Recent Publications
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Walker AR, Komrokji RS, Ifthikharuddin J, Messina P, Mulford D, Becker M, Friedberg J, Oliva J, Phillips G, Liesveld JL, Abboud C
Phase I study of cladribine, cytarabine (Ara-C), granulocyte colony stimulating factor (G-CSF) (CLAG Regimen) and simultaneous escalating doses of imatinib mesylate (Gleevec) in relapsed/refractory AML.
Leuk Res 2008 Jun 19; [Epub ahead of print]
Laughlin TS, Becker MW, Liesveld JL, Mulford DA, Abboud CN, Brown P, Rothberg PG
Rapid method for detection of mutations in the nucleophosmin gene in acute myeloid leukemia.
J Mol Diagn 2008 Jul;10(4):338-45
Funk RK, Maxwell TJ, Izumi M, Edwin D, Kreisel F, Ley TJ, Cheverud JM, Graubert TA
Quantitative trait loci associated with susceptibility to therapy-related acute murine promyelocytic leukemia in hCG-PML/RARA transgenic mice.
Blood 2008 Jun 13; [Epub ahead of print]
Wildes TM, Augustin KM, Sempek D, Zhang QJ, Vij R, Dipersio JF, Devine SM
Comorbidities, not age, impact outcomes in autologous stem cell transplant for relapsed non-Hodgkin lymphoma.
Biol Blood Marrow Transplant 2008 Jul;14(7):840-6
Martin MG, Abboud CN
Induction therapy for elderly patients with acute myeloid leukemia.
Blood Rev 2008 Jun 6; [Epub ahead of print]
Wang-Gillam A, Valentine J, Sherman AC, Mehta P
Experiences of Institutional Review Board (IRB) and Protocol Review and Monitoring Committee (PRMC) Rotations in Hematology/Oncology Training.
J Cancer Educ 2008 Summer;23(2):71-3
Brown LA, Hoog J, Chin SF, Tao Y, Zayed AA, Chin K, Teschendorff AE, Quackenbush JF, Marioni JC, Leung S, Perou CM, Neilsen TO, Ellis M, Gray JW, Bernard PS, Huntsman DG, Caldas C
ESR1 gene amplification in breast cancer: a common phenomenon?
Nat Genet 2008 Jul;40(7):806-7; author reply 810-2
Read WL, Baggstrom MQ, Fracasso PM, Govindan R
A Phase I Study of Bexarotene and Rosiglitazone in Patients with Refractory Cancers.
Chemotherapy 2008 Jun 18;54(3):236-241
Bartlett NL
Modern treatment of Hodgkin lymphoma.
Curr Opin Hematol 2008 Jul;15(4):408-14
Tan BR, Brenner WS, Picus J, Marsh S, Gao F, Fournier C, Fracasso PM, James J, Yen-Revollo JL, McLeod HL
Phase I study of biweekly oxaliplatin, gemcitabine and capecitabine in patients with advanced upper gastrointestinal malignancies.
Ann Oncol 2008 Jun 4; [Epub ahead of print]
Uluckan O, Eagleton MC, Floyd DH, Morgan EA, Hirbe AC, Kramer M, Dowland N, Prior JL, Piwnica-Worms D, Jeong SS, Chen R, Weilbaecher K
APT102, a novel adpase, cooperates with aspirin to disrupt bone metastasis in mice.
J Cell Biochem 2008 Jul 1;104(4):1311-23
Sadler JE
Von Willebrand factor, ADAMTS13, and thrombotic thrombocytopenic purpura.
Blood 2008 Jul 1;112(1):11-8
Cattano D, Vannucci A, Nicolini A, Nania C, Buzzigoli S, Eby C
Varicella fulminant hepatitis in an adult patient with Factor V Leiden mutation and trisomy 8 related myelodysplastic syndrome.
J Clin Virol 2008 Jun 5; [Epub ahead of print]
Ma X, Tittiger M, Knutsen RH, Kovacs A, Schaller L, Mecham RP, Ponder KP
Upregulation of elastase proteins results in aortic dilatation in mucopolysaccharidosis I mice.
