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SpeakerDateTitle
Abdul-Nabi, AnmaarOct 10, 2008Molecular and Biological Effects of AML-associated Fusion Proteins on Primary Human CD34+ Cells
Abendschein, DanaApr 17, 2015Can We Inhibit Thrombosis Without Increasing Bleeding?
Agovino, DarbyApr 20, 2023Establishing the Molecular Mechanism of Disease Induced by Mutant ENY2
Agre, PeterOct 6, 2022Stanley J. Korsmeyer Memorial Lecture: Aquaporin Water Channels: From Atomic Structure to Malaria
Ailhaud, GerardMar 23, 2001Early Events and Redundancy in Adipogenesis
Alford, ShannonSep 14, 2007Sphingosine 1-phosphate-mediated Endothelial Cell Migration in Human Platelet Poor Plasma
Amend, SarahMar 2, 2012Identification of the Genetic Basis of MGUS and Multiple Myeloma Susceptibility in KaLwRij Mice
Jan 25, 2013Of Mice and Men: Genetic Contributions of Susceptibility to MGUS, the Requisite Precursor of Multiple Myeloma
Anbukumar, DhanamFeb 3, 2012Calcium Binding Studies of von Willebrand Factor Propeptide
Nov 16, 2012Characterizing VWF Propeptide Ca2+ Binding Sites
Dec 20, 2013Cation Dependence of vWF Multimerization
Oct 17, 2014A Calcium Conundrum: The Role of Calcium in VWF Multimerization
Dec 10, 2015The ATP7A Copper Transporter Is Required for VWF Multimerization
Sep 22, 2016Copper Transport in Von Willebrand Factor Biosynthesis
Nov 2, 2017The Involvement of Copper Transport in Von Willebrand Factor Biosynthesis
Mar 21, 2019The Function of Copper Ions in vWF Multimer Assembly
Anderson, RichardApr 21, 2006Phosphoinositide Signaling: From Biochemistry to Human Disease
Anderson, TrishJan 21, 2005Work-in-Progress
Mar 30, 2007ADAMTS13 Structure and Function
Feb 29, 2008ADAMTS13 Spacer Domain and Substrate Recognition
Dec 12, 2008Substrate Recognition by the ADAMTS13 Spacer Domain
Dec 11, 2009More on ADAMTS13 Spacer Domain and VWF Substrate Recognition
Andrews, NancyOct 22, 1993An Erythroid Transcription Factor Regulating Globin Gene Expression and Iron Metabolism
Oct 23, 1998Iron Deficiency and Iron Overload: Insights From Anemic Animals
Armanios, MaryJan 31, 2019The Telomere Syndromes: Implications for Patient Care
Feb 10, 2020The Telomere Syndromes: A Paradigm for Molecular Medicine
Arora, VivekDec 17, 2015Defining Novel Oncogenic Drug Targets in Bladder Cancer
Ataga, KennethFeb 28, 2020Meeting Unmet Needs in Sickle Cell Disease
Atkinson, JohnMay 18, 2001Immune Adherence Revisited
Oct 14, 2005HUS: Not Enough Regulation of Innate Immunity
Apr 6, 2012Atypical Hemolytic Uremic Syndrome
SpeakerDateTitle
Baenziger, JacquesMay 7, 1999The Sulfated Oligosaccharides on LH Reveal the Roles Played by Glycosylation During the Reproductive Cycle
Oct 5, 2007Carbohydrates Determine Hormone Potency in Vivo
Apr 18, 2014Molecular Multi-Tasking: New Insights Into Hepatic Glycan Receptor Function
Baeten, JeremyMar 4, 2021TP53 in Clonal Hematopoiesis
Mar 3, 2022Synergistic Lethality of Decitabine and ATR Inhibition in TP53-Mutant AML
Mar 30, 2023Synergistic Lethality of Decitabine and ATR Inhibition in TP53-Mutant AML
Baldo, GuilhermeMay 13, 2011Pathogenesis of the Aortic Valve Disease in MPS VII
Bankaitis, VytasApr 26, 1996Phosphatidylinositol Transfer Proteins: a New Class of Intracellular Regulatory Molecules
Dec 5, 2007A High Resolution Look at a Superfamily of Nanoreactors That Control Phosphoinositide Signaling in Eukaryotic Cells
Baranski, TomFeb 25, 2000Genetic Analysis of G Protein Signalling
Nov 7, 2003Understanding the Receptor Switch: How Do Hormones Activate G Proteins?
Barnes, Terra (with Stuart Kornfeld)Jan 14, 2011The Mannose 6-Phosphate Lysosomal Targeting Pathway and Persistent Stuttering
Bassler, Bonnie L.Sep 22, 20179th Rosalind Kornfeld Lecture: Bacterial Quorum Sensing and Its Control
Batista, LuisMar 21, 2013Human IPS Cells as a Model to Study Telomere Dysfunction-Induced Disease
May 29, 2015Generation of an Isogenic Model to Study the Consequences of Telomerase Mutations in Human Stem Cells
Sep 8, 2022Misconduct
Bednarski, JeffreySep 29, 2016Physiologic and Genotoxic DNA Damage Activate Distinct Cellular Responses in Developing B Lymphocytes
Beerman, IsabelMar 8, 2016Hematopoietic Stem Cell Aging
Berrien-Elliott, MelissaApr 18, 2019miR-142 Is Required for NK Cell Homeostasis and Function
Bertina, RogierApr 11, 1997Genetic Analysis of Inherited Thrombophilia
Bessler, MonicaNov 8, 1996Molecular Basis of Paroxysmal Nocturnal Hemoglobinuria
Oct 17, 1997A Mouse Model for Paroxysmal Nocturnal Hemoglobinuria: Use of the Cre/LoxP System to Circumvent Embryonic Lethality
Mar 26, 1999Clonal Evolution in Paroxysmal Nocturnal Hemoglobinuria
Nov 3, 2000PNH: the Human Disease and Animal Models
Nov 1, 2002Bone Marrow Failure and Telomerase
Jan 14, 2005Paroxysmal Nocturnal Hemoglobinuria – From Bench to Bedside
Apr 6, 2007Housekeeping Ain’t No Joke! the Importance of Ribosome Biogenesis in Human Blood Disorders
Apr 3, 2009Towards a New Understanding of Bone Marrow Failure
Bhattacharya, DeeptaFeb 7, 2014Convergent Differentiation During Hematopoiesis
Bigg, PaulDec 17, 2010The Pathogenesis of Mitral Valve Disease in Mucopolysaccharidosis VII Dogs
Blumer, KenMay 7, 2004RGS Proteins: New Regulators of Blood Pressure Homeostasis and G Protein-Mediated Vasoconstrictor Signaling
Bock, PaulSep 22, 2006Blood Coagulation Out of Control: Molecular Sexuality Mechanism of Prothrombin Activation by Staphylocoagulase
Bock, SusanApr 22, 1994Antithrombin III and Serpin Structure/Function Studies
Boonen, MarielleOct 2, 2009Mucolipidosis Type II Mice Accumulate Autophagolysosomes in Fibroblasts and Serous/mucous Type Secretory Cells
Mar 20, 2015Cathepsin D and Neuronal Differentiation: Lessons From the Identification of a New Binding Partner
Bose, RonMar 11, 2011Kinase Activation and Signaling: How Does the Her2 Tyrosine Kinase Give Rise to Breast Cancer?
Boucher, PaulMar 11, 2021Adenoviral Vector Mediated Gene Editing of the B Cell Receptor as an HIV Vaccine
Mar 9, 2023Adenovirus Vectors for B Cell Gene Therapy
Brachmann, RainerOct 9, 1998Yeast as a Genetic Tool to Study the Tumor Suppressor Protein P53
Sep 28, 2001Stories of and Around P53
Brakhane, MollyMay 5, 2022Role of Calcium Signaling in Hematopoiesis in MPNs
May 4, 2023Calcium Dysregulation in MPN Platelets
Brass, SkipMay 6, 2011Dynamic Regulation of Platelet Accumulation Following Vascular Injury
Bray, PaulOct 10, 2014Platelet PAR4 Functional Genomics: Racial Disparities in Anti-Platelet Therapy
Mar 31, 2016Plateletomics: Exploring Platelet Biology Via Multi-omic Data Integration
Bredemeyer, AndreaOct 15, 2020Generation of Yolk-Sac-Like and Definitive Macrophages From Human PSCs
Brenner, KirstenFeb 13, 2015Regulation of the Telomerase RNA Component TERC in Human Development and Disease
Mar 24, 2016Telomere-Independent Functions of the Telomerase RNA Component in Human Stem Cells
Oct 20, 2016Telomere-independent Functions of the Telomerase RNA Component in Human Stem Cells
Oct 12, 2017A Telomere-Independent Role for the Telomerase RNA Component in Human Embryonic Stem Cells
Sep 27, 2018A Telomere-Independent Role for the Telomerase RNA Component in Human Embryonic Stem Cells
Brost, TaylorMay 19, 2016Interrogation of Genetically Distinct Clones Using MPN Patient-Specific IPSCs
Brown, RicDec 9, 1994Signal Transduction by Leukocyte Integrins
Broze, GeorgeOct 4, 1996Effects of Tissue Factor and Tissue Factor Pathway Inhibitor Gene Deletion
Dec 18, 1998What About Protein Z?
