Oncology Division
Alphabetical list (active faculty):   
Tanner M. Johanns

Tanner M. Johanns, MD, PhD

Assistant Professor

Department of Medicine

Oncology Division

Medical Oncology

Research Interests

  • Novel immunotherapeutic strategies to treat solid tumors


  • 314-362-5677 (office)
  • 314-362-7086 (fax)
  • Division of Oncology
    Mail Stop 8056-0021-09
    Washington University
    660 South Euclid Avenue
    St. Louis, MO 63110
  • 11th Floor Mid-Campus Center (office)

Peer-reviewed Manuscripts

  • Characterization of the Genomic and Immunological Diversity of Malignant Brain Tumors Through Multi-Sector Analysis
    Schaettler MO, Richters MM, Wang AZ, Skidmore ZL, Fisk B, Miller KE, Vickery TL, Kim AH, Chicoine MR, Osbun JW, Leuthardt EC, Dowling JL, Zipfel GJ, Dacey RG, Lu HC, Johanns TM, Griffith OL, Mardis ER, Griffith M, Dunn GP
    Cancer Discov 2021 Oct 5; [Epub ahead of print]
  • Salvage Therapies for Radiation-Relapsed Isocitrate Dehydrogenase-Mutant Astrocytoma and 1p/19q Codeleted Oligodendroglioma
    Ma S, Rudra S, Campian JL, Chheda MG, Johanns TM, Ansstas G, Abraham CD, Chicoine MR, Leuthardt EC, Dowling JL, Dunn GP, Kim AH, Huang J
    Neurooncol Adv 2021 Jun 18;3(1):vdab081
  • Irradiation-Modulated Murine Brain Microenvironment Enhances GL261-Tumor Growth and Inhibits Anti-PD-L1 Immunotherapy
    Garbow JR, Johanns TM, Ge X, Engelbach JA, Yuan L, Dahiya S, Tsien CI, Gao F, Rich KM, Ackerman JJH
    Front Oncol 2021 Jun 24;11:693146
  • BRAF-MEK Inhibitors as Steroid-Sparing Bridge Prior to Checkpoint Blockade Therapy in Symptomatic Intracranial Melanoma
    Khaddour K, Johanns TM, Ansstas G
    Melanoma Manag 2021 Feb 15;8(2):MMT55
  • Optimized Polyepitope Neoantigen DNA Vaccines Elicit Neoantigen-Specific Immune Responses in Preclinical Models and in Clinical Translation
    Li L, Zhang X, Wang X, Kim SW, Herndon JM, Becker-Hapak MK, Carreno BM, Myers NB, Sturmoski MA, McLellan MD, Miller CA, Johanns TM, Tan BR, Dunn GP, Fleming TP, Hansen TH, Goedegebuure SP, Gillanders WE
    Genome Med 2021 Apr 21;13(1):56
  • Cytokine Profiling in Plasma From Patients With Brain Tumors Versus Healthy Individuals Using 2 Different Multiplex Immunoassay Platforms
    Bender DE, Schaettler MO, Sheehan KC, Johanns TM, Dunn GP
    Biomark Insights 2021 Mar 30;16:11772719211006666
  • Successful Administration of Sequential TVEC and Pembrolizumab Followed by Temozolomide in Immunotherapy Refractory Intracranial Metastatic Melanoma With Acquired B2M Mutation
    Khaddour K, Dowling J, Huang J, Council M, Chen D, Cornelius L, Johanns T, Dahiya S, Ansstas G
    Oncotarget 2020 Dec 29;11(52):4836-4844
  • Prognostic Impact of CDKN2A/B Deletion, TERT Mutation, and EGFR Amplification on Histological and Molecular IDH-Wildtype Glioblastoma
    Ma S, Rudra S, Campian JL, Dahiya S, Dunn GP, Johanns T, Goldstein M, Kim AH, Huang J
    Neurooncol Adv 2020 Sep 18;2(1):vdaa126
  • The Landscape of Novel Therapeutics and Challenges in Glioblastoma Multiforme: Contemporary State and Future Directions
    Khaddour K, Johanns TM, Ansstas G
    Pharmaceuticals (Basel) 2020 Nov 14;13(11)
  • GATA2 Regulates Constitutive PD-L1 and PD-L2 Expression in Brain Tumors
    Fu Y, Liu CJ, Kobayashi DK, Johanns TM, Bowman-Kirigin JA, Schaettler MO, Mao DD, Bender D, Kelley DG, Uppaluri R, Bi WL, Dunn IF, Tao Y, Luo J, Kim AH, Dunn GP
    Sci Rep 2020 Jun 3;10(1):9027
