Oncology Division
Alphabetical list (active faculty):   
Angela C. Hirbe

Angela C. Hirbe, MD, PhD

Assistant Professor

Department of Medicine

Oncology Division

Medical Oncology

Department of Pediatrics

Clinical Interests

  • Sarcoma
  • Cancer predisposition syndromes

Research Interests

  • Malignant peripheral nerve sheath tumors
  • Neurofibromatosis type 1
  • Genomics


  • 314-747-3096 (office)
  • 314-362-7086 (fax)
  • Division of Oncology
    Mail Stop 8056-0041-03
    Washington University
    660 South Euclid Avenue
    St. Louis, MO 63110
  • Room 3304, Couch Biomedical Research Building (lab)

Peer-reviewed Manuscripts

  • Genetic Characterization, Current Model Systems and Prognostic Stratification in PAX Fusion-Negative Vs. PAX Fusion-Positive Rhabdomyosarcoma
    Dehner CA, Armstrong AE, Yohe M, Shern JF, Hirbe AC
    Genes (Basel) 2021 Sep 25;12(10):12101500
  • A Phase I Study of the Combination of Pexidartinib and Sirolimus to Target Tumor-Associated Macrophages in Unresectable Sarcoma and Malignant Peripheral Nerve Sheath Tumors
    Manji GA, Van Tine BA, Lee SM, Raufi AG, Pellicciotta I, Hirbe AC, Pradhan J, Chen A, Rabadan R, Schwartz GK
    Clin Cancer Res 2021 Oct 15;27(20):5519-5527
  • A Genetic Mouse Model With Postnatal Nf1 and p53 Loss Recapitulates the Histology and Transcriptome of Human Malignant Peripheral Nerve Sheath Tumor
    Inoue A, Janke LJ, Gudenas BL, Jin H, Fan Y, Pare J, Clay MR, Northcott PA, Hirbe AC, Cao X
    Neurooncol Adv 2021 Sep 10;3(1):vdab129
  • Phase II Study of Dacarbazine Given With Modern Prophylactic Anti-Emetics and Growth Factor Support to Patients With Metastatic, Resistant Soft Tissue, and Bone Sarcoma
    Van Tine BA, Weiss MC, Hirbe AC, Oppelt PJ, Abaricia S, Trinkaus K, Luo J, Berry S, Ruff T, Callahan C, Toensikoetter J, Ley J, Siegel MJ, Dehdashti F, Siegel BA, Adkins DR
    Rare Tumors 2021 Oct 8;13:20363613211052498
  • Patterns of Extrapulmonary Metastases in Sarcoma Surveillance
    Hong Z, England P, Rhea L, Hirbe A, McDonald D, Cipriano CA
    Cancers (Basel) 2021 Sep 17;13(18):13184669
  • Cell-Free DNA Ultra-Low-Pass Whole Genome Sequencing to Distinguish Malignant Peripheral Nerve Sheath Tumor (MPNST) From Its Benign Precursor Lesion: A Cross-Sectional Study
    Szymanski JJ, Sundby RT, Jones PA, Srihari D, Earland N, Harris PK, Feng W, Qaium F, Lei H, Roberts D, Landeau M, Bell J, Huang Y, Hoffman L, Spencer M, Spraker MB, Ding L, Widemann BC, Shern JF, Hirbe AC, Chaudhuri AA
    PLoS Med 2021 Aug 31;18(8):e1003734
  • TYK2 in Cancer Metastases: Genomic and Proteomic Discovery
    Borcherding DC, He K, Amin NV, Hirbe AC
    Cancers (Basel) 2021 Aug 19;13(16):3164171
  • Phase II Study of Pazopanib With Oral Topotecan in Patients With Metastatic and Non-Resectable Soft Tissue and Bone Sarcomas