Oct 20, 2000Protein Z and Thrombosis
Dec 13, 2002Regulation of Coagulation by Protein Z
Apr 22, 2005TFPI α and β
Mar 9, 2007Protein Z-Dependent Protease Inhibitor
Sep 25, 2009Regulation of Coagulation
Dec 10, 2010Tissue Factor Pathway Inhibitor
Feb 15, 2013Translational Studies of Tissue Factor Inhibitors
Bruchas, MichaelJan 26, 2017Dissecting Neuromodulatory Circuits in Affective Behavior
Brugge, JoanMar 18, 2020Oxidative Stress Defenses in Cancer
Jan 13, 2023Mechanisms of Cancer Therapy Resistance
Brunelli, AngeloJan 21, 2021Pevonedistat Targets Malignant Cells in Myeloproliferative Neoplasms in Vitro and in Vivo Via NFkB Pathway Inhibition
Bu, GuojunApr 9, 2004The LDL Receptor Family: What These Receptors Don’t Do
Byun, MinjiNov 5, 2015Searching for the Genetic Etiology of Infectious Diseases
SpeakerDateTitle
Camargo, FernandoNov 17, 2016Clonal Analysis of Native Hematopoiesis
Feb 9, 2023Ancestry and Function in the Hematopoietic System
Challen, GrantDec 13, 2013The Epigenetics of Hematopoietic Stem Cell Self-Renewal and Transformation
Chan, AndyMar 4, 1994Protein Tyrosine Kinases in T Cell Activation: Bench to Bedside
Chang, SandyMay 7, 2010How Telomeres Repress the DNA Damage Response
Chang, Shao-ChunSep 10, 2004The Pathway to Inositol Hexakisphosphate Synthesis
Chavez, MoniqueOct 29, 2020Investigating Lenalidomide Treatment-Based Secondary B-Cell Acute Lymphoblastic Leukemia
Oct 28, 2021A Mouse Model of Subclonal Gene Mutations in Myelodysplastic Syndrome
Nov 10, 2022The Contribution of Subclonal Gene Mutations in Myelodysplastic Syndrome Progression
Cheng, EmilySep 24, 2004Apoptotic Checkpoints at the Mitochondrion
Dec 14, 2007Regulation of Cell Death by BCL-2 Family and Beyond
Cherian, MathewMar 1, 2013Role of PI3K-Akt-mTOR in HTLV-Tax Induced Transformation
Apr 25, 2014Role of the PI3K-Akt mTOR Pathway in Human T Cell Leukemia Induced Transformation
Mar 13, 2015Role of the PI3K-Akt-mTOR Pathway in HTLV Induced Leukemogenesis
Cheung, Vivian G.Oct 27, 201745th Carl Moore Lecture: It’s in the RNA: Implications for Human Disease
Chheda, MilanFeb 9, 2017Developing a Synthetic Lethal Genetic Screen to Identify Vulnerabilities in IDH1 Mutant Gliomas
Chiquetto, LuanaFeb 17, 2022The Role of Stathmin-1 in the Regulation of HSCs
May 4, 2023The Role of Stathmin-1 in Regulation of HSCs
Choi, JaebokJan 20, 2012Interferon Gamma Receptor Signaling and T Cell Trafficking in Graft vs. Host Disease
Choi, KyungheeApr 20, 2012Regulation of Hematopoietic and Vascular Development
Cho, Jaehyung (Gus)Feb 14, 2020Mechanisms Regulating Intravascular Cell-Cell Interactions in Thrombosis and Inflammation
Christopher, MattApr 10, 2015Cold Shock Domain Proteins in Normal and Malignant Hematopoiesis
Feb 11, 2016WT1 in Normal and Malignant Hematopoiesis
Clevers, HansMar 2, 201643rd Carl Moore Lecture: Lgr5 Stem Cell-Grown Organoids and Their Applications
Cocco, LucioApr 30, 2010Nuclear Phospholipase C Beta1 Signalling, MDS and AML: From Bench to Clinics
Cole, ChristopherMar 22, 2013Role of DNMT3A in Acute Promyelocytic Leukemia
Mar 28, 2014The Role of Dnmt3a in Acute Promyelocytic Leukemia
Collier, TimothyMay 3, 2013Probing the Structure and Dimerization of EGFR Family Tyrosine Kinases
Collins, TaylorFeb 16, 2017Utilizing iPSCs as a Model System to Interrogate Genetically Distinct Clones in Myeloproliferative Neoplasms
Oct 5, 2017Interrogation of ASXL1 Mutations in Combination With the JAK2 V617F Mutation in MPNs
Dec 13, 2018Interrogation of ASXL1 Mutations in Combination With the JAK2 V617F Mutation in MPNs
Sep 19, 2019Interrogating the Role of ASXL1 and JAK2 Mutations in MPNs Utilizing Human Pluripotent Stem Cells
Cooper, JohnJan 19, 1996Control of Actin Assembly by Capping Protein
Cordes, EthanNov 10, 2022TGS1 Depletion Increases Telomerase RNA Stability in Dyskeratosis Congenita
Cottrell, KyleApr 18, 2019Upregulation of 5’TOP mRNAs Following Loss of the Tumor Suppressor ARF
Crabtree, GeraldNov 9, 201240th Carl Moore Lecture: Chromatin Regulation: New Methods and Concepts
Creamer, PhilipFeb 1, 2018Investigating Gene Expression During Human Definitive Hematopoietic Specification
Feb 14, 2019Defining the Role of CDX4 During Human Definitive Hematopoietic Specification
Crispino, JohnApr 6, 2023Mechanisms of Leukemogenesis in Down Syndrome
Crowley, StephanieMay 13, 2021BCLAF1 Regulation of Hematopoietic Stem Cell Repopulating Capacity
Apr 7, 2022Bclaf1 Promotes Hematopoietic Stem Cell Repopulating Capacity
Cummings, RickFeb 2, 1996The Glycobiology of Schistosomiasis: From Molecular Mimicry to Autoimmunity
SpeakerDateTitle
Dahms, NancyFeb 27, 1998Insight Into Lysosomal Enzyme Recognition by the Mannose 6-Phosphate Receptors
Dalla-Favera, RiccardoOct 10, 2017Stanley J. Korsmeyer Memorial Lecture: Molecular Genetics of B Cell Lymphoma
Dang, LukeMar 19, 2010Two Histidine Residues Required for the pH Dependent Multimerization of Von Willebrand Factor
Das Thakur, MeghnaMar 16, 2007
The Role of LIM Proteins in Cell-Cell Adhesion and Epithelial Polarity
May 16, 2008Role of the Ajuba LIM Protein in Size Control in Drosophila Epithelia
Davidson, NickMay 30, 2003RNA Editing: Molecular Mechanisms and Biological Consequences
Day, RyanFeb 4, 2021Distinct Profiles of CBF Leukemias
Dean, DougFeb 16, 1996Mechanism of Action of the Retinoblastoma Tumor Suppressor
Oct 26, 2001The Role for Rb in Tumor Suppression
Dege, CarissaMay 5, 2016Characterization of Human Pluripotent Stem Cell Derived Natural Killer Cells
Oct 27, 2016Generation and Characterization of Human Pluripotent Stem Cell-derived Natural Killer Cells
Oct 12, 2017Natural Born Killers? Determining Function and Ontological Origins of Two Distinct Natural Killer Cell Populations Derived From Human Pluripotent Stem Cells
Sep 27, 2018Ontogeny Is a Critical Determinant of Human Pluripotent Stem Cell Derived Natural Killer Cell Function
Oct 3, 2019Potently Cytotoxic Natural Killer Cell Potential Initially Emerges From Erythro-Myeloid Progenitors During Mammalian Development
Degen, JayMay 10, 1996Hard Knocks to the Hemostatic Balance: Fibrinogen and Plasminogen Deficiency in Mice
DeNardo, DavidSep 6, 2013Reprogramming Macrophages to Improve Responses to Chemo- and Immunotherapy
DePinho, RonaldDec 8, 200028th Carl Moore Lecture: Telomerase, Tumor Suppressors and Tumorigenesis
