Faculty
Oncology Division
Alphabetical list (active faculty):   
James J. Hsieh

James J. Hsieh, MD, PhD

Professor

Department of Medicine

Oncology Division

Molecular Oncology

Medical Oncology

Clinical Interests

  • Kidney cancer

Research Interests

  • Kidney cancer metabolomics
  • Genomics, Epigenetics
  • Therapeutics, Precision Medicine
  • Translational kidney cancer research
  • Mouse tumor models, Mouse development
  • Drug development
  • Taspase1, Notch, MLL, Stem cells

Contact

  • 314-454-8681 (office)
  • 314-273-1688 (lab)
  • 314-362-7086 (fax)
  • Division of Oncology
    Campus Box 8069
    Washington University
    660 South Euclid Avenue
    St. Louis, MO 63110
  • 554 McDonnell Medical Sciences Building (office)

Peer-reviewed Articles

  • Targeting Aurora B Kinase Prevents and Overcomes Resistance to EGFR Inhibitors in Lung Cancer by Enhancing BIM- and PUMA-Mediated Apoptosis
    Tanaka K, Yu HA, Yang S, Han S, Selcuklu SD, Kim K, Ramani S, Ganesan YT, Moyer A, Sinha S, Xie Y, Ishizawa K, Osmanbeyoglu HU, Lyu Y, Roper N, Guha U, Rudin CM, Kris MG, Hsieh JJ, Cheng EH
    Cancer Cell 2021 Sep 13;39(9):1245-1261
  • Diagnostic Utility of RNA-Seq for Evaluation of PD-L1 Expression in Clear Cell Renal Cell Carcinoma
    Sorokina M, Stupichev D, Lyu Y, Ramachandran A, Miheecheva N, Brown JH, Nomie K, Postovalova E, Bagaev A, Tsiper M, Hsieh JJ
    Clin Genitourin Cancer 2021 Jul 10; [Epub ahead of print]
  • Taspase1 Orchestrates Fetal Liver Hematopoietic Stem Cell and Vertebrae Fates by Cleaving TFIIA
    Niizuma H, Searleman AC, Takeda S, Armstrong SA, Park CY, Cheng EH, Hsieh JJ
    JCI Insight 2021 Aug 9;6(15):e149382
  • Structural Insights Into the Function of the Catalytically Active Human Taspase1
    Nagaratnam N, Delker SL, Jernigan R, Edwards TE, Snider J, Thifault D, Williams D, Nannenga BL, Stofega M, Sambucetti L, Hsieh JJ, Flint AJ, Fromme P, Martin-Garcia JM
    Structure 2021 Aug 5;29(8):873-885
  • The Human Tumor Atlas Network: Charting Tumor Transitions Across Space and Time at Single-Cell Resolution
    Rozenblatt-Rosen O, Regev A, Oberdoerffer P, Nawy T, Hupalowska A, Rood JE, Ashenberg O, Cerami E, Coffey RJ, Demir E, Ding L, Esplin ED, Ford JM, Goecks J, Ghosh S, Gray JW, Guinney J, Hanlon SE, Hughes SK, Hwang ES, Iacobuzio-Donahue CA, Jane-Valbuena J, Johnson BE, Lau KS, Lively T, Mazzilli SA, Pe'er D, Santagata S, Shalek AK, Schapiro D, Snyder MP, Sorger PK, Spira AE, Srivastava S, Tan K, West RB, Williams EH
    Human Tumor Atlas Network (Contributors include: Hsieh JJ)

    Cell 2020 Apr 16;181(2):236-249
  • Resource-Efficient Pooled Sequencing Expands Translational Impact in Solid Tumors
    DiNatale RG, Mano R, Makarov V, Rusk N, Drill E, Winer A, Sankin A, Yoo A, Freeman BA, Hsieh JJ, Chen YB, Coleman JA, Berger M, Ostrovnaya I, Chan TA, Russo P, Reznik E, Hakimi AA
    Kidney Cancer J 2021 Jun;19(2):18-23
  • A Single-Arm, Multicenter, Phase 2 Study of Lenvatinib Plus Everolimus in Patients With Advanced Non-Clear Cell Renal Cell Carcinoma
    Hutson TE, Michaelson MD, Kuzel TM, Agarwal N, Molina AM, Hsieh JJ, Vaishampayan UN, Xie R, Bapat U, Ye W, Jain RK, Fishman MN
    Eur Urol 2021 Aug;80(2):162-170
  • Lenvatinib Plus Pembrolizumab in Patients With Either Treatment-Naive or Previously Treated Metastatic Renal Cell Carcinoma (Study 111/KEYNOTE-146): A Phase 1b/2 Study
    Lee CH, Shah AY, Rasco D, Rao A, Taylor MH, Di Simone C, Hsieh JJ, Pinto A, Shaffer DR, Girones Sarrio R, Cohn AL, Vogelzang NJ, Bilen MA, Gunnestad Ribe S, Goksel M, Tennoe OK, Richards D, Sweis RF, Courtright J, Heinrich D, Jain S, Wu J, Schmidt EV, Perini RF, Kubiak P, Okpara CE, Smith AD, Motzer RJ
    Lancet Oncol 2021 Jul;22(7):946-958
  • Single-Cell Spatial Proteomic Revelations on the Multiparametric MRI Heterogeneity of Clinically Significant Prostate Cancer
    Pachynski RK, Kim EH, Miheecheva N, Kotlov N, Ramachandran A, Postovalova E, Galkin I, Svekolkin V, Lyu Y, Zou Q, Cao D, Gaut J, Ippolito JE, Bagaev A, Bruttan M, Gancharova O, Nomie K, Tsiper M, Andriole GL, Ataullakhanov R, Hsieh JJ
    Clin Cancer Res 2021 Jun 15;27(12):3478-3490
  • The 2021 Variant Histology Issue
    Hsieh JJ
    Clin Genitourin Cancer 2021 Apr;19(2):93-94
  • Nivolumab Plus Cabozantinib Versus Sunitinib for Advanced Renal-Cell Carcinoma
    Choueiri TK, Powles T, Burotto M, Escudier B, Bourlon MT, Zurawski B, Oyervides Juarez VM, Hsieh JJ, Basso U, Shah AY, Suarez C, Hamzaj A, Goh JC, Barrios C, Richardet M, Porta C, Kowalyszyn R, Feregrino JP, Zolnierek J, Pook D, Kessler ER, Tomita Y, Mizuno R, Bedke J, Zhang J, Maurer MA, Simsek B, Ejzykowicz F, Schwab GM, Apolo AB, Motzer RJ
    CheckMate 9ER Investigators

