Malachi Griffith.jpg

Malachi Griffith, PhD

Assistant Professor
Department of Medicine
Oncology Division
Stem Cell Biology
McDonnell Genome Institute

Research Interests

  • Cancer informatics
  • Bioinformatics
  • Genomics
  • Precision medicine


  • 314-286-1274 (phone)
  • 314-286-1810 (fax)
  • Room 5139, 4444 Forest Park Avenue (lab)
  • McDonnell Genome Institute
    Washington University
    Campus Box 8501
    4444 Forest Park Avenue
    St. Louis, MO 63108
  • Website


1996-2002 BSc in Biology (Honors) and Biochemistry, University of Winnipeg, Winnipeg, MB, Canada
2004-2005 Molecular Biology Graduate Exchange, Simon Fraser University, Burnaby, BC, Canada
2004-2010 PhD in Medical Genetics, University of British Columbia, Vancouver, BC, Canada
Academic Positions & Employment
2010-2011 Post-Doctoral Fellow, Michael Smith Genome Sciences Center, Vancouver, BC, Canada
2011-2014 Research Instructor, Genetics, Washington University School of Medicine, St. Louis, MO
2011-2014 Genome Fellow, McDonnell Genome Institute, Washington University School of Medicine, St. Louis, MO
2011-present Instructor, Cold Spring Harbor Laboratory, NY
2011-present Instructor, Canadian Bioinformatics Workshops, Toronto, ON, Canada
2014-2016 Research Assistant Professor, Genetics, Washington University School of Medicine, St. Louis, MO
2014-present Assistant Director, McDonnell Genome Institute, Washington University School of Medicine, St. Louis, MO
2017-present Assistant Professor, Medicine, Washington University School of Medicine, St. Louis, MO
Professional Experience
2000-2003 Research Assistant - Biochemistry and Medical Genetics, Health Sciences Centre, University of Manitoba, Winnipeg, MB, Canada
2003-2004 Computational Biologist/Sequence Finisher, Canada's Michael Smith Genome Sciences Centre, Vancouver, BC, Canada
2012-2013 Consultant, Omic Medicine, St. Louis, MO
2013-present Founder and Consultant, Iterative Genomics, St. Louis, MO
2016-present Consultant, Gerson Lehrman Group, New York, NY
Awards & Honors
1996 University of Winnipeg - Special Entrance Scholarship
1999 University of Winnipeg - Academic Proficiency Scholarship
1999-2002 University of Winnipeg - Student of Highest Distinction
2001 Dr. Edgar Van Nuys Allen Scholarship
2004 University of British Columbia - PhD Tuition Award
2004 Michael Smith Foundation for Health Research - Junior Trainee Award
2004 Natural Sciences and Engineering Research Council - Masters Award
2004 University of British Columbia - Graduate Entrance Scholarship
2005 Natural Sciences and Engineering Research Council - Doctoral Award
2006 Michael Smith Foundation for Health Research - Senior Trainee Award
2008 NCIC and Terry Fox Foundation - Research Studentship
2009 John Bosdet Memorial Fund - Graduate Student Travel Scholarship
2009 Lloyd Skarsgard Research Excellence Prize
2015-2019 NIH/NHGRI K99/R00 Grant
Professional Responsibilities
2007 Conference chair - Discovery2Diagnostics Conference, 'Emerging Microarrays and Technologies', Philadelphia, PA
2015 Conference chair - The Clinical Genome Conference, 'Understanding Wellness' session, San Francisco, CA
2016 Methods workshop chair - American Association of Cancer Research Annual Meeting, Interpretation of Variants in Cancer, New Orleans, LA
2008-2010 Founding Member, Open Regulatory Annotation Consortium
2012-present Editor, Biostar Consulting LLC
2012-2015 Member, Illumina Sequencing Experts Panel
2013-present Co-organizer, Cancer Informatics Journal Club, The Genome Institute, Washington University
2014-present Professional Member, International Society for Computational Biology (ISCB)
2015-present Active Member, American Association for Cancer Research (AACR)
Bioinformatics Resources Created
2006-present ORegAnno - Open Regulatory Annotation (www.oreganno.org)
2011-present Alternative Expression Analysis of RNA-seq (www.alexaplatform.org)
2012-present RNA-seq analysis workshops (www.bioinformatics.ca/workshops/)
2012-present Bioinformatics tutorials (www.biostars.org/u/3034/)
2013-present GMS - Genome Modeling System (www.github.com/genome/gms/wiki)
2013-present DGIdb - Drug Gene Interaction database (www.dgidb.org)
2013-present rnaseq.wiki - transcriptome analysis on the cloud (www.rnaseq.wiki)
2014-present DoCM - Database of Curated Mutations (www.docm.info)
2015-present CIViC - Clinical interpretation of variants in cancer (www.civicdb.org)
2016-present GenVisR - Genome visualizations in R (github.com/griffithlab/GenVisR)
2016-present pVAC-Seq - A cancer immunotherapy pipeline for the identification of personalized Variant Antigens by Cancer Sequencing (github.com/griffithlab/pVAC-Seq)
2016-present RegTools - Integrated analysis of DNA-seq and RNA-seq data to help identify mutations that have a regulatory effect (github.com/griffithlab/regtools)