    Schulte B, Mohindra N, Milhem M, Attia S, Robinson S, Monga V, Hirbe AC, Oppelt P, Charlson J, Helenowski I, Abbinanti S, Cehic R, Okuno S, Van Tine BA, Agulnik M
    Br J Cancer 2021 Aug;125(4):528-533
  • An Open-Label Single-Arm Phase II Study of Regorafenib for the Treatment of Angiosarcoma
    Agulnik M, Schulte B, Robinson S, Hirbe AC, Kozak K, Chawla SP, Attia S, Rademaker A, Zhang H, Abbinanti S, Cehic R, Monga V, Milhem M, Okuno S, Van Tine BA
    Eur J Cancer 2021 Sep;154:201-208
  • Interim Analysis of the Phase II Study: Noninferiority Study of Doxorubicin With Upfront Dexrazoxane Plus Olaratumab for Advanced or Metastatic Soft-Tissue Sarcoma
    Van Tine BA, Hirbe AC, Oppelt P, Frith AE, Rathore R, Mitchell JD, Wan F, Berry S, Landeau M, Heberton GA, Gorcsan J 3rd, Huntjens PR, Soyama Y, Vader JM, Alvarez-Cardona JA, Zhang KW, Lenihan DJ, Krone RJ
    Clin Cancer Res 2021 Jul 15;27(14):3854-3860
  • Chromosome 8 Gain Is Associated With High-Grade Transformation in MPNST
    Dehner C, Moon CI, Zhang X, Zhou Z, Miller C, Xu H, Wan X, Yang K, Mashl J, Gosline SJ, Wang Y, Zhang X, Godec A, Jones PA, Dahiya S, Bhatia H, Primeau T, Li S, Pollard K, Rodriguez FJ, Ding L, Pratilas CA, Shern JF, Hirbe AC
    JCI Insight 2021 Mar 22;6(6)
  • Preferentially Expressed Antigen in Melanoma (PRAME) Expression in Malignant, but Not Benign, Peripheral Nerve Sheath Tumors
    Cadwell CR, Yuksek GE, Hirbe AC, Srihari D, LeBoit P, Dahiya S, Pekmezci M
    J Neuropathol Exp Neurol 2021 Mar 22;80(4):384-386
  • Vascularized Ulnar Transposition and Radioulnoscapholunate Fusion With Volar Locking Plate in a Dorsal Position Following Resection of Giant Cell Tumor of the Distal Radius
    Van Handel AC, Galvez MG, Brogan DM, Boyer MI, Cipriano CA, Hirbe AC, Pet MA
    Tech Hand Up Extrem Surg 2020 Sep;24(3):142-150
  • Special Issue: "Genomics and Models of Nerve Sheath Tumors"
    Hirbe AC, Dodd RD, Pratilas CA
    Genes (Basel) 2020 Sep 1;11(9)
  • A Phase II Study of Pazopanib as Front-Line Therapy in Patients With Non-Resectable or Metastatic Soft-Tissue Sarcomas Who Are Not Candidates for Chemotherapy
    Hirbe AC, Eulo V, Moon CI, Luo J, Myles S, Seetharam M, Toeniskoetter J, Kershner T, Haarberg S, Agulnik M, Monga V, Milhem M, Parkes A, Robinson S, Okuno S, Attia S, Van Tine BA
    Eur J Cancer 2020 Sep;137:1-9
  • A Retrospective Analysis of the Efficacy of Immunotherapy in Metastatic Soft-Tissue Sarcomas
    Monga V, Skubitz KM, Maliske S, Mott SL, Dietz H, Hirbe AC, Van Tine BA, Oppelt P, Okuno S, Robinson S, O'Connor M, Seetharam M, Attia S, Charlson J, Agulnik M, Milhem M
    Cancers (Basel) 2020 Jul 11;12(7)
  • Non-Conventional Treatments for Conventional Chondrosarcoma