Deuel, TomMar 29, 1996Mechanisms of Transcriptional Regulation by the Wilms Tumor Suppressor Gene
Jun 1, 2011Shaping the Tumor Phenotype and Microenvironment: New Pathways, New Therapeutic Targets
DeWeerd, RachelMar 18, 2021The Experimentally-Defined APOBEC3A Signature Is Prevalent in Human Cancers
Di Cera, EnricoFeb 13, 1998Thrombin Allostery
Oct 8, 2004Rational Design of a Thrombin Mutant With Potent and Safe Anticoagulant/Antithrombotic Activity in Vivo
Diacovo, TomDec 10, 1999Platelets and the Molecular and Cellular Interactions Governing Their Adhesion: From Arterial Injury to Venular Inflammation
Dick, JohnNov 19, 1993Modeling Normal and Leukemic Hematopoiesis in SCID Mice
Dietz, HalNov 19, 201038th Carl Moore Lecture: TGFβ in the Pathogenesis and Prevention of Aneurysm: Embracing Paradox
Dinauer, MaryMar 9, 2012Getting a License to Kill: Regulation of the Leukocyte NADPH Oxidase
DiPaola, JorgeJan 7, 2019Studying Megakaryocytes, From Inherited Disorders to Old Age Platelets
DiPersio, JohnDec 19, 1997Cytokine Signaling Pathways
Dolatshahi, LeiliFeb 22, 2013Adjuvant Low Dose Rituximab for Patients with TTP
Doray, BalrajJan 7, 2005Work-in-Progress
Mar 3, 2006Work-in-Progress
Feb 2, 2007The α/σ2 Hemicomplex of Clathrin Adaptor AP-2 Harbors the Dileucine Recognition Site
Oct 26, 2007Identification of Acidic-dileucine Signals That Bind to GGAs and AP-1/AP-2
Feb 13, 2009Understanding the GGA Null Phenotype
Dec 11, 2009Characterization of Mouse GGA2 Antibodies
Mar 4, 2011GGA Autoinhibition Re-revisited: Do Internal Dileucines Bind GGA VHS Domains
Feb 17, 2012GGA Null Mice: The Final Chapter? Or Not?
Jan 11, 2013Gga2 Knockout Mice Revisited
Dec 20, 2013Influence of Genetic Background on Lethality of GGA2 Knockout Mice
Nov 14, 2014Assembly of UDP-GlcNAc-1-Phosphotransferase, a Multi-Subunit Protein
Sep 10, 2015Understanding How GlcNAc-1-Phosphotransferase Recognizes Lysosomal Enzymes: Part I
Nov 4, 2021Insight Into Regulation of GlcNAc-1-Phosphotransferase Function as Revealed Through Cryo-EM Analysis
Doudna, JenniferNov 13, 20158th Rosalind Kornfeld Lecture: The CRISPR-Cas9 Genome Engineering Revolution
Druker, BrianMar 3, 2000CML and STI 571: Validating the Promise of Molecularly Targeted Therapy
Dubielecka, PatrycjaOct 17, 2019Signaling at the Crossroads: From Inflammaging to Cancer
Duckett, ColinApr 24, 2001Role of IAP Proteins in the Control of Cell Survival
Du, Hong-YanOct 28, 2005Work-in-Progress
Feb 9, 2007TERT Haploinsufficiency and Telomere Length in Individuals with 5p- Syndrome
Jan 18, 2008The Significance of Telomere Length Measurement in the Diagnosis of Dyskeratosis Congenita
Dunbar, AndrewMar 16, 2023Molecular Pathogenesis and Therapy of Myeloproliferative Neoplasms
Duncavage, EricFeb 28, 2014Detection of Subclonal Population in MDS
Oct 31, 2014Sequencing Based Detection of Low Frequency Variants in MDS
Dustin, MikeJun 4, 1999Visualizing Molecular Events in the Immune Response: Building an Immunological Synapse
Du, XiaopingSep 2, 2021Novel Mechanisms of Integrin Outside-In Signaling and the Concept of Treating Thrombosis and Inflammation Without Causing Bleeding
SpeakerDateTitle
Elefanty, AndrewAug 30, 2018Dissection of Human Haematopoiesis From Pluripotent Stem Cells
Elf, ShannonNov 17, 2022Type 1 and Type 2 Calreticulin Mutations Activate Discrete Unfolded Protein Response Pathways to Drive Myeloproliferative Neoplasms
Mar 28, 2023The Pathobiology of Type 1 Versus Type 2 Calreticulin-Mutated Myeloproliferative Neoplasms
Ellenberger, TomFeb 8, 2008Chemical Biology of DNA Repair
Ellisen, LeifMar 24, 2000Acute Leukemia, Telomeres and DNA Damage Responses
Ellis, MatthewOct 4, 2013The Genomics and Proteomics of Breast Cancer
Engle, ElizabethMay 3, 2013Genetic Complexity and Clonal Evolution in Myeloproliferative Neoplasms
May 23, 2014Genetic Complexity and Disease Evolution in Myeloproliferative Neoplasms
Feb 27, 2015Intersection of Dysregulated Cytokines and Signaling in Myeloproliferative Neoplasms
Epple, HollyMay 5, 2006Work-in-Progress
Jan 19, 2007From the Skeleton to the Cytoskeleton: Mechanisms of Osteoclast Function
SpeakerDateTitle
Fager, AmmonJan 11, 2016Human Platelets Express Endothelial Protein C Receptor Which Contributes to the Binding and Activity of rFVIIa
Fehniger, ToddNov 1, 2013Molecular Regulation of NK Cell Development and Function
Feng, YunfengMay 13, 2005Work-in-Progress
Oct 13, 2006RNAi Oriented Loss of Function Research on α-Actinin
Feb 29, 2008Regulation of Cell Migration by α-actinin
Feys, HendrikMay 16, 2008Understanding ADAMTS13 When Under (Shear) Stress
Field, JoshuaApr 4, 2014The Potential Role of Invariant NKT Cells in Sickle Cell Disease
Fields, MelanieMay 8, 2015MR Measurements of Cerebral Blood Flow and Oxygen Extraction Fraction in Pediatric Sickle Cell Disease
Apr 21, 2016Functional Connectivity in Sickle Cell Disease
Mar 30, 2017Cerebral Oxygen Metabolism and Vasoreactivity in Sickle Cell Disease
Fisher, DanielJan 20, 2012Mass Cytometry Study of Human Myeloproliferative Neoplasia
Oct 26, 2012Genomic Study of Myeloproliferative Neoplasia
Feb 14, 2014Signaling in Myeloproliferative Neoplasms Studied by Single Cell Mass Cytometry
Sep 26, 2014Mass Cytometry Study Identifies NFκB Signaling as a Potential Disease Driver in Myeloproliferative Neoplasms
Sep 10, 2015NFkB Hyperactivation in Myeloproliferative Neoplasms
Apr 13, 2017Cytokines and Intracellular Signaling Abnormalities in Myeloproliterative Neoplasms
Jan 25, 2018Utilizing Mass Cytometry and Mouse Models to Understand Myeloproliferative Neoplasms
Jan 24, 2019Interacting Roles of Hyperactive Signaling and Cytokine Overproduction in Myeloproliferative Neoplasms
Jan 30, 2020NFκB Hyperactivation in Myeloproliferative Neoplasms: Insights From Human Patients and Mouse Models
Sep 17, 2020NF kappa B Hyperactivation in Myeloproliferative Neoplasms
Sep 23, 2021JAK2 and NF Kappa B Hyperactivation in Mouse Hematopoiesis and Myeloproliferative Neoplasms
Flaumenhaft, RobertMar 9, 2020Test Tube to Trial: Protein Disulfide Isomerase as an Antithrombotic Target
Fleischman, AngelaSep 28, 2017Inflammation as a Driver of Clonal Expansion in Myeloproliferative Neoplasm
Fok, WilsonNov 14, 2014Telomere Dysfunction in Stem Cell Proliferation and Differentiation