Mol Genet Metab 2008 Jul;94(3):298-304
Field JJ, Glassberg J, Gilmore A, Howard J, Patankar S, Yan Y, Davies SC, Debaun MR, Strunk RC
Longitudinal analysis of pulmonary function in adults with sickle cell disease.
Am J Hematol 2008 Jul;83(7):574-6
Capoccia BJ, Gregory AD, Link DC
Recruitment of the inflammatory subset of monocytes to sites of ischemia induces angiogenesis in a monocyte chemoattractant protein-1-dependent fashion.
J Leukoc Biol 2008 Jun 11; [Epub ahead of print]
Hunter MG, McLemore M, Link DC, Loveland M, Copelan A, Avalos BR
Divergent pathways in COS-7 cells mediate defective internalization and intracellular routing of truncated G-CSFR forms in SCN/AML.
PLoS ONE 2008 Jun 18;3(6):e2452
Sorscher SM, Hill A, Sorscher EJ
Evolutionary maintenance of oncogenesis.
J Cancer Res Clin Oncol 2008 May 30; [Epub ahead of print]
Baker S, Verweij J, Cusatis G, van Schaik R, Marsh S, Orwick S, Franke R, Hu S, Schuetz E, Lamba V, Messersmith W, Wolff A, Carducci M, Sparreboom A
Pharmacogenetic Pathway Analysis of Docetaxel Elimination.
Clin Pharmacol Ther 2008 May 28; [Epub ahead of print]
Sleeper MM, Kusiak CM, Shofer FS, O'Donnell P, Bryan C, Ponder KP, Haskins ME
Clinical characterization of cardiovascular abnormalities associated with feline mucopolysaccharidosis I and VI.
J Inherit Metab Dis 2008 May 23; [Epub ahead of print]
Gao W, Anderson PJ, Sadler JE
Extensive contacts between ADAMTS13 exosites and von Willebrand factor domain A2 contribute to substrate specificity.
Blood 2008 May 20; [Epub ahead of print]
Ma X, Tittiger M, Knutsen RH, Kovacs A, Schaller L, Mecham RP, Ponder KP
Upregulation of elastase proteins results in aortic dilatation in mucopolysaccharidosis I mice.
Mol Genet Metab 2008 May 12; [Epub ahead of print]
Zhang J, Tu Y, Lu L, Lasky N, Broze GJ Jr
Protein Z-dependent protease inhibitor deficiency produces a more severe murine phenotype than protein Z deficiency.
Blood 2008 May 15;111(10):4973-8
Rosova I, Dao M, Capoccia B, Link D, Nolta JA
Hypoxic Preconditioning Results in Increased Motility and Improved Therapeutic Potential of Human Mesenchymal Stem Cells.
Stem Cells 2008 May 29; [Epub ahead of print]
Zhang JR, Coleman T, Langmade SJ, Scherrer DE, Lane L, Lanier MH, Feng C, Sands MS, Schaffer JE, Semenkovich CF, Ory DS
Niemann-Pick C1 protects against atherosclerosis in mice via regulation of macrophage intracellular cholesterol trafficking.
J Clin Invest 2008 May 15; [Epub ahead of print]
Hernandez JM, Floyd DH, Weilbaecher KN, Green PL, Boris-Lawrie K
Multiple facets of junD gene expression are atypical among AP-1 family members.
Oncogene 2008 Apr 21; [Epub ahead of print]
Salim A, Ratner L
Modulation of beta-catenin and E-cadherin interaction by Vpu increases human immunodeficiency virus type 1 particle release.
J Virol 2008 Apr;82(8):3932-8
Feng X, Ratner L
Human T-cell leukemia virus type 1 blunts signaling by interferon alpha.
Virology 2008 Apr 25;374(1):210-6
Meyerrose TE, Roberts M, Ohlemiller KK, Vogler CA, Wirthlin L, Nolta JA, Sands MS
Lentiviral-transduced human mesenchymal stem cells persistently express therapeutic levels of enzyme in a xenotransplantation model of human disease.
Stem Cells 2008 Apr 24; [Epub ahead of print]
Devine SM, Vij R, Rettig M, Todt L, McGlauchlen K, Fisher N, Devine H, Link DC, Calandra G, Bridger G, Westervelt P, Dipersio JF
Rapid mobilization of functional donor hematopoietic cells without G-CSF using plerixafor, an antagonist of the CXCR4/SDF-1 interaction.