    N Engl J Med 2021 Mar 4;384(9):829-841
  • The 2021 COVID-19 Artificial Intelligence Issue
    Hsieh JJ
    Clin Genitourin Cancer 2021 Feb;19(1):1-2
  • The 2020 NccRCC Immunotherapy Issue
    Hsieh JJ
    Clin Genitourin Cancer 2020 Dec;18(6):423-424
  • The Pan-Omics Landscape of Renal Cell Carcinoma and Its Implication on Future Clinical Practice
    Huang JJ, Hsieh JJ
    Kidney Cancer 2020 Sep 16;4(3):121-129
  • TGF-Beta Suppresses Type 2 Immunity to Cancer
    Liu M, Kuo F, Capistrano KJ, Kang D, Nixon BG, Shi W, Chou C, Do MH, Stamatiades EG, Gao S, Li S, Chen Y, Hsieh JJ, Hakimi AA, Taniuchi I, Chan TA, Li MO
    Nature 2020 Nov;587(7832):115-120
  • Elective Cytoreductive Nephrectomy After Checkpoint Inhibitor Immunotherapy in Patients With Initially Unresectable Metastatic Clear Cell Renal Cell Carcinoma
    Reimers MA, Figenshau RS, Kim EH, Tucker J, Kasten N, Khan AS, Hanneken JM, Smith ZL, Hsieh JJ
    Clin Genitourin Cancer 2020 Oct;18(5):361-366
  • The 2020 Prostate Cancer Issue
    Hsieh JJ
    Clin Genitourin Cancer 2020 Oct;18(5):341-342
  • Laparoscopic Cytoreductive Nephrectomy Is Associated With Significantly Improved Survival Compared With Open Cytoreductive Nephrectomy or Targeted Therapy Alone
    Zhao K, Kim EH, Vetter JM, Hsieh JJ, Venkatesh R, Bhayani SB, Figenshau RS
    Mol Clin Oncol 2020 Dec;13(6):71
  • Targeting Metabolic Pathways in Kidney Cancer: Rationale and Therapeutic Opportunities
    Hoerner CR, Miao SY, Hsieh JJ, Fan AC
    Cancer J 2020 Sep/Oct;26(5):407-418
  • The 2020 Kidney Cancer Treatment Sequence Issue
    Hsieh JJ
    Clin Genitourin Cancer 2020 Aug;18(4):241-243
  • The Efficacy of Lenvatinib Plus Everolimus in Patients With Metastatic Renal Cell Carcinoma Exhibiting Primary Resistance to Front-Line Targeted Therapy or Immunotherapy
    Hamieh L, Beck RL, Le VH, Hsieh JJ
    Clin Genitourin Cancer 2020 Aug;18(4):252-257
  • Exploiting the Circuit Breaker Cancer Evolution Model in Human Clear Cell Renal Cell Carcinoma
    Hsieh JJ, Cheng EH
    Cell Stress 2020 Jun 25;4(8):191-198
  • The 2020 Bladder Cancer Discrepancy Issue
    Hsieh JJ
    Clin Genitourin Cancer 2020 Jun;18(3):161
  • Modeling Biological and Genetic Diversity in Upper Tract Urothelial Carcinoma With Patient Derived Xenografts
    Kim K, Hu W, Audenet F, Almassi N, Hanrahan AJ, Murray K, Bagrodia A, Wong N, Clinton TN, Dason S, Mohan V, Jebiwott S, Nagar K, Gao J, Penson A, Hughes C, Gordon B, Chen Z, Dong Y, Watson PA, Alvim R, Elzein A, Gao SP, Cocco E, Santin AD, Ostrovnaya I, Hsieh JJ, Sagi I, Pietzak EJ, Hakimi AA, Rosenberg JE, Iyer G, Vargas HA, Scaltriti M, Al-Ahmadie H, Solit DB, Coleman JA
    Nat Commun 2020 Apr 24;11(1):1975
  • The Gender Issue
    Hsieh JJ
    Clin Genitourin Cancer 2020 Apr;18(2):77
  • Molecular Characterization of Sarcomatoid Clear Cell Renal Cell Carcinoma Unveils New Candidate Oncogenic Drivers
    Malouf GG, Flippot R, Dong Y, Dinatale RG, Chen YB, Su X, Comperat E, Roupret M, Mano R, Blum KA, Yao H, Mouawad R, Spano JP, Khayat D, Karam JA, Ho TH, Tickoo SK, Russo P, Hsieh JJ, Tannir NM, Hakimi AA
    Sci Rep 2020 Jan 20;10(1):701
  • Characterizing Recurrent and Lethal Small Renal Masses in Clear Cell Renal Cell Carcinoma Using Recurrent Somatic Mutations
    Manley BJ, Reznik E, Ghanaat M, Kashan M, Becerra MF, Casuscelli J, Tennenbaum D, Redzematovic A, Carlo MI, Sato Y, Arcila M, Voss MH, Feldman DR, Motzer RJ, Russo P, Coleman J, Hsieh JJ, Hakimi AA
    Urol Oncol 2019 Jan;37(1):12-17
  • Integrated Proteogenomic Characterization of Clear Cell Renal Cell Carcinoma
    Clark DJ, Dhanasekaran SM, Petralia F, Pan J, Song X, Hu Y, da Veiga Leprevost F, Reva B, Lih TM, Chang HY, Ma W, Huang C, Ricketts CJ, Chen L, Krek A, Li Y, Rykunov D, Li QK, Chen LS, Ozbek U, Vasaikar S, Wu Y, Yoo S, Chowdhury S, Wyczalkowski MA, Ji J, Schnaubelt M, Kong A, Sethuraman S, Avtonomov DM, Ao M, Colaprico A, Cao S, Cho KC, Kalayci S, Ma S, Liu W, Ruggles K, Calinawan A, Gumus ZH, Geizler D, Kawaler E, Teo GC, Wen B, Zhang Y, Keegan S, Li K, Chen F, Edwards N, Pierorazio PM, Chen XS, Pavlovich CP, Hakimi AA, Brominski G, Hsieh JJ, Antczak A, Omelchenko T, Lubinski J, Wiznerowicz M, Linehan WM, Kinsinger CR, Thiagarajan M, Boja ES, Mesri M, Hiltke T, Robles AI, Rodriguez H, Qian J, Fenyo D, Zhang B, Ding L, Schadt E, Chinnaiyan AM, Zhang Z, Omenn GS, Cieslik M, Chan DW, Nesvizhskii AI, Wang P, Zhang H
    Clinical Proteomic Tumor Analysis Consortium

    Cell 2019 Oct 31;179(4):964-983e31
  • Linking Binary Gene Relationships to Drivers of Renal Cell Carcinoma Reveals Convergent Function in Alternate Tumor Progression Paths
    Poehlman WL, Hsieh JJ, Feltus FA
    Sci Rep 2019 Feb 27;9(1):2899
  • Abnormal Oxidative Metabolism in a Quiet Genomic Background Underlies Clear Cell Papillary Renal Cell Carcinoma
    Xu J, Reznik E, Lee HJ, Gundem G, Jonsson P, Sarungbam J, Bialik A, Sanchez-Vega F, Creighton CJ, Hoekstra J, Zhang L, Sajjakulnukit P, Kremer D, Tolstyka Z, Casuscelli J, Stirdivant S, Tang J, Schultz N, Jeng P, Dong Y, Su W, Cheng EH, Russo P, Coleman JA, Papaemmanuil E, Chen YB, Reuter VE, Sander C, Kennedy SR, Hsieh JJ, Lyssiotis CA, Tickoo SK, Hakimi AA
    Elife 2019 Apr 1;8
  • Chromophobe Renal Cell Carcinoma: Results From a Large Single-Institution Series
    Casuscelli J, Becerra MF, Seier K, Manley BJ, Benfante N, Redzematovic A, Stief CG, Hsieh JJ, Tickoo SK, Reuter VE, Coleman JA, Russo P, Ostrovnaya I, Hakimi AA
    Clin Genitourin Cancer 2019 Oct;17(5):373-379e4
  • Hyperpolarized MRI Visualizes Warburg Effects and Predicts Treatment Response to mTOR Inhibitors in Patient-Derived CcRCC Xenograft Models
    Dong Y, Eskandari R, Ray C, Granlund KL, Santos-Cunha LD, Miloushev VZ, Tee SS, Jeong S, Aras O, Chen YB, Cheng EH, Hsieh JJ, Keshari KR
    Cancer Res 2019 Jan 1;79(1):242-250
  • Characterization and Impact of TERT Promoter Region Mutations on Clinical Outcome in Renal Cell Carcinoma
    Casuscelli J, Becerra MF, Manley BJ, Zabor EC, Reznik E, Redzematovic A, Arcila ME, Tennenbaum DM, Ghanaat M, Kashan M, Stief CG, Carlo M, Voss MH, Feldman DR, Motzer RJ, Chen Y, Reuter VE, Coleman JA, Russo P, Hsieh JJ, Hakimi AA
    Eur Urol Focus 2019 Jul;5(4):642-649
  • PTEN Expression, Not Mutation Status in TSC1, TSC2, or mTOR, Correlates With the Outcome on Everolimus in Patients With Renal Cell Carcinoma Treated on the Randomized RECORD-3 Trial
    Voss MH, Chen D, Reising A, Marker M, Shi J, Xu J, Ostrovnaya I, Seshan VE, Redzematovic A, Chen YB, Patel P, Han X, Hsieh JJ, Hakimi AA, Motzer RJ
    Clin Cancer Res 2019 Jan 15;25(2):506-514
  • BH3-Dependent and Independent Activation of BAX and BAK in Mitochondrial Apoptosis
    Jeng PS, Inoue-Yamauchi A, Hsieh JJ, Cheng EH
    Curr Opin Physiol 2018 Jun;3:71-81
  • Genomically Annotated Risk Model for Advanced Renal-Cell Carcinoma: A Retrospective Cohort Study
    Voss MH, Reising A, Cheng Y, Patel P, Marker M, Kuo F, Chan TA, Choueiri TK, Hsieh JJ, Hakimi AA, Motzer RJ
    Lancet Oncol 2018 Dec;19(12):1688-1698
  • Prospective Evaluation of Unprocessed Core Needle Biopsy DNA and RNA Yield From Lung, Liver, and Kidney Tumors: Implications for Cancer Genomics
    Silk MT, Mikkilineni N, Silk TC, Zabor EC, Ostrovnaya I, Hakimi AA, Hsieh JJ, Ziv E, Rekhtman N, Solomon SB, Durack JC
    Anal Cell Pathol (Amst) 2018 Dec 10;2018:2898962
  • Prognostic Value of a Long Non-Coding RNA Signature in Localized Clear Cell Renal Cell Carcinoma
    Qu L, Wang ZL, Chen Q, Li YM, He HW, Hsieh JJ, Xue S, Wu ZJ, Liu B, Tang H, Xu XF, Xu F, Wang J, Bao Y, Wang AB, Wang D, Yi XM, Zhou ZK, Shi CJ, Zhong K, Sheng ZC, Zhou YL, Jiang J, Chu XY, He J, Ge JP, Zhang ZY, Zhou WQ, Chen C, Yang JH, Sun YH, Wang LH
    Eur Urol 2018 Dec;74(6):756-763
  • Plasma Glycosaminoglycans as Diagnostic and Prognostic Biomarkers in Surgically Treated Renal Cell Carcinoma
    Gatto F, Blum KA, Hosseini SS, Ghanaat M, Kashan M, Maccari F, Galeotti F, Hsieh JJ, Volpi N, Hakimi AA, Nielsen J
    European Urology Cancer 2018
  • The Clinical Activity of PD-1/PD-L1 Inhibitors in Metastatic Non-Clear Cell Renal Cell Carcinoma
    McKay RR, Bosse D, Xie W, Wankowicz SAM, Flaifel A, Brandao R, Lalani AA, Martini DJ, Wei XX, Braun DA, Van Allen E, Castellano D, De Velasco G, Wells JC, Heng DY, Fay AP, Schutz FA, Hsu J, Pal SK, Lee JL, Hsieh JJ, Harshman LC, Signoretti S, Motzer RJ, Feldman D, Choueiri TK
    Cancer Immunol Res 2018 Jul;6(7):758-765
  • KMT2C Mediates the Estrogen Dependence of Breast Cancer Through Regulation of ERalpha Enhancer Function
    Gala K, Li Q, Sinha A, Razavi P, Dorso M, Sanchez-Vega F, Chung YR, Hendrickson R, Hsieh JJ, Berger M, Schultz N, Pastore A, Abdel-Wahab O, Chandarlapaty S
    Oncogene 2018 Aug;37(34):4692-4710
  • Tracking Cancer Evolution Reveals Constrained Routes to Metastases: TRACERx Renal
    Turajlic S, Xu H, Litchfield K, Rowan A, Chambers T, Lopez JI, Nicol D, O'Brien T, Larkin J, Horswell S, Stares M, Au L, Jamal-Hanjani M, Challacombe B, Chandra A, Hazell S, Eichler-Jonsson C, Soultati A, Chowdhury S, Rudman S, Lynch J, Fernando A, Stamp G, Nye E, Jabbar F, Spain L, Lall S, Guarch R, Falzon M, Proctor I, Pickering L, Gore M, Watkins TBK, Ward S, Stewart A, DiNatale R, Becerra MF, Reznik E, Hsieh JJ, Richmond TA, Mayhew GF, Hill SM, McNally CD, Jones C, Rosenbaum H, Stanislaw S, Burgess DL, Alexander NR, Swanton C
    PEACE