    Monga V, Mani H, Hirbe A, Milhem M
    Cancers (Basel) 2020 Jul 19;12(7)
  • Neurofibromatosis Type 1-Related Tumours in Paediatrics: An Evolving Treatment Landscape
    Armstrong AE, Brossier NM, Hirbe AC
    Lancet Child Adolesc Health 2020 Jul;4(7):488-490
  • Multi-Institutional Analysis of Stereotactic Body Radiotherapy for Sarcoma Pulmonary Metastases: High Rates of Local Control With Favorable Toxicity
    Baumann BC, Bernstein KA, DeLaney TF, Simone CB 2nd, Kolker JD, Choy E, Levin WP, Weber KL, Muniappan A, Berman AT, Staddon A, Hartner L, Van Tine B, Hirbe A, Glatstein E, Hahn SM, Nagda SN, Chen YL
    J Surg Oncol 2020 Oct;122(5):877-883
  • Epithelioid and Spindle Cell Rhabdomyosarcoma With FUS-TFCP2 or EWSR1-TFCP2 Fusion: Report of Two Cases
    Chrisinger JSA, Wehrli B, Dickson BC, Fasih S, Hirbe AC, Shultz DB, Zadeh G, Gupta AA, Demicco EG
    Virchows Arch 2020 Nov;477(5):725-732
  • Does Advanced Imaging Have a Role in Detecting Local Recurrence of Soft-Tissue Sarcoma?
    England P, Hong Z, Rhea L, Hirbe A, McDonald D, Cipriano C
    Clin Orthop Relat Res 2020 Dec;478(12):2812-2820
  • Unmasking Intra-Tumoral Heterogeneity and Clonal Evolution in NF1-MPNST
    Moon CI, Tompkins W, Wang Y, Godec A, Zhang X, Pipkorn P, Miller CA, Dehner C, Dahiya S, Hirbe AC
    Genes (Basel) 2020 May 1;11(5)
  • Genomics of MPNST (GeM) Consortium: Rationale and Study Design for Multi-Omic Characterization of NF1-Associated and Sporadic MPNSTs
    Miller DT, Cortes-Ciriano I, Pillay N, Hirbe AC, Snuderl M, Bui MM, Piculell K, Al-Ibraheemi A, Dickson BC, Hart J, Jones K, Jordan JT, Kim RH, Lindsay D, Nishida Y, Ullrich NJ, Wang X, Park PJ, Flanagan AM
    Genes (Basel) 2020 Apr 2;11(4)
  • Secondary Sarcomas: Biology, Presentation, and Clinical Care
    Eulo V, Lesmana H, Doyle LA, Nichols KE, Hirbe AC
    Am Soc Clin Oncol Educ Book 2020 Mar;40:1-12
  • Integrative Analysis Identifies Candidate Tumor Microenvironment and Intracellular Signaling Pathways That Define Tumor Heterogeneity in NF1
    Banerjee J, Allaway RJ, Taroni JN, Baker A, Zhang X, Moon CI, Pratilas CA, Blakeley JO, Guinney J, Hirbe A, Greene CS, Gosline SJ
    Genes (Basel) 2020 Feb 21;11(2)
  • Diagnosis and Management of Malignant Peripheral Nerve Sheath Tumors: Current Practice and Future Perspectives
    Prudner BC, Ball T, Rathore R, Hirbe AC
    Neurooncol Adv 2019 Nov 14;2(Suppl 1):i40-i49
  • Whole Exome Sequencing Reveals the Maintained Polyclonal Nature From Primary to Metastatic Malignant Peripheral Nerve Sheath Tumor in Two Patients With NF1
    Godec A, Jayasinghe R, Chrisinger JSA, Prudner B, Ball T, Wang Y, Srihari D, Kaushal M, Dietz H, Zhang X, Pekmezci M, Dahiya S, Tao Y, Luo J, Van Tine BA, Ding L, Gutmann DH, Hirbe AC
