Grant Challen.jpg

Grant A. Challen, PhD

Assistant Professor
Department of Medicine
Oncology Division
Stem Cell Biology

Research Interests

  • Hematopoietic stem cells
  • Leukemia stem cells
  • Epigenetic modifications


  • 314-362-0987 (tel)
  • 314-362-1953 (fax)
  • Room 744 Southwest Tower (lab)
  • Washington University School of Medicine
    Division of Oncology
    Campus Box 8056
    660 South Euclid Avenue
    St. Louis, MO 63110
  • Challen Lab Website

Invited Publications

  • Dominating the negative: how DNMT3A mutations contribute to AML pathogenesis
    Challen GA
    Cell Stem Cell 2017 Jan 5;20(1):7-8
  • The epigenetic basis of hematopoietic stem cell aging
    Kramer A, Challen GA
    Semin Hematol 2017 Jan;54(1):19-24
  • Inflammatory signals in HSPC development and homeostasis: too much of a good thing?
    Luis TC, Tremblay CS, Manz MG, North TE, King KY, Challen GA
    Exp Hematol 2016 Oct;44(10):908-12
  • DNA methylation in normal and malignant hematopoiesis
    Celik H, Kramer A, Challen GA
    Int J Hematol 2016 Jun;103(6):617-626
  • Two new routes to make blood: Hematopoietic specification from pluripotent cell lines versus reprogramming of somatic cells
    Singbrant S, van Galen P, Lucas D, Challen G, Rossi DJ, Daley GQ
    Exp Hematol 2015 Sep;43(9):756-759
  • Isolation and characterization of mouse side population cells
    Ergen AV, Jeong M, Lin KK, Challen GA, Goodell MA
    Methods Mol Biol 2013;946:151-62
  • Hematopoietic stem cell properties, markers, and therapeutics
    Lin KK, Challen GA, Goodell MA
    In: Principles of Regenerative Medicine. Elsevier/Academic Press 2011, pp 273-284
  • Bridge over troubled stem cells
    Challen GA, Goodell MA
    Mol Ther 2011 Oct;19(10):1756-8
  • The potential of the side population in regenerative nephrology
    Little MH, Challen GA
    In: Regenerative Nephrology (Goligorsky, ed), Academic Press 2011
  • Hematopoietic stem cell characterization and isolation
    Rossi L, Challen GA, Sirin O, Lin KK, Goodell MA
    Methods Mol Biol 2011;750:47-59
  • Where new approaches can stem from: focus on stem cell identification
    Adams V, Challen GA, Zuba-Surma E, Ulrich H, Vereb G, Tarnok A
    Cytometry A 2009 Jan;75(1):1-3
  • Mouse hematopoietic stem cell identification and analysis
    Challen GA, Boles N, Lin KK, Goodell MA
    Cytometry A 2009 Jan;75(1):14-24
  • A side order of stem cells: the SP phenotype
    Challen GA, Little MH
    Stem Cells 2006 Jan;24(1):3-12
  • Post-transcription regulation of mRNA and hormone synthesis and release at the anterior pituitary gland: Information derived from the recovery of pituitary gonadotrope cell function after therapy with a GnRH agonist
    D’Occhio MJ, Challen GA, Braga DPAF, Aspden WJ, Trigg TE
    Ann Rev Bio Sci 2000;2:91-112