Faculty
Oncology Division
Alphabetical list (active faculty):   
Malachi Griffith

Malachi Griffith, PhD

Associate Professor

Department of Medicine

Oncology Division

Stem Cell Biology

Department of Genetics

McDonnell Genome Institute

Research Interests

  • Cancer informatics
  • Bioinformatics
  • Genomics
  • Precision medicine
  • Immunogenomics

Contact

  • 314-286-1274 (office)
  • 314-286-1810 (fax)
  • McDonnell Genome Institute
    Mail Stop 8501-0066-05
    Washington University
    4444 Forest Park Avenue
    St. Louis, MO 63108
  • Room 5139, 4444 Forest Park Avenue (lab)

Peer-reviewed Publications

  • Phase I/Dose Expansion Trial of Brentuximab Vedotin/Lenalidomide in Relapsed or Refractory Diffuse Large B-Cell Lymphoma
    Ward J, Berrien-Elliott MM, Gomez F, Luo J, Becker-Hapak M, Cashen AF, Wagner-Johnston ND, Maddocks K, Mosior M, Foster M, Krysiak K, Schmidt A, Skidmore ZL, Desai S, Watkins MP, Fischer A, Griffith M, Griffith OL, Fehniger TA, Bartlett NL
    Blood 2021 Nov 15; [Epub ahead of print]
  • Characterization of the Genomic and Immunological Diversity of Malignant Brain Tumors Through Multi-Sector Analysis
    Schaettler MO, Richters MM, Wang AZ, Skidmore ZL, Fisk B, Miller KE, Vickery TL, Kim AH, Chicoine MR, Osbun JW, Leuthardt EC, Dowling JL, Zipfel GJ, Dacey RG, Lu HC, Johanns TM, Griffith OL, Mardis ER, Griffith M, Dunn GP
    Cancer Discov 2021 Oct 5; [Epub ahead of print]
  • Exploring the Genomic Landscape of Cancer Patient Cohorts With GenVisR
    Skidmore ZL, Campbell KM, Cotto KC, Griffith M, Griffith OL
    Curr Protoc 2021 Sep;1(9):e252
  • Bam-Readcount -- Rapid Generation of Basepair-Resolution Sequence Metrics
    Khanna A, Larson DE, Srivatsan SN, Mosior M, Abbott TE, Kiwala S, Ley TJ, Duncavage EJ, Walter MJ, Walker JR, Griffith OL, Griffith M, Miller CA
    ArXiv 2021 Jul 27:
  • Immunogenomic Profiling and Pathological Response Results From a Clinical Trial of Docetaxel and Carboplatin in Triple-Negative Breast Cancer
    Ademuyiwa FO, Chen I, Luo J, Rimawi MF, Hagemann IS, Fisk B, Jeffers G, Skidmore ZL, Basu A, Richters M, Ma CX, Weilbaecher K, Davis J, Suresh R, Peterson LL, Bose R, Bagegni N, Rigden CE, Frith A, Rearden TP, Hernandez-Aya LF, Roshal A, Clifton K, Opyrchal M, Akintola-Ogunremi O, Lee BH, Ferrando-Martinez S, Church SE, Anurag M, Ellis MJ, Gao F, Gillanders W, Griffith OL, Griffith M
    Breast Cancer Res Treat 2021 Aug;189(1):187-202
  • Epigenomic Regulation of Human T-Cell Leukemia Virus by Chromatin-Insulator CTCF
    Cheng X, Joseph A, Castro V, Chen-Liaw A, Skidmore Z, Ueno T, Fujisawa JI, Rauch DA, Challen GA, Martinez MP, Green P, Griffith M, Payton JE, Edwards JR, Ratner L
    PLoS Pathog 2021 May 21;17(5):e1009577
  • Yap1 Mediates Trametinib Resistance in Head and Neck Squamous Cell Carcinomas
    Mudianto T, Campbell KM, Webb J, Zolkind P, Skidmore ZL, Riley R, Barnell EK, Ozgenc I, Giri T, Dunn GP, Adkins DR, Griffith M, Egloff AM, Griffith OL, Uppaluri R
    Clin Cancer Res 2021 Apr 15;27(8):2326-2339
  • Phase I Trial of N-803, an IL15 Receptor Agonist, With Rituximab in Patients With Indolent Non-Hodgkin Lymphoma
    Foltz JA, Hess BT, Bachanova V, Bartlett NL, Berrien-Elliott MM, McClain E, Becker-Hapak M, Foster M, Schappe T, Kahl B, Mehta-Shah N, Cashen AF, Marin ND, McDaniels K, Moreno C, Mosior M, Gao F, Griffith OL, Griffith M, Wagner JA, Epperla N, Rock AD, Lee J, Petti AA, Soon-Shiong P, Fehniger TA
    Clin Cancer Res 2021 Jun 15;27(12):3339-3350
  • Unraveling the Chaotic Genomic Landscape of Primary and Metastatic Canine Appendicular Osteosarcoma With Current Sequencing Technologies and Bioinformatic Approaches
    Chu S, Skidmore ZL, Kunisaki J, Walker JR, Griffith M, Griffith OL, Bryan JN
    PLoS One 2021 Feb 8;16(2):e0246443
  • Impact of a 40-Gene Targeted Panel Test on Physician Decision Making for Patients With Acute Myeloid Leukemia
    Barnell EK, Newcomer KF, Skidmore ZL, Krysiak K, Anderson SR, Wartman LD, Oh ST, Welch JS, Stockerl-Goldstein KE, Vij R, Cashen AF, Pusic I, Westervelt P, Abboud CN, Ghobadi A, Uy GL, Schroeder MA, DiPersio JF, Politi MC, Spencer DH, Duncavage EJ, Ley TJ, Griffith M, Jacoby MA, Griffith OL
    JCO Precis Oncol 2021 Jan 14;5
  • Integration of the Drug-Gene Interaction Database (DGIdb 4.0) With Open Crowdsource Efforts
    Freshour SL, Kiwala S, Cotto KC, Coffman AC, McMichael JF, Song JJ, Griffith M, Griffith OL, Wagner AH
    Nucleic Acids Res 2021 Jan 8;49(D1):D1144-D1151
  • Neoadjuvant and Adjuvant Pembrolizumab in Resectable Locally Advanced, Human Papillomavirus-Unrelated Head and Neck Cancer: A Multicenter, Phase II Trial
    Uppaluri R, Campbell KM, Egloff AM, Zolkind P, Skidmore ZL, Nussenbaum B, Paniello RC, Rich JT, Jackson R, Pipkorn P, Michel LS, Ley J, Oppelt P, Dunn GP, Barnell EK, Spies NC, Lin T, Li T, Mulder DT, Hanna Y, Cirlan I, Pugh TJ, Mudianto T, Riley R, Zhou L, Jo VY, Stachler MD, Hanna GJ, Kass J, Haddad R, Schoenfeld JD, Gjini E, Lako A, Thorstad W, Gay HA, Daly M, Rodig SJ, Hagemann IS, Kallogjeri D, Piccirillo JF, Chernock RD, Griffith M, Griffith OL, Adkins DR
    Clin Cancer Res 2020 Oct 1;26(19):5140-5152
  • Collaborative, Multidisciplinary Evaluation of Cancer Variants Through Virtual Molecular Tumor Boards Informs Local Clinical Practices
    Rao S, Pitel B, Wagner AH, Boca SM, McCoy M, King I, Gupta S, Park BH, Warner JL, Chen J, Rogan PK, Chakravarty D, Griffith M, Griffith OL, Madhavan S
    JCO Clin Cancer Inform 2020 Jul;4:602-613
  • The Clonal Evolution of Metastatic Colorectal Cancer
    Dang HX, Krasnick BA, White BS, Grossman JG, Strand MS, Zhang J, Cabanski CR, Miller CA, Fulton RS, Goedegebuure SP, Fronick CC, Griffith M, Larson DE, Goetz BD, Walker JR, Hawkins WG, Strasberg SM, Linehan DC, Lim KH, Lockhart AC, Mardis ER, Wilson RK, Ley TJ, Maher CA, Fields RC
    Sci Adv 2020 Jun 10;6(24):eaay9691
  • Neoantigen Prediction and Computational Perspectives Towards Clinical Benefit: Recommendations From the ESMO Precision Medicine Working Group
    De Mattos-Arruda L, Vazquez M, Finotello F, Lepore R, Porta E, Hundal J, Amengual-Rigo P, Ng CKY, Valencia A, Carrillo J, Chan TA, Guallar V, McGranahan N, Blanco J, Griffith M
    Ann Oncol 2020 Aug;31(8):978-990
  • A Harmonized Meta-Knowledgebase of Clinical Interpretations of Somatic Genomic Variants in Cancer
    Wagner AH, Walsh B, Mayfield G, Tamborero D, Sonkin D, Krysiak K, Deu-Pons J, Duren RP, Gao J, McMurry J, Patterson S, Del Vecchio Fitz C, Pitel BA, Sezerman OU, Ellrott K, Warner JL, Rieke DT, Aittokallio T, Cerami E, Ritter DI, Schriml LM, Freimuth RR, Haendel M, Raca G, Madhavan S, Baudis M, Beckmann JS, Dienstmann R, Chakravarty D, Li XS, Mockus S, Elemento O, Schultz N, Lopez-Bigas N, Lawler M, Goecks J, Griffith M^, Griffith OL^, Margolin AA (^correspinding author)
    Variant Interpretation for Cancer Consortium