Blood 2008 Apr 21; [Epub ahead of print]
Cahan P, Godfrey LE, Eis PS, Richmond TA, Selzer RR, Brent M, McLeod HL, Ley TJ, Graubert TA
wuHMM: a robust algorithm to detect DNA copy number variation using long oligonucleotide microarray data.
Nucleic Acids Res 2008 Apr;36(7):e41
Graubert T
AML1 and Evi1: coconspirators in MDS/AML?
Blood 2008 Apr 15;111(8):3916-7
Wernig G, Gonneville JR, Crowley BJ, Rodrigues MS, Reddy MM, Hudon HE, Walz C, Reiter A, Podar K, Royer Y, Constantinescu SN, Tomasson MH, Griffin JD, Gilliland DG, Sattler M
The Jak2V617F oncogene associated with myeloproliferative diseases requires a functional FERM domain for transformation and for expression of the Myc and Pim proto-oncogenes.
Blood 2008 Apr 1;111(7):3751-9
Cashen AF, Shah AK, Todt L, Fisher N, Dipersio J
Pharmacokinetics of decitabine administered as a 3-h infusion to patients with acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS).
Cancer Chemother Pharmacol 2008 Apr;61(5):759-66
Ndonwi M, Broze G Jr
Protein S enhances the TFPI inhibition of factor Xa but not its inhibition of factor VIIa/tissue factor.
J Thromb Haemost 2008 Apr 14; [Epub ahead of print]
Field JJ, Austin PF, An P, Yan Y, Debaun MR
Enuresis Is a Common and Persistent Problem Among Children and Young Adults with Sickle Cell Anemia.
Urology 2008 Apr 1; [Epub ahead of print]
Hood JL, Eby CS
Evaluation of a prolonged prothrombin time.
Clin Chem 2008 Apr;54(4):765-8; discussion 768-9
He L, Giri TK, Vicente CP, Tollefsen DM
Vascular dermatan sulfate regulates the antithrombotic activity of heparin cofactor II.
Blood 2008 Apr 15;111(8):4118-25
Werneck CC, Vicente CP, Weinberg JS, Shifren A, Pierce RA, Broekelmann TJ, Tollefsen DM, Mecham RP
Mice lacking the extracellular matrix protein MAGP1 display delayed thrombotic occlusion following vessel injury.
Blood 2008 Apr 15;111(8):4137-44
Caldwell MD, Awad T, Johnson JA, Gage BF, Falkowski M, Gardina P, Hubbard J, Turpaz Y, Langaee TY, Eby C, King CR, Brower A, Schmelzer JR, Glurich I, Vidaillet HJ, Yale SH, Qi Zhang K, Berg RL, Burmester JK
CYP4F2 genetic variant alters required warfarin dose.
Blood 2008 Apr 15;111(8):4106-12
Lu L, Feng Y, Hucker WJ, Oswald SJ, Longmore GD, Yin FC
Actin stress fiber pre-extension in human aortic endothelial cells.
Cell Motil Cytoskeleton 2008 Apr;65(4):281-94
Mast AE, Blinder MA, Dietzen DJ
Reticulocyte hemoglobin content.
Am J Hematol 2008 Apr;83(4):307-10
Fracasso PM, Picus J, Wildi JD, Goodner SA, Creekmore AN, Gao F, Govindan R, Ellis MJ, Tan BR, Linette GP, Fu CJ, Pentikis HS, Zumbrun SC, Egorin MJ, Bellet RE
Phase 1 and pharmacokinetic study of weekly docosahexaenoic acid-paclitaxel, Taxoprexin((R)), in resistant solid tumor malignancies.
Cancer Chemother Pharmacol 2008 Apr 15; [Epub ahead of print]
Scott LC, Yao JC, Benson AB 3rd, Thomas AL, Falk S, Mena RR, Picus J, Wright J, Mulcahy MF, Ajani JA, Evans TR
A phase II study of pegylated-camptothecin (pegamotecan) in the treatment of locally advanced and metastatic gastric and gastro-oesophageal junction adenocarcinoma.
Cancer Chemother Pharmacol 2008 Apr 9; [Epub ahead of print]
Marsh S
Pharmacogenetics: global clinical markers.
