Faculty
Oncology Division
Alphabetical list (active faculty):   
Milan G. Chheda

Milan G. Chheda, MD

Associate Professor

Department of Medicine

Oncology Division

Molecular Oncology

Clinical Interests

  • Aggressive treatment of brain tumors
  • Maintenance of excellent quality of life

Research Interests

  • Cancer stem cells
  • Oncolytic viruses
  • Functional genomics of brain tumors

Contact

  • 314-747-2712 (office)
  • 314-362-7086 (fax)
  • Division of Oncology
    Mail Stop 8069-0004-07
    Washington University
    660 South Euclid Avenue
    St. Louis, MO 63110
  • Center for Advanced Medicine, Suite 7A (clinic)
    --
    Room 7609 BJC Institute of Health (office)

Peer-reviewed Manuscripts

  • Salvage Therapies for Radiation-Relapsed Isocitrate Dehydrogenase-Mutant Astrocytoma and 1p/19q Codeleted Oligodendroglioma
    Ma S, Rudra S, Campian JL, Chheda MG, Johanns TM, Ansstas G, Abraham CD, Chicoine MR, Leuthardt EC, Dowling JL, Dunn GP, Kim AH, Huang J
    Neurooncol Adv 2021 Jun 18;3(1):vdab081
  • The Human Tumor Atlas Network: Charting Tumor Transitions Across Space and Time at Single-Cell Resolution
    Rozenblatt-Rosen O, Regev A, Oberdoerffer P, Nawy T, Hupalowska A, Rood JE, Ashenberg O, Cerami E, Coffey RJ, Demir E, Ding L, Esplin ED, Ford JM, Goecks J, Ghosh S, Gray JW, Guinney J, Hanlon SE, Hughes SK, Hwang ES, Iacobuzio-Donahue CA, Jane-Valbuena J, Johnson BE, Lau KS, Lively T, Mazzilli SA, Pe'er D, Santagata S, Shalek AK, Schapiro D, Snyder MP, Sorger PK, Spira AE, Srivastava S, Tan K, West RB, Williams EH
    Human Tumor Atlas Network (Contributors include: Chheda MG)

    Cell 2020 Apr 16;181(2):236-249
  • The State of Neuro-Oncology During the COVID-19 Pandemic: A Worldwide Assessment
    Mrugala MM, Ostrom QT, Pressley SM, Taylor JW, Thomas AA, Wefel JS, Coven SL, Acquaye AA, Haynes C, Agnihotri S, Lim M, Peters KB, Sulman EP, Salcido JT, Butowski NA, Hervey-Jumper S, Mansouri A, Oliver KR, Porter AB, Nassiri F, Schiff D, Dunbar EM, Hegi ME, Armstrong TS, van den Bent MJ, Chang SM, Zadeh G, Chheda MG
    Neurooncol Adv 2021 Feb 20;3(1):vdab035
  • Re-Evaluating Biopsy for Recurrent Glioblastoma: A Position Statement by the Christopher Davidson Forum Investigators
    Nduom EK, Gephart MH, Chheda MG, Suva ML, Amankulor N, Battiste JD, Campian JL, Dacey RG, Das S, Fecci PE, Hadjipanayis CG, Hoang KB, Jalali A, Orringer D, Patel AJ, Placantonakis D, Rodriguez A, Yang I, Yu JS, Zipfel GJ, Dunn GP, Leuthardt EC, Kim AH
    Neurosurgery 2021 Jun 15;89(1):129-132
  • Proteogenomic and Metabolomic Characterization of Human Glioblastoma
    Wang LB, Karpova A, Gritsenko MA, Kyle JE, Cao S, Li Y, Rykunov D, Colaprico A, Rothstein JH, Hong R, Stathias V, Cornwell M, Petralia F, Wu Y, Reva B, Krug K, Pugliese P, Kawaler E, Olsen LK, Liang WW, Song X, Dou Y, Wendl MC, Caravan W, Liu W, Cui Zhou D, Ji J, Tsai CF, Petyuk VA, Moon J, Ma W, Chu RK, Weitz KK, Moore RJ, Monroe ME, Zhao R, Yang X, Yoo S, Krek A, Demopoulos A, Zhu H, Wyczalkowski MA, McMichael JF, Henderson BL, Lindgren CM, Boekweg H, Lu S, Baral J, Yao L, Stratton KG, Bramer LM, Zink E, Couvillion SP, Bloodsworth KJ, Satpathy S, Sieh W, Boca SM, Schurer S, Chen F, Wiznerowicz M, Ketchum KA, Boja ES, Kinsinger CR, Robles AI, Hiltke T, Thiagarajan M, Nesvizhskii AI, Zhang B, Mani DR, Ceccarelli M, Chen XS, Cottingham SL, Li QK, Kim AH, Fenyo D, Ruggles KV, Rodriguez H, Mesri M, Payne SH, Resnick AC, Wang P, Smith RD, Iavarone A, Chheda MG, Barnholtz-Sloan JS, Rodland KD, Liu T, Ding L
    Clinical Proteomic Tumor Analysis Consortium

