Oncology Division
Alphabetical list (active faculty):   
Patrick M. Grierson

Patrick M. Grierson, MD, PhD


Department of Medicine

Oncology Division

Medical Oncology

Clinical Interests

  • Pancreatic cancer
  • Cholangiocarcinoma
  • Hepatocellular carcinoma
  • Colon cancer

Research Interests

  • Targeted therapy
  • Immunotherapy


  • 314-996-3362 (office)
  • 314-747-2797 (fax)
  • Division of Oncology
    Mail Stop 8056-0029-11
    Washington University
    660 South Euclid Avenue
    St. Louis, MO 63110
  • Room 11319F Mid-Campus Center (office)

Peer-reviewed Articles

  • Vorolanib (X-82), an Oral Anti-VEGFR/PDGFR/CSF1R Tyrosine Kinase Inhibitor, With Everolimus in Solid Tumors: Results of a Phase I Study
    Pedersen KS, Grierson PM, Picus J, Lockhart AC, Roth BJ, Liu J, Morton A, Chan E, Huffman J, Liang C, Wang-Gillam A, Tan B
    Invest New Drugs 2021 Oct;39(5):1298-1305
  • Proteomics Reveal MK2/Hsp27 Axis as a Major Survival Mechanism Following Genotoxic Stress
    Grierson PM, Dodhiawala P, Cheng Y, Hung-Po Chen T, Ali Khawar I, Wei Q, Zhang D, et al.
    Science Translational Medicine. Accepted for publication on 2021 Aug 11
  • Stroma-Targeting Strategies in Pancreatic Cancer: Past Lessons, Challenges and Prospects
    Polani F, Grierson PM, Lim KH
    World J Gastroenterol 2021 May 14;27(18):2105-2121
  • Combined Systemic and Hepatic Artery Infusion Pump Chemo-Therapy as a Liver-Directed Therapy for Colorectal Liver Metastasis-Review of Literature and Case Discussion
    Chaudhry S, Fields RC, Grierson PM, Lim KH
    Cancers (Basel) 2021 Mar 13;13(6):1283
  • CC Chemokine Receptor 2-Targeting Copper Nanoparticles for Positron Emission Tomography-Guided Delivery of Gemcitabine for Pancreatic Ductal Adenocarcinoma
    Zhang X, Detering L, Sultan D, Luehmann H, Li L, Heo GS, Zhang X, Lou L, Grierson PM, Greco S, Ruzinova M, Laforest R, Dehdashti F, Lim KH, Liu Y
    ACS Nano 2021 Jan 26;15(1):1186-1198
  • TPL2 Enforces RAS-Induced Inflammatory Signaling and Is Activated by Point Mutations
    Dodhiawala PB, Khurana N, Zhang D, Cheng Y, Li L, Wei Q, Seehra K, Jiang H, Grierson PM, Wang-Gillam A, Lim KH
    J Clin Invest 2020 Sep 1;130(9):4771-4790
  • Phase Ib/II Study Combining Tosedostat With Capecitabine in Patients With Advanced Pancreatic Adenocarcinoma
    Grierson P, Teague A, Suresh R, Lim KH, Amin M, Pedersen K, Tan B, Huffman J, Boice N, Du L, Liu J, Lockhart AC, Wang-Gillam A
    J Gastrointest Oncol 2020 Feb;11(1):61-67
  • IRAK4 Mediates Colitis-Induced Tumorigenesis and Chemoresistance in Colorectal Cancer
    Li Q, Chen Y, Zhang D, Grossman J, Li L, Khurana N, Jiang H, Grierson PM, Herndon J, DeNardo DG, Challen GA, Liu J, Ruzinova MB, Fields RC, Lim KH
    JCI Insight 2019 Oct 3;4(19):130867
  • Concurrent HER or PI3K Inhibition Potentiates the Antitumor Effect of the ERK Inhibitor Ulixertinib in Preclinical Pancreatic Cancer Models
    Jiang H, Xu M, Li L, Grierson P, Dodhiawala P, Highkin M, Zhang D, Li Q, Wang-Gillam A, Lim KH
    Mol Cancer Ther 2018 Oct;17(10):2144-2155
  • Regulation of BLM Nucleolar Localization
    Tangeman L, McIlhatton MA, Grierson P, Groden J, Acharya S
    Genes (Basel) 2016 Sep 21;7(9)
  • Collaborating Functions of BLM and DNA Topoisomerase I in Regulating Human RDNA Transcription
    Grierson PM, Acharya S, Groden J
    Mutat Res 2013 Mar-Apr;743-744:89-96
  • BLM Helicase Facilitates RNA Polymerase I-Mediated Ribosomal RNA Transcription
    Grierson PM, Lillard K, Behbehani GK, Combs KA, Bhattacharyya S, Acharya S, Groden J
    Hum Mol Genet 2012 Mar 1;21(5):1172-83
  • Chromosome Breakage Is Regulated by the Interaction of the BLM Helicase and Topoisomerase IIalpha
    Russell B, Bhattacharyya S, Keirsey J, Sandy A, Grierson P, Perchiniak E, Kavecansky J, Acharya S, Groden J
    Cancer Res 2011 Jan 15;71(2):561-71

Case Reports

  • Rapid Clinical and Radiographic Response With Combined Dabrafenib and Trametinib in Adults With BRAF-Mutated High-Grade Glioma
    Johanns TM, Ferguson CJ, Grierson PM, Dahiya S, Ansstas G
    J Natl Compr Canc Netw 2018 Jan;16(1):4-10
  • Distinct Clinical and Magnetic Resonance Features of Metastatic Hepatocellular Carcinoma Treated With Pembrolizumab: A Case Report of Late Response After Pseudoprogression
    Grierson P, Crites D, Ruzinova MB, Yano M, Lim KH
    Hepatol Commun 2017 Dec 19;2(2):148-151



Book Chapters

  • Pancreas and Hepatobiliary Cancer
    Grierson P, Pedersen KS
    In: DeVita, Hellman, and Rosenberg's Cancer: Principles & Practice of Oncology Review, 5th Edition (Morgensztern D, Govindan R, Devarakonda S, Trikalinos NA, Editors), Wolters Kluwer, Philadelphia, 2022
  • Approach to a Prolonged Prothrombin Time/Partial Thromboplastin Time
    Grierson PM, Battle NC
    In: The Washington Manual, General Internal Medicine Consult 3rd Ed (Ciesielski TM, ed); Lippincott Williams & Wilkins; Saint Louis, MO; 2017