Faculty
Hematology Division
Girard.jpg

Thomas J. Girard, PhD

Assistant Professor
Department of Medicine
Hematology Division

Research Interests

  • Blood coagulation
  • Tissue factor pathway inhibitor
  • Protein Z-dependent protease inhibitor

Contact

  • (314) 362-8863 (tel)
  • (314) 362-8826 (fax)
  • Room 8804 Clinical Sciences Research Building (lab)
  • Hematology Division
    Campus Box 8125
    Washington University School of Medicine
    660 South Euclid Avenue
    St. Louis, MO  63110

Peer-reviewed Manuscripts

  • Suppressing Protein Z-Dependent Inhibition of Factor Xa Improves Coagulation in Hemophilia A
    Girard TJ, Lasky NM, Grunz K, Broze GJJ
    J Thromb Haemost 2019 Jan;17(1):149-156
  • Re-Evaluation of Mouse Tissue Factor Pathway Inhibitor and Comparison of Mouse and Human Tissue Factor Pathway Inhibitor Physiology
    Girard TJ, Grunz K, Lasky NM, Malone JP, Broze GJJ
    J Thromb Haemost 2018 Nov;16(11):2246-2257
  • Protein Z, Protein Z-Dependent Protease Inhibitor (SerpinA10), and the Acute-Phase Response
    Girard TJ, Lasky NM, Tuley EA, Broze GJ Jr
    J Thromb Haemost 2013 Feb;11(2):375-8
  • TFPIbeta Is the GPI-Anchored TFPI Isoform on Human Endothelial Cells and Placental Microsomes
    Girard TJ, Tuley E, Broze GJ Jr
    Blood 2012 Feb 2;119(5):1256-62
  • The C-Terminus of Tissue Factor Pathway Inhibitor Alpha Is Required for Its Interaction With Factors V and Va
    Ndonwi M, Girard TJ, Broze GJ Jr
    J Thromb Haemost 2012 Sep;10(9):1944-6
  • Piperazinyl Glutamate Pyridines as Potent Orally Bioavailable P2Y12 Antagonists for Inhibition of Platelet Aggregation
    Parlow JJ, Burney MW, Case BL, Girard TJ, Hall KA, Harris PK, Hiebsch RR, Huff RM, Lachance RM, Mischke DA, Rapp SR, Woerndle RS, Ennis MD
    J Med Chem 2010 Mar 11;53(5):2010-37
  • Part II: Piperazinyl-Glutamate-Pyridines as Potent Orally Bioavailable P2Y12 Antagonists for Inhibition of Platelet Aggregation
    Parlow JJ, Burney MW, Case BL, Girard TJ, Hall KA, Harris PK, Hiebsch RR, Huff RM, Lachance RM, Mischke DA, Rapp SR, Woerndle RS, Ennis MD
    Bioorg Med Chem Lett 2010 Feb 15;20(4):1388-94
  • Piperazinyl-Glutamate-Pyrimidines as Potent P2Y12 Antagonists for Inhibition of Platelet Aggregation
    Parlow JJ, Burney MW, Case BL, Girard TJ, Hall KA, Hiebsch RR, Huff RM, Lachance RM, Mischke DA, Rapp SR, Woerndle RS, Ennis MD
    Bioorg Med Chem Lett 2009 Nov 1;19(21):6148-56
  • Piperazinyl-Glutamate-Pyridines as Potent Orally Bioavailable P2Y12 Antagonists for Inhibition of Platelet Aggregation
    Parlow JJ, Burney MW, Case BL, Girard TJ, Hall KA, Hiebsch RR, Huff RM, Lachance RM, Mischke DA, Rapp SR, Woerndle RS, Ennis MD
    Bioorg Med Chem Lett 2009 Aug 15;19(16):4657-63
  • A Factor X-TFPI Hybrid Protein Inhibits B16 Melanoma Metastatic Growth in Mice
    Girard TJ
    Thromb Res 2007;121(3):427-8
  • Design, Parallel Synthesis, and Crystal Structures of Pyrazinone Antithrombotics as Selective Inhibitors of the Tissue Factor VIIa Complex
    Parlow JJ, Case BL, Dice TA, Fenton RL, Hayes MJ, Jones DE, Neumann WL, Wood RS, Lachance RM, Girard TJ, Nicholson NS, Clare M, Stegeman RA, Stevens AM, Stallings WC, Kurumbail RG, South MS
    J Med Chem 2003 Sep 11;46(19):4050-62
  • Polymer-Assisted Solution-Phase Library Synthesis and Crystal Structure of Alpha-Ketothiazoles as Tissue Factor VIIa Inhibitors
    Parlow JJ, Dice TA, Lachance RM, Girard TJ, Stevens AM, Stegeman RA, Stallings WC, Kurumbail RG, South MS
    J Med Chem 2003 Sep 11;46(19):4043-9
  • Polymer-Assisted Solution-Phase (PASP) Parallel Synthesis of an Alpha-Ketothiazole Library as Tissue Factor VIIa Inhibitors
    South MS, Dice TA, Girard TJ, Lachance RM, Stevens AM, Stegeman RA, Stallings WC, Kurumbail RG, Parlow JJ
    Bioorg Med Chem Lett 2003 Jul 21;13(14):2363-7
  • Structure-Based Drug Design of Pyrazinone Antithrombotics as Selective Inhibitors of the Tissue Factor VIIa Complex
