Faculty
Oncology Division
Alphabetical list (active faculty):   
Jian Li Campian

Jian Li Campian, MD, PhD

Associate Professor

Department of Medicine

Oncology Division

Medical Oncology

Department of Neurological Surgery

Clinical Interests

  • Brain tumors

Research Interests

  • Neuro-oncology:
  • - Immunotherapy
  • - Target therapy
  • - Early phase clinic trial development

Contact

  • 314-362-5817 (office)
  • 314-362-7086 (fax)
  • Division of Oncology
    Campus Box 8056
    Washington University
    660 South Euclid Avenue
    St. Louis, MO 63110
  • 11th Floor Mid-Campus Center (office)

Original Articles

  • Validation of Diffusion MRI as a Biomarker for Efficacy Using Randomized Phase III Trial of Bevacizumab With or Without VB-111 in Recurrent Glioblastoma
    Ellingson BM, Patel K, Wang C, Raymond C, Brenner A, de Groot JF, Butowski NA, Zach L, Campian JL, Schlossman J, Rizvi S, Cohen YC, Lowenton-Spier N, Minei TR, Shmueli SF, Wen PY, Cloughesy TF
    Neurooncol Adv 2021 Jun 19;3(1):vdab082
  • Salvage Therapies for Radiation-Relapsed Isocitrate Dehydrogenase-Mutant Astrocytoma and 1p/19q Codeleted Oligodendroglioma
    Ma S, Rudra S, Campian JL, Chheda MG, Johanns TM, Ansstas G, Abraham CD, Chicoine MR, Leuthardt EC, Dowling JL, Dunn GP, Kim AH, Huang J
    Neurooncol Adv 2021 Jun 18;3(1):vdab081
  • Association of Convalescent Plasma Therapy With Survival in Patients With Hematologic Cancers and COVID-19
    Thompson MA, Henderson JP, Shah PK, Rubinstein SM, Joyner MJ, Choueiri TK, Flora DB, Griffiths EA, Gulati AP, Hwang C, Koshkin VS, Papadopoulos EB, Robilotti EV, Su CT, Wulff-Burchfield EM, Xie Z, Yu PP, Mishra S, Senefeld JW, Shah DP, Warner JL
    COVID-19 and Cancer Consortium (Contributors include: Campian JL)