    Nat Genet 2020 Apr;52(4):448-457
  • Wikidata as a Knowledge Graph for the Life Sciences
    Waagmeester A, Stupp G, Burgstaller-Muehlbacher S, Good BM, Griffith M, Griffith OL, Hanspers K, Hermjakob H, Hudson TS, Hybiske K, Keating SM, Manske M, Mayers M, Mietchen D, Mitraka E, Pico AR, Putman T, Riutta A, Queralt-Rosinach N, Schriml LM, Shafee T, Slenter D, Stephan R, Thornton K, Tsueng G, Tu R, Ul-Hasan S, Willighagen E, Wu C, Su AI
    Elife 2020 Mar 17;9
  • CIViCpy: A Python Software Development and Analysis Toolkit for the CIViC Knowledgebase
    Wagner AH, Kiwala S, Coffman AC, McMichael JF, Cotto KC, Mooney TB, Barnell EK, Krysiak K, Danos AM, Walker J, Griffith OL^, Griffith M^ (^corresponding author)
    JCO Clin Cancer Inform 2020 Mar;4:245-253
  • PVACtools: A Computational Toolkit to Identify and Visualize Cancer Neoantigens
    Hundal J, Kiwala S, McMichael J, Miller CA, Xia H, Wollam AT, Liu CJ, Zhao S, Feng YY, Graubert AP, Wollam AZ, Neichin J, Neveau M, Walker J, Gillanders WE, Mardis ER, Griffith OL^, Griffith M^ (^corresponding author)
    Cancer Immunol Res 2020 Mar;8(3):409-420
  • Text-Mining Clinically Relevant Cancer Biomarkers for Curation Into the CIViC Database
    Lever J, Jones MR, Danos AM, Krysiak K, Bonakdar M, Grewal JK, Culibrk L, Griffith OL^, Griffith M^, Jones SJM^ (^corresponding author)
    Genome Med 2019 Dec 3;11(1):78
  • Standard Operating Procedure for Curation and Clinical Interpretation of Variants in Cancer
    Danos AM, Krysiak K, Barnell EK, Coffman AC, McMichael JF, Kiwala S, Spies NC, Sheta LM, Pema SP, Kujan L, Clark KA, Wollam AZ, Rao S, Ritter DI, Sonkin D, Raca G, Lin WH, Grisdale CJ, Kim RH, Wagner AH, Madhavan S, Griffith M^, Griffith OL^ (^corresponding author)
    Genome Med 2019 Nov 29;11(1):76
  • Immunological Ignorance Is an Enabling Feature of the Oligo-Clonal T Cell Response to Melanoma Neoantigens
    Linette GP, Becker-Hapak M, Skidmore ZL, Baroja ML, Xu C, Hundal J, Spencer DH, Fu W, Cummins C, Robnett M, Kaabinejadian S, Hildebrand WH, Magrini V, Demeter R, Krupnick AS, Griffith OL, Griffith M, Mardis ER, Carreno BM
    Proc Natl Acad Sci U S A 2019 Nov 19;116(47):23662-23670
  • Open-Sourced CIViC Annotation Pipeline to Identify and Annotate Clinically Relevant Variants Using Single-Molecule Molecular Inversion Probes
    Barnell EK, Waalkes A, Mosior MC, Penewit K, Cotto KC, Danos AM, Sheta LM, Campbell KM, Krysiak K, Rieke D, Spies NC, Skidmore ZL, Pritchard CC, Fehniger TA, Uppaluri R, Govindan R, Griffith M^, Salipante SJ^, Griffith OL^ (^corresponding author)
    JCO Clin Cancer Inform 2019 Oct;3:1-12
  • Rapid Progression of Adult T-Cell Leukemia/Lymphoma as Tumor-Infiltrating Tregs After PD-1 Blockade
    Rauch DA, Conlon KC, Janakiram M, Brammer JE, Harding JC, Ye BH, Zang X, Ren X, Olson S, Cheng X, Miljkovic MD, Sundaramoorthi H, Joseph A, Skidmore ZL, Griffith OL, Griffith M, Waldmann TA, Ratner L
    Blood 2019 Oct 24;134(17):1406-1414
  • A Spontaneous Aggressive ERalpha+ Mammary Tumor Model Is Driven by Kras Activation
    Campbell KM, O'Leary KA, Rugowski DE, Mulligan WA, Barnell EK, Skidmore ZL, Krysiak K, Griffith M, Schuler LA, Griffith OL
    Cell Rep 2019 Aug 6;28(6):1526-1537e4
  • Noninvasive Detection of High-Risk Adenomas Using Stool-Derived Eukaryotic RNA Sequences as Biomarkers
    Barnell EK, Kang Y, Wurtzler EM, Griffith M, Chaudhuri AA, Griffith OL
    Geneoscopy Scientists

