Faculty
Hematology Division
Alphabetical list (active faculty):   
Brenda J. Grossman

Brenda J. Grossman, MD, MPH

Professor

Department of Medicine

Hematology Division

Department of Pathology & Immunology

Clinical Interests

  • Immunohematology
  • Transfusion practice
  • Therapeutic apheresis
  • Photophersis

Contact

  • 314-362-6032 (office)
  • 314-362-1461 (fax)
  • Division of Laboratory & Genomic Medicine
    Mail Stop 8118-0004-04
    Washington University
    660 South Euclid Avenue
    St. Louis, MO 63110
  • 4th Floor BJC Institute of Health (office)

Peer-reviewed Manuscripts

  • ABO Blood Group and SARS-CoV-2 Antibody Response in a Convalescent Donor Population
    Bloch EM, Patel EU, Marshall C, Littlefield K, Goel R, Grossman BJ, Winters JL, Shrestha R, Burgess I, Laeyendecker O, Shoham S, Sullivan D, Gehrie EA, Redd AD, Quinn TC, Casadevall A, Pekosz A, Tobian AAR
    Vox Sang 2021 Aug;116(7):766-773
  • Convalescent Plasma Therapy for COVID-19: A Graphical Mosaic of the Worldwide Evidence
    Klassen SA, Senefeld JW, Senese KA, Johnson PW, Wiggins CC, Baker SE, van Helmond N, Bruno KA, Pirofski LA, Shoham S, Grossman BJ, Henderson JP, Wright RS, Fairweather D, Paneth NS, Carter RE, Casadevall A, Joyner MJ
    Front Med (Lausanne) 2021 Jun 7;8:684151
  • The Effect of Convalescent Plasma Therapy on Mortality Among Patients With COVID-19: Systematic Review and Meta-Analysis
    Klassen SA, Senefeld JW, Johnson PW, Carter RE, Wiggins CC, Shoham S, Grossman BJ, Henderson JP, Musser J, Salazar E, Hartman WR, Bouvier NM, Liu STH, Pirofski LA, Baker SE, van Helmond N, Wright RS, Fairweather D, Bruno KA, Wang Z, Paneth NS, Casadevall A, Joyner MJ
    Mayo Clin Proc 2021 May;96(5):1262-1275
  • COVID-19 Convalescent Plasma: Interim Recommendations From the AABB
    Cohn CS, Estcourt L, Grossman BJ, Pagano MB, Allen ES, Bloch EM, Casadevall A, Devine DV, Dunbar NM, Foroutan F, Gniadek TJ, Goel R, Gorlin J, Joyner MJ, Metcalf RA, Raval JS, Rice TW, Shaz BH, Vassallo RR, Winters JL, Beaudoin G, Tobian AAR
    Transfusion 2021 Apr;61(4):1313-1323
  • Therapeutic Plasma Exchange for Iatrogenic Hypertrigylceridemia
    Gau N, Grossman BJ
    Transfusion 2020 Dec;60(12):2785-2786
  • The Assessment of Convalescent Plasma Efficacy Against COVID-19
    Casadevall A, Grossman BJ, Henderson JP, Joyner MJ, Shoham S, Pirofski LA, Paneth N
    Med (N Y) 2020 Dec 18;1(1):66-77
  • Deployment of Convalescent Plasma for the Prevention and Treatment of COVID-19
    Bloch EM, Shoham S, Casadevall A, Sachais BS, Shaz B, Winters JL, van Buskirk C, Grossman BJ, Joyner M, Henderson JP, Pekosz A, Lau B, Wesolowski A, Katz L, Shan H, Auwaerter PG, Thomas D, Sullivan DJ, Paneth N, Gehrie E, Spitalnik S, Hod EA, Pollack L, Nicholson WT, Pirofski LA, Bailey JA, Tobian AA
    J Clin Invest 2020 Jun 1;130(6):2757-2765
  • The CELLEX Is Comparable to the UVAR-XTS for the Treatment of Acute and Chronic Graft Versus Host Disease (GVHD)
    Afzal A, Tarbunova M, Despotis G, Grossman BJ
    Transfusion 2020 Feb;60(2):351-357
  • Familial Haploidentical Stem Cell Transplant in Children and Adolescents With High-Risk Sickle Cell Disease: A Phase 2 Clinical Trial
    Cairo MS, Talano JA, Moore TB, Shi Q, Weinberg RS, Grossman B, Shenoy S
    JAMA Pediatr 2019 Dec 9;174(2):195-197
  • Pathogen Reduced Plasma Products: A Clinical Practice Scientific Review From the AABB
    Cushing MM, Pagano MB, Jacobson J, Schwartz J, Grossman BJ, Kleinman S, Han MA, Cohn CS
    AABB Clinical Transfusion Medicine Committee