    Cell 2018 Apr 19;173(3):581-594e12
  • The Cancer Genome Atlas Comprehensive Molecular Characterization of Renal Cell Carcinoma
    Ricketts CJ, De Cubas AA, Fan H, Smith CC, Lang M, Reznik E, Bowlby R, Gibb EA, Akbani R, Beroukhim R, Bottaro DP, Choueiri TK, Gibbs RA, Godwin AK, Haake S, Hakimi AA, Henske EP, Hsieh JJ, Ho TH, Kanchi RS, Krishnan B, Kwaitkowski DJ, Lui W, Merino MJ, Mills GB, Myers J, Nickerson ML, Reuter VE, Schmidt LS, Shelley CS, Shen H, Shuch B, Signoretti S, Srinivasan R, Tamboli P, Thomas G, Vincent BG, Vocke CD, Wheeler DA, Yang L, Kim WT, Robertson AG, Spellman PT, Rathmell WK, Linehan WM
    Cancer Genome Atlas Research Network

    Cell Rep 2018 Apr 3;23(1):313-326e5
  • In Vivo PET Assay of Tumor Glutamine Flux and Metabolism: In-Human Trial of (18)F-(2S,4R)-4-Fluoroglutamine
    Dunphy MPS, Harding JJ, Venneti S, Zhang H, Burnazi EM, Bromberg J, Omuro AM, Hsieh JJ, Mellinghoff IK, Staton K, Pressl C, Beattie BJ, Zanzonico PB, Gerecitano JF, Kelsen DP, Weber W, Lyashchenko SK, Kung HF, Lewis JS
    Radiology 2018 May;287(2):667-675
  • Comparative Genomic Profiling of Matched Primary and Metastatic Tumors in Renal Cell Carcinoma
    Becerra MF, Reznik E, Redzematovic A, Tennenbaum DM, Kashan M, Ghanaat M, Casuscelli J, Manley B, Jonsson P, DiNatale RG, Blum KA, Durack JC, Solomon SB, Arcila ME, Bourque C, Socci N, Carlo MI, Lee CH, Voss MH, Feldman DR, Motzer RJ, Coleman JA, Russo P, Cheng EH, Hakimi AA, Hsieh JJ
    Eur Urol Focus 2018 Dec;4(6):986-994
  • DeltaNp63 Inhibits Oxidative Stress-Induced Cell Death, Including Ferroptosis, and Cooperates With the BCL-2 Family to Promote Clonogenic Survival
    Wang GX, Tu HC, Dong Y, Skanderup AJ, Wang Y, Takeda S, Ganesan YT, Han S, Liu H, Hsieh JJ, Cheng EH
    Cell Rep 2017 Dec 5;21(10):2926-2939
  • SETD2 Alterations Impair DNA Damage Recognition and Lead to Resistance to Chemotherapy in Leukemia
    Mar BG, Chu SH, Kahn JD, Krivtsov AV, Koche R, Castellano CA, Kotlier JL, Zon RL, McConkey ME, Chabon J, Chappell R, Grauman PV, Hsieh JJ, Armstrong SA, Ebert BL
    Blood 2017 Dec 14;130(24):2631-2641
  • Pan-Urologic Cancer Genomic Subtypes That Transcend Tissue of Origin
    Chen F, Zhang Y, Bosse D, Lalani AA, Hakimi AA, Hsieh JJ, Choueiri TK, Gibbons DL, Ittmann M, Creighton CJ
    Nat Commun 2017 Aug 4;8(1):199
  • Recommendations for the Management of Rare Kidney Cancers
    Giles RH, Choueiri TK, Heng DY, Albiges L, Hsieh JJ, Linehan WM, Pal S, Maskens D, Paseman B, Jonasch E, Malouf G, Molina AM, Pickering L, Shuch B, Srinivas S, Srinivasan R, Tannir NM, Bex A
    Eur Urol 2017 Dec;72(6):974-983
  • Benign and Tumor Parenchyma Metabolomic Profiles Affect Compensatory Renal Growth in Renal Cell Carcinoma Surgical Patients
    Rosenzweig B, Rubinstein ND, Reznik E, Shingarev R, Juluru K, Akin O, Hsieh JJ, Jaimes EA, Russo P, Susztak K, Coleman JA, Hakimi AA
    PLoS One 2017 Jul 20;12(7):e0180350
  • Genomic Alterations and Outcomes With VEGF-Targeted Therapy in Patients With Clear Cell Renal Cell Carcinoma
    Carlo MI, Manley B, Patilc S, Woo KM, Coskey DT, Redzematovic A, Arcila M, Ladanyi M, Lee W, Chen YB, Lee CH, Feldman DR, Hakimi AA, Motzer RJ, Hsieh JJ, Voss MH
    Kidney Cancer 2017
  • Targeting the Differential Addiction to Anti-Apoptotic BCL-2 Family for Cancer Therapy
    Inoue-Yamauchi A, Jeng PS, Kim K, Chen HC, Han S, Ganesan YT, Ishizawa K, Jebiwott S, Dong Y, Pietanza MC, Hellmann MD, Kris MG, Hsieh JJ, Cheng EH
    Nat Commun 2017 Jul 17;8:16078
  • Genomic Landscape and Evolution of Metastatic Chromophobe Renal Cell Carcinoma
    Casuscelli J, Weinhold N, Gundem G, Wang L, Zabor EC, Drill E, Wang PI, Nanjangud GJ, Redzematovic A, Nargund AM, Manley BJ, Arcila ME, Donin NM, Cheville JC, Thompson RH, Pantuck AJ, Russo P, Cheng EH, Lee W, Tickoo SK, Ostrovnaya I, Creighton CJ, Papaemmanuil E, Seshan VE, Hakimi AA, Hsieh JJ
    JCI Insight 2017 Jun 15;2(12)
  • Potential Abscopal Response to Dual Checkpoint Blockade in RCC After Reirradiation Using Dose-Painting SBRT
    LaPlant Q, Deselm C, Lockney NA, Hsieh J, Yamada Y
    Pract Radiat Oncol 2017 Nov - Dec;7(6):396-399
  • Analysis of Renal Cancer Cell Lines From Two Major Resources Enables Genomics-Guided Cell Line Selection
    Sinha R, Winer AG, Chevinsky M, Jakubowski C, Chen YB, Dong Y, Tickoo SK, Reuter VE, Russo P, Coleman JA, Sander C, Hsieh JJ, Hakimi AA
    Nat Commun 2017 May 10;8:15165
  • Persistent Severe Hyperlactatemia and Metabolic Derangement in Lethal Succinate Dehydrogenase B Mutated Metastatic Kidney Cancer: Clinical Challenges and Examples of Extreme Warburg Effect
    Lee CH, Gundem G, Lee W, Chen YB, Cross JR, Dong Y, Redzematovic A, Mano R, Wei EY, Cheng EH, Srinivasan R, Oschwald D, Hakimi AA, Dunphy MP, Linehan WM, Papaemmanuil E, Hsieh JJ
    J Clin Oncol Precision Oncology 2017
  • Genomic Characterization of Renal Medullary Carcinoma and Treatment Outcomes
    Carlo MI, Chaim J, Patil S, Kemel Y, Schram AM, Woo K, Coskey D, Nanjangud GJ, Voss MH, Feldman DR, Hsieh JJ, Hakimi AA, Chen YB, Motzer RJ, Lee CH
    Clin Genitourin Cancer 2017 Dec;15(6):e987-e994
  • Genomic Alterations as Predictors of Survival Among Patients Within a Combined Cohort With Clear Cell Renal Cell Carcinoma Undergoing Cytoreductive Nephrectomy
    Tennenbaum DM, Manley BJ, Zabor E, Becerra MF, Carlo MI, Casuscelli J, Redzematovic A, Khan N, Arcila ME, Voss MH, Feldman DR, Motzer RJ, Benfante NE, Coleman JA, Russo P, Hsieh JJ, Hakimi AA
    Urol Oncol 2017 Aug;35(8):532e7-532e13
  • The SWI/SNF Protein PBRM1 Restrains VHL-Loss-Driven Clear Cell Renal Cell Carcinoma
    Nargund AM, Pham CG, Dong Y, Wang PI, Osmangeyoglu HU, Xie Y, Aras O, Han S, Oyama T, Takeda S, Ray CE, Dong Z, Berge M, Hakimi AA, Monette S, Lekaye CL, Koutcher JA, Leslie CS, Creighton CJ, Weinhold N, Lee W, Tickoo SK, Wang Z, Cheng EH, Hsieh JJ
