Faculty
Oncology Division
Alphabetical list (active faculty):   
Meagan A. Jacoby

Meagan A. Jacoby, MD, PhD

Associate Professor

Department of Medicine

Oncology Division

Bone Marrow Transplantation & Leukemia

Research Interests

  • Genomics
  • Acute myeloid leukemia
  • Myelodysplastic syndromes

Contact

  • 314-362-9405 (office)
  • 314-362-9333 (fax)
  • Division of Oncology
    Mail Stop 8007-0029-11
    Washington University
    660 South Euclid Avenue
    St. Louis, MO 63110
  • 11th Floor Mid-Campus Center (office)

Peer-reviewed Manuscripts

  • Systemic IL-15 Promotes Allogeneic Cell Rejection in Patients Treated With Natural Killer Cell Adoptive Therapy
    Berrien-Elliott MM, Becker-Hapak M, Cashen AF, Jacobs MT, Wong P, Foster M, McClain E, Desai S, Pence P, Cooley S, Brunstein CG, Gao F, Abboud CN, Uy GL, Westervelt P, Jacoby MA, Pusic I, Stockerl-Goldstein K, Schroeder MA, DiPersio JF, Soon-Shiong P, Miller JS, Fehniger TA
    Blood 2021 Nov 19; [Epub ahead of print]
  • Combination of Dociparstat Sodium (DSTAT), a CXCL12/CXCR4 Inhibitor, With Azacitidine for the Treatment of Hypomethylating Agent Refractory AML and MDS
    Huselton E, Rettig MP, Campbell K, Cashen AF, DiPersio JF, Gao F, Jacoby MA, Pusic I, Romee R, Schroeder MA, Uy GL, Marcus S, Westervelt P
    Leuk Res 2021 Nov;110:106713
  • Frequency of Infusion-Related Reactions With CPX-351 Treatment in an Observational Study in Adults With Newly Diagnosed Therapy-Related AML or AML With Myelodysplasia-Related Changes (AML-MRC)
    Jacoby MA, Finn L, Emadi A, Saba NS, Powell BL, Seiter K, Garcia R, Faderl S, Male HJ
    Leuk Lymphoma 2021 Oct;62(10):2539-2542
  • Impact of a 40-Gene Targeted Panel Test on Physician Decision Making for Patients With Acute Myeloid Leukemia
    Barnell EK, Newcomer KF, Skidmore ZL, Krysiak K, Anderson SR, Wartman LD, Oh ST, Welch JS, Stockerl-Goldstein KE, Vij R, Cashen AF, Pusic I, Westervelt P, Abboud CN, Ghobadi A, Uy GL, Schroeder MA, Dipersio JF, Politi MC, Spencer DH, Duncavage EJ, Ley TJ, Griffith M, Jacoby MA, Griffith OL
    JCO Precis Oncol 2021 Jan 14;5:182
  • Genome Sequencing as an Alternative to Cytogenetic Analysis in Myeloid Cancers
    Duncavage EJ, Schroeder MC, O'Laughlin M, Wilson R, MacMillan S, Bohannon A, Kruchowski S, Garza J, Du F, Hughes AEO, Robinson J, Hughes E, Heath SE, Baty JD, Neidich J, Christopher MJ, Jacoby MA, Uy GL, Fulton RS, Miller CA, Payton JE, Link DC, Walter MJ, Westervelt P, DiPersio JF, Ley TJ, Spencer DH
    N Engl J Med 2021 Mar 11;384(10):924-935
  • A Systematic Review of Higher-Risk Myelodysplastic Syndromes Clinical Trials to Determine the Benchmark of Azacitidine and Explore Alternative Endpoints for Overall Survival
    Garcia JS, Swords RT, Roboz GJ, Jacoby MA, Garcia-Manero G, Hong WJ, Yang X, Zhou Y, Platzbecker U, Steensma DP, Wolff JE, Fenaux P
    Leuk Res 2021 May;104:106555
  • Daratumumab in Transfusion-Dependent Patients With Low or Intermediate-1 Risk Myelodysplastic Syndromes
    Garcia-Manero G, Diez-Campelo M, Vellenga E, Jacoby MA, Merchan B, Breems D, Cortelezzi A, Doronin V, Gomez V, Beckers M, Della Porta MG, Varsos H, Xiu L, DeAngelis N, Nnane I, Rose E, van Eygen K
    Am J Hematol 2021 Apr 1;96(4):E111-E114
  • NCCN Guidelines Insights: Acute Myeloid Leukemia, Version 2.2021
    Pollyea DA, Bixby D, Perl A, Bhatt VR, Altman JK, Appelbaum FR, de Lima M, Fathi AT, Foran JM, Gojo I, Hall AC, Jacoby M, Lancet J, Mannis G, Marcucci G, Martin MG, Mims A, Neff J, Nejati R, Olin R, Percival ME, Prebet T, Przespolewski A, Rao D, Ravandi-Kashani F, Shami PJ, Stone RM, Strickland SA, Sweet K, Vachhani P, Wieduwilt M, Gregory KM, Ogba N, Tallman MS
    J Natl Compr Canc Netw 2021 Jan 6;19(1):16-27
  • A Pilot Study of Lenalidomide Maintenance Therapy After Autologous Transplantation in Relapsed or Refractory Classical Hodgkin Lymphoma
    Shea L, Watkins MP, Wan F, Cashen AF, Wagner-Johnston ND, Jacoby MA, Abboud CN, DiPersio JF, Hurd DD, Jaglowski SM, Bartlett NL, Fehniger TA
    Biol Blood Marrow Transplant 2020 Dec;26(12):2223-2228
  • Multidimensional Analyses of Donor Memory-Like NK Cells Reveal New Associations With Response After Adoptive Immunotherapy for Leukemia
    Berrien-Elliott MM, Cashen AF, Cubitt CC, Neal CC, Wong P, Wagner JA, Foster M, Schappe T, Desai S, McClain E, Becker-Hapak M, Foltz JA, Cooper ML, Jaeger N, Srivatsan SN, Gao F, Romee R, Abboud CN, Uy GL, Westervelt P, Jacoby MA, Pusic I, Stockerl-Goldstein KE, Schroeder MA, DiPersio J, Fehniger TA
    Cancer Discov 2020 Dec;10(12):1854-1871
  • Comparison of Patient Age Groups in Transplantation for Myelodysplastic Syndrome: The Medicare Coverage With Evidence Development Study
    Atallah E, Logan B, Chen M, Cutler C, Deeg J, Jacoby M, Champlin R, Nishihori T, Confer D, Gajewski J, Farnia S, Greenberg P, Warlick E, Weisdorf D, Saber W, Horowitz MM, Rizzo JD
    JAMA Oncol 2019 Dec 12;6(4):486-493
  • Acute Myeloid Leukemia, Version 3.2019, NCCN Clinical Practice Guidelines in Oncology
    Tallman MS, Wang ES, Altman JK, Appelbaum FR, Bhatt VR, Bixby D, Coutre SE, De Lima M, Fathi AT, Fiorella M, Foran JM, Hall AC, Jacoby M, Lancet J, LeBlanc TW, Mannis G, Marcucci G, Martin MG, Mims A, O'Donnell MR, Olin R, Peker D, Perl A, Pollyea DA, Pratz K, Prebet T, Ravandi F, Shami PJ, Stone RM, Strickland SA, Wieduwilt M, Gregory KM, Hammond L, Ogba N
    OCN