Pharmacogenomics 2008 Apr;9(4):371-3
Epple H, Cremasco V, Zhang K, Mao D, Longmore GD, Faccio R
PLCgamma2 modulates integrin signaling in the osteoclast by affecting the localization and activation of Src kinase.
Mol Cell Biol 2008 Mar 31; [Epub ahead of print]
Nakayama T, Matsushita T, Yamamoto K, Mutsuga N, Kojima T, Katsumi A, Nakao N, Sadler JE, Naoe T, Saito H
Identification of amino acid residues responsible for von Willebrand factor binding to sulfatide by charged-to-alanine-scanning mutagenesis.
Int J Hematol 2008 Mar 29; [Epub ahead of print]
Venteicher AS, Meng Z, Mason PJ, Veenstra TD, Artandi SE
Identification of ATPases pontin and reptin as telomerase components essential for holoenzyme assembly.
Cell 2008 Mar 21;132(6):945-57
Hou Z, Peng H, Ayyanathan K, Yan K, Langer EM, Longmore GD, Rauscher FJ 3rd
The LIM protein AJUBA recruits protein arginine methyltransferase 5 (PRMT5) to mediate SNAIL-dependent transcriptional repression.
Mol Cell Biol 2008 Mar 17; [Epub ahead of print]
Zhang J, Tu Y, Lu L, Lasky N, Broze GJ Jr
Protein Z-dependent protease inhibitor deficiency produces a more severe murine phenotype than protein Z deficiency.
Blood 2008 Mar 14; [Epub ahead of print]
Vaira S, Johnson T, Hirbe AC, Alhawagri M, Anwisye I, Sammut B, O'Neal J, Zou W, Weilbaecher KN, Faccio R, Novack DV
RelB is the NF-kappaB subunit downstream of NIK responsible for osteoclast differentiation.
Proc Natl Acad Sci U S A 2008 Mar 11;105(10):3897-902
Cahan P, Godfrey LE, Eis PS, Richmond TA, Selzer RR, Brent M, McLeod HL, Ley TJ, Graubert TA
wuHMM: a robust algorithm to detect DNA copy number variation using long oligonucleotide microarray data.
Nucleic Acids Res 2008 Mar 11; [Epub ahead of print]
Hoskins JM, Marcuello E, Altes A, Marsh S, Maxwell T, Van Booven DJ, Pare L, Culverhouse R, McLeod HL, Baiget M
Irinotecan pharmacogenetics: influence of pharmacodynamic genes.
Clin Cancer Res 2008 Mar 15;14(6):1788-96
Wildi JD, Baggstrom MQ, Suresh R, Read W, Fracasso PM, Govindan R
A phase I study of docetaxel and bexarotene.
Chemotherapy 2008;54(2):125-30
Dehdashti F, Mortimer JE, Trinkaus K, Naughton MJ, Ellis M, Katzenellenbogen JA, Welch MJ, Siegel BA
PET-based estradiol challenge as a predictive biomarker of response to endocrine therapy in women with estrogen-receptor-positive breast cancer.
Breast Cancer Res Treat 2008 Mar 9; [Epub ahead of print]
Uluckan O, Eagleton MC, Floyd DH, Morgan EA, Hirbe AC, Kramer M, Dowland N, Prior JL, Piwnica-Worms D, Jeong SS, Chen R, Weilbaecher K
APT102, a novel adpase, cooperates with aspirin to disrupt bone metastasis in mice.
J Cell Biochem 2008 Feb 7; [Epub ahead of print]
Salim A, Ratner L
Modulation of {beta}-Catenin and E-Cadherin Interaction by Vpu Increases HIV-1 Particle Release.
J Virol 2008 Feb 6; [Epub ahead of print]
Cheng X, Belshan M, Ratner L
Hsp40 facilitates nuclear import of the human immunodeficiency virus type 2 Vpx-mediated preintegration complex.
J Virol 2008 Feb;82(3):1229-37
He L, Giri TK, Vicente CP, Tollefsen DM
Vascular dermatan sulfate regulates the antithrombotic activity of heparin cofactor II.
