Faculty
Oncology Division
Alphabetical list (active faculty):   
Linda G. Eissenberg

Linda G. Eissenberg, PhD

Assistant Professor

Department of Medicine

Oncology Division

Stem Cell Biology

Research Interests

  • Gene therapy / suicide gene
  • Chimeric antigen receptor / bispecific targeting reagents
  • T cells
  • Leukemia / graft vs. host disease
  • Mobilization of hematopoietic stem cells
  • Chemosensitization by mobilizing leukemia cells

Contact

  • 314-362-7558 (office)
  • 314-362-9333 (fax)
  • Division of Oncology
    Mail Stop 8007-0057-07
    Washington University
    660 South Euclid Avenue
    St. Louis, MO 63110
  • Room 626P Southwest Tower (lab)

Peer-reviewed Manuscripts

  • Targeting VLA4 Integrin and CXCR2 Mobilizes Serially Repopulating Hematopoietic Stem Cells
    Karpova D, Rettig MP, Ritchey J, Cancilla D, Christ S, Gehrs L, Chendamarai E, Evbuomwan MO, Holt M, Zhang J, Abou-Ezzi G, Celik H, Wiercinska E, Yang W, Gao F, Eissenberg LG, Heier RF, Arnett SD, Meyers MJ, Prinsen MJ, Griggs DW, Trumpp A, Ruminski PG, Morrow DM, Bonig HB, Link DC, DiPersio JF
    J Clin Invest 2019 May 14;130
  • Preclinical Development of a Bispecific Antibody That Safely and Effectively Targets CD19 and CD47 for the Treatment of B-Cell Lymphoma and Leukemia
    Buatois V, Johnson Z, Salgado-Pires S, Papaioannou A, Hatterer E, Chauchet X, Richard F, Barba L, Daubeuf B, Cons L, Broyer L, D'Asaro M, Matthes T, LeGallou S, Fest T, Tarte K, Clarke Hinojosa RK, Genesca Ferrer E, Ribera JM, Dey A, Bailey K, Fielding AK, Eissenberg L, Ritchey J, Rettig M, DiPersio JF, Kosco-Vilbois MH, Masternak K, Fischer N, Shang L, Ferlin WG
    Mol Cancer Ther 2018 Aug;17(8):1739-1751
  • Ixazomib, an Oral Proteasome Inhibitor, Induces Rapid Mobilization of Hematopoietic Progenitor Cells in Mice
    Ghobadi A, Rettig MP, Holt MS, Ritchey JK, Kennerly K, Chendamarai E, Eissenberg L, DiPersio JF
    Blood 2018 Jun 7;131(23):2594-2596
  • An "Off-The-Shelf" Fratricide-Resistant CAR-T for the Treatment of T Cell Hematologic Malignancies
    Cooper ML, Choi J, Staser K, Ritchey JK, Devenport JM, Eckardt K, Rettig MP, Wang B, Eissenberg LG, Ghobadi A, Gehrs LN, Prior JL, Achilefu S, Miller CA, Fronick CC, O'Neal J, Gao F, Weinstock DM, Gutierrez A, Fulton RS, DiPersio JF
    Leukemia 2018 Sep;32(9):1970-1983
  • Enhanced in Utero Allogeneic Engraftment in Mice After Mobilizing Fetal HSCs by Alpha4beta1/7 Inhibition
    Kim AG, Vrecenak JD, Boelig MM, Eissenberg L, Rettig MP, Riley JS, Holt MS, Conner MA, Loukogeorgakis SP, Li H, DiPersio JF, Flake AW, Peranteau WH
    Blood 2016 Nov 17;128(20):2457-2461
  • Phase I Study of Azacitidine Following Donor Lymphocyte Infusion for Relapsed Acute Myeloid Leukemia Post Allogeneic Stem Cell Transplantation
    Ghobadi A, Choi J, Fiala MA, Fletcher T, Liu J, Eissenberg LG, Abboud C, Cashen A, Vij R, Schroeder MA, Pusic I, Stockerl-Goldstein K, Jacoby M, Uy G, DiPersio J, Westervelt P
    Leuk Res 2016 Oct;49:1-6
  • Targeting CD123 in Acute Myeloid Leukemia Using a T-Cell-Directed Dual-Affinity Retargeting Platform
    Al-Hussaini M, Rettig MP, Ritchey JK, Karpova D, Uy GL, Eissenberg LG, Gao F, Eades WC, Bonvini E, Chichili GR, Moore PA, Johnson S, Collins L, DiPersio JF
    Blood 2016 Jan 7;127(1):122-31
  • [(18)F]FHBG PET/CT Imaging of CD34-TK75 Transduced Donor T Cells in Relapsed Allogeneic Stem Cell Transplant Patients: Safety and Feasibility
    Eissenberg LG, Rettig MP, Ritchey JK, Prior JL, Schwarz SW, Frye J, White BS, Fulton RS, Ghobadi A, Cooper ML, Couriel DR, Seegulam ME, Piwnica-Worms D, Dehdashti F, Cornetta K, DiPersio JF
    Mol Ther 2015 Jun;23(6):1110-22
  • Bortezomib Is a Rapid Mobilizer of Hematopoietic Stem Cells in Mice Via Modulation of the VCAM-1/VLA-4 Axis
    Ghobadi A, Rettig MP, Cooper ML, Holt MS, Ritchey JK, Eissenberg L, DiPersio JF
    Blood 2014 Oct 23;124(17):2752-4
  • Histoplasma Capsulatum Alpha-(1,3)-Glucan Blocks Innate Immune Recognition by the Beta-Glucan Receptor
    Rappleye CA, Eissenberg LG, Goldman WE
    Proc Natl Acad Sci U S A 2007 Jan 23;104(4):1366-70
  • Phenotypic Variation and Intracellular Parasitism by Histoplasma Capsulatum
    Kugler S*, Schurtz-Sebghati T*, Eissenberg LG*, Goldman WE (*contributed equally)
    Proc Natl Acad Sci U S A 2000 Aug 1;97(16):8794-8
  • Alterations to the Cell Wall of Histoplasma Capsulatum Yeasts During Infection of Macrophages or Epithelial Cells
    Eissenberg LG, Moser SA, Goldman WE
    J Infect Dis 1997 Jun;175(6):1538-44
  • Phenotypic Variation and Persistence of Histoplasma Capsulatum Yeasts in Host Cells
    Eissenberg LG, Poirier S, Goldman WE
    Infect Immun 1996 Dec;64(12):5310-4
  • Histoplasma Capsulatum Modulates the Acidification of Phagolysosomes
    Eissenberg LG, Goldman WE, Schlesinger PH
    J Exp Med 1993 Jun 1;177(6):1605-11
  • Infection of P388D1 Macrophages and Respiratory Epithelial Cells by Histoplasma Capsulatum: Selection of Avirulent Variants and Their Potential Role in Persistent Histoplasmosis
    Eissenberg LG, West JL, Woods JP, Goldman WE
    Infect Immun 1991 May;59(5):1639-46
  • Phagosome-Lysosome Fusion in P388D1 Macrophages Infected With Histoplasma Capsulatum
    Eissenberg LG, Schlesinger PH, Goldman WE
    J Leukoc Biol 1988 Jun;43(6):483-91
  • Histoplasma Capsulatum Fails to Trigger Release of Superoxide From Macrophages
    Eissenberg LG, Goldman WE
    Infect Immun 1987 Jan;55(1):29-34
  • Chlamydia Psittaci Elementary Body Envelopes: Ingestion and Inhibition of Phagolysosome Fusion
    Eissenberg LG, Wyrick PB, Davis CH, Rumpp JW
    Infect Immun 1983 May;40(2):741-51
  • Inhibition of Phagolysosome Fusion Is Localized to Chlamydia Psittaci-Laden Vacuoles
    Eissenberg LG, Wyrick PB
    Infect Immun 1981 May;32(2):889-96