    Gastroenterology 2019 Sep;157(3):884-887e3
  • Standard Operating Procedure for Somatic Variant Refinement of Sequencing Data With Paired Tumor and Normal Samples
    Barnell EK, Ronning P, Campbell KM, Krysiak K, Ainscough BJ, Sheta LM, Pema SP, Schmidt AD, Richters M, Cotto KC, Danos AM, Ramirez C, Skidmore ZL, Spies NC, Hundal J, Sediqzad MS, Kunisaki J, Gomez F, Trani L, Matlock M, Wagner AH, Swamidass SJ, Griffith M^, Griffith OL^ (^corresponding author)
    Genet Med 2019 Apr;21(4):972-981
  • Accounting for Proximal Variants Improves Neoantigen Prediction
    Hundal J, Kiwala S, Feng YY, Liu CJ, Govindan R, Chapman WC, Uppaluri R, Swamidass SJ, Griffith OL, Mardis ER, Griffith M
    Nat Genet 2019 Jan;51(1):175-179
  • A Deep Learning Approach to Automate Refinement of Somatic Variant Calling From Cancer Sequencing Data
    Ainscough BJ, Barnell EK, Ronning P, Campbell KM, Wagner AH, Fehniger TA, Dunn GP, Uppaluri R, Govindan R, Rohan TE, Griffith M, Mardis ER, Swamidass SJ, Griffith OL
    Nat Genet 2018 Dec;50(12):1735-1743
  • Adapting Crowdsourced Clinical Cancer Curation in CIViC to the ClinGen Minimum Variant Level Data Community-Driven Standards
    Danos AM, Ritter DI, Wagner AH, Krysiak K, Sonkin D, Micheel C, McCoy M, Rao S, Raca G, Boca SM, Roy A, Barnell EK, McMichael JF, Kiwala S, Coffman AC, Kujan L, Kulkarni S^, Griffith M^, Madhavan S^, Griffith OL^ (^corresponding author)
    Clinical Genome Resource Somatic Working Group and Clinical Interpretation of Variants in Cancer team members