Blood 2008 Feb 15; [Epub ahead of print]
Werneck CC, Vicente CP, Weinberg JS, Shifren A, Pierce RA, Broekelmann TJ, Tollefsen DM, Mecham RP
Mice lacking the extracellular matrix protein MAGP1 display delayed thrombotic occlusion following vessel injury.
Blood 2008 Feb 15; [Epub ahead of print]
Caldwell MD, Awad T, Johnson JA, Gage BF, Falkowski M, Gardina P, Hubbard J, Turpaz Y, Langaee TY, Eby C, King C, Brower A, Schmelzer JR, Glurich I, Vidaillet HJ, Yale SH, Zhang KQ, Berg RL, Burmester JK
CYP4F2 genetic variant alters required warfarin dose.
Blood 2008 Feb 4; [Epub ahead of print]
Lee I, Doray B, Govero J, Kornfeld S
Binding of cargo sorting signals to AP-1 enhances its association with ADP ribosylation factor 1-GTP.
J Cell Biol 2008 Feb 11;180(3):467-72
Ponder KP, Srivastava A
Walk a mile in the moccasins of people with haemophilia.
Haemophilia 2008 Feb 2; [Epub ahead of print]
Liu F, Kunter G, Krem MM, Eades WC, Cain JA, Tomasson MH, Hennighausen L, Link DC
Csf3r mutations in mice confer a strong clonal HSC advantage via activation of Stat5.
J Clin Invest 2008 Feb 21; [Epub ahead of print]
Chang LW, Payton JE, Yuan W, Ley TJ, Nagarajan R, Stormo GD
Computational identification of the normal and perturbed genetic networks involved in myeloid differentiation and acute promyelocytic leukemia.
Genome Biol 2008 Feb 21;9(2):R38
Tomasson MH, Xiang Z, Walgren R, Zhao Y, Kasai Y, Miner T, Ries RE, Lubman O, Fremont D, McLellan MD, Payton JE, Westervelt P, Dipersio JF, Link DC, Walter MJ, Graubert TA, Watson M, Baty J, Heath S, Shannon WD, Nagarajan R, Bloomfield CD, Mardis ER, Wilson RK, Ley TJ
Somatic mutations and germline sequence variants in the expressed tyrosine kinase genes of patients with de novo acute myeloid leukemia.
Blood 2008 Feb 12; [Epub ahead of print]
Winston DJ, Young JA, Pullarkat V, Papanicolaou GA, Vij R, Vance E, Alangaden GJ, Chemaly RF, Petersen F, Chao N, Klein J, Sprague K, Villano SA, Boeckh M
Maribavir prophylaxis for prevention of cytomegalovirus infection in allogeneic stem-cell transplant recipients: a multicenter, randomized, double-blind, placebo-controlled, dose-ranging study.
Blood 2008 Feb 19; [Epub ahead of print]
Gage B, Eby C, Johnson J, Deych E, Rieder M, Ridker P, Milligan P, Grice G, Lenzini P, Rettie A, Aquilante C, Grosso L, Marsh S, Langaee T, Farnett L, Voora D, Veenstra D, Glynn R, Barrett A, McLeod H
Use of Pharmacogenetic and Clinical Factors to Predict the Therapeutic Dose of Warfarin.
Clin Pharmacol Ther 2008 Feb 27; [Epub ahead of print]
Morgensztern D, Goodgame B, Baggstrom MQ, Gao F, Govindan R
The effect of FDG-PET on the stage distribution of non-small cell lung cancer.
J Thorac Oncol 2008 Feb;3(2):135-9
Goodgame B, Pillot GA, Yang Z, Shriki J, Meyers BF, Zoole J, Gao F, Dehdashti F, Patterson A, Siegel BA, Govindan R
Prognostic value of preoperative positron emission tomography in resected stage I non-small cell lung cancer.
J Thorac Oncol 2008 Feb;3(2):130-4
Wang J, Day R, Dong Y, Weintraub SJ, Michel L
Identification of Trop-2 as an oncogene and an attractive therapeutic target in colon cancers.
Mol Cancer Ther 2008 Feb;7(2):280-5
Sorscher S, Hill AE, Sorscher EJ
Is oncogenesis a normal cellular defense mechanism?