    Cell Rep 2017 Mar 21;18(12):2893-2906
  • Molecular Subtypes Improve Prognostic Value of International Metastatic Renal Cell Carcinoma Database Consortium Prognostic Model
    de Velasco G, Culhane AC, Fay AP, Ari Hakimi A, Voss MH, Tannir NM, Tamboli P, Appleman LJ, Bellmunt J, Kimryn Rathmell W, Albiges L, Hsieh JJ, Heng DY, Signoretti S, Choueiri TK
    Oncologist 2017 Mar;22(3):286-292
  • Genomic Biomarkers of a Randomized Trial Comparing First-Line Everolimus and Sunitinib in Patients With Metastatic Renal Cell Carcinoma
    Hsieh JJ, Chen D, Wang PI, Marker M, Redzematovic A, Chen YB, Selcuklu SD, Weinhold N, Bouvier N, Huberman KH, Bhanot U, Chevinsky MS, Patel P, Pinciroli P, Won HH, You D, Viale A, Lee W, Hakimi AA, Berger MF, Socci ND, Cheng EH, Knox J, Voss MH, Voi M, Motzer RJ
    Eur Urol 2017 Mar;71(3):405-414
  • The Difficulty in Selecting Patients for Cytoreductive Nephrectomy: An Evaluation of Previously Described Predictive Models
    Manley BJ, Tennenbaum DM, Vertosick EA, Hsieh JJ, Sjoberg DD, Assel M, Benfante NE, Strope SA, Kim E, Casuscelli J, Becerra MF, Coleman JA, Hakimi AA, Russo P
    Urol Oncol 2017 Jan;35(1):35e1-35e5
  • Tumor Xenografts of Human Clear Cell Renal Cell Carcinoma but Not Corresponding Cell Lines Recapitulate Clinical Response to Sunitinib: Feasibility of Using Biopsy Samples
    Dong Y, Manley BJ, Becerra MF, Redzematovic A, Casuscelli J, Tennenbaum DM, Reznik E, Han S, Benfante N, Chen YB, Arcila ME, Aras O, Voss MH, Feldman DR, Motzer RJ, Fabbri N, Healey JH, Boland PJ, Chawla M, Durack JC, Lee CH, Coleman JA, Russo P, Hakimi AA, Cheng EH, Hsieh JJ
    Eur Urol Focus 2017 Dec;3(6):590-598
  • Integration of Recurrent Somatic Mutations With Clinical Outcomes: A Pooled Analysis of 1049 Patients With Clear Cell Renal Cell Carcinoma
    Manley BJ, Zabor EC, Casuscelli J, Tennenbaum DM, Redzematovic A, Becerra MF, Benfante N, Sato Y, Morikawa T, Kume H, Fukayama M, Homma Y, Ogawa S, Arcila ME, Voss MH, Feldman DR, Coleman JA, Reuter VE, Motzer RJ, Russo P, Hsieh JJ, Hakimi AA
    Eur Urol Focus 2017 Oct;3(4-5):421-427
  • Immune-Related Alopecia (Areata and Universalis) in Cancer Patients Receiving Immune Checkpoint Inhibitors
    Zarbo A, Belum VR, Sibaud V, Oudard S, Postow MA, Hsieh JJ, Motzer RJ, Busam KJ, Lacouture ME
    Br J Dermatol 2017 Jun;176(6):1649-1652
  • Mechanistically Distinct Cancer-Associated mTOR Activation Clusters Predict Sensitivity to Rapamycin
    Xu J, Pham CG, Albanese SK, Dong Y, Oyama T, Lee CH, Rodrik-Outmezguine V, Yao Z, Han S, Chen D, Parton DL, Chodera JD, Rosen N, Cheng EH, Hsieh JJ
    J Clin Invest 2016 Sep 1;126(9):3526-40
  • NUP98 Fusion Proteins Interact With the NSL and MLL1 Complexes to Drive Leukemogenesis
    Xu H, Valerio DG, Eisold ME, Sinha A, Koche RP, Hu W, Chen CW, Chu SH, Brien GL, Park CY, Hsieh JJ, Ernst P, Armstrong SA
    Cancer Cell 2016 Dec 12;30(6):863-878
  • Tumor Immune Microenvironment Characterization in Clear Cell Renal Cell Carcinoma Identifies Prognostic and Immunotherapeutically Relevant Messenger RNA Signatures
    Senbabaoglu Y, Gejman RS, Winer AG, Liu M, Van Allen EM, de Velasco G, Miao D, Ostrovnaya I, Drill E, Luna A, Weinhold N, Lee W, Manley BJ, Khalil DN, Kaffenberger SD, Chen Y, Danilova L, Voss MH, Coleman JA, Russo P, Reuter VE, Chan TA, Cheng EH, Scheinberg DA, Li MO, Choueiri TK, Hsieh JJ, Sander C, Hakimi AA
    Genome Biol 2016 Nov 17;17(1):231
  • Molecular Analysis of Aggressive Renal Cell Carcinoma With Unclassified Histology Reveals Distinct Subsets
    Chen YB, Xu J, Skanderup AJ, Dong Y, Brannon AR, Wang L, Won HH, Wang PI, Nanjangud GJ, Jungbluth AA, Li W, Ojeda V, Hakimi AA, Voss MH, Schultz N, Motzer RJ, Russo P, Cheng EH, Giancotti FG, Lee W, Berger MF, Tickoo SK, Reuter VE, Hsieh JJ
    Nat Commun 2016 Oct 7;7:13131
  • Modeling Tumor Growth for Kidney Cancer Based on Nuclei Clusters of Pathology Slides
    Saribudak A, Dong Y, Hsieh JJ, Uyar MU
    Inter J Engineering and Technology 2016 Oct;8(5):375-9
  • Phase II Trial and Correlative Genomic Analysis of Everolimus Plus Bevacizumab in Advanced Non-Clear Cell Renal Cell Carcinoma
    Voss MH, Molina AM, Chen YB, Woo KM, Chaim JL, Coskey DT, Redzematovic A, Wang P, Lee W, Selcuklu SD, Lee CH, Berger MF, Tickoo SK, Reuter VE, Patil S, Hsieh JJ, Motzer RJ, Feldman DR
    J Clin Oncol 2016 Nov 10;34(32):3846-3853
  • Tumor Mutational Load and Immune Parameters Across Metastatic Renal Cell Carcinoma Risk Groups
    de Velasco G, Miao D, Voss MH, Hakimi AA, Hsieh JJ, Tannir NM, Tamboli P, Appleman LJ, Rathmell WK, Van Allen EM, Choueiri TK
    Cancer Immunol Res 2016 Oct;4(10):820-822
  • A Phase Ib Study of BEZ235, a Dual Inhibitor of Phosphatidylinositol 3-Kinase (PI3K) and Mammalian Target of Rapamycin (mTOR), in Patients With Advanced Renal Cell Carcinoma
    Carlo MI, Molina AM, Lakhman Y, Patil S, Woo K, DeLuca J, Lee CH, Hsieh JJ, Feldman DR, Motzer RJ, Voss MH
    Oncologist 2016 Jul;21(7):787-8
  • Multilevel Genomics-Based Taxonomy of Renal Cell Carcinoma
    Chen F, Zhang Y, Senbabaoglu Y, Ciriello G, Yang L, Reznik E, Shuch B, Micevic G, De Velasco G, Shinbrot E, Noble MS, Lu Y, Covington KR, Xi L, Drummond JA, Muzny D, Kang H, Lee J, Tamboli P, Reuter V, Shelley CS, Kaipparettu BA, Bottaro DP, Godwin AK, Gibbs RA, Getz G, Kucherlapati R, Park PJ, Sander C, Henske EP, Zhou JH, Kwiatkowski DJ, Ho TH, Choueiri TK, Hsieh JJ, Akbani R, Mills GB, Hakimi AA, Wheeler DA, Creighton CJ
    Cell Rep 2016 Mar 15;14(10):2476-89
  • Circulating Biomarkers and Outcome From a Randomised Phase II Trial of Sunitinib Vs Everolimus for Patients With Metastatic Renal Cell Carcinoma
    Voss MH, Chen D, Marker M, Hakimi AA, Lee CH, Hsieh JJ, Knox JJ, Voi M, Motzer RJ
    Br J Cancer 2016 Mar 15;114(6):642-9