    Hum Mutat 2018 Nov;39(11):1721-1732
  • Recurrent WNT Pathway Alterations Are Frequent in Relapsed Small Cell Lung Cancer
    Wagner AH, Devarakonda S, Skidmore ZL, Krysiak K, Ramu A, Trani L, Kunisaki J, Masood A, Waqar SN, Spies NC, Morgensztern D, Waligorski J, Ponce J, Fulton RS, Maggi LB Jr, Weber JD, Watson MA, O'Conor CJ, Ritter JH, Olsen RR, Cheng H, Mukhopadhyay A, Can I, Cessna MH, Oliver TG, Mardis ER, Wilson RK, Griffith M^, Griffith OL^, Govindan R^ (^corresponding author)
    Nat Commun 2018 Sep 17;9(1):3787
  • The Prognostic Effects of Somatic Mutations in ER-Positive Breast Cancer
    Griffith OL, Spies NC, Anurag M, Griffith M, Luo J, Tu D, Yeo B, Kunisaki J, Miller CA, Krysiak K, Hundal J, Ainscough BJ, Skidmore ZL, Campbell K, Kumar R, Fronick C, Cook L, Snider JE, Davies S, Kavuri SM, Chang EC, Magrini V, Larson DE, Fulton RS, Liu S, Leung S, Voduc D, Bose R, Dowsett M, Wilson RK, Nielsen TO, Mardis ER, Ellis MJ
    Nat Commun 2018 Sep 4;9(1):3476
  • Oral Cavity Squamous Cell Carcinoma Xenografts Retain Complex Genotypes and Intertumor Molecular Heterogeneity
    Campbell KM, Lin T, Zolkind P, Barnell EK, Skidmore ZL, Winkler AE, Law JH, Mardis ER, Wartman LD, Adkins DR, Chernock RD, Griffith M, Uppaluri R, Griffith OL
    Cell Rep 2018 Aug 21;24(8):2167-2178
  • A Case of Acute Myeloid Leukemia With Promyelocytic Features Characterized by Expression of a Novel RARG-CPSF6 Fusion
    Miller CA, Tricarico C, Skidmore ZL, Uy GL, Lee YS, Hassan A, O'Laughlin MD, Schmidt H, Tian L, Duncavage EJ, Griffith M, Griffith OL, Welch JS, Wartman LD
    Blood Adv 2018 Jun 12;2(11):1295-1299
  • Standardizing and Democratizing Access to Cancer Molecular Diagnostic Test Data From Patients to Drive Translational Research
    Madhavan S, Ritter D, Micheel C, Rao S, Roy A, Sonkin D, Mccoy M, Griffith M, Griffith OL, Mcgarvey P, Kulkarni S
    AMIA Jt Summits Transl Sci Proc 2018 May 18;2017:152-159
  • ClinGen Cancer Somatic Working Group - Standardizing and Democratizing Access to Cancer Molecular Diagnostic Data to Drive Translational Research
    Madhavan S, Ritter D, Micheel C, Rao S, Roy A, Sonkin D, Mccoy M, Griffith M, Griffith OL, Mcgarvey P, Kulkarni S
    Pac Symp Biocomput 2018;23:247-258
  • DGIdb 3.0: A Redesign and Expansion of the Drug-Gene Interaction Database
    Cotto KC, Wagner AH, Feng YY, Kiwala S, Coffman AC, Spies G, Wollam A, Spies NC, Griffith OL, Griffith M
    Nucleic Acids Res 2018 Jan 4;46(D1):D1068-D1073
  • Single-Agent Ibrutinib in Relapsed or Refractory Follicular Lymphoma: A Phase 2 Consortium Trial
    Bartlett NL, Costello BA, LaPlant BR, Ansell SM, Kuruvilla JG, Reeder CB, Thye LS, Anderson DM, Krysiak K, Ramirez C, Qi J, Siegel BA, Griffith M, Griffith OL, Gomez F, Fehniger TA
    Blood 2018 Jan 11;131(2):182-190
  • A Phase II Trial of Neoadjuvant MK-2206, an AKT Inhibitor, With Anastrozole in Clinical Stage II or III PIK3CA-Mutant ER-Positive and HER2-Negative Breast Cancer
    Ma CX, Suman V, Goetz MP, Northfelt D, Burkard ME, Ademuyiwa F, Naughton M, Margenthaler J, Aft R, Gray R, Tevaarwerk A, Wilke L, Haddad T, Moynihan T, Loprinzi C, Hieken T, Barnell EK, Skidmore ZL, Feng YY, Krysiak K, Hoog J, Guo Z, Nehring L, Wisinski KB, Mardis E, Hagemann IS, Vij K, Sanati S, Al-Kateb H, Griffith OL, Griffith M, Doyle L, Erlichman C, Ellis MJ
    Clin Cancer Res 2017 Nov 15;23(22):6823-6832
  • Comprehensive Discovery of Noncoding RNAs in Acute Myeloid Leukemia Cell Transcriptomes
    Zhang J, Griffith M, Miller CA, Griffith OL, Spencer DH, Walker JR, Magrini V, McGrath SD, Ly A, Helton NM, Trissal M, Link DC, Dang HX, Larson DE, Kulkarni S, Cordes MG, Fronick CC, Fulton RS, Klco JM, Mardis ER, Ley TJ, Wilson RK, Maher CA
    Exp Hematol 2017 Nov;55:19-33
  • Melorheostosis: Exome Sequencing of an Associated Dermatosis Implicates Postzygotic Mosaicism of Mutated KRAS
    Whyte MP, Griffith M, Trani L, Mumm S, Gottesman GS, McAlister WH, Krysiak K, Lesurf R, Skidmore ZL, Campbell KM, Rosman IS, Bayliss S, Bijanki VN, Nenninger A, Van Tine BA, Griffith OL, Mardis ER
    Bone 2017 Aug;101:145-155
  • NeoPalAna: Neoadjuvant Palbociclib, a Cyclin-Dependent Kinase 4/6 Inhibitor, and Anastrozole for Clinical Stage 2 or 3 Estrogen Receptor-Positive Breast Cancer
    Ma CX, Gao F, Luo J, Northfelt DW, Goetz M, Forero A, Hoog J, Naughton M, Ademuyiwa F, Suresh R, Anderson KS, Margenthaler J, Aft R, Hobday T, Moynihan T, Gillanders W, Cyr A, Eberlein TJ, Hieken T, Krontiras H, Guo Z, Lee MV, Spies NC, Skidmore ZL, Griffith OL, Griffith M, Thomas S, Bumb C, Vij K, Bartlett CH, Koehler M, Al-Kateb H, Sanati S, Ellis MJ
    Clin Cancer Res 2017 Aug 1;23(15):4055-4065
  • Genomic Characterization of HER2-Positive Breast Cancer and Response to Neoadjuvant Trastuzumab and Chemotherapy-Results From the ACOSOG Z1041 (Alliance) Trial
    Lesurf R, Griffith OL, Griffith M, Hundal J, Trani L, Watson MA, Aft R, Ellis MJ, Ota D, Suman VJ, Meric-Bernstam F, Leitch AM, Boughey JC, Unzeitig G, Buzdar AU, Hunt KK, Mardis ER
    Ann Oncol 2017 May 1;28(5):1070-1077
  • CIViC Is a Community Knowledgebase for Expert Crowdsourcing the Clinical Interpretation of Variants in Cancer
    Griffith M*^, Spies NC*, Krysiak K*, McMichael JF, Coffman AC, Danos AM, Ainscough BJ, Ramirez CA, Rieke DT, Kujan L, Barnell EK, Wagner AH, Skidmore ZL, Wollam A, Liu CJ, Jones MR, Bilski RL, Lesurf R, Feng YY, Shah NM, Bonakdar M, Trani L, Matlock M, Ramu A, Campbell KM, Spies GC, Graubert AP, Gangavarapu K, Eldred JM, Larson DE, Walker JR, Good BM, Wu C, Su AI, Dienstmann R, Margolin AA, Tamborero D, Lopez-Bigas N, Jones SJ, Bose R, Spencer DH, Wartman LD, Wilson RK, Mardis ER, Griffith OL^ (*equal contribution; ^corresponding author)
    Nat Genet 2017 Jan 31;49(2):170-174
  • Recurrent Somatic Mutations Affecting B-Cell Receptor Signaling Pathway Genes in Follicular Lymphoma
    Krysiak K, Gomez F, White BS, Matlock M, Miller CA, Trani L, Fronick CC, Fulton RS, Kreisel F, Cashen AF, Carson KR, Berrien-Elliott MM, Bartlett NL, Griffith M^, Griffith OL^, Fehniger TA^ (^corresponding author)
    Blood 2017 Jan 26;129(4):473-483
  • Cancer Immunogenomics: Computational Neoantigen Identification and Vaccine Design
    Hundal J, Miller CA, Griffith M, Griffith OL, Walker J, Kiwala S, Graubert A, McMichael J, Coffman A, Mardis ER
    Cold Spring Harb Symp Quant Biol 2016;81:105-111
  • GenVisR: Genomic Visualizations in R
    Skidmore ZL, Wagner AH, Lesurf R, Campbell KM, Kunisaki J, Griffith OL, Griffith M
    Bioinformatics 2016 Oct 1;32(19):3012-4
  • DoCM: A Database of Curated Mutations in Cancer
    Ainscough BJ, Griffith M^, Coffman AC, Wagner AH, Kunisaki J, Choudhary MN, McMichael JF, Fulton RS, Wilson RK, Griffith OL^, Mardis ER (^corresponding author)
    Nat Methods 2016 Sep 29;13(10):806-7