Oct 15, 2015Telomere Dysfunction in Stem Cell Proliferation and Differentiation
Sep 22, 2016p53 Stabilization Following Progressive Telomere Shortening Differentially Regulates Human Hematopoietic Specification
Oct 5, 2017Understanding How Telomere Dysfunction and RNA Processing Defects Lead to Human Disease
Oct 25, 2018Inhibition of Polyadenylation Activity by Silencing of PAPD5 Restores Telomerase and Rescues Hematopoietic Failure in Dyskeratosis Congenita
Fowles, JaredApr 27, 2017Genomic Dissection of Age-Related Differences in Polycythemia Vera
Feb 1, 2018Genomic Dissection of Age-Related Differences in Polycythemia Vera
Feb 21, 2019Investigating the Genomic and Inflammatory Profiles of Young and Old Polycythemia Patients
Nov 5, 2020Dysregulated Inflammation in Myeloproliferative Neoplasms and Disease Progression
Frazier, BillOct 13, 1995Thrombospondin as a Regulator of Endothelial Phenotype
Mar 22, 2002Integrin Associated Protein (CD47): a Receptor With Multiple Roles in Vascular Disease
French, AnthonyApr 3, 2015Regulation of NK Cell Proliferation
Friedman, JeffreyOct 24, 199725th Carl Moore Lecture: Leptin, Leptin Receptors and the Control of Body Weight
Fuh, KatherineMar 31, 2016Functional Genomics of Ovarian Cancer Metastasis
Fujiki, YukioMar 5, 2010Peroxisome Biogenesis and Its Dysfunctions in Humans
SpeakerDateTitle
Gadue, Paul J.Apr 5, 2018Megakaryocyte Development From Stem Cell Sources
Gailani, DaveApr 7, 1995The Role of Factor XI in a Revised Model of Blood Coagulation
Mar 26, 2010Factor XI and the Intrinsic Pathway in Normal and Pathologic Coagulation
Ganem, DonaldNov 21, 200836th Carl Moore Lecture: Small Noncoding RNAs and the Biology of Kaposi’s Sarcoma-Associated Herpesvirus
Ganz, TomasJan 23, 2015Systemic Iron Homeostasis and Its Disorders
Gao, WeiqiangOct 21, 2005Work-in-Progress
Sep 15, 2006A C-terminal Exosite of von Willebrand Factor Domain A2 Interacts with ADAMTS13 Spacer Domain to Accelerate Substrate Cleavage
Oct 26, 2007Contacts Between Several ADAMTS13 Structural Domains and Von Willebrand Factor Domain A2 Contribute to Substrate Cleavage
Apr 10, 2009Fluorescent VWF Substrates for ADAMTS13
May 21, 2010Functional Differences of the Non-Catalytic Domains in Human ADAMTS13 and ADAMTS5 in Substrate Cleavage
Gao, XinFeb 14, 2023Regulation of Hematopoietic Stem Cell Mobilization by the Bone Marrow Niche
Ge, JingpingMay 4, 2007Study of the Function of Dyskerin in a Liver Specific Knock-out Mouse Model
Apr 11, 2008Is Dyskerin Essential for Cell Survival and Proliferation?
Jan 30, 2009Microarray Analysis of snoRNA Expression in Dyskerin Knockout Mice
Feb 5, 2010The Consequences of Dyskerin Ablation in Mouse Liver
Germain, DavidMay 23, 2014DNMT3A Mutations in AML
Geuze, HansDec 16, 1993New Observations on the Class II Compartment in B Lymphoblasts
Gilligan, DianaMar 7, 2000Knockout of Beta-Adducin Causes Spherocytosis in Mice
Gilliland, GaryOct 14, 1994Early Mutations in Leukemia
Ginsburg, DavidFeb 21, 2003Disorders of Hemostasis Due to Genes Outside of the Coagulation System
Jan 7, 2021FV/FVIII and Cargo Receptors in the ER: From Bedside to Bench
Girard, TomJan 7, 2011The Ups and Downs of Protein Z and the Z-dependent Protease Inhibitor
Feb 3, 2012Tissue Factor Pathway Inhibitor – βefore and αfter
Nov 16, 2012Protein Z, Protein Z-Dependent Protease Inhibitor (SerpinA10) and the Acute Phase Response
Oct 25, 2013Tissue Factor Pathway Inhibitor Structures, Functions and Physiology
Sep 5, 2014Impact of Coagulation Regulators in Mouse Models of Various Diseases
Dec 10, 2015Evaluating Blockade of the Protein Z-Dependent Protease Inhibitor Pathway as a Potential Treatment for Hemophilia
Jan 12, 2017The Roles of Tissue Factor Pathway Inhibitor in Health and Disease
Feb 15, 2018A Balance Between Pro- and Anti-Coagulant Factors to Abate Bleeding and Avoid Thrombosis
May 2, 2019The TFPIαβ (γKO) Mouse Is a Better Model for Studying Human TF-Related Diseases
Giri, TusarMar 10, 2006Work-in-Progress
Gitlin, JonathanMay 9, 1997Aceruloplasminemia
Oct 6, 2000The Copper Chaperones
May 2, 2008Copper Homeostasis in Early Development
Glimcher, LaurieOct 31, 2019Stanley J. Korsmeyer Memorial Lecture: ER Stress: Reprogramming the Tumor Microenvironment
Goate, AlisonJan 13, 2006A Novel Risk Factor for Alzheimer’s Disease on Chromosome 10
Goldberg, DanApr 24, 1998The Pathway of Hemoglobin Degradation in the Malaria Parasite P. falciparum
Jan 10, 2003Falciparum Malaria: a Hematological Infectious Disease
Apr 4, 2008Targeting Intraerythrocytic Malaria Parasites for Chemical Destruction
Dec 14, 2012Trial by Fire and Famine: How the Malaria Parasite Survives in Its Host Erythrocyte
Goldsmith, MarkJun 9, 1994Structure/Function Relationships Within the IL-2 Receptor Complex
Gopalan, PriyaOct 10, 2008Regulation of Hematopoietic Stem Cells by the Bone Marrow Niche
Govero, JenniferApr 18, 2008Characterization of the GGA Null Mice
Nov 14, 2008Characterization of the GGA Null Mice
Mar 19, 2010All GGAs Are Not Created Equal
Feb 4, 2011Strain Dependent Lethality of GGA2 Null Mice: Embryonic vs Neonatal
Grainger, StephanieApr 20, 2021From Fish to Dish and Back Again: Deciphering Wnt/Fzd Cues in Hematopoietic Stem Cell Development
Graubert, TimMar 14, 2003Modeling T(8;21) Associated Acute Myelogenous Leukemia in Mice
May 23, 2008Genetic Basis of Susceptibility to Therapy-Related Leukemia
Greenberg, ZevFeb 28, 2019Regulation of Early B Cell Development by the Tetraspanin CD53
Jan 30, 2020Loss of CD53 Impairs B Cell Migration
Apr 21, 2022The Tetraspanin CD53 Protects Hematopoietic Stem Cells Following Cellular Stress Through Induction of DREAM Complex-Mediated Quiescence
Green, EricNov 11, 200533rd Carl Moore Lecture: Comparative Genomics: Using Evolution to Decode the Human Genome
Grierson, PatrickMay 9, 2019Overcoming the MK2/ Hsp27 Axis to Potentiate the Effect of Chemotherapy in Pancreatic Ductal Adenocarcinoma (PDAC)
Jan 9, 2020The MK2/Hsp27 Axis Determines Sensitivity to Chemotherapy in Pancreatic Ductal Adenocarcinoma
Gu, BaiweiOct 27, 2006Molecular Mechanism of Mouse Dyskerin Mutation in Telomere Maintenance and Ribosomal RNA Processing
Oct 12, 2007Dyskerin, Telomerase and DNA Damage
Sep 19, 2008Is Dyskerin Crucial for Telomere Maintenance, DNA Damage Response and Ageing?