    Transfusion 2019 Sep;59(9):2974-2988
  • International Assessment of Massive Transfusion Protocol Contents and Indications for Activation
    Thomasson RR, Yazer MH, Gorham JD, Dunbar NM
    MTP Use Study Investigators, on behalf of the Biomedical Excellence for Safer Transfusion (BEST) Collaborative

    Transfusion 2019 May;59(5):1637-1643
  • The Efficacy of Extracorporeal Photopheresis to Arrest Bronchiolitis Obliterans in Lung Allograft Recipients Was Compared Between Two Automated Photopheresis Instruments
    Chionis L, Grossman BJ, Hachem R, Commean P, Derfler MC, Vedantham S, Dodds K, Spitznagel E, Atkinson J, Despotis G
    Transfusion 2018 Dec;58(12):2933-2941
  • Transfusion Requirements and 30-Day Mortality Predictors for Adult Hemophagocytic Lymphohistiocytosis
    Otrock ZK, Grossman BJ, Eby CS
    Int J Hematol 2018 Nov;108(5):485-490
  • The B Antigen Protects Against the Development of Red Meat Allergy
    Brestoff JR, Tesfazghi MT, Zaydman MA, Jackups R Jr, Kim BS, Scott MG, Gronowski AM, Grossman BJ
    J Allergy Clin Immunol Pract 2018 Sep - Oct;6(5):1790-1791e3
  • Transfusion-Related Acute Lung Injury Risk Mitigation: An Update
    Otrock ZK, Liu C, Grossman BJ
    Vox Sang 2017 Nov;112(8):694-703
  • Results of a Prospective Randomized, Open-Label, Noninferiority Study of Tbo-Filgrastim (Granix) Versus Filgrastim (Neupogen) in Combination With Plerixafor for Autologous Stem Cell Mobilization in Patients With Multiple Myeloma and Non-Hodgkin Lymphoma
    Bhamidipati PK, Fiala MA, Grossman BJ, DiPersio JF, Stockerl-Goldstein K, Gao F, Uy GL, Westervelt P, Schroeder MA, Cashen AF, Abboud CN, Vij R
    Biol Blood Marrow Transplant 2017 Dec;23(12):2065-2069
  • Fresh or Cryopreserved CD34+-Selected Mobilized Peripheral Blood Stem and Progenitor Cells for the Treatment of Poor Graft Function After Allogeneic Hematopoietic Cell Transplantation
    Ghobadi A, Fiala MA, Ramsingh G, Gao F, Abboud CN, Stockerl-Goldstein K, Uy GL, Grossman BJ, Westervelt P, DiPersio JF
    Biol Blood Marrow Transplant 2017 Jul;23(7):1072-1077
  • Safety and Collection Efficiency With a Lower Transfusion Threshold for Extracorporeal Photopheresis in Adult Patients With Graft-Versus-Host Disease
    Liu C, Schindler E, LeRoy M, Martin-Bredahl K, Dino M, Shah K, Dynis M, Eby CS, Grossman BJ
    Vox Sang 2017 May;112(4):379-387
  • Untreated Donor Specific Antibodies Against HLA Are Associated With Poor Outcomes in Peripheral Blood Haploidentical Hematopoietic Cell Transplantation
    Zou J, Romee R, Slade M, Phelan D, Keller J, Mohanakumar T, Grossman BJ
    Bone Marrow Transplant 2017 Jun;52(6):898-901
  • Adverse Events of Cryopreserved Hematopoietic Stem Cell Infusions in Adults: A Single-Center Observational Study
    Otrock ZK, Sempek DS, Carey S, Grossman BJ
    Transfusion 2017 Jun;57(6):1522-1526
  • Using Direct Antiglobulin Test Results to Reduce Unnecessary Cold Agglutinin Testing
    Wilen CB, Booth GS, Grossman BJ, Lane WJ, Szklarski PC, Jackups R Jr
    Transfusion 2017 Jun;57(6):1480-1484
  • Extracorporeal Photopheresis Practice Patterns: An International Survey by the ASFA ECP Subcommittee
    Dunbar NM, Raval JS, Johnson A, Abikoff CM, Adamski J, Cooling LL, Grossman B, Kim HC, Marques MB, Morgan S, Schmidt AE, Sloan SR, Su LL, Szczepiorkowski ZM, West FB, Wong E, Schneiderman J
    J Clin Apher 2017 Aug;32(4):215-223
  • Prozone Phenomenon Complicates Detection of Donor Specific Antibodies in Haploidentical Hematopoietic Cell Transplant Patient
    Zou J, Slade M, Romee R, Phelean D, Willey P, Mohanakumar T, Grossman BJ
    Transplant Res J 2016;1(2): doi http://dx.doi. org/10.16966/2473-1730.108
  • Clinical Practice Guidelines From the AABB: Red Blood Cell Transfusion Thresholds and Storage
    Carson JL, Guyatt G, Heddle NM, Grossman BJ, Cohn CS, Fung MK, Gernsheimer T, Holcomb JB, Kaplan LJ, Katz LM, Peterson N, Ramsey G, Rao SV, Roback JD, Shander A, Tobian AA
    JAMA 2016 Nov 15;316(19):2025-2035
  • AABB Committee Report: Reducing Transfusion-Transmitted Cytomegalovirus Infections
    Heddle NM, Boeckh M, Grossman B, Jacobson J, Kleinman S, Tobian AA, Webert K, Wong EC, Roback JD
    AABB, Clinical Transfusion Medicine Committee

