Faculty
Hematology Division
Alphabetical list (active faculty):   
Balraj Doray

Balraj Doray, PhD

Associate Professor

Department of Medicine

Hematology Division

Contact

  • 314-362-8828 (lab)
  • Division of Hematology
    Mail Stop 8125-0020-08
    Washington University
    660 South Euclid Avenue
    St. Louis, MO 63110
  • Room 8828, Clinical Sciences Research Building (lab)

Original Articles

  • A Weak COPI Binding Motif in the Cytoplasmic Tail of SARS-CoV-2 Spike Glycoprotein Is Necessary for Its Cleavage, Glycosylation, and Localization
    Jennings BC, Kornfeld S, Doray B
    FEBS Lett 2021 Jul;595(13):1758-1767
  • Elevated mRNA Expression and Defective Processing of Cathepsin D in HeLa Cells Lacking the Mannose 6-Phosphate Pathway
    Liu L, Doray B
    FEBS Open Bio 2021 Jun;11(6):1695-1703
  • Inactivation of the Three GGA Genes in HeLa Cells Partially Compromises Lysosomal Enzyme Sorting
    Doray B, Liu L, Lee WS, Jennings BC, Kornfeld S
    FEBS Open Bio 2021 Feb;11(2):367-374
  • Disease-Causing Missense Mutations Within the N-Terminal Transmembrane Domain of GlcNAc-1-Phosphotransferase Impair Endoplasmic Reticulum Translocation or Golgi Retention
    Lee WS, Jennings BC, Doray B, Kornfeld S
    Hum Mutat 2020 Jul;41(7):1321-1328
  • Recycling of Golgi Glycosyltransferases Requires Direct Binding to Coatomer
    Liu L, Doray B, Kornfeld S
    Proc Natl Acad Sci U S A 2018 Sep 4;115(36):8984-8989
  • Engineering of GlcNAc-1-Phosphotransferase for Production of Highly Phosphorylated Lysosomal Enzymes for Enzyme Replacement Therapy
    Liu L, Lee WS, Doray B, Kornfeld S
    Mol Ther Methods Clin Dev 2017 Mar 29;5:59-65
  • Role of Spacer-1 in the Maturation and Function of GlcNAc-1-Phosphotransferase
    Liu L, Lee WS, Doray B, Kornfeld S
    FEBS Lett 2017 Jan;591(1):47-55
  • Multiple Domains of GlcNAc-1-Phosphotransferase Mediate Recognition of Lysosomal Enzymes
    van Meel E, Lee WS, Liu L, Qian Y, Doray B, Kornfeld S
    J Biol Chem 2016 Apr 8;291(15):8295-307
  • A Clathrin Coat Assembly Role for the Muniscin Protein Central Linker Revealed by TALEN-Mediated Gene Editing
    Umasankar PK, Ma L, Thieman JR, Jha A, Doray B, Watkins SC, Traub LM
    Elife 2014 Oct 10;3
  • Impact of Genetic Background on Neonatal Lethality of Gga2 Gene-Trap Mice
    Doray B, Govero J, Kornfeld S
    G3 (Bethesda) 2014 Mar 17;4(5):885-90
  • Postmortem Changes in Brain Levels of GGA1 and GGA3 in Mice
    Doray B, Kornfeld S
    J Alzheimer’s Dis 2013 Oct 8; Letter to the editor
  • Do GGA Adaptors Bind Internal DXXLL Motifs?
    Doray B, Misra S, Qian Y, Brett TJ, Kornfeld S
    Traffic 2012 Oct;13(10):1315-25
  • Analysis of Gga Null Mice Demonstrates a Non-Redundant Role for Mammalian GGA2 During Development
    Govero J*, Doray B*, Bai H, Kornfeld S (*Equal contribution by both authors)
    PLoS One 2012;7(1):e30184
  • Clathrin Regulates the Association of PIPKIgamma661 With the AP-2 Adaptor Beta2 Appendage
    Thieman JR, Mishra SK, Ling K, Doray B, Anderson RA, Traub LM
    J Biol Chem 2009 May 15;284(20):13924-39
  • Identification of Acidic Dileucine Signals in LRP9 That Interact With Both GGAs and AP-1/AP-2
    Doray B*, Knisely JM*, Wartman L, Bu G, Kornfeld S (*Equal contribution by both authors)
    Traffic 2008 Sep;9(9):1551-62