  • An Integrated Metabolic Atlas of Clear Cell Renal Cell Carcinoma
    Hakimi AA, Reznik E, Lee CH, Creighton CJ, Brannon AR, Luna A, Aksoy BA, Liu EM, Shen R, Lee W, Chen Y, Stirdivant SM, Russo P, Chen YB, Tickoo SK, Reuter VE, Cheng EH, Sander C, Hsieh JJ
    Cancer Cell 2016 Jan 11;29(1):104-16
  • Validation and Genomic Interrogation of the MET Variant Rs11762213 as a Predictor of Adverse Outcomes in Clear Cell Renal Cell Carcinoma
    Hakimi AA, Ostrovnaya I, Jacobsen A, Susztak K, Coleman JA, Russo P, Winer AG, Mano R, Sankin AI, Motzer RJ, Voss MH, Offit K, Purdue M, Pomerantz M, Freedman M, Choueiri TK, Hsieh JJ, Klein RJ
    Cancer 2016 Feb 1;122(3):402-10
  • Comprehensive Molecular Characterization of Papillary Renal-Cell Carcinoma
    Linehan WM, Spellman PT, Ricketts CJ, Creighton CJ, Fei SS, Davis C, Wheeler DA, Murray BA, Schmidt L, Vocke CD, Peto M, Al Mamun AA, Shinbrot E, Sethi A, Brooks S, Rathmell WK, Brooks AN, Hoadley KA, Robertson AG, Brooks D, Bowlby R, Sadeghi S, Shen H, Weisenberger DJ, Bootwalla M, Baylin SB, Laird PW, Cherniack AD, Saksena G, Haake S, Li J, Liang H, Lu Y, Mills GB, Akbani R, Leiserson MD, Raphael BJ, Anur P, Bottaro D, Albiges L, Barnabas N, Choueiri TK, Czerniak B, Godwin AK, Hakimi AA, Ho TH, Hsieh J, Ittmann M, Kim WY, Krishnan B, Merino MJ, Mills Shaw KR, Reuter VE, Reznik E, Shelley CS, Shuch B, Signoretti S, Srinivasan R, Tamboli P, Thomas G, Tickoo S, Burnett K, Crain D, Gardner J, Lau K, Mallery D, Morris S, Paulauskis JD, Penny RJ, Shelton C, Shelton WT, Sherman M, Thompson E, Yena P, Avedon MT, Bowen J, Gastier-Foster JM, Gerken M, Leraas KM, Lichtenberg TM, Ramirez NC, Santos T, Wise L, Zmuda E, Demchok JA, Felau I, Hutter CM, Sheth M, Sofia HJ, Tarnuzzer R, Wang Z, Yang L, Zenklusen JC, Zhang J, Ayala B, Baboud J, Chudamani S, Liu J, Lolla L, Naresh R, Pihl T, Sun Q, Wan Y, Wu Y, Ally A, Balasundaram M, Balu S, Beroukhim R, Bodenheimer T, Buhay C, Butterfield YS, Carlsen R, Carter SL, Chao H, Chuah E, Clarke A, Covington KR, Dahdouli M, Dewal N, Dhalla N, Doddapaneni HV, Drummond JA, Gabriel SB, Gibbs RA, Guin R, Hale W, Hawes A, Hayes DN, Holt RA, Hoyle AP, Jefferys SR, Jones SJ, Jones CD, Kalra D, Kovar C, Lewis L, Li J, Ma Y, Marra MA, Mayo M, Meng S, Meyerson M, Mieczkowski PA, Moore RA, Morton D, Mose LE, Mungall AJ, Muzny D, Parker JS, Perou CM, Roach J, Schein JE, Schumacher SE, Shi Y, Simons JV, Sipahimalani P, Skelly T, Soloway MG, Sougnez C, Tam A, Tan D, Thiessen N, Veluvolu U, Wang M, Wilkerson MD, Wong T, Wu J, Xi L, Zhou J, Bedford J, Chen F, Fu Y, Gerstein M, Haussler D, Kasaian K, Lai P, Ling S, Radenbaugh A, Van Den Berg D, Weinstein JN, Zhu J, Albert M, Alexopoulou I, Andersen JJ, Auman JT, Bartlett J, Bastacky S, Bergsten J, Blute ML, Boice L, Bollag RJ, Boyd J, Castle E, Chen YB, Cheville JC, Curley E, Davies B, DeVolk A, Dhir R, Dike L, Eckman J, Engel J, Harr J, Hrebinko R, Huang M, Huelsenbeck-Dill L, Iacocca M, Jacobs B, Lobis M, Maranchie JK, McMeekin S, Myers J, Nelson J, Parfitt J, Parwani A, Petrelli N, Rabeno B, Roy S, Salner AL, Slaton J, Stanton M, Thompson RH, Thorne L, Tucker K, Weinberger PM, Winemiller C, Zach LA, Zuna R
    N Engl J Med 2016 Jan 14;374(2):135-45
  • The Genomic Landscape of Renal Oncocytoma Identifies a Metabolic Barrier to Tumorigenesis
    Joshi S, Tolkunov D, Aviv H, Hakimi AA, Yao M, Hsieh JJ, Ganesan S, Chan CS, White E
    Cell Rep 2015 Dec 1;13(9):1895-908
  • Genomic Characterisation of Two Cancers of Unknown Primary Cases Supports a Kidney Cancer Origin
    Wei EY, Chen YB, Hsieh JJ
    BMJ Case Rep 2015 Oct 22;2015 pii: bcr2015212685
  • Taspase1 Processing Alters TFIIA Cofactor Properties in the Regulation of TFIID
    Malecova B, Caputo VS, Lee DF, Hsieh JJ, Oelgeschlager T
    Transcription 2015;6(2):21-32
  • An Interconnected Hierarchical Model of Cell Death Regulation by the BCL-2 Family
    Chen HC, Kanai M, Inoue-Yamauchi A, Tu HC, Huang Y, Ren D, Kim H, Takeda S, Reyna DE, Chan PM, Ganesan YT, Liao CP, Gavathiotis E, Hsieh JJ, Cheng EH
    Nat Cell Biol 2015 Oct;17(10):1270-81
  • Mathematical Models of Tumor Growth Using Voronoi Tessellations in Pathology Slides of Kidney Cancer
    Saribudak A, Yiyu Dong, Gundry S, Hsieh J, Uyar MU
    Conf Proc IEEE Eng Med Biol Soc 2015 Aug;2015:4454-7
  • Grade-Dependent Metabolic Reprogramming in Kidney Cancer Revealed by Combined Proteomics and Metabolomics Analysis
    Wettersten HI, Hakimi AA, Morin D, Bianchi C, Johnstone ME, Donohoe DR, Trott JF, Aboud OA, Stirdivant S, Neri B, Wolfert R, Stewart B, Perego R, Hsieh JJ, Weiss RH
    Cancer Res 2015 Jun 15;75(12):2541-52
  • TCEB1-Mutated Renal Cell Carcinoma: A Distinct Genomic and Morphological Subtype
    Hakimi AA, Tickoo SK, Jacobsen A, Sarungbam J, Sfakianos JP, Sato Y, Morikawa T, Kume H, Fukayama M, Homma Y, Chen YB, Sankin AI, Mano R, Coleman JA, Russo P, Ogawa S, Sander C, Hsieh JJ, Reuter VE
    Mod Pathol 2015 Jun;28(6):845-53
  • Taspase1-Dependent TFIIA Cleavage Coordinates Head Morphogenesis by Limiting Cdkn2a Locus Transcription
    Takeda S, Sasagawa S, Oyama T, Searleman AC, Westergard TD, Cheng EH, Hsieh JJ
    J Clin Invest 2015 Mar 2;125(3):1203-14
  • Expression of Ror2 Mediates Invasive Phenotypes in Renal Cell Carcinoma
    Rasmussen NR, Debebe Z, Wright TM, Brooks SA, Sendor AB, Brannon AR, Hakimi AA, Hsieh JJ, Choueiri TK, Tamboli P, Maranchie JK, Hinds P, Wallen EM, Simpson C, Norris JL, Janzen WP, Rathmell WK
    PLoS One 2014 Dec 26;9(12):e116101
  • Genomic Investigation of Etiologic Heterogeneity: Methodologic Challenges
    Begg CB, Seshan VE, Zabor EC, Furberg H, Arora A, Shen R, Maranchie JK, Nielsen ME, Rathmell WK, Signoretti S, Tamboli P, Karam JA, Choueiri TK, Hakimi AA, Hsieh JJ
    BMC Med Res Methodol 2014 Dec 22;14:138
  • The Impact of Genetic Heterogeneity on Biomarker Development in Kidney Cancer Assessed by Multiregional Sampling