    JAMA Oncol 2021 Jun 17; [Epub ahead of print]
  • Re-Evaluating Biopsy for Recurrent Glioblastoma: A Position Statement by the Christopher Davidson Forum Investigators
    Nduom EK, Gephart MH, Chheda MG, Suva ML, Amankulor N, Battiste JD, Campian JL, Dacey RG, Das S, Fecci PE, Hadjipanayis CG, Hoang KB, Jalali A, Orringer D, Patel AJ, Placantonakis D, Rodriguez A, Yang I, Yu JS, Zipfel GJ, Dunn GP, Leuthardt EC, Kim AH
    Neurosurgery 2021 Jun 15;89(1):129-132
  • Evaluation of Interim MRI Changes During Limited-Field Radiation Therapy for Glioblastoma and Implications for Treatment Planning
    Hassanzadeh C, Rudra S, Ma S, Brenneman R, Huang Y, Henke L, Abraham C, Campian J, Tsien C, Huang J
    Radiother Oncol 2021 May;158:237-243
  • Temozolomide Chronotherapy in Patients With Glioblastoma: A Retrospective Single-Institute Study
    Damato AR, Luo J, Katumba RGN, Talcott GR, Rubin JB, Herzog ED, Campian JL
    Neurooncol Adv 2021 Mar 2;3(1):vdab041
  • The Predictive Value of Absolute Lymphocyte Counts on Tumor Progression and Pseudoprogression in Patients With Glioblastoma
    Xi J, Hassan B, Katumba RGN, Khaddour K, Govindan A, Luo J, Huang J, Campian JL
    BMC Cancer 2021 Mar 16;21(1):285
  • Defining Phenotypic and Functional Heterogeneity of Glioblastoma Stem Cells by Mass Cytometry
    Galdieri L, Jash A, Malkova O, Mao DD, DeSouza P, Chu YE, Salter A, Campian JL, Naegle KM, Brennan CW, Wakimoto H, Oh ST, Kim AH, Chheda MG
    JCI Insight 2021 Feb 22;6(4)
  • A Systematic Framework to Rapidly Obtain Data on Patients With Cancer and COVID-19: CCC19 Governance, Protocol, and Quality Assurance
    COVID-19 and Cancer Consortium (Contributors include: Campian JL)
    Cancer Cell 2020 Dec 14;38(6):761-766
  • Development of Aplastic Anemia During Treatment of Anaplastic Astrocytoma With Temozolomide
    Khaddour K, Harrison N, Govindan A, Campian JL
    Case Rep Oncol 2020 Oct 13;13(3):1244-1251
  • Prognostic Impact of CDKN2A/B Deletion, TERT Mutation, and EGFR Amplification on Histological and Molecular IDH-Wildtype Glioblastoma
    Ma S, Rudra S, Campian JL, Dahiya S, Dunn GP, Johanns T, Goldstein M, Kim AH, Huang J
    Neurooncol Adv 2020 Sep 18;2(1):vdaa126
  • Central Nervous System Cancers, Version 3.2020, NCCN Clinical Practice Guidelines in Oncology
    Nabors LB, Portnow J, Ahluwalia M, Baehring J, Brem H, Brem S, Butowski N, Campian JL, Clark SW, Fabiano AJ, Forsyth P, Hattangadi-Gluth J, Holdhoff M, Horbinski C, Junck L, Kaley T, Kumthekar P, Loeffler JS, Mrugala MM, Nagpal S, Pandey M, Parney I, Peters K, Puduvalli VK, Robins I, Rockhill J, Rusthoven C, Shonka N, Shrieve DC, Swinnen LJ, Weiss S, Wen PY, Willmarth NE, Bergman MA, Darlow SD
    J Natl Compr Canc Netw 2020 Nov 2;18(11):1537-1570
  • Diffusion Histology Imaging Combining Diffusion Basis Spectrum Imaging (DBSI) and Machine Learning Improves Detection and Classification of Glioblastoma Pathology
    Ye Z, Price RL, Liu X, Lin J, Yang Q, Sun P, Wu AT, Wang L, Han RH, Song C, Yang R, Gary SE, Mao DD, Wallendorf M, Campian JL, Li J, Dahiya S, Kim AH, Song SK
    Clin Cancer Res 2020 Oct 15;26(20):5388-5399
  • A Randomized Controlled Phase III Study of VB-111 Combined With Bevacizumab Vs Bevacizumab Monotherapy in Patients With Recurrent Glioblastoma (GLOBE)
    Cloughesy TF, Brenner A, de Groot JF, Butowski NA, Zach L, Campian JL, Ellingson BM, Freedman LS, Cohen YC, Lowenton-Spier N, Rachmilewitz Minei T, Fain Shmueli S, Patrick Y W
    GLOBE Study Investigators