    Neurooncol Adv 2019 Sep 10;2(Suppl 1):i75-i84
  • Understanding a Complicated Gal-1
    Hirbe AC, Gutmann DH
    Neuro Oncol 2019 Nov 4;21(11):1341-1343
  • Targeting Sporadic and Neurofibromatosis Type 1 (NF1) Related Refractory Malignant Peripheral Nerve Sheath Tumors (MPNST) in a Phase II Study of Everolimus in Combination With Bevacizumab (SARC016)
    Widemann BC, Lu Y, Reinke D, Okuno SH, Meyer CF, Cote GM, Chugh R, Milhem MM, Hirbe AC, Kim A, Turpin B, Pressey JG, Dombi E, Jayaprakash N, Helman LJ, Onwudiwe N, Cichowski K, Perentesis JP
    Sarcoma 2019 Jul 24;2019:7656747
  • TYK2 Promotes Malignant Peripheral Nerve Sheath Tumor Progression Through Inhibition of Cell Death
    Qin W, Godec A, Zhang X, Zhu C, Shao J, Tao Y, Bu X, Hirbe AC
    Cancer Med 2019 Sep;8(11):5232-5241
  • Arginine Starvation and Docetaxel Induce c-MYC-Driven HENT1 Surface Expression to Overcome Gemcitabine Resistance in ASS1-Negative Tumors
    Prudner BC, Rathore R, Robinson AM, Godec A, Chang SF, Hawkins WG, Hirbe AC, Van Tine BA
    Clin Cancer Res 2019 Aug 15;25(16):5122-5134
  • Diagnosis and Treatment of Myxoid Liposarcomas: Histology Matters
    Abaricia S, Hirbe AC
    Curr Treat Options Oncol 2018 Oct 25;19(12):64
  • Aberrant ATRX Protein Expression Is Associated With Poor Overall Survival in NF1-MPNST
    Lu HC, Eulo V, Apicelli AJ, Pekmezci M, Tao Y, Luo J, Hirbe AC, Dahiya S
    Oncotarget 2018 May 1;9(33):23018-23028
  • Beta-III-Spectrin Immunohistochemistry as a Potential Diagnostic Tool With High Sensitivity for Malignant Peripheral Nerve Sheath Tumors
    Hirbe AC, Zhang X, Dahiya S, Godec A, Chrisinger J, Tao Y, Luo J, Gutmann DH
    Neuro Oncol 2018 May 18;20(6):858-860
  • A Phase II Study of Tumor Ablation in Patients With Metastatic Sarcoma Stable on Chemotherapy
    Hirbe AC, Jennings J, Saad N, Giardina JD, Tao Y, Luo J, Berry S, Toeniskoetter J, Van Tine BA
    Oncologist 2018 Jul;23(7):760-e76
  • Gastrointestinal Stromal Tumors (GISTs): Point Mutations Matter in Management, a Review
    Oppelt PJ, Hirbe AC, Van Tine BA
    J Gastrointest Oncol 2017 Jun;8(3):466-473
  • Neoadjuvant Ifosfamide and Epirubicin in the Treatment of Malignant Peripheral Nerve Sheath Tumors
    Hirbe AC, Cosper PF, Dahiya S, Van Tine BA
    Sarcoma 2017;2017:3761292
  • Clinical Genomic Profiling Identifies TYK2 Mutation and Overexpression in Patients With Neurofibromatosis Type 1-Associated Malignant Peripheral Nerve Sheath Tumors
    Hirbe AC, Kaushal M, Sharma MK, Dahiya S, Pekmezci M, Perry A, Gutmann DH
    Cancer 2017 Apr 1;123(7):1194-1201
  • Spatially- And Temporally-Controlled Postnatal p53 Knockdown Cooperates With Embryonic Schwann Cell Precursor Nf1 Gene Loss to Promote Malignant Peripheral Nerve Sheath Tumor Formation