Sep 18, 2009DNA Damage Accumulation, Accelerated Hematopoietic Stem Cell Aging, and Partial Reversal by Antioxidant Treatment in a Mouse Model of Dyskeratosis Congenita
Gu, MinxiangJun 12, 1998Characterization of a Novel Protein Tyrosine Phosphatase – PTPMEG
Gupta, GarimaMar 1, 2013Non-catalytic Interaction Between VWF and ADAMTS-13
SpeakerDateTitle
Hahn, WilliamApr 21, 2000Telomerase Immortality in Cancer
Hajjar, KathyApr 8, 1994Annexin II: a New Thromboregulatory Protein?
Halldorsdottir, Anna MargretSep 30, 2005Work-in-Progress
Hambleton, JulieApr 5, 1996Activation of MAP Kinase Signaling Pathways in Monocyte/Macrophage Cells
Hancock, JohnMar 3, 1995Ras Proteins: Membrane Targeting and Biochemical Function
Sep 17, 1999Caveolae, Cholesterol and Trafficking: New Insights Into Biological Differences Between the Ras Proteins
Harris, DavidMay 23, 1997Prion Diseases: a Cell Biological Perspective
Feb 22, 2002Molecular Mechanisms Underlying Familial Prion Diseases
He, FanFeb 11, 2021The Characteristics of Platelets in Essential Thrombocythemia
Feb 10, 2022The Metabolic Dysregulation of Platelets in MPN Disease
Mar 2, 2023Single-Cell Analysis Reveals Galectin-1 as a Novel Monocyte Marker and Therapeutic Target in MPN
Heinecke, JayJan 11, 2002Regulation of Matrix Metalloproteinase Activation and Plaque Rupture by Myeloperoxidase
He, JunFeb 18, 2005Work-in-Progress
May 19, 2006Work-in-Progress
Heldermon, CoySep 5, 2008The Effect of Bone Marrow Transplant and Intracranial Gene Therapy in Mucopolysaccharidosis IIIB Mice
He, LiApr 29, 2005Work-in-Progress
Herzog, BrettOct 24, 2019Reactive Fibrosis in Lung Cancer: Impact on Immunity and Progression
Apr 15, 2021Restoring Immune-Mediated Tumor Control in the Fibrotic NSCLC Microenvironment
Heslop, HelenApr 21, 1995Use of Virus-Specific Cytotoxic T Lymphocytes to Control Epstein-Barr Virus-Related Lymphoproliferation
High, KatherineApr 12, 1996Gene Therapy for Hemophilia
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Sep 19, 2014Phil Majerus Symposium: Molecular Basis of Infantile Batten Disease
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Feb 18, 2011Calcium and pH-Dependent Interactions Within VWF Tubule
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Nov 8, 2013VWF Tubular Assembly in Vitro by D Domains
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Jan 28, 2016pH-Dependent Association Within N-terminal D Domains of Von Willebrand Factor
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Lee, AngelNov 12, 1993CSF-1 Receptor: Mechanisms of Intracellular Signalling
Lee, IntaekOct 13, 2006Crosstalk Between Two Cargo Binding Sites of Adaptor Protein Complex AP-1
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Sep 16, 2011Update on Studies of Mutations Found in the Gene Encoding Uncovering Enzyme in Individuals with Persistent Stuttering
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Apr 11, 2014Analysis of Missense Mutations in the α,β-Subunit of GlcNAc-Phosphotransferase Associated with Stuttering
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Feb 27, 2020Analysis of Lysosomal Storage Disease-Causing Missense Mutations Within the Transmembrane Domain of GlcNAc-1-Phosphotransferase
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Levy, JoanneApr 7, 2000Iron Metabolism: Insights From Mutant Mice
Ley, TimJan 14, 2000How Do Cytotoxic Lymphocytes Kill Their Target?
Dec 13, 2001Modeling Acute Promyelocytic Leukemia in the Mouse
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Li, AnguoMar 14, 2008Differential Gene Expression of Injured Arteries in HCII Knockout Mice
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Lifton, RichardNov 8, 200230th Carl Moore Lecture: New Insights Into Cardiovascular, Renal, and Bone Disease From Human Genetic Studies
Lim, Kian-HuatMay 1, 2015Toll-like Receptor Signaling in Human Cancer
Linder, MaurineMar 1, 1996G-Protein Palmitoylation: Reversible and Regulated Acylation
Linette, GerryJan 25, 2002Melanoma Cell Death
Link, DanMay 5, 1995G-CSF Receptor Signals
Nov 14, 1997Role of G-CSF in Hematopoiesis: Lessons From the G-CSF Receptor Knockout Mice
Mar 7, 2003Regulation of Hematopoiesis by G-CSF
Nov 30, 2007Regulation of the Hematopoietic Stem Cell Niche by G-CSF
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Oct 19, 2012Characterizing the Stem Cell Niche
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Littman, DanNov 15, 201341st Carl Moore Lecture: Shaping of the Immune Response by the Commensal Microbiota
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Mar 29, 2018Rapid High-Resolution HLA Typing by Nanopore Sequencing
Liu, FangJan 4, 2008The Characteristic of Signaling Pathways Involved in Stx B-induced von Willebrand Factor Secretion
Mar 13, 2009Cell Signaling in Stx B Subunit-induced VWF Secretion
May 28, 2010The Mechanism of VWF Basolateral Secretion in HUVECs
Liu, LinApr 7, 2016Uncovering Novel Regulatory Roles of the “Spacer 1” Region of the GlcNAc-1-Phosphotransferase
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Li, WeikaiMay 4, 2012Structure and Function of Vitamin K Epoxide Reductase: Connecting Oxidative Protein Folding With Blood Coagulation
Li, YeddaMar 24, 2016Combination Therapy Increases Lifespan and Improves Clinicobehavioral Performance in the Murine Model of Globoid Cell Leukodystrophy
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Longmore, GregNov 1, 1996Erythropoietin Receptor Signalling and Red Cell Development
May 8, 1998Cytokine Regulation of Lineage Commitment During Hematopoiesis
Feb 26, 1999Role of LIM Proteins in Cell Growth
Apr 20, 2001Red Blood Cell Development and Leukemogenesis
Jan 24, 2003The Role of Lim Proteins in Cell Adhesion and Motility
Dec 17, 2004Role of LIM Proteins in Cell Adhesion and Migration
Jan 26, 2007LIM Proteins and Epithelial Development and Cancer
Sep 11, 2009Epithelial Morphogenesis in Development and Cancer
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Look, TomMay 19, 1995Chimeric Transcriptional Control Genes in Human Acute Leukemia
Lopez, JoseApr 13, 2021The Significance of Endothelium-Bound von Willebrand Factor
Luderer, HilaryFeb 3, 2006Work-in-Progress
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Luff, StephanieMar 15, 2018Twice Spliced: Exploring HOXA9 Variants in Embryonic Hematopoiesis
Feb 28, 2019Recapitulating Intraembryonic Hematopoiesis in the Dish
Oct 24, 2019Top Notch Blood: The Involvement of NOTCH Signaling in Extra-Embryonic Hematopoiesis
Lunn, CaraNov 12, 2010Discovery of Mutations in Myelodysplastic Syndrome Genomes
Nov 11, 2011U2AF1 Mutations in Myelodysplastic Syndromes
Sep 14, 2012U2AF1 Splicing Factor Mutations in Myelodysplastic Syndromes
Lu, RongJan 3, 2013Systems Analysis of Mouse Hematopoietic Stem Cells in Vivo at the Single Cell Level
Lyons, SusanFeb 9, 2001Hematopoietic Studies in the Zebra Fish Model
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MacArthur, CraigJan 30, 1998FGF-8 in Development and Tumorigenesis
Mackman, NigelApr 1, 2022
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Majerus, ElaineOct 22, 2004Regulation of VWF Cleaving Protease (ADAMTS13) Activity
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May 18, 2007Studies on ADAMTS13
Apr 17, 2009Studies on ADAMTS13 and Protein O-Fucosyltransferase 2
Apr 8, 2011Studies With an Enhancer of VWF Cleavage – a Novel Potential Anti-Thrombotic?