  • Truncating Prolactin Receptor Mutations Promote Tumor Growth in Murine Estrogen Receptor-Alpha Mammary Carcinomas
    Griffith OL, Chan SR, Griffith M, Krysiak K, Skidmore ZL, Hundal J, Allen JA, Arthur CD, Runci D, Bugatti M, Miceli AP, Schmidt H, Trani L, Kanchi KL, Miller CA, Larson DE, Fulton RS, Vermi W, Wilson RK, Schreiber RD, Mardis ER
    Cell Rep 2016 Sep 27;17(1):249-60
  • Aromatase Inhibition Remodels the Clonal Architecture of Estrogen-Receptor-Positive Breast Cancers
    Miller CA, Gindin Y, Lu C, Griffith OL, Griffith M, Shen D, Hoog J, Li T, Larson DE, Watson M, Davies SR, Hunt K, Suman VJ, Snider J, Walsh T, Colditz GA, DeSchryver K, Wilson RK, Mardis ER, Ellis MJ
    Nat Commun 2016 Aug 9;7:12498
  • Comprehensive Genomic Analysis Reveals FLT3 Activation and a Therapeutic Strategy for a Patient With Relapsed Adult B-Lymphoblastic Leukemia
    Griffith M*^, Griffith OL*, Krysiak K, Skidmore ZL, Christopher MJ, Klco JM, Ramu A, Lamprecht TL, Wagner AH, Campbell KM, Lesurf R, Hundal J, Zhang J, Spies NC, Ainscough BJ, Larson DE, Heath SE, Fronick C, O'Laughlin S, Fulton RS, Magrini V, McGrath S, Smith SM, Miller CA, Maher CA, Payton JE, Walker JR, Eldred JM, Walter MJ, Link DC, Graubert TA, Westervelt P, Kulkarni S, DiPersio JF, Mardis ER, Wilson RK, Ley TJ^ (*equal contribution; ^corresponding author)
    Exp Hematol 2016 Jul;44(7):603-13
  • A Genomic Analysis of Philadelphia Chromosome-Negative AML Arising in Patients With CML
    Krysiak K, Christopher MJ, Skidmore ZL, Demeter RT, Magrini V, Kunisaki J, O'Laughlin M, Duncavage EJ, Miller CA, Ozenberger BA, Griffith M, Wartman LD, Griffith OL
    Blood Cancer J 2016 Apr 8;6:e413
  • A Phase I Trial of BKM120 (Buparlisib) in Combination With Fulvestrant in Postmenopausal Women With Estrogen Receptor-Positive Metastatic Breast Cancer
    Ma CX, Luo J, Naughton M, Ademuyiwa F, Suresh R, Griffith M, Griffith OL, Skidmore ZL, Spies NC, Ramu A, Trani L, Pluard T, Nagaraj G, Thomas S, Guo Z, Hoog J, Han J, Mardis E, Lockhart C, Ellis MJ
    Clin Cancer Res 2016 Apr 1;22(7):1583-91
  • A Genomic Case Study of Mixed Fibrolamellar Hepatocellular Carcinoma
    Griffith OL*, Griffith M*, Krysiak K, Magrini V, Ramu A, Skidmore ZL, Kunisaki J, Austin R, McGrath S, Zhang J, Demeter R, Graves T, Eldred JM, Walker J, Larson DE, Maher CA, Lin Y, Chapman W, Mahadevan A, Miksad R, Nasser I, Hanto DW, Mardis ER (*equal contribution)
    Ann Oncol 2016 Jun;27(6):1148-54
  • PVAC-Seq: A Genome-Guided in Silico Approach to Identifying Tumor Neoantigens
    Hundal J, Carreno BM, Petti AA, Linette GP, Griffith OL, Mardis ER, Griffith M
    Genome Med 2016 Jan 29;8(1):11
  • ORegAnno 3.0: A Community-Driven Resource for Curated Regulatory Annotation
    Lesurf R, Cotto KC, Wang G, Griffith M, Kasaian K, Jones SJ, Montgomery SB, Griffith OL
    Nucleic Acids Res 2016 Jan 4;44(D1):D126-32
  • DGIdb 2.0: Mining Clinically Relevant Drug-Gene Interactions
    Wagner AH, Coffman AC, Ainscough BJ, Spies NC, Skidmore ZL, Campbell KM, Krysiak K, Pan D, McMichael JF, Eldred JM, Walker JR, Wilson RK, Mardis ER, Griffith M^, Griffith OL^ (^corresponding author)
    Nucleic Acids Res 2016 Jan 4;44(D1):D1036-44
  • A Common Founding Clone With TP53 and PTEN Mutations Gives Rise to a Concurrent Germ Cell Tumor and Acute Megakaryoblastic Leukemia
    Lu C, Riedell P, Miller CA, Hagemann IS, Westervelt P, Ozenberger BA, O'Laughlin M, Magrini V, Demeter RT, Duncavage EJ, Griffith M, Griffith OL, Wartman LD
    Cold Spring Harb Mol Case Stud 2016 Jan;2(1):a000687
  • RNA Sequencing of Tumor-Associated Microglia Reveals Ccl5 as a Stromal Chemokine Critical for Neurofibromatosis-1 Glioma Growth
    Solga AC, Pong WW, Kim KY, Cimino PJ, Toonen JA, Walker J, Wylie T, Magrini V, Griffith M, Griffith OL, Ly A, Ellisman MH, Mardis ER, Gutmann DH
    Neoplasia 2015 Oct;17(10):776-88
  • Optimizing Cancer Genome Sequencing and Analysis
    Griffith M*, Miller CA*, Griffith OL, Krysiak K, Skidmore ZL, Ramu A, Walker JR, Dang HX, Trani L, Larson DE, Demeter RT, Wendl MC, McMichael JF, Austin RE, Magrini V, McGrath SD, Ly A, Kulkarni S, Cordes MG, Fronick CC, Fulton RS, Maher CA, Ding L, Klco JM, Mardis ER, Ley TJ, Wilson RK (*equal contribution)
    Cell Syst 2015 Sep 23;1(3):210-223
  • Association Between Mutation Clearance After Induction Therapy and Outcomes in Acute Myeloid Leukemia
    Klco JM, Miller CA, Griffith M, Petti A, Spencer DH, Ketkar-Kulkarni S, Wartman LD, Christopher M, Lamprecht TL, Helton NM, Duncavage EJ, Payton JE, Baty J, Heath SE, Griffith OL, Shen D, Hundal J, Chang GS, Fulton R, O'Laughlin M, Fronick C, Magrini V, Demeter RT, Larson DE, Kulkarni S, Ozenberger BA, Welch JS, Walter MJ, Graubert TA, Westervelt P, Radich JP, Link DC, Mardis ER, DiPersio JF, Wilson RK, Ley TJ
    JAMA 2015 Aug 25;314(8):811-22
  • Informatics for RNA Sequencing: A Web Resource for Analysis on the Cloud
    Griffith M^, Walker JR, Spies NC, Ainscough BJ, Griffith OL^ (^corresponding author)
    PLoS Comput Biol 2015 Aug 6;11(8):e1004393
  • Genome Modeling System: A Knowledge Management Platform for Genomics
    Griffith M*^, Griffith OL*^, Smith SM, Ramu A, Callaway MB, Brummett AM, Kiwala MJ, Coffman AC, Regier AA, Oberkfell BJ, Sanderson GE, Mooney TP, Nutter NG, Belter EA, Du F, Long RL, Abbott TE, Ferguson IT, Morton DL, Burnett MM, Weible JV, Peck JB, Dukes A, McMichael JF, Lolofie JT, Derickson BR, Hundal J, Skidmore ZL, Ainscough BJ, Dees ND, Schierding WS, Kandoth C, Kim KH, Lu C, Harris CC, Maher N, Maher CA, Magrini VJ, Abbott BS, Chen K, Clark E, Das I, Fan X, Hawkins AE, Hepler TG, Wylie TN, Leonard SM, Schroeder WE, Shi X, Carmichael LK, Weil MR, Wohlstadter RW, Stiehr G, McLellan MD, Pohl CS, Miller CA, Koboldt DC, Walker JR, Eldred JM, Larson DE, Dooling DJ, Ding L, Mardis ER, Wilson RK (*equal contribution; ^corresponding author)
    PLoS Comput Biol 2015 Jul 9;11(7):e1004274
  • Mutant U2AF1 Expression Alters Hematopoiesis and Pre-mRNA Splicing in Vivo
    Shirai CL, Ley JN, White BS, Kim S, Tibbitts J, Shao J, Ndonwi M, Wadugu B, Duncavage EJ, Okeyo-Owuor T, Liu T, Griffith M, McGrath S, Magrini V, Fulton RS, Fronick C, O'Laughlin M, Graubert TA, Walter MJ
    Cancer Cell 2015 May 11;27(5):631-43
  • U2AF1 Mutations Alter Sequence Specificity of Pre-mRNA Binding and Splicing
    Okeyo-Owuor T, White BS, Chatrikhi R, Mohan DR, Kim S, Griffith M, Ding L, Ketkar-Kulkarni S, Hundal J, Laird KM, Kielkopf CL, Ley TJ, Walter MJ, Graubert TA
    Leukemia 2015 Apr;29(4):909-17
  • RNA-Sequencing Reveals Oligodendrocyte and Neuronal Transcripts in Microglia Relevant to Central Nervous System Disease
    Solga AC, Pong WW, Walker J, Wylie T, Magrini V, Apicelli AJ, Griffith M, Griffith OL, Kohsaka S, Wu GF, Brody DL, Mardis ER, Gutmann DH