    Transfusion 2016 Jun;56(6pt2):1581-1587
  • Reducing the Risk of Transfusion-Transmitted Cytomegalovirus Infection: A Systematic Review and Meta-Analysis
    Mainou M, Alahdab F, Tobian AA, Asi N, Mohammed K, Murad MH, Grossman BJ
    Transfusion 2016 Jun;56(6pt2):1569-1580
  • Red Blood Cell Transfusion for Hematologic Disorders
    Liu C, Grossman BJ
    Hematology Am Soc Hematol Educ Program 2015 Dec 5;2015(1):454-61
  • A Quantitative Model to Predict Blood Use in Adult Orthotopic Liver Transplantation
    Liu C, Vachharajani N, Song S, Cooke R, Kangrga I, Chapman WC, Grossman BJ
    Transfus Apher Sci 2015 Dec;53(3):386-92
  • Platelet Transfusion in Thrombotic Thrombocytopenic Purpura
    Otrock ZK, Liu C, Grossman BJ
    Vox Sang 2015 Aug;109(2):168-172
  • Platelet Transfusion: A Clinical Practice Guideline From the AABB
    Kaufman RM, Djulbegovic B, Gernsheimer T, Kleinman S, Tinmouth AT, Capocelli KE, Cipolle MD, Cohn CS, Fung MK, Grossman BJ, Mintz PD, O'Malley BA, Sesok-Pizzini DA, Shander A, Stack GE, Webert KE, Weinstein R, Welch BG, Whitman GJ, Wong EC, Tobian AA
    Ann Intern Med 2015 Feb 3;162(3):205-213
  • Platelet Transfusion: A Systematic Review of the Clinical Evidence
    Kumar A, Mhaskar R, Grossman BJ, Kaufman RM, Tobian AA, Kleinman S, Gernsheimer T, Tinmouth AT, Djulbegovic B
    Transfusion 2015 May;55(5):1116-27
  • Efficacy of Extracorporeal Photopheresis in Clearance of Antibodies to Donor-Specific and Lung-Specific Antigens in Lung Transplant Recipients
    Baskaran G, Tiriveedhi V, Ramachandran S, Aloush A, Grossman B, Hachem R, Mohanakumar T
    J Heart Lung Transplant 2014 Sep;33(9):950-6
  • Sterility Testing of Apheresis Hematopoietic Progenitor Cell Products Using an Automated Blood Culture System
    Liu C, Weber C, Sempek DS, Grossman BJ, Burnham CA
    Transfusion 2013 Nov;53(11):2659-66
  • Linear Relationship Between Lymphocyte Counts in Peripheral Blood and Buffy Coat Collected During Extracorporeal Photopheresis
    Liu C, Shah K, Dynis M, Eby CS, Grossman BJ
    Transfusion 2013 Nov;53(11):2635-43
  • Antibody of Undetermined Specificity: Frequency, Laboratory Features, and Natural History
    Liu C, Grossman BJ
    Transfusion 2013 May;53(5):931-8
  • Platelet Recovery Rate During Plasma Exchange Predicts Early and Late Responses in Patients With Thrombotic Thrombocytopenic Purpura
    Liu C, Kallogjeri D, Dynis M, Grossman BJ
    Transfusion 2013 May;53(5):1096-107
  • Red Blood Cell Transfusion: A Clinical Practice Guideline From the AABB
    Carson JL, Grossman BJ, Kleinman S, Tinmouth AT, Marques MB, Fung MK, Holcomb JB, Illoh O, Kaplan LJ, Katz LM, Rao SV, Roback JD, Shander A, Tobian AA, Weinstein R, Swinton McLaughlin LG, Djulbegovic B
    Ann Intern Med 2012 Jul 3;157(1):49-58
  • Red Cell Transfusion Decreases Hemoglobin A1c in Patients With Diabetes
    Spencer DH, Grossman BJ, Scott MG
    Clin Chem 2011 Feb;57(2):344-6
  • What Is Your Guess: A Donor Going Green?
    Jackups R, Grossman, BJ
    Clin Chem 2010;56:1905-6