    J Natl Compr Canc Netw 2019 Jun 1;17(6):721-749
  • Exome Analysis of Treatment-Related AML After APL Suggests Secondary Evolution
    Wang T, Jacoby MA, Duncavage EJ, Miller CA, Heath S, Rahme R, Fenaux P, Ades L, Renneville A, Cassinat B, Takeshita A, Asou N, Miyazaki Y, Kiyoi H, Ravandi F, Westervelt P, Wartman LD, Welch JS
    Br J Haematol 2019 Jun;185(5):984-987
  • Mutation Clearance After Transplantation for Myelodysplastic Syndrome
    Jacoby MA, Trinkaus K, Walter MJ
    N Engl J Med 2018 Dec 13;379(24):2380
  • Mutation Clearance After Transplantation for Myelodysplastic Syndrome
    Duncavage EJ*, Jacoby MA*, Chang GS*, Miller CA, Edwin N, Shao J, Elliott K, Robinson J, Abel H, Fulton RS, Fronick CC, O'Laughlin M, Heath SE, Brendel K, Saba R, Wartman LD, Christopher MJ, Pusic I, Welch JS, Uy GL, Link DC, DiPersio JF, Westervelt P, Ley TJ, Trinkaus K, Graubert TA, Walter MJ (*contributed equally)
    N Engl J Med 2018 Sep 13;379(11):1028-1041
  • Subclones Dominate at MDS Progression Following Allogeneic Hematopoietic Cell Transplant
    Jacoby MA, Duncavage EJ, Chang GS, Miller CA, Shao J, Elliott K, Robinson J, Fulton RS, Fronick CC, O'Laughlin M, Heath SE, Pusic I, Welch JS, Link DC, DiPersio JF, Westervelt P, Ley TJ, Graubert TA, Walter MJ
    JCI Insight 2018 Mar 8;3(5)
  • Safety and Efficacy of Selinexor in Relapsed or Refractory Multiple Myeloma and Waldenstrom Macroglobulinemia
    Chen C, Siegel D, Gutierrez M, Jacoby M, Hofmeister CC, Gabrail N, Baz R, Mau-Sorensen M, Berdeja JG, Savona M, Savoie L, Trudel S, Areethamsirikul N, Unger TJ, Rashal T, Hanke T, Kauffman M, Shacham S, Reece D
    Blood 2018 Feb 22;131(8):855-863
  • Patterns of Infectious Complications in Acute Myeloid Leukemia and Myelodysplastic Syndromes Patients Treated With 10-Day Decitabine Regimen
    Ali AM, Weisel D, Gao F, Uy GL, Cashen AF, Jacoby MA, Wartman LD, Ghobadi A, Pusic I, Romee R, Fehniger TA, Stockerl-Goldstein KE, Vij R, Oh ST, Abboud CN, Schroeder MA, Westervelt P, DiPersio JF, Welch JS
    Cancer Med 2017 Dec;6(12):2814-2821
  • Selective Inhibition of Nuclear Export With Selinexor in Patients With Non-Hodgkin Lymphoma
    Kuruvilla J, Savona M, Baz R, Mau-Sorensen PM, Gabrail N, Garzon R, Stone R, Wang M, Savoie L, Martin P, Flinn I, Jacoby M, Unger TJ, Saint-Martin JR, Rashal T, Friedlander S, Carlson R, Kauffman M, Shacham S, Gutierrez M
    Blood 2017 Jun 15;129(24):3175-3183
  • Virescent Tongue
    Ali AM, Jacoby M, Romee R
    Ann Hematol 2017 May;96(5):883-884
  • A Phase 1/2 Study of Chemosensitization With Plerixafor Plus G-CSF in Relapsed or Refractory Acute Myeloid Leukemia
    Uy GL, Rettig MP, Stone RM, Konopleva MY, Andreeff M, McFarland K, Shannon W, Fletcher TR, Reineck T, Eades W, Stockerl-Goldstein K, Abboud CN, Jacoby MA, Westervelt P, DiPersio JF
    Blood Cancer J 2017 Mar 10;7(3):e542
  • Mutational Landscape and Response Are Conserved in Peripheral Blood of AML and MDS Patients During Decitabine Therapy