Majerus, PhilSep 20, 1996Role of Inositol Phosphates in Intracellular Signalling
May 21, 1999Phosphatidyl Inositols in Cell Signaling
Apr 6, 2001Intracellular Signaling by Inositol Phosphates
Sep 13, 2002Inositol Signaling
Dec 10, 2004Inositol Phosphate Signaling
Mar 23, 2007Phosphatidylinositol Signaling and Human Disease
Jan 9, 2009Inositols Do It All
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Jan 30, 2015Interactions Between Dnmt3a and Repressive Chromatin Regulate Hematopoietic Stem Cell Function and Transformation
Mann, KenDec 16, 1994Modeling the Tissue Factor Pathway to Thrombosis: the Coagulation Explosion
Marjanovic, JasnaApr 13, 2007Phosphatidylinositol-5-phosphate is a Novel Phospholipase C (PLC) Substrate
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Mar 6, 2003Bone Marrow Failure Caused by Inherited Telomerase Deficiency
Mar 25, 2005Bone Marrow Failure Caused by Inherited Defects in Telomerase
Apr 20, 2007Telomeres, Ribosomes and Bone Marrow Failure
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Apr 27, 2021The TFPI Anticoagulant Activity Modulates Cerebrovascular Development
Mathias, BrendanMar 17, 2022MYSM1 in DNA Damage Signaling During B Cell Development
Ma, XiucuaMar 2, 2007Mechanism of Up-regulation of MMP-12 and Cathepsin S in the Aorta of Mucopolysaccharidosis I Mice
May 9, 2008A Self-inactivating Retroviral Vector with Improved Safety for Gene Therapy in Mucopolysaccharidosis I Mice
McCaffrey, AntonApr 7, 2006Keep It Down: There’s More Than One Way to Silence a Gene
McCormick, FrankMay 12, 2016Stanley J. Korsmeyer Memorial Lecture: New Ways of Targeting Ras
McDonald, SharonMay 8, 2009Investigating the Interaction of Dyskerin and Pot1b
McLemore, MorganMar 9, 2001The Effect of Granulocyte Colony-Stimulating Factor Receptor (G-CSFR) Mutations on Granulopoiesis
McLeod, HowardMar 8, 2002Cancer Pharmacogenomics
Mecham, BobOct 27, 1995Intracellular Forms of Extracellular Proteins: Novel Pathway for Cell Regulation
Sep 12, 2003Developmental Adaptation of the Mouse Cardiovascular System to Elastin Haploinsufficiency
Nov 4, 2011Regulation of Growth Factor Activity by Extracellular Matrix
Metcalf, JasonSep 15, 2006The Role of Fibroblast Growth Factor Signaling in Mucopolysaccharidosis Bone Defects
May 9, 2008Pathogenesis of Short Bones in Mucopolysaccharidosis VII
May 15, 2009A New and Safer Gene Therapy Vector for Mucopolysaccharidosis I
Michel, LorenMar 7, 2008Oncogenic Role and Therapeutic Targeting of the Transmembrane Protein Trop-2 in Epithelial Tumors
Mikulka, ChristinaApr 26, 2018Cell-Autonomous Expression of the Lysosomal Enzyme GALC in the Twitcher Mouse
Mar 28, 2019Cell-Autonomous Expression of the Lysosomal Hydrolase GALC: A New Model of Krabbe Disease
Milbrandt, JeffNov 21, 2003Ret Signaling in Development and Disease
Millman, JeffreyOct 29, 2015Generation of Functional Human Pancreatic β Cells from Pluripotent Stem Cells In Vitro
Mills, JasonOct 8, 2015Stem Cells, Reprogramming, and the Origins of Cancer
Min, SangMar 9, 2015Role of Phosphoinositides in Platelet-Mediated Inflammation and Thrombosis
Monlish, DarleneOct 25, 2018Differential Effects of TLR1/2 and TLR2/6 Signaling on Normal and Premalignant Hematopoietic Stem and Progenitor Cells
Morceau-Gaudry, FrancoisNov 22, 2002Gene Therapy of a Mouse Model of Protoporphyria With an Erythroid-Specific Lentiviral Vector
Morrissey, JamesMar 23, 2012Platelet Polyphosphate at the Nexus of Blood Clotting and Inflammation
Mosammaparast, NimaFeb 4, 2016Ubiquitin Dependent Regulatory Mechanisms in the Alkylation Damage Response
Muglia, LouDec 2, 2005Glucocorticoid Receptor Action During Inflammation
Muia, JoshuaFeb 17, 2012An Optimized Fluorogenic Assay for ADAMTS13 and Inhibitors in Thrombotic Thrombocytopenic Purpura Patients
Jan 11, 2013pH Dependent Activity of ADAMTS13 and Self-regulatory Mechanisms
Mar 28, 2014ADAMTS13 is Conformationally Autoinhibited by its Distal Domains and is Allosterically Activated by Von Willebrand Factor
Jan 30, 2015Insights Into ADAMTS13 Diversity Across Multiple Animal Species
Oct 15, 2015In Search of the Minimalist ADAMTS13 Using Evolutionary Variations in its Allosteric Properties
Oct 20, 2016Evolution and Allosteric Regulation of ADAMTS13
Nov 30, 2017Two Metalloproteases Involved in Cardiovascular Disease
Oct 11, 2018Insights Into the Structure and Regulation of a Metalloprotease Involved in Cardiovascular Disease
Mullally, AnnFeb 9, 2012Characterizing and Therapeutically Targeting MPN Stem Cells in Vivo
Mullaney, CatesJan 7, 2016The Role of Kdm6b in Hematopoiesis
Munroe, MichaelSep 10, 2020Telomere Dysfunction Inpairs Hepatocyte Development and Function Via Repression of HNF4A
Murphy, KenMar 6, 2015Dendritic Cell Diversification
Muslin, TonyOct 31, 1997The Role of 14-3-3 Protein in Ras-Mediated Signal Transduction
Oct 24, 2003Signaling Protein Function in Cardiovascular Disease
Mysorekar, IndiraApr 20, 2017Understanding Pathogenesis of Maternal Fetal Transmission of the Emerging Zika Virus
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Nandakumar, SatishFeb 23, 2021How Can We Learn About Healthy and Diseased Hematopoiesis From Human Genetic Studies?
Ndonwi, MatthewApr 15, 2005Work-in-Progress
Jan 20, 2006Work-in-Progress
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Jan 16, 2009Malarial Histidine Rich Protein II (HRPII) and Blood Coagulation
Oct 16, 2009Effect of Malarial Histidine-rich Protein II (HRPII) on Blood Coagulation
Oct 15, 2010Interaction of TFPI with Factor V
Oct 14, 2011Studies on Lipoprotein-free and Lipoprotein-associated Plasma Tissue Factor Pathway Inhibitor
Nesheim, MikeApr 19, 1996Isolation, Characterization, and Thrombin-thrombomodulin Dependent Activation of TAFI
Neufeld, ElizabethOct 31, 20081st Rosalind Kornfeld Lecture: Four Decades of Research on MPS
Niero, EvandroMar 2, 2017Teleomere Shortening Impairs Hepatocyte Differentiation by DNA Damage Signaling Activation
Nolta, JanJan 30, 2004Immune Deficient Mouse Models for Studying Human Hematopoietic Stem Cell Biology
Norris, AndyApr 10, 1998The Regulation of PI 3-Kinase Signaling by Inositol Polyphosphate 4-Phosphatases
Novack, DebJan 10, 2014NIK’ing the Bone: Mechanisms for Control of the Osteoclast
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O’Leary, DavidApr 28, 2022Loss of SMC5/6 Sensitizes Leukemia Cells to APOBEC3A Cytosine Deaminase Activity
O’Shea, ErinSep 10, 20103rd Rosalind Kornfeld Lecture: Translating DNA Sequence Into Gene Expression Output
Odom, AudreyOct 23, 2009Essential Isoprenoids in Plasmodium Falciparum Malaria
Oh, SteveMay 20, 2011The Missing LNK: Mechanisms of Dysregulated Signaling in Myeloproliferative Neoplasms
May 18, 2012JAK2 and Beyond: Genomics and Signaling in Myeloproliferative Neoplasms
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Orkin, StuartNov 11, 199422nd Carl Moore Lecture: Multi-layered Regulation of Hematopoietic Development and Transcription
Orlowski, RachelMar 27, 2009Studies with Protein O-fucosyltransferase 2
Ornitz, DaveOct 7, 1994Regulation of FGF/FGF Receptor Activity
Apr 19, 2002FGF and FGF Receptor Signaling in Skeletal Development and Genetic Disease
Ory, DanNov 20, 2009The Niemann-Pick C Pathway: a Key Regulator of Cholesterol Homeostasis
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Parks, BillJan 16, 2004Extracellular Proteolysis in Epithelial Repair and Defense