    Neuro Oncol 2020 May 15;22(5):705-717
  • Optimizing Eligibility Criteria and Clinical Trial Conduct to Enhance Clinical Trial Participation for Primary Brain Tumor Patients
    Lee EQ, Weller M, Sul J, Bagley SJ, Sahebjam S, van den Bent M, Ahluwalia M, Campian JL, Galanis E, Gilbert MR, Holdhoff M, Lesser GJ, Lieberman FS, Mehta MP, Penas-Prado M, Schreck KC, Strowd RE, Vogelbaum MA, Walbert T, Chang SM, Nabors LB, Grossman S, Reardon DA, Wen PY
    Neuro Oncol 2020 May 15;22(5):601-612
  • Pituitary Carcinoma: Two Case Reports and Review of Literature
    Xu L, Khaddour K, Chen J, Rich KM, Perrin RJ, Campian JL
    World J Clin Oncol 2020 Feb 24;11(2):91-102
  • Multicenter, Prospective, Phase II and Biomarker Study of High-Dose Bevacizumab as Induction Therapy in Patients With Neurofibromatosis Type 2 and Progressive Vestibular Schwannoma
    Plotkin SR, Duda DG, Muzikansky A, Allen J, Blakeley J, Rosser T, Campian JL, Clapp DW, Fisher MJ, Tonsgard J, Ullrich N, Thomas C, Cutter G, Korf B, Packer R, Karajannis MA
    J Clin Oncol 2019 Dec 10;37(35):3446-3454
  • A Multicenter Phase II Study of Temozolomide Plus Disulfiram and Copper for Recurrent Temozolomide-Resistant Glioblastoma
    Huang J, Chaudhary R, Cohen AL, Fink K, Goldlust S, Boockvar J, Chinnaiyan P, Wan L, Marcus S, Campian JL
    J Neurooncol 2019 May;142(3):537-544
  • Impact of Overall Corticosteroid Exposure During Chemoradiotherapy on Lymphopenia and Survival of Glioblastoma Patients
    Hui CY, Rudra S, Ma S, Campian JL, Huang J
    J Neurooncol 2019 May;143(1):129-136
  • Association of Posttreatment Lymphopenia and Elevated Neutrophil-To-Lymphocyte Ratio With Poor Clinical Outcomes in Patients With Human Papillomavirus-Negative Oropharyngeal Cancers
    Lin AJ, Gang M, Rao YJ, Campian JL, Daly M, Gay H, Oppelt PJ, Jackson RS, Rich J, Paniello R, Zevallos J, Hallahan D, Adkins DR, Thorstad W
    JAMA Otolaryngol Head Neck Surg 2019 May 1;145(5):413-421
  • Detection of Neoantigen-Specific T Cells Following a Personalized Vaccine in a Patient With Glioblastoma
    Johanns TM, Miller CA, Liu CJ, Perrin RJ, Bender D, Kobayashi DK, Campian JL, Chicoine MR, Dacey RG, Huang J, Fritsch EF, Gillanders WE, Artyomov MN, Mardis ER, Schreiber RD, Dunn GP
    Oncoimmunology 2019 Jan 25;8(4):e1561106
  • Neutrophil-To-Lymphocyte Ratio as a Predictor of Survival in Patients With Triple-Negative Breast Cancer
    Patel DA, Xi J, Luo J, Hassan B, Thomas S, Ma CX, Campian JL
    Breast Cancer Res Treat 2019 Apr;174(2):443-452
  • Cardiac Dose Is Associated With Immunosuppression and Poor Survival in Locally Advanced Non-Small Cell Lung Cancer
    Contreras JA, Lin AJ, Weiner A, Speirs C, Samson P, Mullen D, Campian J, Bradley J, Roach M, Robinson C
    Radiother Oncol 2018 Sep;128(3):498-504
  • First Results on Survival From a Large Phase 3 Clinical Trial of an Autologous Dendritic Cell Vaccine in Newly Diagnosed Glioblastoma
    Liau LM, Ashkan K, Tran DD, Campian JL, Trusheim JE, Cobbs CS, Heth JA, Salacz M, Taylor S, D'Andre SD, Iwamoto FM, Dropcho EJ, Moshel YA, Walter KA, Pillainayagam CP, Aiken R, Chaudhary R, Goldlust SA, Bota DA, Duic P, Grewal J, Elinzano H, Toms SA, Lillehei KO, Mikkelsen T, Walbert T, Abram SR, Brenner AJ, Brem S, Ewend MG, Khagi S, Portnow J, Kim LJ, Loudon WG, Thompson RC, Avigan DE, Fink KL, Geoffroy FJ, Lindhorst S, Lutzky J, Sloan AE, Schackert G, Krex D, Meisel HJ, Wu J, Davis RP, Duma C, Etame AB, Mathieu D, Kesari S, Piccioni D, Westphal M, Baskin DS, New PZ, Lacroix M, May SA, Pluard TJ, Tse V, Green RM, Villano JL, Pearlman M, Petrecca K, Schulder M, Taylor LP, Maida AE, Prins RM, Cloughesy TF, Mulholland P, Bosch ML
