J. Evan Sadler, M.D., Ph.D.

Invited Publications

• Sadler JE, Poncz M
  Antibody-mediated thrombotic disorders: thrombotic thrombocytopenic purpura and heparin induced thrombocytopenia.
  In: Williams Hematology, Eighth Edition (MA Lichtman, E Beutler, K Kaushansky, TJ Kipps, U Seligsohn, JT Prchal, eds.) McGraw-Hill, New York, in press
• Sadler JE
  Low vWF: sometimes a risk factor and sometimes a disease.
  Hematology (Am Soc Hematol Educ Program) 2009: in press
• Sadler JE
  von Willebrand factor assembly and secretion.
  J Thromb Haemost 2009 Jul;7(s1State of the Art 2009):24-27
• Nichols WL, Rick ME, Ortel TL, Montgomery RR, Sadler JE, Yawn BP, James AH, Hultin MB, Manco-Johnson MJ, Weinstein M
  Clinical and laboratory diagnosis of von Willebrand disease: a synopsis of the 2008 NHLBI/NIH guidelines.
  Am J Hematol 2009 Jun;84(6):366-70
• McCrae KR, Sadler JE, Cines D
  Thrombotic thrombocytopenic purpura and hemolytic uremic syndrome.
  In: Hematology: Basic Principles and Practice, Fifth Edition (R Hoffman, EJ Benz, SJ Shattil, B Furie, LE Silberstein, P McGlave, HE Heslop, eds.) Elsevier Churchill Livingstone, Philadelphia, 2009; 2099-2111
• White GC II, Sadler JE
  Von Willebrand disease: clinical aspects and therapy.
  In: Hematology: Basic Principles and Practice, Fifth Edition (R Hoffman, EJ Benz, SJ Shattil, B Furie, LE Silberstein, P McGlave, HE Heslop, eds.) Elsevier Churchill Livingstone, Philadelphia, 2009; 1961-1972
• Zheng XL, Kitamoto Y, Sadler JE
  Enteropeptidase, a type II transmembrane serine protease.
  Front Biosci (Elite Ed) 2009 Jun 1;1:242-249
• Nichols WL, Hultin MB, James AH, Manco-Johnson MJ, Montgomery RR, Ortel TL, Rick ME, Sadler JE, Weinstein M, Yawn BP
  Von Willebrand factor content in Alphanate (Laurence J. Logan) – reply.
  Haemophilia 2009;15:370-1
• Sadler JE
  Von Willebrand factor, ADAMTS13, and thrombotic thrombocytopenic purpura.
  Blood 2008 Jul 1;112(1):11-8
• Zheng XL, Sadler JE
  Pathogenesis of thrombotic microangiopathies.
  Annu Rev Pathol 2008 Mar 3;249-277
• Sadler JE
  Diagnosing VWD type 1: when is it useful and when illogical?
  Blood 2007;109:4106
• Sadler JE
  Interesting variations on how a disease is defined: comparisons of von Willebrand disease and Glanzmann thrombasthenia. Reply to a rebuttal.
  J Thromb Haemost 2007 Mar;5(3):649-51
• Sadler JE
  VWD data worth 10,000 words.
  Blood 2007;109:3
• Sadler JE
  Thrombotic thrombocytopenic purpura: a moving target.
  Hematology Am Soc Hematol Educ Program 2006;:415-20
• McCrae KR, Cines DB, Sadler JE
  Thrombotic microangiopathies: thrombotic thrombocytopenic purpura and the hemolytic uremic syndrome.
  In: Thrombocytopenia (KR McCrae, ed.) Taylor and Francis, London, UK, 2006; 247-265
• Zheng XL, Sadler JE
  Thrombotic thrombocytopenic purpura and hemolytic uremic syndrome.
  In: Clinical Hematology (NS Young, SL Gerson, KA High, eds) Mosby Elsevier, Philadelphia, 2006; 802-813
• Sadler JE, Blinder M
  von Willebrand disease.
  In: Hemostasis and Thrombosis: Basic Principles and Clinical Practice, Fifth Edition (RW Colman, VJ Marder, AW Clowes, JN George, and SZ Goldhaber, eds) Lippincott Williams & Wilkins, Philadelphia, 2006; 905-921
• Sadler JE, Poncz M
  Antibody-mediated thrombotic disorders: thrombotic thrombocytopenic purpura and heparin induced thrombocytopenia.