    Hirbe AC, Dahiya S, Friedmann-Morvinski D, Verma IM, Clapp DW, Gutmann DH
    Oncotarget 2016 Feb 16;7(7):7403-14
  • Whole Exome Sequencing Reveals the Order of Genetic Changes During Malignant Transformation and Metastasis in a Single Patient With NF1-Plexiform Neurofibroma
    Hirbe AC, Dahiya S, Miller CA, Li T, Fulton RS, Zhang X, McDonald S, DeSchryver K, Duncavage EJ, Walrath J, Reilly KM, Abel HJ, Pekmezci M, Perry A, Ley TJ, Gutmann DH
    Clin Cancer Res 2015 Sep 15;21(18):4201-11
  • Morphologic and Immunohistochemical Features of Malignant Peripheral Nerve Sheath Tumors and Cellular Schwannomas
    Pekmezci M, Reuss DE, Hirbe AC, Dahiya S, Gutmann DH, von Deimling A, Horvai AE, Perry A
    Mod Pathol 2015 Feb;28(2):187-200
  • Neurofibromatosis Type 1: A Multidisciplinary Approach to Care
    Hirbe AC, Gutmann DH
    Lancet Neurol 2014 Aug;13(8):834-43
  • BRAFV600E Mutation in Sporadic and Neurofibromatosis Type 1-Related Malignant Peripheral Nerve Sheath Tumors
    Hirbe AC, Pekmezci M, Dahiya S, Apicelli AJ, Van Tine BA, Perry A, Gutmann DH
    Neuro Oncol 2014 Mar;16(3):466-7
  • Novel Pathways and Molecular Targets for the Treatment of Sarcoma
    Frith AE, Hirbe AC, Van Tine BA
    Curr Oncol Rep 2013 Aug;15(4):378-85
  • The ADP Receptor P2RY12 Regulates Osteoclast Function and Pathologic Bone Remodeling
    Su X, Floyd DH, Hughes A, Xiang J, Schneider JG, Uluckan O, Heller E, Deng H, Zou W, Craft CS, Wu K, Hirbe AC, Grabowska D, Eagleton MC, Townsley S, Collins L, Piwnica-Worms D, Steinberg TH, Novack DV, Conley PB, Hurchla MA, Rogers M, Weilbaecher KN
    J Clin Invest 2012 Oct;122(10):3579-92
  • CD8+ T Cells Regulate Bone Tumor Burden Independent of Osteoclast Resorption
    Zhang K, Kim S, Cremasco V, Hirbe AC, Collins L, Piwnica-Worms D, Novack DV, Weilbaecher K, Faccio R
    Cancer Res 2011 Jul 15;71(14):4799-808
  • The CXCR4/SDF-1 Chemokine Axis: A Potential Therapeutic Target for Bone Metastases?
    Hirbe AC, Morgan EA, Weilbaecher KN
    Curr Pharm Des 2010;16(11):1284-90
  • The Bisphosphonate Zoledronic Acid Decreases Tumor Growth in Bone in Mice With Defective Osteoclasts
    Hirbe AC, Roelofs AJ, Floyd DH, Deng H, Becker SN, Lanigan LG, Apicelli AJ, Xu Z, Prior JL, Eagleton MC, Piwnica-Worms D, Rogers MJ, Weilbaecher K
    Bone 2009 May;44(5):908-16
  • RelB Is the NF-KappaB Subunit Downstream of NIK Responsible for Osteoclast Differentiation
    Vaira S, Johnson T, Hirbe AC, Alhawagri M, Anwisye I, Sammut B, O'Neal J, Zou W, Weilbaecher KN, Faccio R, Novack DV
    Proc Natl Acad Sci U S A 2008 Mar 11;105(10):3897-902
  • APT102, a Novel Adpase, Cooperates With Aspirin to Disrupt Bone Metastasis in Mice
    Uluckan O, Eagleton MC, Floyd DH, Morgan EA, Hirbe AC, Kramer M, Dowland N, Prior JL, Piwnica-Worms D, Jeong SS, Chen R, Weilbaecher K