  • Treatment of an Aggressive Orthotopic Murine Glioblastoma Model With Combination Checkpoint Blockade and a Multivalent Neoantigen Vaccine
    Liu CJ, Schaettler M, Blaha DT, Bowman-Kirigin JA, Kobayashi DK, Livingstone AJ, Bender D, Miller CA, Kranz DM, Johanns TM, Dunn GP
    Neuro Oncol 2020 Sep 29;22(9):1276-1288
  • An Innovative Immunotherapy Vaccine With Combination Checkpoint Blockade as a First Line Treatment for Glioblastoma in the Context of Current Treatments
    Coxon AT, Johanns TM, Dunn GP
    Mo Med 2020 Jan-Feb;117(1):45-49
  • Implication of Rituximab Infusion Reactions on Clinical Outcomes in Patients With Diffuse Large B-Cell Lymphoma: A Single Institution Experience
    Patel DA, Johanns TM, Trinkaus K, Bartlett NL, Wagner-Johnston N, Cashen AF
    Clin Lymphoma Myeloma Leuk 2019 Dec;19(12):806-811
  • Detection of Neoantigen-Specific T Cells Following a Personalized Vaccine in a Patient With Glioblastoma
    Johanns TM, Miller CA, Liu CJ, Perrin RJ, Bender D, Kobayashi DK, Campian JL, Chicoine MR, Dacey RG, Huang J, Fritsch EF, Gillanders WE, Artyomov MN, Mardis ER, Schreiber RD, Dunn GP
    Oncoimmunology 2019 Jan 25;8(4):e1561106
  • Late Effects of Radiation Prime the Brain Microenvironment for Accelerated Tumor Growth
    Duan C, Yang R, Yuan L, Engelbach JA, Tsien CI, Rich KM, Dahiya SM, Johanns TM, Ackerman JJH, Garbow JR
    Int J Radiat Oncol Biol Phys 2019 Jan 1;103(1):190-194
  • T-Cell Exhaustion Signatures Vary With Tumor Type and Are Severe in Glioblastoma
    Woroniecka K, Chongsathidkiet P, Rhodin K, Kemeny H, Dechant C, Farber SH, Elsamadicy AA, Cui X, Koyama S, Jackson C, Hansen LJ, Johanns TM, Sanchez-Perez L, Chandramohan V, Yu YA, Bigner DD, Giles A, Healy P, Dranoff G, Weinhold KJ, Dunn GP, Fecci PE
    Clin Cancer Res 2018 Sep 1;24(17):4175-4186
  • Stereotactic Radiosurgery and Immunotherapy in Melanoma Brain Metastases: Patterns of Care and Treatment Outcomes
    Gabani P, Fischer-Valuck BW, Johanns TM, Hernandez-Aya LF, Keller JW, Rich KM, Kim AH, Dunn GP, Robinson CG, Chicoine MR, Huang J, Abraham CD
    Radiother Oncol 2018 Aug;128(2):266-273
  • Use of Extracranial Radiation Therapy in Metastatic Melanoma Patients Receiving Immunotherapy
    Gabani P, Robinson CG, Ansstas G, Johanns TM, Huang J
    Radiother Oncol 2018 May;127(2):310-317
  • Rapid Clinical and Radiographic Response With Combined Dabrafenib and Trametinib in Adults With BRAF-Mutated High-Grade Glioma
    Johanns TM, Ferguson CJ, Grierson PM, Dahiya S, Ansstas G
    J Natl Compr Canc Netw 2018 Jan;16(1):4-10
  • Cancer Immunogenomic Approach to Neoantigen Discovery in a Checkpoint Blockade Responsive Murine Model of Oral Cavity Squamous Cell Carcinoma
    Zolkind P, Przybylski D, Marjanovic N, Nguyen L, Lin T, Johanns T, Alexandrov A, Zhou L, Allen CT, Miceli AP, Schreiber RD, Artyomov M, Dunn GP, Uppaluri R
    Oncotarget 2017 Dec 28;9(3):4109-4119
  • Management of Intracranial Melanomas in the Era of Precision Medicine
    Young GJ, Bi WL, Wu WW, Johanns TM, Dunn GP, Dunn IF
    Oncotarget 2017 Jul 13;8(51):89326-89347
  • Comprehensive Analysis of Hypermutation in Human Cancer