    South MS, Case BL, Wood RS, Jones DE, Hayes MJ, Girard TJ, Lachance RM, Nicholson NS, Clare M, Stevens AM, Stegeman RA, Stallings WC, Kurumbail RG, Parlow JJ
    Bioorg Med Chem Lett 2003 Jul 21;13(14):2319-25
  • Pharmacological Intervention at Disparate Sites in the Coagulation Cascade: Comparison of Anti-Thrombotic Efficacy Vs Bleeding Propensity in a Rat Model of Acute Arterial Thrombosis
    Szalony JA, Taite BB, Girard TJ, Nicholson NS, LaChance RM
    J Thromb Thrombolysis 2002 Oct;14(2):113-21
  • Structural Requirements for TFPI-Mediated Inhibition of Neointimal Thickening After Balloon Injury in the Rat
    Han X, Girard TJ, Baum P, Abendschein DR, Broze GJ Jr
    Arterioscler Thromb Vasc Biol 1999 Oct;19(10):2563-7
  • Inhibitory Activity of Unsaturated Fatty Acids and Anacardic Acids Toward Soluble Tissue Factor-Factor VIIa Complex
    Wang D, Girard TJ, Kasten TP, LaChance RM, Miller-Wideman MA, Durley RC
    J Nat Prod 1998 Nov;61(11):1352-5
  • Long-Term Inhibition of Murine Experimental Autoimmune Encephalomyelitis Using CTLA-4-Fc Supports a Key Role for CD28 Costimulation
    Cross AH, Girard TJ, Giacoletto KS, Evans RJ, Keeling RM, Lin RF, Trotter JL, Karr RW
    J Clin Invest 1995 Jun;95(6):2783-9
  • Complementary DNA Sequencing of Canine Tissue Factor Pathway Inhibitor Reveals a Unique Nanomeric Repetitive Sequence Between the Second and Third Kunitz Domains
    Girard TJ, Gailani D, Broze GJ Jr
    Biochem J 1994 Nov 1;303 ( Pt 3):923-8
  • Tissue Factor Pathway Inhibitor: The Carboxy-Terminus Is Required for Optimal Inhibition of Factor Xa
    Wesselschmidt R, Likert K, Girard T, Wun TC, Broze GJ Jr
    Blood 1992 Apr 15;79(8):2004-10
  • Structure of the Human Lipoprotein-Associated Coagulation Inhibitor Gene. Intro/Exon Gene Organization and Localization of the Gene to Chromosome 2
    Girard TJ, Eddy R, Wesselschmidt RL, MacPhail LA, Likert KM, Byers MG, Shows TB, Broze GJ Jr
    J Biol Chem 1991 Mar 15;266(8):5036-41
  • cDNA Sequence of Rabbit Lipoprotein-Associated Coagulation Inhibitor
    Wesselschmidt RL, Girard TJ, Broze GJ Jr
    Nucleic Acids Res 1990 Nov 11;18(21):6440
  • Endogenous Phosphorylation of the Lipoprotein-Associated Coagulation Inhibitor at Serine-2
    Girard TJ, McCourt D, Novotny WF, MacPhail LA, Likert KM, Broze GJ Jr
    Biochem J 1990 Sep 15;270(3):621-5
  • Regulation of Coagulation by a Multivalent Kunitz-Type Inhibitor
    Broze GJ Jr, Girard TJ, Novotny WF
    Biochemistry 1990 Aug 21;29(33):7539-46
  • Inhibition of Factor VIIa-Tissue Factor Coagulation Activity by a Hybrid Protein
    Girard TJ, MacPhail LA, Likert KM, Novotny WF, Miletich JP, Broze GJ Jr
    Science 1990 Jun 15;248(4961):1421-4
  • Purification and Characterization of the Lipoprotein-Associated Coagulation Inhibitor From Human Plasma
    Novotny WF, Girard TJ, Miletich JP, Broze GJ Jr
    J Biol Chem 1989 Nov 5;264(31):18832-7
  • Identification of the 1.4 Kb and 4.0 Kb Messages for the Lipoprotein Associated Coagulation Inhibitor and Expression of the Encoded Protein
    Girard TJ, Warren LA, Novotny WF, Bejcek BE, Miletich JP, Broze GJ Jr
    Thromb Res 1989 Jul 1;55(1):37-50
  • Functional Significance of the Kunitz-Type Inhibitory Domains of Lipoprotein-Associated Coagulation Inhibitor
    Girard TJ, Warren LA, Novotny WF, Likert KM, Brown SG, Miletich JP, Broze GJ Jr
    Nature 1989 Apr 6;338(6215):518-20
  • Platelets Secrete a Coagulation Inhibitor Functionally and Antigenically Similar to the Lipoprotein Associated Coagulation Inhibitor
    Novotny WF, Girard TJ, Miletich JP, Broze GJ Jr
    Blood 1988 Dec;72(6):2020-5
  • Cloning and Characterization of a cDNA Coding for the Lipoprotein-Associated Coagulation Inhibitor Shows That It Consists of Three Tandem Kunitz-Type Inhibitory Domains
    Wun TC, Kretzmer KK, Girard TJ, Miletich JP, Broze GJ Jr
    J Biol Chem 1988 May 5;263(13):6001-4