    J Transl Med 2018 May 29;16(1):142
  • Radiologic Response and Disease Control of Recurrent Intracranial Meningiomas Treated With Reirradiation
    Lin AJ, Hui C, Dahiya S, Lu HC, Kim AH, Campian JL, Tsien C, Zipfel GJ, Rich KM, Chicoine M, Huang J
    Int J Radiat Oncol Biol Phys 2018 Sep 1;102(1):194-203
  • Final Results of a Phase I Dose-Escalation, Dose-Expansion Study of Adding Disulfiram With or Without Copper to Adjuvant Temozolomide for Newly Diagnosed Glioblastoma
    Huang J, Campian JL, Gujar AD, Tsien C, Ansstas G, Tran DD, DeWees TA, Lockhart AC, Kim AH
    J Neurooncol 2018 May;138(1):105-111
  • Effect of Radiation Treatment Volume Reduction on Lymphopenia in Patients Receiving Chemoradiotherapy for Glioblastoma
    Rudra S, Hui C, Rao YJ, Samson P, Lin AJ, Chang X, Tsien C, Fergus S, Mullen D, Yang D, Thotala D, Hallahan D, Campian JL, Huang J
    Int J Radiat Oncol Biol Phys 2018 May 1;101(1):217-225
  • Association of 1p/19q Codeletion and Radiation Necrosis in Adult Cranial Gliomas After Proton or Photon Therapy
    Acharya S, Robinson CG, Michalski JM, Mullen D, DeWees TA, Campian JL, Chundury A, Bottani B, Hallahan DE, Bradley JD, Huang J
    Int J Radiat Oncol Biol Phys 2018 Jun 1;101(2):334-343
  • Post-Operative Radiation Effects on Lymphopenia, Neutrophil to Lymphocyte Ratio, and Clinical Outcomes in Palatine Tonsil Cancers
    Lin AJ, Rao YJ, Chin RI, Campian J, Mullen D, Thotala D, Daly M, Gay H, Oppelt P, Hallahan D, Adkins D, Thorstad W
    Oral Oncol 2018 Nov;86:1-7
  • Severe Treatment-Related Lymphopenia in Patients With Newly Diagnosed Rectal Cancer
    Campian JL, Ye X, Sarai G, Herman J, Grossman SA
    Cancer Invest 2018;36(6):356-361
  • Impact of Concurrent Versus Adjuvant Chemotherapy on the Severity and Duration of Lymphopenia in Glioma Patients Treated With Radiation Therapy
    Lin AJ, Campian JL, Hui C, Rudra S, Rao YJ, Thotala D, Hallahan D, Huang J
    J Neurooncol 2018 Jan;136(2):403-411
  • Biological and Therapeutic Implications of Multisector Sequencing in Newly Diagnosed Glioblastoma
    Mahlokozera T, Vellimana AK, Li T, Mao DD, Zohny ZS, Kim DH, Tran DD, Marcus DS, Fouke SJ, Campian JL, Dunn GP, Miller CA, Kim AH
    Neuro Oncol 2018 Mar 27;20(4):472-483
  • Serial Changes in Lymphocyte Subsets in Patients With Newly Diagnosed High Grade Astrocytomas Treated With Standard Radiation and Temozolomide
    Campian JL, Piotrowski AF, Ye X, Hakim FT, Rose J, Yan XY, Lu Y, Gress R, Grossman SA
    J Neurooncol 2017 Nov;135(2):343-351
  • Rindopepimut With Temozolomide for Patients With Newly Diagnosed, EGFRvIII-Expressing Glioblastoma (ACT IV): A Randomised, Double-Blind, International Phase 3 Trial
    Weller M, Butowski N, Tran DD, Recht LD, Lim M, Hirte H, Ashby L, Mechtler L, Goldlust SA, Iwamoto F, Drappatz J, O'Rourke DM, Wong M, Hamilton MG, Finocchiaro G, Perry J, Wick W, Green J, He Y, Turner CD, Yellin MJ, Keler T, Davis TA, Stupp R, Sampson JH
    ACT IV trial investigators (Contributors include: Campian J)