    Sankin A, Hakimi AA, Mikkilineni N, Ostrovnaya I, Silk MT, Liang Y, Mano R, Chevinsky M, Motzer RJ, Solomon SB, Cheng EH, Durack JC, Coleman JA, Russo P, Hsieh JJ
    Cancer Med 2014 Dec;3(6):1485-92
  • Taspase1 Cleaves MLL1 to Activate Cyclin E for HER2/Neu Breast Tumorigenesis
    Dong Y, Van Tine BA, Oyama T, Wang PI, Cheng EH, Hsieh JJ
    Cell Res 2014 Nov;24(11):1354-66
  • The Somatic Genomic Landscape of Chromophobe Renal Cell Carcinoma
    Davis CF, Ricketts CJ, Wang M, Yang L, Cherniack AD, Shen H, Buhay C, Kang H, Kim SC, Fahey CC, Hacker KE, Bhanot G, Gordenin DA, Chu A, Gunaratne PH, Biehl M, Seth S, Kaipparettu BA, Bristow CA, Donehower LA, Wallen EM, Smith AB, Tickoo SK, Tamboli P, Reuter V, Schmidt LS, Hsieh JJ, Choueiri TK, Hakimi AA, Chin L, Meyerson M, Kucherlapati R, Park WY, Robertson AG, Laird PW, Henske EP, Kwiatkowski DJ, Park PJ, Morgan M, Shuch B, Muzny D, Wheeler DA, Linehan WM, Gibbs RA, Rathmell WK, Creighton CJ
    Cancer Cell 2014 Sep 8;26(3):319-30
  • Development of Synchronous VHL Syndrome Tumors Reveals Contingencies and Constraints to Tumor Evolution
    Fisher R, Horswell S, Rowan A, Salm MP, de Bruin EC, Gulati S, McGranahan N, Stares M, Gerlinger M, Varela I, Crockford A, Favero F, Quidville V, Andre F, Navas C, Gronroos E, Nicol D, Hazell S, Hrouda D, O'Brien T, Matthews N, Phillimore B, Begum S, Rabinowitz A, Biggs J, Bates PA, McDonald NQ, Stamp G, Spencer-Dene B, Hsieh JJ, Xu J, Pickering L, Gore M, Larkin J, Swanton C
    Genome Biol 2014 Aug 27;15(8):433
  • Proteasome Inhibitors Evoke Latent Tumor Suppression Programs in Pro-B MLL Leukemias Through MLL-AF4
    Liu H, Westergard TD, Cashen A, Piwnica-Worms DR, Kunkle L, Vij R, Pham CG, DiPersio J, Cheng EH, Hsieh JJ
    Cancer Cell 2014 Apr 14;25(4):530-42
  • Tumor Genetic Analyses of Patients With Metastatic Renal Cell Carcinoma and Extended Benefit From mTOR Inhibitor Therapy
    Voss MH, Hakimi AA, Pham CG, Brannon AR, Chen YB, Cunha LF, Akin O, Liu H, Takeda S, Scott SN, Socci ND, Viale A, Schultz N, Sander C, Reuter VE, Russo P, Cheng EH, Motzer RJ, Berger MF, Hsieh JJ
    Clin Cancer Res 2014 Apr 1;20(7):1955-64
  • ClearCode34: A Prognostic Risk Predictor for Localized Clear Cell Renal Cell Carcinoma
    Brooks SA, Brannon AR, Parker JS, Fisher JC, Sen O, Kattan MW, Hakimi AA, Hsieh JJ, Choueiri TK, Tamboli P, Maranchie JK, Hinds P, Miller CR, Nielsen ME, Rathmell WK
    Eur Urol 2014 Jul;66(1):77-84
  • Impact of Recurrent Copy Number Alterations and Cancer Gene Mutations on the Predictive Accuracy of Prognostic Models in Clear Cell Renal Cell Carcinoma
    Hakimi AA, Mano R, Ciriello G, Gonen M, Mikkilineni N, Sfakianos JP, Kim PH, Motzer RJ, Russo P, Reuter VE, Hsieh JJ, Ostrovnaya I
    J Urol 2014 Jul;192(1):24-9
  • Radiogenomics of Clear Cell Renal Cell Carcinoma: Associations Between CT Imaging Features and Mutations
    Karlo CA, Di Paolo PL, Chaim J, Hakimi AA, Ostrovnaya I, Russo P, Hricak H, Motzer R, Hsieh JJ, Akin O
    Radiology 2014 Feb;270(2):464-71
  • SQSTM1 Is a Pathogenic Target of 5q Copy Number Gains in Kidney Cancer
    Li L, Shen C, Nakamura E, Ando K, Signoretti S, Beroukhim R, Cowley GS, Lizotte P, Liberzon E, Bair S, Root DE, Tamayo P, Tsherniak A, Cheng SC, Tabak B, Jacobsen A, Hakimi AA, Schultz N, Ciriello G, Sander C, Hsieh JJ, Kaelin WG Jr
    Cancer Cell 2013 Dec 9;24(6):738-50
  • Cleavage of TFIIA by Taspase1 Activates TRF2-Specified Mammalian Male Germ Cell Programs
    Oyama T, Sasagawa S, Takeda S, Hess RA, Lieberman PM, Cheng EH, Hsieh JJ
    Dev Cell 2013 Oct 28;27(2):188-200
  • An Epidemiologic and Genomic Investigation Into the Obesity Paradox in Renal Cell Carcinoma
    Hakimi AA, Furberg H, Zabor EC, Jacobsen A, Schultz N, Ciriello G, Mikklineni N, Fiegoli B, Kim PH, Voss MH, Shen H, Laird PW, Sander C, Reuter VE, Motzer RJ, Hsieh JJ, Russo P
    J Natl Cancer Inst 2013 Dec 18;105(24):1862-70
  • Comprehensive Molecular Characterization of Clear Cell Renal Cell Carcinoma
    Cancer Genome Atlas Research Network (Contributors include: Hsieh JJ)
    Nature 2013 Jul 4;499(7456):43-9
  • Long-Term Response to Sunitinib Therapy for Metastatic Renal Cell Carcinoma
    Molina AM, Jia X, Feldman DR, Hsieh JJ, Ginsberg MS, Velasco S, Patil S, Motzer RJ
    Clin Genitourin Cancer 2013 Sep;11(3):297-302
  • HGF-MET Signals Via the MLL-ETS2 Complex in Hepatocellular Carcinoma
    Takeda S, Liu H, Sasagawa S, Dong Y, Trainor PA, Cheng EH, Hsieh JJ
    J Clin Invest 2013 Jul;123(7):3154-65
  • Adverse Outcomes in Clear Cell Renal Cell Carcinoma With Mutations of 3p21 Epigenetic Regulators BAP1 and SETD2: A Report by MSKCC and the KIRC TCGA Research Network
    Hakimi AA, Ostrovnaya I, Reva B, Schultz N, Chen YB, Gonen M, Liu H, Takeda S, Voss MH, Tickoo SK, Reuter VE, Russo P, Cheng EH, Sander C, Motzer RJ, Hsieh JJ
    Clin Cancer Res 2013 Jun 15;19(12):3259-67
  • PUMA and BIM Are Required for Oncogene Inactivation-Induced Apoptosis
    Bean GR, Ganesan YT, Dong Y, Takeda S, Liu H, Chan PM, Huang Y, Chodosh LA, Zambetti GP, Hsieh JJ, Cheng EH
    Sci Signal 2013 Mar 26;6(268):ra20
  • Epigenetic Expansion of VHL-HIF Signal Output Drives Multiorgan Metastasis in Renal Cancer
    Vanharanta S, Shu W, Brenet F, Hakimi AA, Heguy A, Viale A, Reuter VE, Hsieh JJ, Scandura JM, Massague J
    Nat Med 2013 Jan;19(1):50-6
  • Clinical and Pathologic Impact of Select Chromatin-Modulating Tumor Suppressors in Clear Cell Renal Cell Carcinoma
    Hakimi AA, Chen YB, Wren J, Gonen M, Abdel-Wahab O, Heguy A, Liu H, Takeda S, Tickoo SK, Reuter VE, Voss MH, Motzer RJ, Coleman JA, Cheng EH, Russo P, Hsieh JJ
    Eur Urol 2013 May;63(5):848-54
  • A Pharmacologic Inhibitor of the Protease Taspase1 Effectively Inhibits Breast and Brain Tumor Growth