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Permutt, AlanFeb 28, 1997Genetic Analysis of Monogenic and Polygenic Disorders of Glucose Metabolism
Pham, ChristineDec 16, 2005Neutrophil Serine Proteases: Specific Regulatory Effectors of Immunity
Pike, LindaMay 2, 2003EGF Receptors and Lipid Rafts: Bringing Order to Chaos
Jan 15, 2010Bi-Directional Signaling in the EGF Receptor
Piwnica-Worms, DavidMay 5, 2000Molecular Imaging: Functional Identification of MDR1 Pgp Transport Activity in Tumors and Tissues in Vivo
Piwnica-Worms, HelenMay 2, 1997Reversible Phosphorylation and Cell Cycle Control
Sep 26, 2003Cell Cycle- and Checkpoint-Control: the CHK1/CDC25A Regulatory Pathway
Feb 11, 2011Translation of Fundamental Cell Cycle Principles to Targeted Cancer Therapies
Ponder, KathyDec 13, 1996Gene Therapy for Plasma Protein Deficiencies
Mar 12, 1999Hepatic Gene Therapy for Plasma Protein Deficiencies and Lysosomal Storage Diseases
Feb 2, 2001Degradation of Hepatocyte Nuclear Factor 4 Contributes to Liver Failure
May 9, 2003Liver-Directed Gene Therapy Corrects Hemophilia B and Mucopolysaccharidosis VII in Dogs
Jan 28, 2005Reducing Immune Responses After Gene Therapy for Genetic Diseases
Nov 17, 2006Gene Therapy for Mucopolysaccharidosis
Jan 23, 2009The Pathogenesis of Disease in Mucopolysaccharidosis
Apr 22, 2011The Pathogenesis of Mucopolysaccharidosis May Involve Complement Activation
Apr 12, 2013The Effect of Gene Therapy for Mucopolysaccharidosis After a Decade
May 22, 2015Central Nervous System-Directed Gene Therapy for Mucopolysaccharidosis VII
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Prusiner, StanleyNov 5, 199321st Carl Moore Lecture: Transgenetic and Protein Structural Approaches to Unraveling the Enigmas of Prion Diseases
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Apr 14, 2006Work-in-Progress
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Feb 13, 2009pH Dependence of VWF Multimerization and Storage
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Qian, MonicaJan 22, 2010Functions of the α, β and γ Subunits of UDP-GlcNAc:Lysosomal Enzyme N-Acetylglucosamine-1-Phosphotransferase
Dec 17, 2010UDP-GlcNAc:Lysosomal Enzyme N-Acetylglucosamine-1-Phosphotransferase
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Ramsingh, GiriMay 15, 2009Characterizing MicroRNAs in Acute Myeloid Leukemia
Randi, AnnaApr 26, 2013Von Willebrand Factor Regulates Angiogenesis and Endothelial Progenitors’ Function
Ratner, LeeJan 28, 2000Human T-Cell Leukemia Virus Tax, Transactivation, and Transformation
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Ricketts, LindsayJan 12, 2007O-fucosylation of ADAMTS13
Riehl, TerryNov 12, 2010COX-1+/-COX-2-/- Genotype in Mice is Associated with Shortened Time to Carotid Artery Occlusion Through Increased PAI-1
Robledo, SaraApr 13, 2007The Role of Ribosomal Proteins in the Pathogenesis of Diamond Blackfan Anemia
Mar 14, 2008The Role of Human Ribosomal Proteins in the Maturation of rRNA and Ribosome Production
Rohrer, JackDec 15, 1995Sorting of Proteins in the Endosomal/Lysosomal System
Rondina, MatthewJan 31, 2020Platelet Transcriptomics as Discovery Tools in Human Health and Disease
Mar 9, 2022MHC-I Antigen Presentation by Platelets Suppresses CD8+ T Cells During Sepsis
Rosenfeld, MichaelDec 8, 199523rd Carl Moore Lecture: Transcriptional Mechanisms of Organ Commitment
Rowley, JanetOct 10, 200331st Carl Moore Lecture: New Paradigms From Leukemias
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Feb 25, 2021Novel Mutations Contributing to Follicular Lymphoma
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Apr 27, 2023Clinicogenomics of Follicular Lymphoma
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Sabatini, DavidNov 21, 201442nd Carl Moore Lecture: Regulation of Growth by the mTOR Pathway
Sadler, EvanFeb 21, 1997Thrombin Structure and Biological Function
Jan 22, 1999Enteropeptidase, Initiator of a Digestive Protease Cascade
Jan 12, 2001Structure and Function of Von Willebrand Factor
Sep 27, 2002Von Willebrand Factor, ADAMTS13, and Thrombotic Thrombocytopenic Purpura
Feb 11, 2005Von Willebrand Factor, Bleeding, and Thrombosis
Feb 16, 2007Von Willebrand Factor, ADAMTS13, and the Regulation of Platelet Adhesion
Feb 6, 2009Assembly and Destruction of Von Willebrand Factor
Jan 13, 2012Von Willebrand Factor, ADAMTS13, and Thrombotic Microangiopathy
Jan 18, 2013Assembly and Destruction of Von Willebrand Factor
Jan 9, 2015Von Willebrand Factor, ADAMTS13 and Thrombotic Microangiopathy
Saffitz, JeffFeb 27, 2004Mechanisms of Sudden Death in Cardiomyopathies Caused by Mutations in Cell-Cell Junction Proteins
Salvesen, GuySep 24, 1993Inhibition of IL-1β Activation by a Virally Encoded Proteinase Inhibitor
Sands, MarkOct 29, 1993Molecular Characterization of the Genetic Defect and Modes of Treatment in Murine Mucopolysaccharidosis Type 7
Nov 5, 1999Gene Therapy for Lysosomal Storage Diseases
Apr 4, 2003Hematopoietic-Directed Therapies for Lysosomal Storage Diseases
Mar 12, 2010Lysosomal Dysfunction Results in Altered Energy Balance
Sanfilippo, KristenFeb 8, 2013Thrombosis in Myeloma
Feb 14, 2014Zoledronic Acid Versus Pamidronate in Patients with Multiple Myeloma: a Comparative Effectiveness Research Project
Apr 21, 2016Statin Therapy Increases Survival in Myeloma
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Feb 11, 2000Collagen Receptors: From Ligand Binding to Control of Cell Phenotype
Sarma, NayanFeb 27, 2009Molecular Interactions of the Oncogene Nup98-HoxA9
Saunders, ScottOct 7, 2005Heparan Sulfate Proteoglycans: Essential Modulators of Cellular Functions at the Plasma Membrane
Savage, SharonNov 12, 2020The Growing Clinical and Genetic Spectrum of Telomere Biology Disorders
Schaffer, JeanMay 3, 2002Models and Mechanisms of Lipotoxicity
Schmid, SandraOct 24, 20147th Rosalind Kornfeld Lecture: Dynamin: The Master Regulator of Clathrin-Mediated Endocytosis
Schreiber, RobertMay 15, 2014Stanley J. Korsmeyer Memorial Lecture: Cancer Immunoediting: Applying Mechanistic Insights to Cancer Immunotherapy
Schroeder, MarkApr 10, 2009Graft Versus Host Disease: a Novel Mouse Model and Therapy
Feb 4, 2011Exploring Cytokines to Treat Graft-vs-Host Disease
Mar 2, 2012Mobilization of Allogeniec Sibling Peripheral Blood Stem Cell Donors with GM-CSF and Plerixafor – an Interim Analysis
Searleman, AdamApr 1, 2011Determination of In Vivo Signaling Networks Governing Ductal Carcinoma In Situ Progression
Mar 16, 2012Characterization of a Mouse Model of Ductal Carcinoma In Situ of the Breast
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Feb 24, 2012Lipogenesis: Much More Than Making Fat
Semenza, GreggOct 13, 2022Regulation of Erythropoiesis by Hypoxia-Inducible Factors
Oct 13, 202248th Annual Carl Moore Lecture: Regulation of Erythropoiesis by Hypoxia-Inducible Factors
Sfeir, AgnelFeb 22, 2018Protecting Our Genomes: Whenever, Wherever
Shafer, JulesNov 2, 1993Identification of Amino Acid Residues Important for the Heparin-Catalyzed Inactivation of Thrombin by Antithrombin III
Shah, DhvanitFeb 14, 2013Genetic Screen to Identify Genes Regulating Hematopoiesis
Shaw, AndreyFeb 8, 2002Immunological Synapses and T Cell Signaling
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Shen, BoMar 2, 2021Novel Regulators of Bone Marrow Stem Cells: Growth and Mechanical Force
Sherr, ChuckNov 12, 200432nd Carl Moore Lecture: INK4a-ARF: A Marriage of Tumor Suppressors