    Glia 2015 Apr;63(4):531-48
  • Epigenetic and Transcriptional Determinants of the Human Breast
    Gascard P, Bilenky M, Sigaroudinia M, Zhao J, Li L, Carles A, Delaney A, Tam A, Kamoh B, Cho S, Griffith M, Chu A, Robertson G, Cheung D, Li I, Heravi-Moussavi A, Moksa M, Mingay M, Hussainkhel A, Davis B, Nagarajan RP, Hong C, Echipare L, O'Geen H, Hangauer MJ, Cheng JB, Neel D, Hu D, McManus MT, Moore R, Mungall A, Ma Y, Plettner P, Ziv E, Wang T, Farnham PJ, Jones SJ, Marra MA, Tlsty TD, Costello JF, Hirst M
    Nat Commun 2015 Feb 18;6:6351
  • Convergent Loss of PTEN Leads to Clinical Resistance to a PI(3)Kalpha Inhibitor
    Juric D, Castel P, Griffith M, Griffith OL, Won HH, Ellis H, Ebbesen SH, Ainscough BJ, Ramu A, Iyer G, Shah RH, Huynh T, Mino-Kenudson M, Sgroi D, Isakoff S, Thabet A, Elamine L, Solit DB, Lowe SW, Quadt C, Peters M, Derti A, Schegel R, Huang A, Mardis ER, Berger MF, Baselga J, Scaltriti M
    Nature 2015 Feb 12;518(7538):240-4
  • Clonal Architectures and Driver Mutations in Metastatic Melanomas
    Ding L, Kim M, Kanchi KL, Dees ND, Lu C, Griffith M, Fenstermacher D, Sung H, Miller CA, Goetz B, Wendl MC, Griffith O, Cornelius LA, Linette GP, McMichael JF, Sondak VK, Fields RC, Ley TJ, Mule JJ, Wilson RK, Weber JS
    PLoS One 2014 Nov 13;9(11):e111153
  • Hippo Signaling Influences HNF4A and FOXA2 Enhancer Switching During Hepatocyte Differentiation
    Alder O, Cullum R, Lee S, Kan AC, Wei W, Yi Y, Garside VC, Bilenky M, Griffith M, Morrissy AS, Robertson GA, Thiessen N, Zhao Y, Chen Q, Pan D, Jones SJ, Marra MA, Hoodless PA
    Cell Rep 2014 Oct 9;9(1):261-71
  • SciClone: Inferring Clonal Architecture and Tracking the Spatial and Temporal Patterns of Tumor Evolution
    Miller CA, White BS, Dees ND, Griffith M, Welch JS, Griffith OL, Vij R, Tomasson MH, Graubert TA, Walter MJ, Ellis MJ, Schierding W, DiPersio JF, Ley TJ, Mardis ER, Wilson RK, Ding L
    PLoS Comput Biol 2014 Aug 7;10(8):e1003665
  • cDNA Hybrid Capture Improves Transcriptome Analysis on Low-Input and Archived Samples
    Cabanski CR, Magrini V, Griffith M, Griffith OL, McGrath S, Zhang J, Walker J, Ly A, Demeter R, Fulton RS, Pong WW, Gutmann DH, Govindan R, Mardis ER, Maher CA
    J Mol Diagn 2014 Jul;16(4):440-51
  • Single Exon-Resolution Targeted Chromosomal Microarray Analysis of Known and Candidate Intellectual Disability Genes
    Tucker T, Zahir FR, Griffith M, Delaney A, Chai D, Tsang E, Lemyre E, Dobrzeniecka S, Marra M, Eydoux P, Langlois S, Hamdan FF, Michaud JL, Friedman JM
    Eur J Hum Genet 2014 Jun;22(6):792-800
  • Functional Heterogeneity of Genetically Defined Subclones in Acute Myeloid Leukemia
    Klco JM, Spencer DH, Miller CA, Griffith M, Lamprecht TL, O'Laughlin M, Fronick C, Magrini V, Demeter RT, Fulton RS, Eades WC, Link DC, Graubert TA, Walter MJ, Mardis ER, Dipersio JF, Wilson RK, Ley TJ
    Cancer Cell 2014 Mar 17;25(3):379-92
  • Modeling Precision Treatment of Breast Cancer
    Daemen A, Griffith OL, Heiser LM, Wang NJ, Enache OM, Sanborn Z, Pepin F, Durinck S, Korkola JE, Griffith M, Hur JS, Huh N, Chung J, Cope L, Fackler MJ, Umbricht C, Sukumar S, Seth P, Sukhatme VP, Jakkula LR, Lu Y, Mills GB, Cho RJ, Collisson EA, van't Veer LJ, Spellman PT, Gray JW
    Genome Biol 2013;14(10):R110
  • DGIdb: Mining the Druggable Genome
    Griffith M*^, Griffith OL*^, Coffman AC, Weible JV, McMichael JF, Spies NC, Koval J, Das I, Callaway MB, Eldred JM, Miller CA, Subramanian J, Govindan R, Kumar RD, Bose R, Ding L, Walker JR, Larson DE, Dooling DJ, Smith SM, Ley TJ, Mardis ER, Wilson RK (*equal contribution; ^corresponding author)
    Nat Methods 2013 Dec;10(12):1209-10
  • F11R Is a Novel Monocyte Prognostic Biomarker for Malignant Glioma
    Pong WW, Walker J, Wylie T, Magrini V, Luo J, Emnett RJ, Choi J, Cooper ML, Griffith M, Griffith OL, Rubin JB, Fuller GN, Piwnica-Worms D, Feng X, Hambardzumyan D, DiPersio JF, Mardis ER, Gutmann DH
    PLoS One 2013 Oct 11;8(10):e77571
  • Novel mRNA Isoforms and Mutations of Uridine Monophosphate Synthetase and 5-Fluorouracil Resistance in Colorectal Cancer
    Griffith M, Mwenifumbo JC, Cheung PY, Paul JE, Pugh TJ, Tang MJ, Chittaranjan S, Morin RD, Asano JK, Ally AA, Miao L, Lee A, Chan SY, Taylor G, Severson T, Hou YC, Griffith OL, Cheng GS, Novik K, Moore R, Luk M, Owen D, Brown CJ, Morin GB, Gill S, Tai IT, Marra MA
    Pharmacogenomics J 2013 Apr;13(2):148-58
  • Interaction of Cyclin-Dependent Kinase 12/CrkRS With Cyclin K1 Is Required for the Phosphorylation of the C-Terminal Domain of RNA Polymerase II
    Cheng SW, Kuzyk MA, Moradian A, Ichu TA, Chang VC, Tien JF, Vollett SE, Griffith M, Marra MA, Morin GB
    Mol Cell Biol 2012 Nov;32(22):4691-704
  • Genomic Landscape of Non-Small Cell Lung Cancer in Smokers and Never-Smokers
    Govindan R, Ding L, Griffith M, Subramanian J, Dees ND, Kanchi KL, Maher CA, Fulton R, Fulton L, Wallis J, Chen K, Walker J, McDonald S, Bose R, Ornitz D, Xiong D, You M, Dooling DJ, Watson M, Mardis ER, Wilson RK
    Cell 2012 Sep 14;150(6):1121-34
  • The Clonal and Mutational Evolution Spectrum of Primary Triple-Negative Breast Cancers
    Shah SP, Roth A, Goya R, Oloumi A, Ha G, Zhao Y, Turashvili G, Ding J, Tse K, Haffari G, Bashashati A, Prentice LM, Khattra J, Burleigh A, Yap D, Bernard V, McPherson A, Shumansky K, Crisan A, Giuliany R, Heravi-Moussavi A, Rosner J, Lai D, Birol I, Varhol R, Tam A, Dhalla N, Zeng T, Ma K, Chan SK, Griffith M, Moradian A, Cheng SW, Morin GB, Watson P, Gelmon K, Chia S, Chin SF, Curtis C, Rueda OM, Pharoah PD, Damaraju S, Mackey J, Hoon K, Harkins T, Tadigotla V, Sigaroudinia M, Gascard P, Tlsty T, Costello JF, Meyer IM, Eaves CJ, Wasserman WW, Jones S, Huntsman D, Hirst M, Caldas C, Marra MA, Aparicio S
    Nature 2012 Apr 4;486(7403):395-9
  • Extensive Relationship Between Antisense Transcription and Alternative Splicing in the Human Genome
    Morrissy AS, Griffith M, Marra MA
    Genome Res 2011 Aug;21(8):1203-12
  • Frequent Mutation of Histone-Modifying Genes in Non-Hodgkin Lymphoma
    Morin RD, Mendez-Lago M, Mungall AJ, Goya R, Mungall KL, Corbett RD, Johnson NA, Severson TM, Chiu R, Field M, Jackman S, Krzywinski M, Scott DW, Trinh DL, Tamura-Wells J, Li S, Firme MR, Rogic S, Griffith M, Chan S, Yakovenko O, Meyer IM, Zhao EY, Smailus D, Moksa M, Chittaranjan S, Rimsza L, Brooks-Wilson A, Spinelli JJ, Ben-Neriah S, Meissner B, Woolcock B, Boyle M, McDonald H, Tam A, Zhao Y, Delaney A, Zeng T, Tse K, Butterfield Y, Birol I, Holt R, Schein J, Horsman DE, Moore R, Jones SJ, Connors JM, Hirst M, Gascoyne RD, Marra MA
    Nature 2011 Jul 27;476(7360):298-303
  • DeFuse: An Algorithm for Gene Fusion Discovery in Tumor RNA-Seq Data