    Lancet Oncol 2017 Oct;18(10):1373-1385
  • Diagnostic and Therapeutic Strategies for Patients With Malignant Epidural Spinal Cord Compression
    Patel DA, Campian JL
    Curr Treat Options Oncol 2017 Aug 10;18(9):53
  • CNS Tumors in Neurofibromatosis
    Campian J, Gutmann DH
    J Clin Oncol 2017 Jul 20;35(21):2378-2385
  • Impact of Concurrent Chemotherapy With Radiation Therapy for Elderly Patients With Newly Diagnosed Glioblastoma: A Review of the National Cancer Data Base
    Huang J, Samson P, Perkins SM, Ansstas G, Chheda MG, DeWees TA, Tsien CI, Robinson CG, Campian JL
    J Neurooncol 2017 Feb;131(3):593-601
  • Imaging Changes Following Proton Radiation Therapy in Adult Diffuse Gliomas
    Meeks M, Acharya S, Huang J, Robinson CG, Perkins SM, Campian J, Ansstas G, Kim A, Dunn G, Zhao T, Sun B, Rich K, Tsien CI
    Int J Radiat Oncol Biol Phys 2016 Oct 1;96(2S):E106
  • Effect of Single-Agent Concurrent Chemotherapy on Survival in Anaplastic Oligodendroglioma: A Review of the National Cancer Data Base
    Acharya S, Perkins SM, Campian J, Ansstas G, Chheda M, Tsien CI, Robinson CG, Huang J
    Int J Radiat Oncol Biol Phys 2016 Oct 1;96(2S):E76-E77
  • Association Between Treatment-Related Lymphopenia and Overall Survival in Elderly Patients With Newly Diagnosed Glioblastoma
    Mendez JS, Govindan A, Leong J, Gao F, Huang J, Campian JL
    J Neurooncol 2016 Apr;127(2):329-35
  • A Phase I Study to Repurpose Disulfiram in Combination With Temozolomide to Treat Newly Diagnosed Glioblastoma After Chemoradiotherapy
    Huang J, Campian JL, Gujar AD, Tran DD, Lockhart AC, DeWees TA, Tsien CI, Kim AH
    J Neurooncol 2016 Jun;128(2):259-66
  • Hyperthermic Laser Ablation of Recurrent Glioblastoma Leads to Temporary Disruption of the Peritumoral Blood Brain Barrier
    Leuthardt EC, Duan C, Kim MJ, Campian JL, Kim AH, Miller-Thomas MM, Shimony JS, Tran DD
    PLoS One 2016 Feb 24;11(2):e0148613
  • Pre-Radiation Lymphocyte Harvesting and Post-Radiation Reinfusion in Patients With Newly Diagnosed High Grade Gliomas
    Campian JL, Ye X, Gladstone DE, Ambady P, Nirschl TR, Borrello I, Golightly M, King KE, Holdhoff M, Karp J, Drake CG, Grossman SA
    J Neurooncol 2015 Sep;124(2):307-16
  • Survival in Patients With Severe Lymphopenia Following Treatment With Radiation and Chemotherapy for Newly Diagnosed Solid Tumors
    Grossman SA, Ellsworth S, Campian J, Wild AT, Herman JM, Laheru D, Brock M, Balmanoukian A, Ye X
    J Natl Compr Canc Netw 2015 Oct;13(10):1225-31
  • Stem Cell Transfusion Restores Immune Function in Radiation-Induced Lymphopenic C57BL/6 Mice
    Kapoor V, Khudanyan A, de la Puente P, Campian J, Hallahan DE, Azab AK, Thotala D
    Cancer Res 2015 Sep 1;75(17):3442-5
  • Clinical and Dosimetric Predictors of Acute Severe Lymphopenia During Radiation Therapy and Concurrent Temozolomide for High-Grade Glioma
    Huang J, DeWees TA, Badiyan SN, Speirs CK, Mullen DF, Fergus S, Tran DD, Linette G, Campian JL, Chicoine MR, Kim AH, Dunn G, Simpson JR, Robinson CG
    Int J Radiat Oncol Biol Phys 2015 Aug 1;92(5):1000-7
  • The Association Between Chemoradiation-Related Lymphopenia and Clinical Outcomes in Patients With Locally Advanced Pancreatic Adenocarcinoma
    Wild AT, Ye X, Ellsworth SG, Smith JA, Narang AK, Garg T, Campian J, Laheru DA, Zheng L, Wolfgang CL, Tran PT, Grossman SA, Herman JM