Shim, KyuhwanApr 1, 2005Work-in-Progress
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Oct 12, 2007Platelet-von Willebrand Factor Complexes Are Preferred Substrates of ADAMTS13 Under Fluid Shear Stress
Shivdasani, RameshSep 15, 1995Transcriptional Control of Cell Fate Determination and Differentiation in Hematopoiesis: Lessons From Knockout Mice
Shulman, GeraldNov 6, 200937th Carl Moore Lecture: Cellular Mechanisms of Insulin Resistance: Implications for Obesity, Lipodystrophy, Metabolic Syndrome and Type 2 Diabetes
Signer, RobertMay 18, 2023Stem Cell Fitness and Longevity: The Role of Proteostasis
Silberstein, LevApr 10, 2023Keeping Stem Cells Dormnant
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Sly, BillJun 5, 1998Mutations in HFE Protein Cause Hemochromatosis
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Stamatoyannopoulos, JohnOct 14, 201644th Carl Moore Lecture: Decoding the Human Regulatory Genome
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Steet, RichNov 19, 2004COG7 Deficiency: a Novel Congenital Disorder of Glycosylation
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Steitz, JoanOct 30, 20092nd Rosalind Kornfeld Lecture: Regulating the Activity of MicroRNAs in Vertebrate Cells
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Stewart, SheilaMar 24, 2006The Yin and Yang of Cellular Senescence
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Storch, GregMar 7, 2014Virologic, Genomic, and Transcriptomic Analysis of Fever Without a Source in Young Children
Sturgeon, ChrisApr 11, 2013Modeling Developmental Hematopoiesis Using Pluripotent Stem Cells
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Sullivan, RyanSep 30, 2011MicroRNA Deficient Natural Killer Cells Exhibit Decreased Survival but Enhanced Cytokine Production and Degranulation Capacity
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Sep 20, 2013MiR-15/16 Antagonizes Myb to Control Natural Killer Cell Differentiation and Maturation
Sykes, DavidFeb 6, 2017“Curing by Maturing” – Developing Differentiation Therapy for the Treatment of Patients with Acute Myeloid Leukemia
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Tamai, MinoriApr 25, 2019Modeling Infant Leukemia With Human Pluripotent Stem Cells
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Taylor, JamesJan 15, 2016Epidemiologic and Mechanistic Insights into Risk Factors for Death in Adults with Sickle Cell Anemia
Teitelbaum, SteveSep 14, 2001RANK Ligand and Bone Cells
Thomas, MattJan 23, 1998The Regulation of Adhesion and Signal Transduction by Protein Tyrosine Phosphatases
Thompson, CraigOct 20, 200634th Carl Moore Lecture: Programmed Cell Death: Apoptosis, Autophagy, and Necrosis
Tittiger, MindyMay 11, 2007Parallels in Mucopolysaccharidosis (MPS) I and MPS 7 Aortic Disease
Tollefsen, DougJan 24, 1997The Two Faces of Thrombin: Interactions of Exosites I and II With Inhibitors
Feb 12, 1999Allosteric Regulation of Thrombin by a Monoclonal Antibody That Binds to Exosite II
Feb 9, 2001Function of Heparin Cofactor II in Vitro and in Vivo
Apr 18, 2003Heparin Cofactor II and Thrombosis
Feb 25, 2005Activation of Heparin Cofactor II by Vascular Glycosaminoglycans
Jan 5, 2007Heparin Cofactor II Modulates the Response to Arterial Injury
Mar 20, 2009TAP-Annexin V: a Novel Antithrombotic Agent
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Trissal, MariaMay 13, 2011Role of Small Non-coding RNAs in Normal and Malignant Hematopoiesis
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May 6, 2005Selectins and Cancer: Mechanistic Connections and Therapeutic Implications
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Weber, JasonNov 4, 2005Interpretation of Oncogenic Signals by the Nucleolus
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Oct 19, 2007CXCR4 Regulation of Osteoclast Development and Tumor Osteolysis
Feb 26, 2010Hedgehog Signaling in Osteoclasts and Bone Metastasis
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Nov 2, 20125th Rosalind Kornfeld Lecture: Beyond the Pore: From Nuclear MRNA Export to Translation
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Sep 24, 2010A Mouse Model Linking Aberrant Inositol Metabolism to Defects in Neural Development
Sep 21, 2012ITPK1: an Inositol Kinase Linked to Neural Tube Defects
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Yoo, AndrewJan 24, 2014Control of Neuronal Subtype Specificity During MicroRNA-Mediated Neuronal Reprogramming
York, JohnJan 26, 2001Insights Into the Biology of Inositol Signaling
Oct 6, 2006Signaling Specificity: Inositol Polyphosphate Messengers Regulate Drosophila Development
Sep 14, 2011Interdisciplinary Seminar Series: Inositol Phosphate Communication: Insights Into the Cell’s ‘iPhone’
Sep 19, 2014Phil Majerus Symposium: Insights into Inositol Phosphate Cellular Signaling Pathways
Young, AndrewFeb 3, 2022Spacial Characterization of Clonal Mutations in the Bone Marrow
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Young, MargaretFeb 18, 2011Whole Genome Sequencing of Murine Induced Pluripotent Stem Cells
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Yu, JeffMay 11, 2007Investigation of the Biological Function of the C-terminal Domains in ADAMTS13
Yu, ZheyongFeb 1, 2008Modulation of ADAMTS13 Activity by Free Amino Acids
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Zaher, HaniNov 3, 2016Insights Into the Role of the Ribosome During mRNA and Nascent-Protein Quality Control
Zaretsky, JesseFeb 23, 2023Single-Cell Analysis of Neoadjuvant Immunotherapy in Head and Neck Cancer
Zhang, ChunfenMar 27, 2009Identification of Lysine Acetylation Sites on Inositol 1,3,4-Trisphosphate 5/6-Kinase
Apr 23, 2010Lysine Acetylation of Inositol 1,3,4-Trisphosphate 5/6-kinase
Apr 29, 2011Lysine Acetylation of Inositol 1,3,4-Trisphosphate 5/6-kinase
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Zhang, LijuanSep 23, 2005Heparan and Chondroitin Sulfate Glycosaminoglycans: a Journey From Structure to Function
Zhang, LingboMar 16, 2021Understanding and Targeting Hematopoietic Stem and Progenitor Cells
Zhan, HuichunAug 3, 2017The Hematopoietic Niche in Myeloproliferative Neoplasms
Zho, JunJan 19, 2007The Role of Type I PIP2 4-phosphatase in Stress Signaling
Zhu, JianMar 18, 2011Structural and Functional Study of ADAMTS13
Mar 30, 2012Small-angle X-ray Scattering Studies of ADAMTS13 Demonstrate a Conformational Response to Substrate Binding in Solution
Mar 22, 2013Regulation of ADAMTS13 Activity
May 9, 2014Structural Studies of ADAMTS13 Using Small-angle X-ray Scattering
May 8, 2015A Folded ADAMTS13 Conformation Identified by SAXS Can Account for Allosteric Regulation by Distal TSP and CUB Domains
Mar 10, 2016Study of Allosteric Regulation of ADAMTS13 by Small-Angle X-Ray Scattering
Feb 2, 2017The Hunt for the “Minimal” Structure of a Functional ADAMTS13 by Small-Angle X-Ray Scattering
Jan 11, 2018Structural and Functional Studies of ADAMTS13: AUC, HDX, and EM
Zimmerman, MeganDec 13, 2018MDM2 Inhibition in T-Cell Acute Lymphoblastic Leukemia
Zou, JunNov 9, 2007Type I Phosphatidylinositol-4,5-bisphosphate 4-phosphatase Regulates Stress-induced Apoptosis
Jan 16, 2009MTMR9 Increases MTMR6 Enzyme Activity, Stability, and Has a Role in Apoptosis
Apr 23, 2010Characterization of Myotubularin Related Protein 8
Zutter, MaryFeb 14, 2003The α2β1-Integrin Deficient Mouse: Defective Platelet and Mast Cell Function