Malachi Griffith.jpg

Malachi Griffith, PhD

Assistant Professor
Department of Medicine
Oncology Division
Stem Cell Biology
McDonnell Genome Institute

Research Interests

  • Cancer informatics
  • Bioinformatics
  • Genomics
  • Precision medicine


  • 314-286-1274 (phone)
  • 314-286-1810 (fax)
  • Room 5139, 4444 Forest Park Avenue (lab)
  • McDonnell Genome Institute
    Washington University
    Campus Box 8501
    4444 Forest Park Avenue
    St. Louis, MO 63108
  • Website


1996-2002 BSc in Biology (Honors) and Biochemistry, University of Winnipeg, Winnipeg, MB, Canada
2004-2005 Molecular Biology Graduate Exchange, Simon Fraser University, Burnaby, BC, Canada
2004-2010 PhD in Medical Genetics, University of British Columbia, Vancouver, BC, Canada
Academic Positions & Employment
2010-2011 Post-Doctoral Fellow, Michael Smith Genome Sciences Center, Vancouver, BC, Canada
2011-2014 Research Instructor, Genetics, Washington University School of Medicine, St. Louis, MO
2011-2014 Genome Fellow, McDonnell Genome Institute, Washington University School of Medicine, St. Louis, MO
2011-present Instructor, Cold Spring Harbor Laboratory, NY
2011-present Instructor, Canadian Bioinformatics Workshops, Toronto, ON, Canada
2014-2016 Research Assistant Professor, Genetics, Washington University School of Medicine, St. Louis, MO
2014-present Assistant Director, McDonnell Genome Institute, Washington University School of Medicine, St. Louis, MO
2017-present Assistant Professor, Medicine, Washington University School of Medicine, St. Louis, MO
Professional Experience
2000-2003 Research Assistant, Biochemistry and Medical Genetics, Health Sciences Centre, University of Manitoba, Winnipeg, MB, Canada
2003-2004 Computational Biologist/Sequence Finisher, Canada's Michael Smith Genome Sciences Centre, Vancouver, BC, Canada
2012-2013 Consultant, Omic Medicine, St. Louis, MO
2013-present Founder and Consultant, Iterative Genomics, St. Louis, MO
2016-present Consultant, Gerson Lehrman Group, New York, NY
Awards & Honors
1996 University of Winnipeg, Special Entrance Scholarship
1999 University of Winnipeg, Academic Proficiency Scholarship
1999-2002 University of Winnipeg, Student of Highest Distinction
2001 Dr. Edgar Van Nuys Allen Scholarship
2004 University of British Columbia, PhD Tuition Award
2004 Michael Smith Foundation for Health Research, Junior Trainee Award
2004 Natural Sciences and Engineering Research Council, Masters Award
2004 University of British Columbia, Graduate Entrance Scholarship
2005 Natural Sciences and Engineering Research Council, Doctoral Award
2006 Michael Smith Foundation for Health Research, Senior Trainee Award
2008 NCIC and Terry Fox Foundation, Research Studentship
2009 John Bosdet Memorial Fund, Graduate Student Travel Scholarship
2009 Lloyd Skarsgard Research Excellence Prize
2015-2019 NIH/NHGRI K99/R00 Grant
Professional Responsibilities
2007 Conference Chair, Discovery2Diagnostics Conference, 'Emerging Microarrays and Technologies', Philadelphia, PA
2015 Conference Chair, The Clinical Genome Conference, 'Understanding Wellness' session, San Francisco, CA
2016 Methods Workshop Chair, American Association of Cancer Research Annual Meeting, Interpretation of Variants in Cancer, New Orleans, LA
2008-2010 Founding Member, Open Regulatory Annotation Consortium
2012-present Editor, Biostar Consulting LLC
2012-2015 Member, Illumina Sequencing Experts Panel
2013-present Co-organizer, Cancer Informatics Journal Club, The Genome Institute, Washington University
2014-present Professional Member, International Society for Computational Biology (ISCB)
2015-present Active Member, American Association for Cancer Research (AACR)
Bioinformatics Resources Created
2006-present ORegAnno - Open Regulatory Annotation (www.oreganno.org)
2011-present Alternative Expression Analysis of RNA-seq (www.alexaplatform.org)
2012-present RNA-seq analysis workshops (www.bioinformatics.ca/workshops/)
2012-present Bioinformatics tutorials (www.biostars.org/u/3034/)
2013-present GMS - Genome Modeling System (www.github.com/genome/gms/wiki)
2013-present DGIdb - Drug Gene Interaction database (www.dgidb.org)
2013-present rnaseq.wiki - transcriptome analysis on the cloud (www.rnaseq.wiki)
2014-present DoCM - Database of Curated Mutations (www.docm.info)
2015-present CIViC - Clinical interpretation of variants in cancer (www.civicdb.org)
2016-present GenVisR - Genome visualizations in R (github.com/griffithlab/GenVisR)
2016-present pVAC-Seq - A cancer immunotherapy pipeline for the identification of personalized Variant Antigens by Cancer Sequencing (github.com/griffithlab/pVAC-Seq)
2016-present RegTools - Integrated analysis of DNA-seq and RNA-seq data to help identify mutations that have a regulatory effect (github.com/griffithlab/regtools)