    McPherson A, Hormozdiari F, Zayed A, Giuliany R, Ha G, Sun MG, Griffith M, Heravi Moussavi A, Senz J, Melnyk N, Pacheco M, Marra MA, Hirst M, Nielsen TO, Sahinalp SC, Huntsman D, Shah SP
    PLoS Comput Biol 2011 May;7(5):e1001138
  • De Novo Assembly and Analysis of RNA-Seq Data
    Robertson G, Schein J, Chiu R, Corbett R, Field M, Jackman SD, Mungall K, Lee S, Okada HM, Qian JQ, Griffith M, Raymond A, Thiessen N, Cezard T, Butterfield YS, Newsome R, Chan SK, She R, Varhol R, Kamoh B, Prabhu AL, Tam A, Zhao Y, Moore RA, Hirst M, Marra MA, Jones SJ, Hoodless PA, Birol I
    Nat Methods 2010 Nov;7(11):909-12
  • Alternative Expression Analysis by RNA Sequencing
    Griffith M, Griffith OL, Mwenifumbo J, Goya R, Morrissy AS, Morin RD, Corbett R, Tang MJ, Hou YC, Pugh TJ, Robertson G, Chittaranjan S, Ally A, Asano JK, Chan SY, Li HI, McDonald H, Teague K, Zhao Y, Zeng T, Delaney A, Hirst M, Morin GB, Jones SJ, Tai IT, Marra MA
    Nat Methods 2010 Oct;7(10):843-7
  • Evolution of an Adenocarcinoma in Response to Selection by Targeted Kinase Inhibitors
    Jones SJ, Laskin J, Li YY, Griffith OL, An J, Bilenky M, Butterfield YS, Cezard T, Chuah E, Corbett R, Fejes AP, Griffith M, Yee J, Martin M, Mayo M, Melnyk N, Morin RD, Pugh TJ, Severson T, Shah SP, Sutcliffe M, Tam A, Terry J, Thiessen N, Thomson T, Varhol R, Zeng T, Zhao Y, Moore RA, Huntsman DG, Birol I, Hirst M, Holt RA, Marra MA
    Genome Biol 2010;11(8):R82
  • Methods for Transcript Variant Discovery and Alternative Expression Analysis - Application to the Study of 5-FU Resistance in Colorectal Cancer
    Griffith M
    PhD dissertation. 2010. University of British Columbia, Vancouver, BC, Canada
  • The Completion of the Mammalian Gene Collection (MGC)
    Temple G, Gerhard DS, Rasooly R, Feingold EA, Good PJ, Robinson C, Mandich A, Derge JG, Lewis J, Shoaf D, Collins FS, Jang W, Wagner L, Shenmen CM, Misquitta L, Schaefer CF, Buetow KH, Bonner TI, Yankie L, Ward M, Phan L, Astashyn A, Brown G, Farrell C, Hart J, Landrum M, Maidak BL, Murphy M, Murphy T, Rajput B, Riddick L, Webb D, Weber J, Wu W, Pruitt KD, Maglott D, Siepel A, Brejova B, Diekhans M, Harte R, Baertsch R, Kent J, Haussler D, Brent M, Langton L, Comstock CL, Stevens M, Wei C, van Baren MJ, Salehi-Ashtiani K, Murray RR, Ghamsari L, Mello E, Lin C, Pennacchio C, Schreiber K, Shapiro N, Marsh A, Pardes E, Moore T, Lebeau A, Muratet M, Simmons B, Kloske D, Sieja S, Hudson J, Sethupathy P, Brownstein M, Bhat N, Lazar J, Jacob H, Gruber CE, Smith MR, McPherson J, Garcia AM, Gunaratne PH, Wu J, Muzny D, Gibbs RA, Young AC, Bouffard GG, Blakesley RW, Mullikin J, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Hirst M, Zeng T, Tse K, Moksa M, Deng M, Ma K, Mah D, Pang J, Taylor G, Chuah E, Deng A, Fichter K, Go A, Lee S, Wang J, Griffith M, Morin R, Moore RA, Mayo M, Munro S, Wagner S, Jones SJ, Holt RA, Marra MA, Lu S, Yang S, Hartigan J, Graf M, Wagner R, Letovksy S, Pulido JC, Robison K, Esposito D, Hartley J, Wall VE, Hopkins RF, Ohara O, Wiemann S
    Genome Res 2009 Dec;19(12):2324-33
  • In-Depth Characterization of the MicroRNA Transcriptome in a Leukemia Progression Model
    Kuchenbauer F, Morin RD, Argiropoulos B, Petriv OI, Griffith M, Heuser M, Yung E, Piper J, Delaney A, Prabhu AL, Zhao Y, McDonald H, Zeng T, Hirst M, Hansen CL, Marra MA, Humphries RK
    Genome Res 2008 Nov;18(11):1787-97
  • Impact of Whole Genome Amplification on Analysis of Copy Number Variants
    Pugh TJ, Delaney AD, Farnoud N, Flibotte S, Griffith M, Li HI, Qian H, Farinha P, Gascoyne RD, Marra MA
    Nucleic Acids Res 2008 Aug;36(13):e80
  • Application of Massively Parallel Sequencing to MicroRNA Profiling and Discovery in Human Embryonic Stem Cells
    Morin RD, O'Connor MD, Griffith M, Kuchenbauer F, Delaney A, Prabhu AL, Zhao Y, McDonald H, Zeng T, Hirst M, Eaves CJ, Marra MA
    Genome Res 2008 Apr;18(4):610-21
  • ALEXA: A Microarray Design Platform for Alternative Expression Analysis
    Griffith M, Tang MJ, Griffith OL, Morin RD, Chan SY, Asano JK, Zeng T, Flibotte S, Ally A, Baross A, Hirst M, Jones SJ, Morin GB, Tai IT, Marra MA
    Nat Methods 2008 Feb;5(2):118
  • ORegAnno: An Open-Access Community-Driven Resource for Regulatory Annotation
    Griffith OL, Montgomery SB, Bernier B, Chu B, Kasaian K, Aerts S, Mahony S, Sleumer MC, Bilenky M, Haeussler M, Griffith M, Gallo SM, Giardine B, Hooghe B, Van Loo P, Blanco E, Ticoll A, Lithwick S, Portales-Casamar E, Donaldson IJ, Robertson G, Wadelius C, De Bleser P, Vlieghe D, Halfon MS, Wasserman W, Hardison R, Bergman CM, Jones SJ
    Nucleic Acids Res 2008 Jan;36(Database issue):D107-13
  • Analysis of the Prostate Cancer Cell Line LNCaP Transcriptome Using a Sequencing-By-Synthesis Approach
    Bainbridge MN, Warren RL, Hirst M, Romanuik T, Zeng T, Go A, Delaney A, Griffith M, Hickenbotham M, Magrini V, Mardis ER, Sadar MD, Siddiqui AS, Marra MA, Jones SJ
    BMC Genomics 2006 Sep 29;7:246
  • Sequencing and Analysis of 10,967 Full-Length cDNA Clones From Xenopus Laevis and Xenopus Tropicalis Reveals Post-Tetraploidization Transcriptome Remodeling
    Morin RD, Chang E, Petrescu A, Liao N, Griffith M, Chow W, Kirkpatrick R, Butterfield YS, Young AC, Stott J, Barber S, Babakaiff R, Dickson MC, Matsuo C, Wong D, Yang GS, Smailus DE, Wetherby KD, Kwong PN, Grimwood J, Brinkley CP 3rd, Brown-John M, Reddix-Dugue ND, Mayo M, Schmutz J, Beland J, Park M, Gibson S, Olson T, Bouffard GG, Tsai M, Featherstone R, Chand S, Siddiqui AS, Jang W, Lee E, Klein SL, Blakesley RW, Zeeberg BR, Narasimhan S, Weinstein JN, Pennacchio CP, Myers RM, Green ED, Wagner L, Gerhard DS, Marra MA, Jones SJ, Holt RA
    Genome Res 2006 Jun;16(6):796-803
  • Novel Avian Influenza H7N3 Strain Outbreak, British Columbia
    Hirst M, Astell CR, Griffith M, Coughlin SM, Moksa M, Zeng T, Smailus DE, Holt RA, Jones S, Marra MA, Petric M, Krajden M, Lawrence D, Mak A, Chow R, Skowronski DM, Tweed SA, Goh S, Brunham RC, Robinson J, Bowes V, Sojonky K, Byrne SK, Li Y, Kobasa D, Booth T, Paetzel M
    Emerg Infect Dis 2004 Dec;10(12):2192-5
  • The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)
    Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J
    Genome Res 2004 Oct;14(10B):2121-7
  • Systematic Recovery and Analysis of Full-ORF Human cDNA Clones
    Baross A, Butterfield YS, Coughlin SM, Zeng T, Griffith M, Griffith OL, Petrescu AS, Smailus DE, Khattra J, McDonald HL, McKay SJ, Moksa M, Holt RA, Marra MA
    Genome Res 2004 Oct;14(10B):2083-92
  • Escherichia Coli EndA Deletion Strain for Use in Two-Hybrid Shuttle Vector Selection
    Griffith M, Gietz RD
    Biotechniques 2003 Aug;35(2):272-4, 276, 278
  • Genetic Modification of the Escherichia Coli Strain DH5α to Allow the Selection of Plasmids Carrying Complementary Yeast Genes
    Griffith M
    Honors thesis. 2002. University of Winnipeg, Winnipeg, MB, Canada