  • Binding of Cargo Sorting Signals to AP-1 Enhances Its Association With ADP Ribosylation Factor 1-GTP
    Lee I*, Doray B*, Govero J, Kornfeld S (*Equal contribution by both authors)
    J Cell Biol 2008 Feb 11;180(3):467-72
  • The Gamma/Sigma1 and Alpha/Sigma2 Hemicomplexes of Clathrin Adaptors AP-1 and AP-2 Harbor the Dileucine Recognition Site
    Doray B*, Lee I*, Knisely J, Bu G, Kornfeld S (*Equal contribution by both authors)
    Mol Biol Cell 2007 May;18(5):1887-96
  • Discovery of Estrogen Receptor Alpha Target Genes and Response Elements in Breast Tumor Cells
    Lin CY, Strom A, Vega VB, Kong SL, Yeo AL, Thomsen JS, Chan WC, Doray B, Bangarusamy DK, Ramasamy A, Vergara LA, Tang S, Chong A, Bajic VB, Miller LD, Gustafsson JA, Liu ET
    Genome Biol 2004;5(9):R66
  • GGA1 Interacts With the Adaptor Protein AP-1 Through a WNSF Sequence in Its Hinge Region
    Bai H, Doray B, Kornfeld S
    J Biol Chem 2004 Apr 23;279(17):17411-7
  • Cooperation of GGAs and AP-1 in Packaging MPRs at the Trans-Golgi Network
    Doray B*, Ghosh P*, Griffith J, Geuze HJ, Kornfeld S (*Equal contribution by both authors)
    Science 2002 Sep 6;297(5587):1700-3
  • Autoinhibition of the Ligand-Binding Site of GGA1/3 VHS Domains by an Internal Acidic Cluster-Dileucine Motif
    Doray B, Bruns K, Ghosh P, Kornfeld SA
    Proc Natl Acad Sci U S A 2002 Jun 11;99(12):8072-7
  • Interaction of the Cation-Dependent Mannose 6-Phosphate Receptor With GGA Proteins
    Doray B*, Bruns K*, Ghosh P, Kornfeld S (*Equal contribution by both authors)
    J Biol Chem 2002 May 24;277(21):18477-82
  • Gamma Subunit of the AP-1 Adaptor Complex Binds Clathrin: Implications for Cooperative Binding in Coated Vesicle Assembly
    Doray B, Kornfeld S
    Mol Biol Cell 2001 Jul;12(7):1925-35
  • Binding of GGA2 to the Lysosomal Enzyme Sorting Motif of the Mannose 6-Phosphate Receptor
    Zhu Y, Doray B, Poussu A, Lehto VP, Kornfeld S
    Science 2001 Jun 1;292(5522):1716-8
  • N-Terminal Deletions and His-Tag Fusions Dramatically Affect Expression of Cytochrome P450 2C2 in Bacteria
    Doray B, Chen CD, Kemper B
    Arch Biochem Biophys 2001 Sep 1;393(1):143-53
  • Substitutions in the C-Terminal Portion of the Catalytic Domain Partially Reverse Assembly Defects Introduced by Mutations in the N-Terminal Linker Sequence of Cytochrome P450 2C2
    Doray B, Chen CD, Kemper B
    Biochemistry 1999 Sep 14;38(37):12180-6
  • A Conserved Proline-Rich Sequence Between the N-Terminal Signal-Anchor and Catalytic Domains Is Required for Assembly of Functional Cytochrome P450 2C2
    Chen CD, Doray B, Kemper B
    Arch Biochem Biophys 1998 Feb 15;350(2):233-8
  • Efficient Assembly of Functional Cytochrome P450 2C2 Requires a Spacer Sequence Between the N-Terminal Signal Anchor and Catalytic Domains
    Chen CD, Doray B, Kemper B
    J Biol Chem 1997 Sep 5;272(36):22891-7
  • The Cytoplasmic and N-Terminal Transmembrane Domains of Cytochrome P450 Contain Independent Signals for Retention in the Endoplasmic Reticulum
    Szczesna-Skorupa E, Ahn K, Chen CD, Doray B, Kemper B
    J Biol Chem 1995 Oct 13;270(41):24327-33
  • Retardation of RNA Electrophoretic Mobility Due to a Palindromic Region
    Dante M, Michalik SS, Mathew Z, Doray B, Ho LL, Wise KJ, Christianson TW
    Anal Biochem 1995 Mar 1;225(2):348-51