Cancer Chemother Pharmacol 2008 Feb 15; [Epub ahead of print]
Wolff AC, Berry D, Carey LA, Colleoni M, Dowsett M, Ellis M, Garber JE, Mankoff D, Paik S, Pusztai L, Smith ML, Zujewski J
Research issues affecting preoperative systemic therapy for operable breast cancer.
J Clin Oncol 2008 Feb 10;26(5):806-13
Socinski MA, Novello S, Brahmer JR, Rosell R, Sanchez JM, Belani CP, Govindan R, Atkins JN, Gillenwater HH, Pallares C, Tye L, Selaru P, Chao RC, Scagliotti GV
Multicenter, phase II trial of sunitinib in previously treated, advanced non-small-cell lung cancer.
J Clin Oncol 2008 Feb 1;26(4):650-6
Ellis MJ
Improving outcomes for patients with hormone receptor-positive breast cancer: back to the drawing board.
J Natl Cancer Inst 2008 Feb 6;100(3):159-61
Smith SM, Grinblatt D, Johnson JL, Niedzwiecki D, Rizzieri D, Bartlett NL, Cheson BD
Thalidomide has limited single-agent activity in relapsed or refractory indolent non-Hodgkin lymphomas: a phase II trial of the Cancer and Leukemia Group B.
Br J Haematol 2008 Feb;140(3):313-9
Dubberke ER, Sadhu J, Gatti R, Reske KA, Dipersio JF, Devine SM, Fraser VJ
Reply to Jaber et al. *
Infect Control Hosp Epidemiol 2008 Feb;29(2):189-190
Lu L, Feng Y, Hucker WJ, Oswald SJ, Longmore GD, Yin FC
Actin stress fiber pre-extension in human aortic endothelial cells.
Cell Motil Cytoskeleton 2008 Jan 15; [Epub ahead of print]
Huang RH, Wang Y, Roth R, Yu X, Purvis AR, Heuser JE, Egelman EH, Sadler JE
Assembly of Weibel-Palade body-like tubules from N-terminal domains of von Willebrand factor.
Proc Natl Acad Sci U S A 2008 Jan 15;105(2):482-7
Ellis MJ
Improving Outcomes for Patients With Hormone Receptor-Positive Breast Cancer: Back to the Drawing Board.
J Natl Cancer Inst 2008 Jan 29; [Epub ahead of print]
Truscott SM, Wang X, Lybarger L, Biddison WE, McBerry C, Martinko JM, Connolly JM, Linette GP, Fremont DH, Hansen TH, Carreno BM
Human MHC class I molecules with disulfide traps secure disease-related antigenic peptides and exclude competitor peptides.
J Biol Chem 2008 Jan 14; [Epub ahead of print]
Rotolo JA, Maj JG, Feldman R, Ren D, Haimovitz-Friedman A, Cordon-Cardo C, Cheng EH, Kolesnick R, Fuks Z
Bax and Bak Do Not Exhibit Functional Redundancy in Mediating Radiation-Induced Endothelial Apoptosis in the Intestinal Mucosa.
Int J Radiat Oncol Biol Phys 2008 Jan 10; [Epub ahead of print]
Wernig G, Gonneville JR, Crowley BJ, Rodrigues MS, Reddy MM, Hudon HE, Walz C, Reiter A, Podar K, Royer Y, Constantinescu SN, Tomasson MH, Griffin JD, Gilliland DG, Sattler M
The Jak2V617F oncogene associated with myeloproliferative diseases requires a functional FERM domain for transformation and for expression of the Myc and Pim proto-oncogenes.
Blood 2008 Jan 23; [Epub ahead of print]
Detterbeck FC, Socinski MA, Gralla RJ, Edelman MJ, Jahan TM, Loesch DM, Limentani SA, Govindan R, Zaman MB, Ye Z, Monberg MJ, Obasaju CK
Neoadjuvant Chemotherapy with Gemcitabine-Containing Regimens in Patients with Early-Stage Non-small Cell Lung Cancer.
J Thorac Oncol 2008 Jan;3(1):37-45
Sharma KV, Gould JE, Harbour JW, Linette GP, Pilgram TK, Dayani PN, Brown DB
Hepatic arterial chemoembolization for management of metastatic melanoma.
AJR Am J Roentgenol 2008 Jan;190(1):99-104