    Chen DY, Lee Y, Van Tine BA, Searleman AC, Westergard TD, Liu H, Tu HC, Takeda S, Dong Y, Piwnica-Worms DR, Oh KJ, Korsmeyer SJ, Hermone A, Gussio R, Shoemaker RH, Cheng EH, Hsieh JJ
    Cancer Res 2012 Feb 1;72(3):736-46
  • The Ability of MLL to Bind RUNX1 and Methylate H3K4 at PU.1 Regulatory Regions Is Impaired by MDS/AML-Associated RUNX1/AML1 Mutations
    Huang G, Zhao X, Wang L, Elf S, Xu H, Zhao X, Sashida G, Zhang Y, Liu Y, Lee J, Menendez S, Yang Y, Yan X, Zhang P, Tenen DG, Osato M, Hsieh JJ, Nimer SD
    Blood 2011 Dec 15;118(25):6544-52
  • BID, BIM, and PUMA Are Essential for Activation of the BAX- And BAK-Dependent Cell Death Program
    Ren D, Tu HC, Kim H, Wang GX, Bean GR, Takeuchi O, Jeffers JR, Zambetti GP, Hsieh JJ, Cheng EH
    Science 2010 Dec 3;330(6009):1390-3
  • Phosphorylation of MLL by ATR Is Required for Execution of Mammalian S-Phase Checkpoint
    Liu H, Takeda S, Kumar R, Westergard TD, Brown EJ, Pandita TK, Cheng EH, Hsieh JJ
    Nature 2010 Sep 16;467(7313):343-6
  • Taspase1 Functions as a Non-Oncogene Addiction Protease That Coordinates Cancer Cell Proliferation and Apoptosis
    Chen DY, Liu H, Takeda S, Tu HC, Sasagawa S, Van Tine BA, Lu D, Cheng EH, Hsieh JJ
    Cancer Res 2010 Jul 1;70(13):5358-67
  • Stepwise Activation of BAX and BAK by TBID, BIM, and PUMA Initiates Mitochondrial Apoptosis
    Kim H, Tu HC, Ren D, Takeuchi O, Jeffers JR, Zambetti GP, Hsieh JJ, Cheng EH
    Mol Cell 2009 Nov 13;36(3):487-99
  • miR-128b Is a Potent Glucocorticoid Sensitizer in MLL-AF4 Acute Lymphocytic Leukemia Cells and Exerts Cooperative Effects With miR-221
    Kotani A, Ha D, Hsieh J, Rao PK, Schotte D, den Boer ML, Armstrong SA, Lodish HF
    Blood 2009 Nov 5;114(19):4169-78
  • The VDAC2-BAK Rheostat Controls Thymocyte Survival
    Ren D, Kim H, Tu HC, Westergard TD, Fisher JK, Rubens JA, Korsmeyer SJ, Hsieh JJ, Cheng EH
    Sci Signal 2009 Aug 25;2(85):ra48
  • Design, Syntheses, and Evaluation of Taspase1 Inhibitors
    Lee JT, Chen DY, Yang Z, Ramos AD, Hsieh JJ, Bogyo M
    Bioorg Med Chem Lett 2009 Sep 1;19(17):5086-90
  • The p53-Cathepsin Axis Cooperates With ROS to Activate Programmed Necrotic Death Upon DNA Damage
    Tu HC, Ren D, Wang GX, Chen DY, Westergard TD, Kim H, Sasagawa S, Hsieh JJ, Cheng EH
    Proc Natl Acad Sci U S A 2009 Jan 27;106(4):1093-8
  • PRMT6-Mediated Methylation of R2 in Histone H3 Antagonizes H3 K4 Trimethylation
    Hyllus D, Stein C, Schnabel K, Schiltz E, Imhof A, Dou Y, Hsieh J, Bauer UM
    Genes Dev 2007 Dec 15;21(24):3369-80
  • Bimodal Degradation of MLL by SCFSkp2 and APCCdc20 Assures Cell Cycle Execution: A Critical Regulatory Circuit Lost in Leukemogenic MLL Fusions
    Liu H, Cheng EH, Hsieh JJ
    Genes Dev 2007 Oct 1;21(19):2385-98
  • Species Selectivity of Mixed-Lineage Leukemia/Trithorax and HCF Proteolytic Maturation Pathways
    Capotosti F, Hsieh JJ, Herr W
    Mol Cell Biol 2007 Oct;27(20):7063-72
  • Hierarchical Regulation of Mitochondrion-Dependent Apoptosis by BCL-2 Subfamilies
    Kim H, Rafiuddin-Shah M, Tu HC, Jeffers JR, Zambetti GP, Hsieh JJ, Cheng EH
    Nat Cell Biol 2006 Dec;8(12):1348-58
  • Proteolysis of MLL Family Proteins Is Essential for Taspase1-Orchestrated Cell Cycle Progression
    Takeda S, Chen DY, Westergard TD, Fisher JK, Rubens JA, Sasagawa S, Kan JT, Korsmeyer SJ, Cheng EH, Hsieh JJ
    Genes Dev 2006 Sep 1;20(17):2397-409
  • Uncleaved TFIIA Is a Substrate for Taspase 1 and Active in Transcription
    Zhou H, Spicuglia S, Hsieh JJ, Mitsiou DJ, Hoiby T, Veenstra GJ, Korsmeyer SJ, Stunnenberg HG
    Mol Cell Biol 2006 Apr;26(7):2728-35
  • Taspase1: A Threonine Aspartase Required for Cleavage of MLL and Proper HOX Gene Expression
    Hsieh JJ, Cheng EH, Korsmeyer SJ
    Cell 2003 Oct 31;115(3):293-303
  • Proteolytic Cleavage of MLL Generates a Complex of N- And C-Terminal Fragments That Confers Protein Stability and Subnuclear Localization
    Hsieh JJ, Ernst P, Erdjument-Bromage H, Tempst P, Korsmeyer SJ
    Mol Cell Biol 2003 Jan;23(1):186-94
  • A Secreted Delta1-Fc Fusion Protein Functions Both as an Activator and Inhibitor of Notch1 Signaling
    Hicks C, Ladi E, Lindsell C, Hsieh JJ, Hayward SD, Collazo A, Weinmaster G
    J Neurosci Res 2002 Jun 15;68(6):655-67
  • SKIP, a CBF1-Associated Protein, Interacts With the Ankyrin Repeat Domain of NotchIC to Facilitate NotchIC Function
    Zhou S, Fujimuro M, Hsieh JJ, Chen L, Miyamoto A, Weinmaster G, Hayward SD
    Mol Cell Biol 2000 Apr;20(7):2400-10
  • A Role for SKIP in EBNA2 Activation of CBF1-Repressed Promoters
    Zhou S, Fujimuro M, Hsieh JJ, Chen L, Hayward SD
    J Virol 2000 Feb;74(4):1939-47
  • CIR, a Corepressor Linking the DNA Binding Factor CBF1 to the Histone Deacetylase Complex
    Hsieh JJ, Zhou S, Chen L, Young DB, Hayward SD
    Proc Natl Acad Sci U S A 1999 Jan 5;96(1):23-8
  • Epstein-Barr Virus Immortalization: Notch2 Interacts With CBF1 and Blocks Differentiation
    Hsieh JJ, Nofziger DE, Weinmaster G, Hayward SD
    J Virol 1997 Mar;71(3):1938-45
  • Notch Signaling Inhibits Muscle Cell Differentiation Through a CBF1-Independent Pathway
    Shawber C, Nofziger D, Hsieh JJ, Lindsell C, Bogler O, Hayward D, Weinmaster G
    Development 1996 Dec;122(12):3765-73
  • Truncated Mammalian Notch1 Activates CBF1/RBPJk-Repressed Genes by a Mechanism Resembling That of Epstein-Barr Virus EBNA2
    Hsieh JJ, Henkel T, Salmon P, Robey E, Peterson MG, Hayward SD
    Mol Cell Biol 1996 Mar;16(3):952-9
  • Masking of the CBF1/RBPJ Kappa Transcriptional Repression Domain by Epstein-Barr Virus EBNA2
    Hsieh JJ, Hayward SD
    Science 1995 Apr 28;268(5210):560-3
  • EBNA-2 Upregulation of Epstein-Barr Virus Latency Promoters and the Cellular CD23 Promoter Utilizes a Common Targeting Intermediate, CBF1
    Ling PD, Hsieh JJ, Ruf IK, Rawlins DR, Hayward SD
    J Virol 1994 Sep;68(9):5375-83