    Duncavage EJ, Uy GL, Petti AA, Miller CA, Lee YS, Tandon B, Gao F, Fronick CC, O'Laughlin M, Fulton RS, Wilson RK, Jacoby MA, Cashen AF, Wartman LD, Walter MJ, Westervelt P, Link DC, DiPersio JF, Ley TJ, Welch JS
    Blood 2017 Mar 9;129(10):1397-1401
  • Dynamic Changes in the Clonal Structure of MDS and AML in Response to Epigenetic Therapy
    Uy GL, Duncavage EJ, Chang GS, Jacoby MA, Miller CA, Shao J, Heath S, Elliott K, Reineck T, Fulton RS, Fronick CC, O'Laughlin M, Ganel L, Abboud CN, Cashen AF, DiPersio JF, Wilson RK, Link DC, Welch JS, Ley TJ, Graubert TA, Westervelt P, Walter MJ
    Leukemia 2017 Apr;31(4):872-881
  • TP53 and Decitabine in Acute Myeloid Leukemia and Myelodysplastic Syndromes
    Welch JS, Petti AA, Miller CA, Fronick CC, O'Laughlin M, Fulton RS, Wilson RK, Baty JD, Duncavage EJ, Tandon B, Lee YS, Wartman LD, Uy GL, Ghobadi A, Tomasson MH, Pusic I, Romee R, Fehniger TA, Stockerl-Goldstein KE, Vij R, Oh ST, Abboud CN, Cashen AF, Schroeder MA, Jacoby MA, Heath SE, Luber K, Janke MR, Hantel A, Khan N, Sukhanova MJ, Knoebel RW, Stock W, Graubert TA, Walter MJ, Westervelt P, Link DC, DiPersio JF, Ley TJ
    N Engl J Med 2016 Nov 24;375(21):2023-2036
  • Phase I Study of Azacitidine Following Donor Lymphocyte Infusion for Relapsed Acute Myeloid Leukemia Post Allogeneic Stem Cell Transplantation
    Ghobadi A, Choi J, Fiala MA, Fletcher T, Liu J, Eissenberg LG, Abboud C, Cashen A, Vij R, Schroeder MA, Pusic I, Stockerl-Goldstein K, Jacoby M, Uy G, DiPersio J, Westervelt P
    Leuk Res 2016 Oct;49:1-6
  • Targeted Sequencing Informs the Evaluation of Normal Karyotype Cytopenic Patients for Low-Grade Myelodysplastic Syndrome
    Duncavage EJ, O'Brien J, Vij K, Miller CA, Chang GS, Shao J, Jacoby MA, Heath S, Janke MR, Elliott K, Fulton RS, Fronick C, O'Laughlin M, Westervelt P, Ley TJ, Wilson RK, Walter MJ
    Leukemia 2016 Dec;30(12):2422-2426
  • A Study of High-Dose Lenalidomide Induction and Low-Dose Lenalidomide Maintenance Therapy for Patients With Hypomethylating Agent Refractory Myelodysplastic Syndrome
    Cherian MA, Tibes R, Gao F, Fletcher T, Fiala M, Uy GL, Westervelt P, Jacoby MA, Cashen AF, Stockerl-Goldstein K, DiPersio JF, Vij R
    Leuk Lymphoma 2016 Nov;57(11):2535-2540
  • A Phase I Study of Carfilzomib for Relapsed or Refractory Acute Myeloid and Acute Lymphoblastic Leukemia
    Wartman LD, Fiala MA, Fletcher T, Hawkins ER, Cashen A, DiPersio JF, Jacoby MA, Stockerl-Goldstein KE, Pusic I, Uy GL, Westervelt P, Vij R
    Leuk Lymphoma 2016 Mar;57(3):728-730
  • Hand-Foot Syndrome Following Decitabine
    Ali AM, Jacoby M, Welch JS
    Ann Hematol 2016 Feb;95(3):535-6
  • Maintenance Therapy With Decitabine After Allogeneic Stem Cell Transplantation for Acute Myelogenous Leukemia and Myelodysplastic Syndrome
    Pusic I, Choi J, Fiala MA, Gao F, Holt M, Cashen AF, Vij R, Abboud CN, Stockerl-Goldstein KE, Jacoby MA, Uy GL, Westervelt P, DiPersio JF
    Biol Blood Marrow Transplant 2015 Oct;21(10):1761-9
  • A Phase I Dose Escalation Study of Oral Bexarotene in Combination With Intravenous Decitabine in Patients With AML