Invited Publications

  • Genetic Ancestry Correlations With Driver Mutations Suggest Complex Interactions Between Somatic and Germline Variation in Cancer
    Gomez F, Griffith M, Griffith OL
    Cancer Discov 2021 Mar;11(3):534-536
  • Response to GASTRO-D-19-02091
    Barnell EK, Kang Y, Wurtzler EM, Griffith M, Chaudhuri AA, Griffith OL
    Gastroenterology 2020 Feb;158(3):793-794
  • Best Practices for Bioinformatic Characterization of Neoantigens for Clinical Utility
    Richters MM, Xia H, Campbell KM, Gillanders WE, Griffith OL, Griffith M
    Genome Med 2019 Aug 28;11(1):56
  • Clinical Implications of Neoepitope Landscapes for Adult and Pediatric Cancers
    Feng YY, Griffith OL, Griffith M
    Genome Med 2017 Aug 31;9(1):77
  • Neoantigens in Immunotherapy and Personalized Vaccines: Implications for Head and Neck Squamous Cell Carcinoma
    Zolkind P, Dunn GP, Lin T, Griffith M, Griffith OL, Uppaluri R
    Oral Oncol 2017 Aug;71:169-176
  • Nucleic Acid Databases
    Griffith M, Griffith OL
    In: Concise Encyclopaedia of Bioinformatics and Computational Biology. Hancock JM, Zvelebil MJ, editors. John Wiley & Sons. Hoboken, NJ. 2014. ISBN: 978-1-118-59816-0
  • Alternative Expression Analysis: Experimental and Bioinformatic Approaches for the Analysis of Transcript Diversity
    Griffith M, Marra MA
    In: Genes Genomes and Genomics, Volume 2 (Chapter 12), p 201-242, Regency Publications, New Delhi, 2007