  • A National Survey of Transfusion-Related Acute Lung Injury Risk Reduction Policies for Platelets and Plasma in the United States
    Kleinman S, Grossman B, Kopko P
    Transfusion 2010 Jun;50(6):1312-21
  • Liver Donor's Age and Recipient's Serum Creatinine Predict Blood Component Use During Liver Transplantation
    Modanlou KA, Oliver DA, Grossman BJ
    Transfusion 2009 Dec;49(12):2645-51
  • A Retrospective Review of the Outcome of Plasma Exchange and Aggressive Medical Therapy in Antibody Mediated Rejection of Renal Allografts: A Single Center Experience
    Al-Badr W, Kallogjeri D, Madaraty K, Oliver D, Bastani B, Grossman BJ
    J Clin Apher 2008;23(6):178-82
  • Thrombotic Thrombocytopenic Purpura and Graves Disease
    Chaar BT, Kudva GC, Olsen TJ, Silverberg AB, Grossman BJ
    Am J Med Sci 2007 Aug;334(2):133-5
  • RhD Alloimmunization Without Apparent Exposure to RhD Antigen
    Kudva GC, Branson KD, Grossman BJ
    Am J Hematol 2006 Mar;81(3):218
  • Barriers and Motivators to Blood and Cord Blood Donations in Young African-American Women
    Grossman B, Watkins AR, Fleming F, Debaun MR
    Am J Hematol 2005 Mar;78(3):198-202
  • Blood Transfusion-Acquired Hemoglobin C
    Suarez AA, Polski JM, Grossman BJ, Johnston MF
    Arch Pathol Lab Med 1999 Jul;123(7):642-3
  • Multiple False Reactions in Viral Antibody Screening Assays After Influenza Vaccination
    Simonsen L, Buffington J, Shapiro CN, Holman RC, Strine TW, Grossman BJ, Williams AE, Schonberger LB
    Am J Epidemiol 1995 Jun 1;141(11):1089-96
  • Hepatitis B Surface Antigenemia in Blood Donors Following Vaccination
    Kloster B, Kramer R, Eastlund T, Grossman B, Zarvan B
    Transfusion 1995 Jun;35(6):475-7
  • Multiple Unconfirmed-Reactive Screening Tests for Viral Antibodies Among Blood Donors
    Buffington J, Shapiro CN, Holman RC, Strine TW, Grossman BJ, Williams AE, Alter MJ, Schonberger LB
    Transfusion 1994 May;34(5):371-5
  • Blood Donor Deferral Registries: Highlights of a Conference
    Grossman BJ, Springer KM
    Transfusion 1992 Nov-Dec;32(9):868-72
  • Antithrombin III: Physiology, Deficiency, and Replacement Therapy
    Menache D, Grossman BJ, Jackson CM
    Transfusion 1992 Jul-Aug;32(6):580-8
  • Screening Blood Donors for Gastrointestinal Illness: A Strategy to Eliminate Carriers of Yersinia Enterocolitica
    Grossman BJ, Kollins P, Lau PM, Perreten JL, Bowman RJ, Malcolm S, Palko WM
    Transfusion 1991 Jul-Aug;31(6):500-1
  • Autologous Blood: A Greater Risk for the Homologous Recipient
    Grossman BJ, Grindon AJ
    Transfus Sci 1989;10:125-30
  • Neonatal Pretransfusion Testing for Cytomegalovirus Antibody
    Grossman BJ, Smetana DR, Seade BA
    Transfusion 1989 Nov-Dec;29(9):830-1
  • Multiple Arteriovenous Malformations of the Small Intestine in a Patient With Protein S Deficiency
    Guarner J, Grossman B, Judd R, Wideman C, Evatt B
    Am J Clin Pathol 1989 Sep;92(3):374-8
  • Increased Risk of a Positive Test for Antibody to Hepatitis B Core Antigen (Anti-HBC) in Autologous Blood Donors
    Grossman BJ, Stewart NC, Grindon AJ
    Transfusion 1988 May-Jun;28(3):283-5