  In: Williams Hematology, Seventh Edition (MA Lichtman, E Beutler, K Kaushansky, TJ Kipps, U Seligsohn, JT Prchal, eds) McGraw-Hill, New York, 2006; 2031-2054
• Sadler JE
  von Willebrand factor: two sides of a coin.
  J Thromb Haemost 2005 Aug;3(8):1702-9
• Sadler JE
  New concepts in von Willebrand disease.
  Annu Rev Med 2005;56:173-91
• McCrae KR, Sadler JE, Cines D
  Thrombotic thrombocytopenic purpura and hemolytic uremic syndrome.
  In: Hematology: Basic Principles and Practice, Fourth Edition (R Hoffman, EJ Benz, SJ Shattil, B Furie, HJ Cohen, LE Silberstein, P McGlave, eds) Elsevier Churchill Livingstone, Philadelphia, 2005; 2287-2304
• White GC II, Sadler JE
  Von Willebrand disease: Clinical aspects and therapy.
  In: Hematology: Basic Principles and Practice, Fourth Edition (R Hoffman, EJ Benz, SJ Shattil, B Furie, HJ Cohen, LE Silberstein, P McGlave, eds) Elsevier Churchill Livingstone, Philadelphia, 2005; 2121-2136
• Sadler JE, Moake JL, Miyata T, George JN
  Recent advances in thrombotic thrombocytopenic purpura.
  Hematology (Am Soc Hematol Educ Program) 2004;:407-23
• Pike LJ, Sadler JE
  Proteomics, genomics and the future of medical education.
  Mo Med 2004 Sep-Oct;101(5):496-9
• Sadler JE
  Slippery criteria for von Willebrand disease type 1.
  J Thromb Haemost 2004 Oct;2(10):1720-3
• Sadler JE
  Medicine: K is for koagulation.
  Nature 2004 Feb 5;427(6974):493-4
• Chung DW, Sadler JE
  ADAMTS13: von Willebrand factor-cleaving protease.
  In: Handbook of Proteolytic Enzymes, Second Edition (A.J. Barrett, N.D. Rawlings, and J.F. Woessner, Jr., eds) Elsevier Academic Press, London, 2004; 747-749.
• Sadler JE
  Enteropeptidase.
  In: Handbook of Proteolytic Enzymes, Second Edition (A.J. Barrett, N.D. Rawlings, and J.F. Woessner, Jr., eds) Elsevier Academic Press, London, 2004; 1513-1517.
• Sadler JE
  Aortic stenosis, von Willebrand factor, and bleeding.
  N Engl J Med 2003 Jul 24;349(4):323-5
• Sadler JE
  Structural biology. A menage a trois in two configurations.
  Science 2003 Jul 11;301(5630):177-9
• Sadler JE
  A broader look at thrombotic microangiopathy and ADAMTS13.
  Blood 2003;102:2
• Sadler JE
  A new name in thrombosis, ADAMTS13.
  Proc Natl Acad Sci U S A 2002 Sep 3;99(18):11552-4
• Sadler JE
  Biomedicine. Contact--how platelets touch von Willebrand factor.
  Science 2002 Aug 16;297(5584):1128-9
• George JN, Sadler JE, Lammle B
  Platelets: thrombotic thrombocytopenic purpura.
  Hematology (Am Soc Hematol Educ Program) 2002;315-34
• Sadler JE
  Does VWF bind collagen after all?
  Blood 2002;99:3591.
• Zheng X, Majerus EM, Sadler JE
  ADAMTS13 and TTP.
  Curr Opin Hematol 2002 Sep;9(5):389-94
• Sadler JE
  More to TTP than VWFCP.
  Blood 2002;99:397-398
• Sadler JE
  von Willebrand factor.
  In: Encyclopedia of Molecular Medicine (T.E. Creighton, ed.) John Wiley & Sons, New York, 2002; 3392-3395
• Moake JL, Sadler JE, Mannucci P, Ganguly P
  Report on the workshop: Von Willebrand factor and Thrombotic Thrombocytopenic Purpura.
  Am J Hematol 2001 Oct;68(2):122-6
• Sadler JE
  Boosting a natural anticoagulant.
  Blood 2001;97:1523-1524
• Sadler JE
  von Willebrand disease.
  In: The Metabolic and Molecular Bases of Inherited Disease, Eighth Edition (C.R. Scriver, A.L. Beaudet, W.S. Sly, and D. Valle, eds) McGraw-Hill Book Co., New York, 2001; 4415-4431
• Sadler JE, and Davie EW
  Hemophilia A, hemophilia B, and von Willebrand disease.
