Faculty
Oncology Division
Alphabetical list (active faculty):   
Jaebok Choi

Jaebok Choi, PhD

Assistant Professor

Department of Medicine

Oncology Division

Stem Cell Biology

Research Interests

  • Allogeneic hematopoietic stem cell transplantation
  • GvHD
  • IFNγR
  • IL6R
  • JAK-STAT signaling

Contact

  • 314-362-9349 (office)
  • 314-273-0153 (lab)
  • 314-362-1953 (fax)
  • Division of Oncology
    Campus Box 8007
    Washington University
    660 South Euclid Avenue
    St. Louis, MO 63110
  • Room 731 Southwest Tower (office)
  • Room 724 Southwest Tower (lab)

Peer-reviewed Manuscripts

  • Antibody-Drug Conjugates Plus Janus Kinase Inhibitors Enable MHC-Mismatched Allogeneic Hematopoietic Stem Cell Transplantation
    Persaud SP, Ritchey JK, Kim S, Lim S, Ruminski PG, Cooper ML, Rettig MP, Choi J, DiPersio JF
    J Clin Invest 2021 Nov 2; [Epub ahead of print]
  • Baricitinib Prevents GvHD by Increasing Tregs Via JAK3 and Treats Established GvHD by Promoting Intestinal Tissue Repair Via EGFR
    Kim S, Ashami K, Lim S, Staser K, Vij K, Santhanam S, Ritchey J, Peterson S, Gao F, Ciorba MA, Cooper ML, DiPersio JF, Choi J
    Leukemia 2021 Jul 24; [Epub ahead of print]
  • Selective Targeting of Alpha4beta1 Integrin Attenuates Murine Graft Versus Host Disease
    Alahmari B, Cooper ML, Vij K, Ritchey J, Ruminski P, Gao F, Choi J, DiPersio JF
    Leukemia 2020 Nov;34(11):3100-3104
  • Targeting Histone Deacetylases to Modulate Graft-Versus-Host Disease and Graft-Versus-Leukemia
    Kim S, Santhanam S, Lim S, Choi J
    Int J Mol Sci 2020 Jun 16;21(12)
  • Insights Into the Role of the JAK/STAT Signaling Pathway in Graft-Versus-Host Disease
    Abboud R, Choi J, Ruminski P, Schroeder MA, Kim S, Abboud CN, DiPersio JF
    Ther Adv Hematol 2020 Jun 2;11:2040620720914489
  • A Phase 1 Trial of Itacitinib, a Selective JAK1 Inhibitor, in Patients With Acute Graft-Versus-Host Disease
    Schroeder MA, Khoury HJ, Jagasia M, Ali H, Schiller GJ, Staser K, Choi J, Gehrs L, Arbushites MC, Yan Y, Langmuir P, Srinivas N, Pratta M, Perales MA, Chen YB, Meyers G, DiPersio JF
    Blood Adv 2020 Apr 28;4(8):1656-1669
  • Targeting IFNGR/IL6R or Downstream JAK1/JAK2 to Control GvHD
    Ashami K, DiPersio JF, Choi J
    Oncotarget 2018 Nov 6;9(87):35721-35722
  • Selective Targeting of Histone Modification Fails to Prevent Graft Versus Host Disease After Hematopoietic Cell Transplantation
    Alahmari B, Cooper M, Ziga E, Ritchey J, DiPersio JF, Choi J
    PLoS One 2018 Nov 19;13(11):e0207609
  • Baricitinib-Induced Blockade of Interferon Gamma Receptor and Interleukin-6 Receptor for the Prevention and Treatment of Graft-Versus-Host Disease
    Choi J, Cooper ML, Staser K, Ashami K, Vij KR, Wang B, Marsala L, Niswonger J, Ritchey J, Alahmari B, Achilefu S, Tsunoda I, Schroeder MA, DiPersio JF
    Leukemia 2018 Nov;32(11):2483-2494
  • An "Off-The-Shelf" Fratricide-Resistant CAR-T for the Treatment of T Cell Hematologic Malignancies
    Cooper ML, Choi J, Staser K, Ritchey JK, Devenport JM, Eckardt K, Rettig MP, Wang B, Eissenberg LG, Ghobadi A, Gehrs LN, Prior JL, Achilefu S, Miller CA, Fronick CC, O'Neal J, Gao F, Weinstock DM, Gutierrez A, Fulton RS, DiPersio JF
    Leukemia 2018 Sep;32(9):1970-1983
  • Transfer of Cell-Surface Antigens by Scavenger Receptor CD36 Promotes Thymic Regulatory T Cell Receptor Repertoire Development and Allo-Tolerance
    Perry JSA, Russler-Germain EV, Zhou YW, Purtha W, Cooper ML, Choi J, Schroeder MA, Salazar V, Egawa T, Lee BC, Abumrad NA, Kim BS, Anderson MS, DiPersio JF, Hsieh CS
    Immunity 2018 Jun 19;48(6):1271
  • CD36 Mediates Cell-Surface Antigens to Promote Thymic Development of the Regulatory T Cell Receptor Repertoire and Allo-Tolerance
