantation of retroviral transduced hepatocytes.
  Proc Natl Acad Sci U S A 1992 Jan 1;89(1):89-93
• Woo SLC, Sifers RN, Ponder KP
  Genetic control of human alpha1-antitrypsin and hepatic gene therapy.
  In Update of Biochemistry of Pulmonary Emphysema, Springer-Verlag, 1991
• Ponder KP, Dunbar RP, Wilson DR, Darlington GJ, Woo SL
  Evaluation of relative promoter strength in primary hepatocytes using optimized lipofection.
  Hum Gene Ther 1991 Spring;2(1):41-52
• Ponder KP, Gupta S, Leland F, Darlington G, Finegold M, DeMayo J, Ledley FD, Chowdhury JR, Woo SL
  Mouse hepatocytes migrate to liver parenchyma and function indefinitely after intrasplenic transplantation.
  Proc Natl Acad Sci U S A 1991 Feb 15;88(4):1217-21
• Parker KA, Bond U
  Analysis of pre-rRNAs in heat-shocked HeLa cells allows identification of the upstream termination site of human polymerase I transcription.
  Mol Cell Biol 1989 Jun;9(6):2500-12
• Parker KA, Steitz JA
  Determination of RNA-protein and RNA-ribonucleoprotein interactions by nuclease probing.
  Methods Enzymol 1989;180:454-68
• Parker KA, Bruzik JP, Steitz JA
  An in vitro interaction between the human U3 snRNP and 28S rRNA sequences near the alpha-sarcin site.
  Nucleic Acids Res 1988 Nov 25;16(22):10493-509
• Steitz JA, Black DL, Gerke V, Parker KA, Kramer A, Frendeway D, Keller W
  Functions of the abundant U-snRNPs.
  In Small Nuclear Ribonucleoprotein Particles Structure and Functions, ed. by M.L. Birnstall, Springer-Verlag, NY, 1987
• Parker KA, Steitz JA
  Structural analysis of the human U3 ribonucleoprotein particle reveal a conserved sequence available for base pairing with pre-rRNA.
  Mol Cell Biol 1987 Aug;7(8):2899-913
• Parker KA, Tollefsen DM
  The protease specificity of heparin cofactor II. Inhibition of thrombin generated during coagulation.
  J Biol Chem 1985 Mar 25;260(6):3501-5
• Daughaday WH, Parker KA, Borowsky S, Trivedi B, Kapadia M
  Measurement of somatomedin-related peptides in fetal, neonatal, and maternal rat serum by insulin-like growth factor (IGF) I radioimmunoassay, IGF-II radioreceptor assay (RRA), and multiplication- stimulating activity RRA after acid-ethanol extraction.
  Endocrinology 1982 Feb;110(2):575-81