    Welch JS, Niu H, Uy GL, Westervelt P, Abboud CN, Vij R, Stockerl-Goldstein KE, Jacoby M, Pusic I, Schroeder MA, DiPersio JF, Cashen AF
    Am J Hematol 2014 Aug;89(8):E103-8
  • Phase I Study of Oral Clofarabine Consolidation in Adults Aged 60 and Older With Acute Myeloid Leukemia
    Jacoby MA, Martin MG, Uy GL, Westervelt P, DiPersio JF, Cashen A, Stockerl-Goldstein K, Vij R, Luo J, Reineck T, Bernabe N, Abboud CN
    Am J Hematol 2014 May;89(5):487-92
  • Protective Effect of Cytomegalovirus Reactivation on Relapse After Allogeneic Hematopoietic Cell Transplantation in Acute Myeloid Leukemia Patients Is Influenced by Conditioning Regimen
    Manjappa S, Bhamidipati PK, Stokerl-Goldstein KE, DiPersio JF, Uy GL, Westervelt P, Liu J, Schroeder MA, Vij R, Abboud CN, Fehniger TA, Cashen AF, Pusic I, Jacoby M, Meera SJ, Romee R
    Biol Blood Marrow Transplant 2014 Jan;20(1):46-52
  • The DNA Double-Strand Break Response Is Abnormal in Myeloblasts From Patients With Therapy-Related Acute Myeloid Leukemia
    Jacoby MA, De Jesus Pizarro RE, Shao J, Koboldt DC, Fulton RS, Zhou G, Wilson RK, Walter MJ
    Leukemia 2014 Jun;28(6):1242-51
  • Acquired Copy Number Alterations of miRNA Genes in Acute Myeloid Leukemia Are Uncommon
    Ramsingh G, Jacoby MA, Shao J, De Jesus Pizzaro RE, Shen D, Trissal M, Getz AH, Ley TJ, Walter MJ, Link DC
    Blood 2013 Oct 10;122(15):e44-51
  • Systematic Mutagenesis of the Murine Gammaherpesvirus 68 M2 Protein Identifies Domains Important for Chronic Infection
    Herskowitz JH, Siegel AM, Jacoby MA, Speck SH
    J Virol 2008 Apr;82(7):3295-310
  • Murine Gammaherpesvirus 68 Infection Is Associated With Lymphoproliferative Disease and Lymphoma in BALB Beta2 Microglobulin-Deficient Mice
    Tarakanova VL, Suarez F, Tibbetts SA, Jacoby MA, Weck KE, Hess JL, Speck SH, Virgin HW 4th
    J Virol 2005 Dec;79(23):14668-79
  • The Murine Gammaherpesvirus 68 M2 Gene Is Required for Efficient Reactivation From Latently Infected B Cells
    Herskowitz JH, Jacoby MA, Speck SH
    J Virol 2005 Feb;79(4):2261-73
  • Establishment and Maintenance of Gammaherpesvirus Latency Are Independent of Infective Dose and Route of Infection
    Tibbetts SA, Loh J, Van Berkel V, McClellan JS, Jacoby MA, Kapadia SB, Speck SH, Virgin HW 4th
    J Virol 2003 Jul;77(13):7696-701
  • Disruption of the M2 Gene of Murine Gammaherpesvirus 68 Alters Splenic Latency Following Intranasal, but Not Intraperitoneal, Inoculation
    Jacoby MA, Virgin HW 4th, Speck SH
    J Virol 2002 Feb;76(4):1790-801
  • The Murine Gammaherpesvirus 68 V-Cyclin Gene Is an Oncogene That Promotes Cell Cycle Progression in Primary Lymphocytes
    van Dyk LF, Hess JL, Katz JD, Jacoby M, Speck SH, Virgin HW IV
    J Virol 1999 Jun;73(6):5110-22
  • Quantifying Serum Antiplague Antibody With a Fiber-Optic Biosensor
    Anderson GP, King KD, Cao LK, Jacoby M, Ligler FS, Ezzell J
    Clin Diagn Lab Immunol 1998 Sep;5(5):609-12
  • Effectiveness of Protein a for Antibody Immobilization for a Fiber Optic Biosensor
    Anderson GP, Jacoby MA, Ligler FS, King KD
    Biosens Bioelectron 1997;12(4):329-36