  In: The Molecular Basis of Blood Diseases, Third Edition (G. Stamatoyannopoulos, P.W. Majerus, R. M. Perlmutter, and H. Varmus, eds) W.B. Saunders Co., Philadelphia 2001; 680-718
• Sadler JE, Blinder M
  von Willebrand disease.
  In: Hemostasis and Thrombosis Basic Principles and Clinical Practice, Fourth Edition (R.W. Colman, J. Hirsh, V.J. Marder, A.W. Clowes, and J.N. George, eds) Lippincott Williams & Wilkins, Philadelphia 2001; 825-837
• Sadler JE
  Biochemistry and genetics of von Willebrand factor.
  Annu Rev Biochem 1998;67:395-424
• Lu D, Sadler JE
  Enteropeptidase.
  In: Handbook of Proteolytic Enzymes (A.J. Barrett, N.D. Rawlings, and J.F. Woessner, Jr., eds) Academic Press Ltd., London, 1998; 50-54
• Sadler JE
  Thrombomodulin structure and function.
  Thromb Haemost 1997 Jul;78(1):392-5
• Sadler JE
  Combined factors V and VIII deficiency climbs onto the map [editorial].
  J Clin Invest 1997 Feb 15;99(4):555-6
• Sadler JE, Matsushita T, Dong Z, Tuley EA, Westfield LA
  Molecular mechanism and classification of von Willebrand disease.
  Thromb Haemost 1995 Jul;74(1):161-6
• Sadler JE
  von Willebrand disease.
  In: The Metabolic and Molecular Basis of Inherited Disease, Seventh Edition (C.R. Scriver, A.L. Beaudet, W.S. Sly, and D. Valle, eds) McGraw-Hill Book Co., New York 1995; 3269-3287
• Sadler JE, Gralnick HR
  Commentary: a new classification for von Willebrand disease.
  Blood 1994 Aug 1;84(3):676-9
• Matsushita T, Dong Z, Sadler JE
  von Willebrand's factor and von Willebrand's disease.
  Curr Opin Hematol 1994 Sep;1(5):362-8
• Lentz SR, Sadler JE
  The molecular basis of thrombomodulin function.
  In: Thrombomodulin (J.C. Giddings, ed.) R.G. Landes Co, Austin, TX, 1994; 91-120
• Sadler JE
  von Willebrand disease.
  In: Haemostasis and Thrombosis, Third Edition (A.L. Bloom, C.D. Forbes, D.P. Thomas, and E.G.D. Tuddenham, eds) Churchill-Livingstone, Edinburgh 1994; 843-857
• Sadler JE, Davie EW
  Hemophilia A, hemophilia B, and von Willebrand disease.
  In: Molecular Basis of Blood Diseases, Second Edition (G. Stamatoyannopoulos, A.W. Nienhuis, P.W. Majerus, and H. Varmus, eds) W.B. Saunders Co., Philadelphia 1994; 657-700
• Sadler JE, Lentz SR, Sheehan JP, Tsiang M, Wu Q
  Structure-function relationships of the thrombin-thrombomodulin interaction.
  Haemostasis 1993 Mar;23 Suppl 1:183-93
• Sadler JE
  von Willebrand factor.
  J Biol Chem 1991 Dec 5;266(34):22777-80
• Sadler JE, Mancuso DJ, Randi AM, Tuley EA, Westfield LA
  Molecular biology of von Willebrand factor.
  Ann N Y Acad Sci 1991;614:114-24
• Sadler JE
  Recombinant DNA methods in hemophilia A: carrier detection and prenatal diagnosis.
  Semin Thromb Hemost 1990 Oct;16(4):341-7
• Lebo RV, Conneally PM, Flandermeyer RR, Christian C, Bolbus MS, Lovelace RE, Anderson LA, Chance PF, Bird TD, Bruce BD, Slotnick RN, Dyckoff D, Sadler JE, Carver V, Schonberg SA, Fowler WM, Ionasescu V, Kadasi L, Dyck PJ
  The multilocus Charcot-Marie-Tooth syndrome.
  In: Charcot-Marie-Tooth Disorders Pathophysiology, Molecular Genetics, and Therapy (R.E. Lovelace and H.K. Shapiro, eds) Neurology and Neurobiology 53, Alan R. Liss, New York 1990; 307-334
• Mancuso DJ, Sadler JE
  Molekularbiologie des von-Willebrand-Faktors [German].