Invited Publications

  • Blood Safety in the United States: Prevention, Detection, and Pathogen Reduction
    Staley E, Grossman BJ
    Clinical Microbiology Newsletter 2019;41(17):149-57
  • Platelet Transfusions for Patients With Consumptive Thrombocytopenias
    Liu C, Grossman BJ
    Blood Bulletin December 2016. America's Blood Centers, Washington DC
  • Screening Platelet Pheresis Donors for HLA Antibodies
    Zou J, Grossman BJ, Kumar T
    ASHI Quarterly, Fourth Quarter, 2014. 28-32
  • Commentary. Re: Sudden Onset of Severe Anemia in a Patient With Cystic Fibrosis
    Grossman B
    Clin Chem 2012 Sep;58(9):1290
  • Technical Manual (17th Edition)
    Roback JR, Grossman BJ, Harris T, Hillyer CD (editors)
    Bethesda MD: AABB 2011
  • Technical Manual (16th Edition)
    Roback JR, Combs MR, Grossman BJ, Hillyer CD (editors)
    Bethesda MD: AABB 2008
  • Donor Selection and Blood Collection
    Grossman BJ
    In: Brecher M, ed. Technical Manual (15th edition). Bethesda MD: AABB 2005
  • Blood Utilization Management
    Grossman BJ
    In: Brecher M, ed. Technical Manual (15th edition). Bethesda MD: AABB 2005
  • Transfusion Transmitted Disease
    Roseff S, Grossman BJ, Linden J, Brecher M
    In: Brecher M, ed. Technical Manual (15th edition). Bethesda MD: AABB 2005
  • Donor Selection and Blood Collection
    Grossman BJ
    In: Brecher M, ed. Technical Manual (14th edition). Bethesda MD: AABB 2002
  • Blood Component Testing and Labeling
    Grossman BJ
    In: Brecher M, ed. Technical Manual (14th edition). Bethesda MD: AABB 2002
  • Quality Issues
    Motschman T, Grossman BJ
    In: Brecher M, ed. Technical Manual (14th edition). Bethesda MD: AABB 2002
  • Blood Collection, Storage, and Component Preparation Methods
    Sweeny J, Grossman BJ
    In: Brecher M, ed. Technical Manual (14th edition). Bethesda MD: AABB 2002
  • Drugs to Treat Anemia
    Grossman BJ, Brody TM
    In: Wingard LB, Brody TM, Larner J, Schwartz A, eds. Human Pharmacology; Molecular to Clinical. St. Louis: Mosby Yearbook, 1991; 957-9
  • Increasing Concern About Transfusion-Associated Yersinia Enterocolitica in the United States
    Grossman B
    Transfusion Today 1991;10:1-2
  • Diagnosis and Management of Thrombotic Thrombocytopenic Purpura
    Baddoura FK, Grossman BJ
    Check Sample 1989;32(TM 89-5):1-8
  • Transfusion-Related HIV Infection
    Grossman BJ, Grindon AJ
    J Med Assoc Ga 1988 Mar;77(3):165-7