Luis Batista.jpg

Luis F. Z. Batista, PhD

Assistant Professor
Department of Medicine
Hematology Division
Department of Developmental Biology

Research Interests

  • Induced pluripotent stem cells
  • Telomere maintenance


  • 314-362-8816 (office)
  • 314-362-8826 (fax)
  • Room 8816 Clinical Sciences Research Building (lab)
  • Hematology Division
    Campus Box 8125
    Washington University School of Medicine
    660 South Euclid Avenue
    St. Louis, MO 63110
  • Batista Lab


  • Acute Graft-Versus-Host Disease Following Lung Transplantation in a Patient With a Novel TERT Mutation
    Brestoff JR, Vessoni AT, Brenner KA, Uy GL, DiPersio JF, Blinder M, Witt CA, Byers DE, Hachem RR, Truclock EP, Early DS, Anadkat MJ, Musiek A, Javidan-Nejad C, Balfe DM, Rosman IS, Liu C, Zhang L, Despotis GJ, Ruzinova MB, Sehn JK, Amarillo I, Heusel JW, Swat W, Kim BS, Wartman LD, Yusen RD, Batista LFZ
    Thorax 2018 Jan 30; [Epub ahead of print]
  • P53 Mediates Failure of Human Definitive Hematopoiesis in Dyskeratosis Congenita
    Fok WC, Niero ELO, Dege C, Brenner KA, Sturgeon CM, Batista LFZ
    Stem Cell Reports 2017 Aug 8;9(2):409-418
  • Stressed Ends: Telomere Attrition in Chronic Diseases
    Fok WC, Batista LFZ
    Rev Bras Hematol Hemoter 2017 Apr-Jun;39(2):98-99
  • Maintenance of Age in Human Neurons Generated by MicroRNA-Based Neuronal Conversion of Fibroblasts
    Huh CJ, Zhang B, Victor MB, Dahiya S, Batista LF, Horvath S, Yoo AS
    Elife 2016 Sep 20;5
  • Inhibition of Pluripotency Networks by the Rb Tumor Suppressor Restricts Reprogramming and Tumorigenesis
    Kareta MS, Gorges LL, Hafeez S, Benayoun BA, Marro S, Zmoos AF, Cecchini MJ, Spacek D, Batista LF, O'Brien M, Ng YH, Ang CE, Vaka D, Artandi SE, Dick FA, Brunet A, Sage J, Wernig M
    Cell Stem Cell 2015 Jan 8;16(1):39-50
  • Telomere Biology in Stem Cells and Reprogramming
    Batista LF
    Prog Mol Biol Transl Sci 2014;125:67-88
  • Understanding Telomere Diseases Through Analysis of Patient-Derived IPS Cells
    Batista LF, Artandi SE
    Curr Opin Genet Dev 2013 Oct;23(5):526-33
  • TPP1 OB-Fold Domain Controls Telomere Maintenance by Recruiting Telomerase to Chromosome Ends
    Zhong FL, Batista LF, Freund A, Pech MF, Venteicher AS, Artandi SE
    Cell 2012 Aug 3;150(3):481-94
  • Telomere Shortening and Loss of Self-Renewal in Dyskeratosis Congenita Induced Pluripotent Stem Cells
    Batista LF, Pech MF, Zhong FL, Nguyen HN, Xie KT, Zaug AJ, Crary SM, Choi J, Sebastiano V, Cherry A, Giri N, Wernig M, Alter BP, Cech TR, Savage SA, Reijo Pera RA, Artandi SE
    Nature 2011 May 22;474(7351):399-402
  • In Situ Genetic Correction of the Sickle Cell Anemia Mutation in Human Induced Pluripotent Stem Cells Using Engineered Zinc Finger Nucleases
    Sebastiano V, Maeder ML, Angstman JF, Haddad B, Khayter C, Yeo DT, Goodwin MJ, Hawkins JS, Ramirez CL, Batista LF, Artandi SE, Wernig M, Joung JK
    Stem Cells 2011 Nov;29(11):1717-26
  • Effect of the Anti-Neoplastic Drug Doxorubicin on XPD-Mutated DNA Repair-Deficient Human Cells
    Saffi J, Agnoletto MH, Guecheva TN, Batista LF, Carvalho H, Henriques JA, Stary A, Menck CF, Sarasin A
    DNA Repair (Amst) 2010 Jan 2;9(1):40-7
  • The Role Played by Endogenous and Exogenous Electric Fields in DNA Signaling and Repair
    Arruda-Neto JD, Friedberg EC, Bittencourt-Oliveira MC, Segreto HR, Moron MM, Maria DA, Batista LF, Schenberg AC
    DNA Repair (Amst) 2010 Apr 4;9(4):356-7
  • Telomere Uncapping, Chromosomes, and Carcinomas
    Batista LF, Artandi SE
    Cancer Cell 2009 Jun 2;15(6):455-7
  • How DNA Lesions Are Turned Into Powerful Killing Structures: Insights From UV-Induced Apoptosis
    Batista LF, Kaina B, Meneghini R, Menck CF
    Mutat Res 2009 Mar-Jun;681(2-3):197-208
  • P53 Mutant Human Glioma Cells Are Sensitive to UV-C-Induced Apoptosis Due to Impaired Cyclobutane Pyrimidine Dimer Removal
    Batista LF, Roos WP, Kaina B, Menck CF
    Mol Cancer Res 2009 Feb;7(2):237-46
  • Differential Sensitivity of Malignant Glioma Cells to Methylating and Chloroethylating Anticancer Drugs: P53 Determines the Switch by Regulating Xpc, Ddb2, and DNA Double-Strand Breaks
    Batista LF, Roos WP, Christmann M, Menck CF, Kaina B
    Cancer Res 2007 Dec 15;67(24):11886-95
  • Apoptosis in Malignant Glioma Cells Triggered by the Temozolomide-Induced DNA Lesion O6-Methylguanine
    Roos WP, Batista LF, Naumann SC, Wick W, Weller M, Menck CF, Kaina B
    Oncogene 2007 Jan 11;26(2):186-97
  • Involvement of DNA Replication in Ultraviolet-Induced Apoptosis of Mammalian Cells
    Batista LF, Chigancas V, Brumatti G, Amarante-Mendes GP, Menck CF
    Apoptosis 2006 Jul;11(7):1139-48
  • Photorepair of RNA Polymerase Arrest and Apoptosis After Ultraviolet Irradiation in Normal and XPB Deficient Rodent Cells
    Chigancas V, Batista LF, Brumatti G, Amarante-Mendes GP, Yasui A, Menck CF
    Cell Death Differ 2002 Oct;9(10):1099-107