  Hämostaseologie 1989;9:122-129
• Sadler JE
  Von Willebrand disease.
  In: The Metabolic Basis of Inherited Disease, Sixth Edition (C.R. Scriver, A.L. Beaudet, W.S. Sly, and D. Valle, eds) McGraw-Hill Book Co., New York 1989; 2171-2188
• Sadler JE
  Molecular biology of von Willebrand factor.
  In: Coagulation and Bleeding Disorders The Role of Factor VIII and von Willebrand Factor (T.S. Zimmerman and Z. Ruggeri, eds) Marcel Dekker, Inc., New York 1989; 117-135
• Sadler JE
  The molecular biology of von Willebrand factor.
  In Thrombosis and Haemostasis 1987 (M. Verstraete, J. Vermylen, R. Lijnen, and J. Arnout, eds) International Society on Thrombosis and Haemostasis and Leuven University Press, Leuven, Belgium 1987; 61-79
• Sadler JE, Davie EW
  Hemophilia A, hemophilia B, and von Willebrand's disease.
  In: Molecular Basis of Blood Diseases (G. Stamatoyannopoulos, A.W. Nienhuis, P. Leder, and P.W. Majerus, eds) W.B. Saunders Co., Philadelphia 1987; 575-630
• Sadler JE, Shelton-Inloes BB, Sorace JM, Titani K
  Cloning of cDNA and genomic DNA for human von Willebrand factor.
  Cold Spring Harb Symp Quant Biol 1986;51 Pt 1:515-23
• Sadler JE, Shelton-Inloes BB, Sorace JM, Harlan JM, Titani K, Davie EW
  Characterization of two cDNAs coding for human von Willebrand factor and the implications for biosynthesis and evolution.
  In: Factor VIII/von Willebrand Factor: Biological and Clinical Advances  (N. Ciavarella, Z.M. Ruggeri, and T.S. Zimmerman, eds) Wichtig Editore, Milan 1986; 103-109
• Sadler JE, Malinowski DP, Davie EW
  Cloning and structural characterization of the gene for human plasminogen.
  In: Progress in Fibrinolysis, Vol. 7 (J.F. Davidson, M.B. Donati, and S. Coccheri, eds) Churchill Livingstone, Edinburgh 1985; 201-204
• Sadler JE
  Biosynthesis of glycoproteins Formation of O-linked oligosaccharides.
  In: Biology of Carbohydrates, Vol. 2 (V. Ginsburg and P.W. Robbins, eds) John Wiley and Sons, New York 1984; 199-288
• Sadler JE, Beyer TA, Oppenheimer CL, Paulson JC, Prieels JP, Rearick JI, Hill RL
  Purification of mammalian glycosyltransferases.
  Methods Enzymol 1982;83:458-514
• Sadler JE, Beyer TA, Hill RL
  Affinity chromatography of glycosyltransferases.
  J Chromatogr 1981 Oct 23;215:181-94
• Beyer TA, Sadler JE, Rearick JI, Paulson JC, Hill RL
  Glycosyltransferases and their use in assessing oligosaccharide structure and structure-function relationships.
  Adv Enzymol Relat Areas Mol Biol 1981;52:23-175
• Hill RL, Beyer TA, Paulson JC, Prieels J-P, Rearick JI, Sadler JE
  Glycosyltransferases in oligosaccharide biosynthesis and their use in structure-function analysis of glycoproteins.
  In: (IUPAC) Frontiers of Bioorganic Chemistry and Molecular Biology (S.N. Ananchenko, ed.) Pergamon Press, New York 1980; 63-71
• Hill RL, Beyer TA, Rearick JI, Sadler JE, Prieels J-P, Paulson JC
  Glycosyl transferases in glycoconjugate biosynthesis and their use in assessing oligosaccharide structure and function.
  In: Glycoconjugates: Proceedings of the Fifth International Symposium, Kiel, Federal Republic of Germany, (R. Schauer, P. Boer, E. Buddecke, M.F. Kramer, J.F.G. Vliegenthart, and H. Wiegandt, eds) Georg Thieme Publishers, Stuttgart, September 1979; 274-275
• Sadler JE, Rearick JI, Paulson JC, Hill RL
  Purification of two sialyltransferase activities from porcine submaxillary glands.
  In: Glycoconjugate Research Proceedings of the Fourth International Symposium on Glycoconjugates (J.D. Gregory and R.W. Jeanloz, eds) Academic Press, New York 1979; Vol. II: 763-766