    Cancer Cell 2021 Apr 12;39(4):509-528
  • Defining Phenotypic and Functional Heterogeneity of Glioblastoma Stem Cells by Mass Cytometry
    Galdieri L, Jash A, Malkova O, Mao DD, DeSouza P, Chu YE, Salter A, Campian JL, Naegle KM, Brennan CW, Wakimoto H, Oh ST, Kim AH, Chheda MG
    JCI Insight 2021 Feb 22;6(4)
  • Zika Virus Oncolytic Activity Requires CD8+ T Cells and Is Boosted by Immune Checkpoint Blockade
    Nair S, Mazzoccoli L, Jash A, Govero J, Bais SS, Hu T, Fontes-Garfias CR, Shan C, Okada H, Shresta S, Rich JN, Shi PY, Diamond MS, Chheda MG
    JCI Insight 2021 Jan 11;6(1):e144619
  • Extensive Brainstem Infiltration, Not Mass Effect, Is a Common Feature of End-Stage Cerebral Glioblastomas
    Drumm MR, Dixit KS, Grimm S, Kumthekar P, Lukas RV, Raizer JJ, Stupp R, Chheda MG, Kam KL, McCord M, Sachdev S, Kruser T, Steffens A, Javier R, McCortney K, Horbinski C
    Neuro Oncol 2020 Apr 15;22(4):470-479
  • The Impact of Systemic Precision Medicine and Immunotherapy Treatments on Brain Metastases
    Han RH, Dunn GP, Chheda MG, Kim AH
    Oncotarget 2019 Nov 19;10(62):6739-6753
  • CHD4 Regulates the DNA Damage Response and RAD51 Expression in Glioblastoma
    McKenzie LD, LeClair JW, Miller KN, Strong AD, Chan HL, Oates EL, Ligon KL, Brennan CW, Chheda MG
    Sci Rep 2019 Mar 14;9(1):4444
  • Consumption of NADPH for 2-HG Synthesis Increases Pentose Phosphate Pathway Flux and Sensitizes Cells to Oxidative Stress
    Gelman SJ, Naser F, Mahieu NG, McKenzie LD, Dunn GP, Chheda MG, Patti GJ
    Cell Rep 2018 Jan 9;22(2):512-522
  • Zika Virus Has Oncolytic Activity Against Glioblastoma Stem Cells
    Zhu Z, Gorman MJ, McKenzie LD, Chai JN, Hubert CG, Prager BC, Fernandez E, Richner JM, Zhang R, Shan C, Tycksen E, Wang X, Shi PY, Diamond MS, Rich JN, Chheda MG
    J Exp Med 2017 Oct 2;214(10):2843-2857
  • Impact of Concurrent Chemotherapy With Radiation Therapy for Elderly Patients With Newly Diagnosed Glioblastoma: A Review of the National Cancer Data Base
    Huang J, Samson P, Perkins SM, Ansstas G, Chheda MG, DeWees TA, Tsien CI, Robinson CG, Campian JL
    J Neurooncol 2017 Feb;131(3):593-601
  • Vandetanib Plus Sirolimus in Adults With Recurrent Glioblastoma: Results of a Phase I and Dose Expansion Cohort Study
    Chheda MG, Wen PY, Hochberg FH, Chi AS, Drappatz J, Eichler AF, Yang D, Beroukhim R, Norden AD, Gerstner ER, Betensky RA, Batchelor TT
    J Neurooncol 2015 Feb;121(3):627-34
  • ZFHX4 Interacts With the NuRD Core Member CHD4 and Regulates the Glioblastoma Tumor-Initiating Cell State
    Chudnovsky Y, Kim D, Zheng S, Whyte WA, Bansal M, Bray MA, Gopal S, Theisen MA, Bilodeau S, Thiru P, Muffat J, Yilmaz OH, Mitalipova M, Woolard K, Lee J, Nishimura R, Sakata N, Fine HA, Carpenter AE, Silver SJ, Verhaak RG, Califano A, Young RA, Ligon KL, Mellinghoff IK, Root DE, Sabatini DM, Hahn WC, Chheda MG