Book Chapters and Reviews

  • Kidney Cancer
    Huang JJ, Hsieh JJ
    In: The Washington Manual of Oncology, 4th Edition (Morgensztern D, Ghobadi A, Govindan R, Editors), Wolters Kluwer, Philadelphia, 2022
  • The Therapeutic Landscape of Renal Cell Carcinoma: From the Dark Age to the Golden Age
    Huang JJ, Hsieh JJ
    Semin Nephrol 2020 Jan;40(1):28-41
  • Genomics and Genetics of Clear Cell Renal Cell Carcinoma: A Mini-Review
    Le VH, Hsieh JJ
    JTGG 2018
  • Chromosome 3p Loss-Orchestrated VHL, HIF, and Epigenetic Deregulation in Clear Cell Renal Cell Carcinoma
    Hsieh JJ, Le VH, Oyama T, Ricketts CJ, Ho TH, Cheng EH
    J Clin Oncol 2018 Oct 29:JCO2018792549; [Epub ahead of print]
  • BH3-Dependent and Independent Activation of BAX and BAK in Mitochondrial Apoptosis
    Jeng PS, Inoue-Yamauchi A, Hsieh JJ, Cheng EH
    Current Opinion in Physiology 2018;3:71-81
  • Genomic Classifications of Renal Cell Carcinoma: A Critical Step Towards the Future Application of Personalized Kidney Cancer Care With Pan-Omics Precision
    Hsieh JJ, Le V, Cao D, Cheng EH, Creighton CJ
    J Pathol 2018 Apr;244(5):525-537
  • Are We Ready for Adjuvant Sunitinib in High-Risk Renal Cell Carcinoma?
    Casuscelli J, Hsieh JJ
    Eur Urol 2018 Jan;73(1):69-70
  • Molecular Classification of Renal Cell Carcinoma and Its Implication in Future Clinical Practice
    Casuscelli J, Yann-Alexandre V, Fridman WH, Hsieh JJ
    Kidney Cancer 2017;1(1):3-13
  • The Evolution of Metastatic Kidney Cancer Treatment
    Casuscelli J, Hsieh JJ
    BJUI Knowledge 2017
  • SWI/SNF Tumor Suppressor Gene PBRM1/BAF180 in Human Clear Cell Kidney Cancer
    Nargund AM, Osmanbeyoglu HU, Cheng EH, Hsieh JJ
    Mol Cell Oncol 2017 Jun 19;4(4):e1342747
  • Renal Cell Carcinoma
    Hsieh JJ, Purdue MP, Signoretti S, Swanton C, Albiges L, Schmidinger M, Heng DY, Larkin J, Ficarra V
    Nat Rev Dis Primers 2017 Mar 9;3:17009
  • Overcome Tumor Heterogeneity-Imposed Therapeutic Barriers Through Convergent Genomic Biomarker Discovery: A Braided Cancer River Model of Kidney Cancer
    Hsieh JJ, Manley BJ, Khan N, Gao J, Carlo MI, Cheng EH
    Semin Cell Dev Biol 2017 Apr;64:98-106
  • The Panoramic View of Clear Cell Renal Cell Carcinoma Metabolism: Values of Integrated Global Cancer Metabolomics
    Hsieh JJ, Cheng EH
    Transl Androl Urol 2016 Dec;5(6):984-986
  • A Braided Cancer River Connects Tumor Heterogeneity and Precision Medicine
    Hsieh JJ, Cheng EH
    Clin Transl Med 2016 Dec;5(1):42
  • Sarcomatoid Renal Cell Carcinoma: Genomic Insights From Sequencing of Matched Sarcomatous and Carcinomatous Components
    Manley BJ, Hsieh JJ
    Transl Cancer Res 2016 Aug;5(Suppl 2):S160-S165
  • Therapeutic Guide for MTOuRing Through the Braided Kidney Cancer Genomic River
    Voss MH, Hsieh JJ
    Clin Cancer Res 2016 May 15;22(10):2320-2
  • Bevacizumab Monotherapy as Salvage Therapy for Advanced Clear Cell Renal Cell Carcinoma Pretreated With Targeted Drugs
    Lee CH, Hotker AM, Voss MH, Feldman DR, Woo KM, Patil S, Coskey DT, Akin O, Hsieh JJ, Motzer RJ
    Clin Genitourin Cancer 2016 Feb;14(1):56-62
  • PBRM1: A Critical Subunit of the SWI/SNF Chromatin Redmodeling Complex
    Lee CH, Pham CG, Hsieh JJ
    In: Renal Cell Carcinoma: Molecular Targets and Clinical Applications, 3rd Edition, 2015
  • A River Model to Map Convergent Cancer Evolution and Guide Therapy in RCC
    Wei EY, Hsieh JJ
    Nat Rev Urol 2015 Dec;12(12):706-12
  • Taspase 1: A Protease With Many Biological Surprises
    Niizuma H, Cheng EH, Hsieh JJ
    Mol Cell Oncol 2015 Jan 23;2(4):e999513
  • A Systematic Review of Predictive and Prognostic Biomarkers for VEGF-Targeted Therapy in Renal Cell Carcinoma
    Funakoshi T, Lee CH, Hsieh JJ
    Cancer Treat Rev 2014 May;40(4):533-47
  • Treatment Outcome With mTOR Inhibitors for Metastatic Renal Cell Carcinoma With Nonclear and Sarcomatoid Histologies
    Voss MH, Bastos DA, Karlo CA, Ajeti A, Hakimi AA, Feldman DR, Hsieh JJ, Molina AM, Patil S, Motzer RJ
    Ann Oncol 2014 Mar;25(3):663-8
  • A Clear Picture of Renal Cell Carcinoma
    Hakimi AA, Pham CG, Hsieh JJ
    Nat Genet 2013 Aug;45(8):849-50
  • Novel Approaches Targeting the Vascular Endothelial Growth Factor Axis in Renal Cell Carcinoma
    Voss MH, Hsieh JJ, Motzer RJ
    Cancer J 2013 Jul-Aug;19(4):299-306
  • Taspase1
    Cunha L, Tong L, Hsieh JJ
    In: Handbook of Proteolytic Enzymes (Rawlings ND, Salvesen G, Eds.), 2013
  • "Targeting Taspase1 for Cancer Therapy"-Response
    Chen DY, Takeda S, Oyama T, Hsieh JJ
    Cancer Res 2012 Jun 1;72(11):2913
  • MLL Fusions: Pathways to Leukemia
    Liu H, Cheng EH, Hsieh JJ
    Cancer Biol Ther 2009 Jul;8(13):1204-11
  • MLL5 Governs Hematopoiesis: A Step Closer
    Liu H, Westergard TD, Hsieh JJ
    Blood 2009 Feb 12;113(7):1395-6
  • Deadly Splicing: Bax Becomes Almighty
    Kim H, Hsieh JJ, Cheng EH
    Mol Cell 2009 Jan 30;33(2):145-6
  • Biphasic MLL Takes Helm at Cell Cycle Control: Implications in Human Mixed Lineage Leukemia
    Liu H, Takeda S, Cheng EH, Hsieh JJ
    Cell Cycle 2008 Feb 15;7(4):428-35
  • Genomic Approaches to the Pathogenesis and Treatment of Acute Lymphoblastic Leukemias
    Armstrong SA, Hsieh JJ, Korsmeyer SJ
    Curr Opin Hematol 2002 Jul;9(4):339-44
  • Identification of Transactivation, Repression, and Protein-Protein Interaction Domains Using GAL4-Fusion Proteins
    Hsieh JJ, Hayward SD
    Methods Mol Biol 2001;174:259-69