    Am J Clin Oncol 2015 Jun;38(3):259-265
  • Infusion of Cryopreserved Autologous Lymphocytes Using a Standard Peripheral I.V. Catheter
    Gladstone DE, Davis-Sproul J, Campian J, Lemas MV, Malatyali S, Borrello I, King K, Grossman SA
    Bone Marrow Transplant 2014 Aug;49(8):1119-20
  • Association Between Severe Treatment-Related Lymphopenia and Progression-Free Survival in Patients With Newly Diagnosed Squamous Cell Head and Neck Cancer
    Campian JL, Sarai G, Ye X, Marur S, Grossman SA
    Head Neck 2014 Dec;36(12):1747-53
  • Treatment-Related Lymphopenia in Patients With Stage III Non-Small-Cell Lung Cancer
    Campian JL, Ye X, Brock M, Grossman SA
    Cancer Invest 2013 Mar;31(3):183-8
  • Mitochondrial Dysfunction May Explain the Cardiomyopathy of Chronic Iron Overload
    Gao X, Qian M, Campian JL, Marshall J, Zhou Z, Roberts AM, Kang YJ, Prabhu SD, Sun XF, Eaton JW
    Free Radic Biol Med 2010 Aug 1;49(3):401-7
  • Management of Chronic Lymphocytic Leukemia: An Update
    Kaufman M, Campian JL, Rai KR
    Community Oncology 2009;6:271-8
  • Mitochondrial DNA Damage in Iron Overload
    Gao X, Campian JL, Qian M, Sun XF, Eaton JW
    J Biol Chem 2009 Feb 20;284(8):4767-75
  • Generation of Oxidants by Hypoxic Human Pulmonary and Coronary Smooth-Muscle Cells
    Mehta JP, Campian JL, Guardiola J, Cabrera JA, Weir EK, Eaton JW
    Chest 2008 Jun;133(6):1410-4
  • Cytochrome C Oxidase Activity and Oxygen Tolerance
    Campian JL, Gao X, Qian M, Eaton JW
    J Biol Chem 2007 Apr 27;282(17):12430-8
  • Cytotoxic and Mutagenic Effects of Tobacco-Borne Free Fatty Acids
    Gao X, Qian M, Campian JL, Clark DR, Burke TJ, Eaton JW, McGregor WG
    Free Radic Biol Med 2006 Jan 1;40(1):165-72
  • Oxygen Tolerance and Coupling of Mitochondrial Electron Transport
    Campian JL, Qian M, Gao X, Eaton JW
    J Biol Chem 2004 Nov 5;279(45):46580-7
  • Mitochondrial Metabolism Underlies Hyperoxic Cell Damage
    Li J, Gao X, Qian M, Eaton JW
    Free Radic Biol Med 2004 Jun 1;36(11):1460-70
  • Oxygen Toxicity and Mitochondrial Metabolism
    Li J
    PhD Dissertation, University of Louisville, 2003
  • Mitochondrial Metabolism and Oxygen Toxicity
    Li J
    MS Thesis, University of Louisville, 2002
  • The Regulatory Effects of TNF-Alpha, Angiotensin-II and MmLDL on PDGF-B Chain Gene Transcription in Vascular Endothelial Cells
    Li J
    MS Thesis, Peking Union Medical College, 2000

Book Chapters

  • Central Nervous System Neoplasms and Brain Metastases
    Zhou A, Butt OH, Campian JL
    In: DeVita, Hellman, and Rosenberg's Cancer: Principles & Practice of Oncology Review, 5th Edition (Morgensztern D, Govindan R, Devarakonda S, Trikalinos NA, Editors), Wolters Kluwer, Philadelphia, 2022
  • Neuro-Oncology
    Butt OH, Zhou AY, Huang J, Campian JL
    In: The Washington Manual of Oncology, 4th Edition (Morgensztern D, Ghobadi A, Govindan R, Editors), Wolters Kluwer, Philadelphia, 2022
  • CNS Radiation Necrosis
    Co-author
    In: Neuro-Oncology for the Clinical Neurologist
  • Neuro-Oncology
    Lin A, Campian J, Chicoine MR, Huang J, Tran DD
    In: Washington Manual of Oncology, 4th edition, Philadelphia, PA: Lippincott Williams and Wilkins, 2014
  • Endocrinology
    Campian JL
    In: First Aid for the Medicine Clerkship, Third Edition (First Aid Series) by Kaufman M, Stead L, Rusovici A (editors), 2010