    Cell Rep 2014 Jan 30;6(2):313-24
  • Integrative Functional Genomics Identifies RINT1 as a Novel GBM Oncogene
    Quayle SN*, Chheda MG*, Shukla SA, Wiedemeyer R, Tamayo P, Dewan RW, Zhuang L, Huang-Hobbs E, Haidar S, Xiao Y, Ligon KL, Hahn WC, Chin L (* equal contribution)
    Neuro Oncol 2012 Nov;14(11):1325-31
  • Differential Sensitivity of Glioma- Versus Lung Cancer-Specific EGFR Mutations to EGFR Kinase Inhibitors
    Vivanco I, Robins HI, Rohle D, Campos C, Grommes C, Nghiemphu PL, Kubek S, Oldrini B, Chheda MG, Yannuzzi N, Tao H, Zhu S, Iwanami A, Kuga D, Dang J, Pedraza A, Brennan CW, Heguy A, Liau LM, Lieberman F, Yung WK, Gilbert MR, Reardon DA, Drappatz J, Wen PY, Lamborn KR, Chang SM, Prados MD, Fine HA, Horvath S, Wu N, Lassman AB, DeAngelis LM, Yong WH, Kuhn JG, Mischel PS, Mehta MP, Cloughesy TF, Mellinghoff IK
    Cancer Discov 2012 May;2(5):458-71
  • Emerging Insights Into the Molecular and Cellular Basis of Glioblastoma
    Dunn GP, Rinne ML, Wykosky J, Genovese G, Quayle SN, Dunn IF, Agarwalla PK, Chheda MG, Campos B, Wang A, Brennan C, Ligon KL, Furnari F, Cavenee WK, Depinho RA, Chin L, Hahn WC
    Genes Dev 2012 Apr 15;26(8):756-84
  • Pattern of Retinoblastoma Pathway Inactivation Dictates Response to CDK4/6 Inhibition in GBM
    Wiedemeyer WR, Dunn IF, Quayle SN, Zhang J, Chheda MG, Dunn GP, Zhuang L, Rosenbluh J, Chen S, Xiao Y, Shapiro GI, Hahn WC, Chin L
    Proc Natl Acad Sci U S A 2010 Jun 22;107(25):11501-6
  • PLAGL2 Regulates Wnt Signaling to Impede Differentiation in Neural Stem Cells and Gliomas
    Zheng H, Ying H, Wiedemeyer R, Yan H, Quayle SN, Ivanova EV, Paik JH, Zhang H, Xiao Y, Perry SR, Hu J, Vinjamoori A, Gan B, Sahin E, Chheda MG, Brennan C, Wang YA, Hahn WC, Chin L, DePinho RA
    Cancer Cell 2010 May 18;17(5):497-509
  • CDK8 Is a Colorectal Cancer Oncogene That Regulates Beta-Catenin Activity
    Firestein R, Bass AJ, Kim SY, Dunn IF, Silver SJ, Guney I, Freed E, Ligon AH, Vena N, Ogino S, Chheda MG, Tamayo P, Finn S, Shrestha Y, Boehm JS, Jain S, Bojarski E, Mermel C, Barretina J, Chan JA, Baselga J, Tabernero J, Root DE, Fuchs CS, Loda M, Shivdasani RA, Meyerson M, Hahn WC
    Nature 2008 Sep 25;455(7212):547-51
  • Hepatitis B Reactivation During Glioblastoma Treatment With Temozolomide: A Cautionary Note
    Chheda MG, Drappatz J, Greenberger NJ, Kesari S, Weiss SE, Gigas DC, Doherty LM, Wen PY
    Neurology 2007 Mar 20;68(12):955-6
  • Two NOTCH4 Polymorphisms and Their Relation to Schizophrenia Susceptibility and Different Personality Traits
    Carmine A, Chheda MG, Jonsson EG, Sedvall GC, Farde L, Gustavsson JP, Bergman H, Anvret M, Buervenich S, Olson L
    Psychiatr Genet 2003 Mar;13(1):23-8
  • Phosphorylation of Snapin by PKA Modulates Its Interaction With the SNARE Complex
    Chheda MG, Ashery U, Thakur P, Rettig J, Sheng ZH
    Nat Cell Biol 2001 Apr;3(4):331-8

Invited Publications