    Perry JSA, Russler-Germain EV, Zhou YW, Purtha W, Cooper ML, Choi J, Schroeder MA, Salazar V, Egawa T, Lee BC, Abumrad NA, Kim BS, Anderson MS, DiPersio JF, Hsieh CS
    Immunity 2018 May 15;48(5):923-936e4
  • The Role of Janus Kinase Signaling in Graft-Versus-Host Disease and Graft Versus Leukemia
    Schroeder MA, Choi J, Staser K, DiPersio JF
    Biol Blood Marrow Transplant 2018 Jun;24(6):1125-1134
  • OMIP-042: 21-Color Flow Cytometry to Comprehensively Immunophenotype Major Lymphocyte and Myeloid Subsets in Human Peripheral Blood
    Staser KW, Eades W, Choi J, Karpova D, DiPersio JF
    Cytometry A 2018 Feb;93(2):186-189
  • Azacitidine Mitigates Graft-Versus-Host Disease Via Differential Effects on the Proliferation of T Effectors and Natural Regulatory T Cells in Vivo
    Cooper ML, Choi J, Karpova D, Vij K, Ritchey J, Schroeder MA, DiPersio JF
    J Immunol 2017 May 1;198(9):3746-3754
  • Phase I Study of Azacitidine Following Donor Lymphocyte Infusion for Relapsed Acute Myeloid Leukemia Post Allogeneic Stem Cell Transplantation
    Ghobadi A, Choi J, Fiala MA, Fletcher T, Liu J, Eissenberg LG, Abboud C, Cashen A, Vij R, Schroeder MA, Pusic I, Stockerl-Goldstein K, Jacoby M, Uy G, DiPersio J, Westervelt P
    Leuk Res 2016 Oct;49:1-6
  • GPR18 Controls Reconstitution of Mouse Small Intestine Intraepithelial Lymphocytes Following Bone Marrow Transplantation
    Becker AM, Callahan DJ, Richner JM, Choi J, DiPersio JF, Diamond MS, Bhattacharya D
    PLoS One 2015 Jul 21;10(7):e0133854
  • Maintenance Therapy With Decitabine After Allogeneic Stem Cell Transplantation for Acute Myelogenous Leukemia and Myelodysplastic Syndrome
    Pusic I, Choi J, Fiala MA, Gao F, Holt M, Cashen AF, Vij R, Abboud CN, Stockerl-Goldstein KE, Jacoby MA, Uy GL, Westervelt P, DiPersio JF
    Biol Blood Marrow Transplant 2015 Oct;21(10):1761-9
  • Pharmacologic Blockade of JAK1/JAK2 Reduces GvHD and Preserves the Graft-Versus-Leukemia Effect
    Choi J, Cooper ML, Alahmari B, Ritchey J, Collins L, Holt M, DiPersio JF
    PLoS One 2014 Oct 7;9(10):e109799
  • IFNγR Signaling as a Therapeutic Target to Prevent GVHD After Allo-HSCT
    Choi J, Cooper ML
    Austin Journal of Cancer and Clinical Research 2014;1:2-3
  • Effect of Epigallocatechin-3-Gallate on Graft-Versus-Host Disease
    Choi J, Cooper ML, Ziga ED, Ritchey J, DiPersio JF
    Cell Transplant 2014;23(9):1163-6
  • F11R Is a Novel Monocyte Prognostic Biomarker for Malignant Glioma
    Pong WW, Walker J, Wylie T, Magrini V, Luo J, Emnett RJ, Choi J, Cooper ML, Griffith M, Griffith OL, Rubin JB, Fuller GN, Piwnica-Worms D, Feng X, Hambardzumyan D, DiPersio JF, Mardis ER, Gutmann DH
    PLoS One 2013 Oct 11;8(10):e77571
  • IFNγR Signaling Mediates Alloreactive T-Cell Trafficking and GVHD
    Choi J, Ziga ED, Ritchey J, Collins L, Prior JL, Cooper ML, Piwnica-Worms D, DiPersio JF
    Blood 2012 Nov 8;120(19):4093-103
  • In Vivo Administration of Hypomethylating Agents Mitigate Graft-Versus-Host Disease Without Sacrificing Graft-Versus-Leukemia
    Choi J, Ritchey J, Prior JL, Holt M, Shannon WD, Deych E, Piwnica-Worms DR, DiPersio JF
    Blood 2010 Jul 8;116(1):129-39
  • AFF-1, a FOS-1-Regulated Fusogen, Mediates Fusion of the Anchor Cell in C. Elegans
    Sapir A*, Choi J*, Leikina E, Avinoam O, Valansi C, Chernomordik LV, Newman AP, Podbilewicz B (* equal contribution)
    Dev Cell 2007 May;12(5):683-98
  • N-Ethylmaleimide Sensitive Factor Is Required for Fusion of the C. Elegans Uterine Anchor Cell
    Choi J, Richards KL, Cinar HN, Newman AP
    Dev Biol 2006 Sep 1;297(1):87-102
  • A Two-Promoter System of Gene Expression in C. Elegans
    Choi J, Newman AP
    Dev Biol 2006 Aug 15;296(2):537-44