Invited Publications

  • Suicide Genes: Monitoring Cells in Patients With a Safety Switch
    Eissenberg LG, Rettig M, Dehdashti F, Piwnica-Worms D, DiPersio JF
    Front Pharmacol 2014 Nov 6;5:241
  • BiTEs, DARTs, and CARs: Novel Targeted Therapies for Lymphoid Malignancies
    Eissenberg L, DiPersio JF
    Hematological Malignancies, Issue 10, Siteman Cancer Center, 2012: 1-2
  • Application of CXCR4 Inhibitors in Leukemia
    Ansstas G, Mir F, Rettig MP, Schroeder M, Eissenberg L, DiPersio JF
    Chapter 17, Novel Developments in Stem Cell Mobilization: Focus on CXCR4, 2012: 335-349
  • The Interplay Between Histoplasma Capsulatum and Its Host Cells
    Eissenberg LG, Goldman WE
    Baillière's Clinical Infectious Diseases 1994;1:265-283
  • Histoplasma Variation and Adaptive Strategies for Parasitism: New Perspectives on Histoplasmosis
    Eissenberg LG, Goldman WE
    Clin Microbiol Rev 1991 Oct;4(4):411-21
  • Fusion of Lysosomes With Phagosomes Containing Histoplasma Capsulatum: Use of Fluoresceinated Dextran
    Eissenberg LG, Goldman WE
    Adv Exp Med Biol 1988;239:53-61

Invited Publications for Lay Audience