    J Cell Biochem 2008 Jul 1;104(4):1311-23
  • A Non-Tumor Suppressor Role for Basal p19ARF in Maintaining Nucleolar Structure and Function
    Apicelli AJ, Maggi LB Jr, Hirbe AC, Miceli AP, Olanich ME, Schulte-Winkeler CL, Saporita AJ, Kuchenreuther M, Sanchez J, Weilbaecher K, Weber JD
    Mol Cell Biol 2008 Feb;28(3):1068-80
  • Disruption of CXCR4 Enhances Osteoclastogenesis and Tumor Growth in Bone
    Hirbe AC, Rubin J, Uluckan O, Morgan EA, Eagleton MC, Prior JL, Piwnica-Worms D, Weilbaecher KN
    Proc Natl Acad Sci U S A 2007 Aug 28;104(35):14062-7
  • Granulocyte Colony-Stimulating Factor Enhances Bone Tumor Growth in Mice in an Osteoclast-Dependent Manner
    Hirbe AC, Uluckan O, Morgan EA, Eagleton MC, Prior JL, Piwnica-Worms D, Trinkaus K, Apicelli A, Weilbaecher K
    Blood 2007 Apr 15;109(8):3424-31
  • Skeletal Complications of Breast Cancer Therapies
    Hirbe A, Morgan EA, Uluckan O, Weilbaecher K
    Clin Cancer Res 2006 Oct 15;12(20 Pt 2):6309s-6314s
  • HTLV-1 Tax Transgenic Mice Develop Spontaneous Osteolytic Bone Metastases Prevented by Osteoclast Inhibition
    Gao L, Deng H, Zhao H, Hirbe A, Harding J, Ratner L, Weilbaecher K
    Blood 2005 Dec 15;106(13):4294-302
  • MRI Detection of Early Bone Metastases in B16 Mouse Melanoma Models
    Gauvain KM, Garbow JR, Song SK, Hirbe AC, Weilbaecher K
    Clin Exp Metastasis 2005;22(5):403-11
  • Functional Analysis of Neurofibromatosis 2 (NF2) Missense Mutations
    Gutmann DH, Hirbe AC, Haipek CA
    Hum Mol Genet 2001 Jul 1;10(14):1519-29
  • The Protein 4.1 Tumor Suppressor, DAL-1, Impairs Cell Motility, but Regulates Proliferation in a Cell-Type-Specific Fashion
    Gutmann DH, Hirbe AC, Huang ZY, Haipek CA
    Neurobiol Dis 2001 Apr;8(2):266-78
  • Developmental Regulation of a Neuron-Specific Neurofibromatosis 1 Isoform
    Gutmann DH, Zhang Y, Hirbe A
    Ann Neurol 1999 Nov;46(5):777-82
  • Molecular Analysis of Malignant Triton Tumors
    Strauss BL, Gutmann DH, Dehner LP, Hirbe A, Zhu X, Marley EF, Liapis H
    Hum Pathol 1999 Aug;30(8):984-8

Books and Book Chapters

  • Sarcoma
    Van Tine BA, Hirbe AC
    In: DeVita, Hellman, and Rosenberg's Cancer: Principles & Practice of Oncology Review, 5th Edition (Morgensztern D, Govindan R, Devarakonda S, Trikalinos NA, Editors), Wolters Kluwer, Philadelphia, 2022
  • Washington Manual of Medical Therapeutics, 34th Edition
    Godara H, Hirbe A, Nassif M, Otepka H, Rosenstock A (editors)
    Lippincott Williams and Wilkins, 2014
  • Skeletal Complications of Breast and Prostate Cancer Therapies
    Hirbe A, Morgan E, Uluckan O, Weilbaecher K
    In: Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism (Favus MJ, ed), 6th ed, ASBMR, Washington, DC, USA, pp 390-395, 2006