Invited Publications

  • Identifying Molecular Markers of Relapse in Myelodysplastic Syndrome
    Jacoby MA, Walter M
    Oncology (Williston Park) 2018 Dec 17;32(12)
  • Clonal Hematopoiesis and Cytopenias in the Elderly
    Guy D, Afzal A, Jacoby MA* (*corresponding author)
    In: Anemia in the Young and Old (Means R Jr, ed). Springer. 2019
  • Enhancing the Response to BCL2 Inhibition in Acute Myeloid Leukemia: A Review
    Afzal A, Jacoby M* (*corresponding author)
    Ann Leuk Res 2018;1(1):001-0010
  • Implications of Tumor Clonal Heterogeneity in the Era of Next-Generation Sequencing
    Jacoby MA, Duncavage EJ, Walter MJ
    Trends Cancer 2015 Dec;1(4):231-241
  • Detection of Copy Number Alterations in Acute Myeloid Leukemia and Myelodysplastic Syndromes
    Jacoby MA, Walter MJ
    Expert Rev Mol Diagn 2012 Apr;12(3):253-64
  • Sickle Cell Disease
    Jacoby MA
    In: Washington Manual Hematology and Oncology Subspecialty Consult 2nd ed. (Cashen AF, Wildes TM, eds.), Philadelphia: Lippincott, Williams & Wilkins, 2008, pp 112-24
  • Thrombotic Disease
    Jacoby MA, Martin NR
    In: Washington Manual Hematology and Oncology Subspecialty Consult 2nd ed. (Cashen AF, Wildes TM, eds.), Philadelphia: Lippincott, Williams & Wilkins, 2008, pp 58-70