    Campbell BB, Light N, Fabrizio D, Zatzman M, Fuligni F, de Borja R, Davidson S, Edwards M, Elvin JA, Hodel KP, Zahurancik WJ, Suo Z, Lipman T, Wimmer K, Kratz CP, Bowers DC, Laetsch TW, Dunn GP, Johanns TM, Grimmer MR, Smirnov IV, Larouche V, Samuel D, Bronsema A, Osborn M, Stearns D, Raman P, Cole KA, Storm PB, Yalon M, Opocher E, Mason G, Thomas GA, Sabel M, George B, Ziegler DS, Lindhorst S, Issai VM, Constantini S, Toledano H, Elhasid R, Farah R, Dvir R, Dirks P, Huang A, Galati MA, Chung J, Ramaswamy V, Irwin MS, Aronson M, Durno C, Taylor MD, Rechavi G, Maris JM, Bouffet E, Hawkins C, Costello JF, Meyn MS, Pursell ZF, Malkin D, Tabori U, Shlien A
    Cell 2017 Nov 16;171(5):1042-1056e10
  • Immune Checkpoint Inhibition in Patients With Brain Metastases
    Johanns T, Waqar SN, Morgensztern D
    Ann Transl Med 2016 Oct;4(Suppl 1):S9
  • High Incidence of TERT Mutation in Brain Tumor Cell Lines
    Johanns TM, Fu Y, Kobayashi DK, Mei Y, Dunn IF, Mao DD, Kim AH, Dunn GP
    Brain Tumor Pathol 2016 Jul;33(3):222-7
  • Endogenous Neoantigen-Specific CD8 T Cells Identified in Two Glioblastoma Models Using a Cancer Immunogenomics Approach
    Johanns TM, Ward JP, Miller CA, Wilson C, Kobayashi DK, Bender D, Fu Y, Alexandrov A, Mardis ER, Artyomov MN, Schreiber RD, Dunn GP
    Cancer Immunol Res 2016 Dec;4(12):1007-1015
  • Immunogenomics of Hypermutated Glioblastoma: A Patient With Germline POLE Deficiency Treated With Checkpoint Blockade Immunotherapy
    Johanns TM, Miller CA, Dorward IG, Tsien C, Chang E, Perry A, Uppaluri R, Ferguson C, Schmidt RE, Dahiya S, Ansstas G, Mardis ER, Dunn GP
    Cancer Discov 2016 Nov;6(11):1230-1236
  • Selective Culling of High Avidity Antigen-Specific CD4+ T Cells After Virulent Salmonella Infection
    Ertelt JM, Johanns TM, Mysz MA, Nanton MR, Rowe JH, Aguilera MN, Way SS
    Immunology 2011 Dec;134(4):487-97
  • Early Eradication of Persistent Salmonella Infection Primes Antibody-Mediated Protective Immunity to Recurrent Infection
    Johanns TM, Law CY, Kalekar LA, O'Donnell H, Ertelt JM, Rowe JH, Way SS
    Microbes Infect 2011 Apr;13(4):322-30
  • Regulatory T Cell Suppressive Potency Dictates the Balance Between Bacterial Proliferation and Clearance During Persistent Salmonella Infection
    Johanns TM, Ertelt JM, Rowe JH, Way SS
    PLoS Pathog 2010 Aug 12;6(8):e1001043
  • Naturally Occurring Altered Peptide Ligands Control Salmonella-Specific CD4+ T Cell Proliferation, IFN-Gamma Production, and Protective Potency
    Johanns TM, Ertelt JM, Lai JC, Rowe JH, Avant RA, Way SS
    J Immunol 2010 Jan 15;184(2):869-76
  • Interleukin (IL)-21-Independent Pathogen-Specific CD8+ T-Cell Expansion, and IL-21-Dependent Suppression of CD4+ T-Cell IL-17 Production
    Ertelt JM, Johanns TM, Rowe JH, Way SS
    Immunology 2010 Oct;131(2):183-91
  • Selective Priming and Expansion of Antigen-Specific Foxp3- CD4+ T Cells During Listeria Monocytogenes Infection
    Ertelt JM, Rowe JH, Johanns TM, Lai JC, McLachlan JB, Way SS
    J Immunol 2009 Mar 1;182(5):3032-8
  • Cytotoxic T-Lymphocyte Antigen 4 Blockade Augments the T-Cell Response Primed by Attenuated Listeria Monocytogenes Resulting in More Rapid Clearance of Virulent Bacterial Challenge
    Rowe JH, Johanns TM, Ertelt JM, Lai JC, Way SS
    Immunology 2009 Sep;128(1 Suppl):e471-8
  • PDL-1 Blockade Impedes T Cell Expansion and Protective Immunity Primed by Attenuated Listeria Monocytogenes
    Rowe JH, Johanns TM, Ertelt JM, Way SS
    J Immunol 2008 Jun 1;180(11):7553-7
  • Glutamate-Induced Protease-Mediated Loss of Plasma Membrane Ca2+ Pump Activity in Rat Hippocampal Neurons
    Pottorf WJ 2nd, Johanns TM, Derrington SM, Strehler EE, Enyedi A, Thayer SA
    J Neurochem 2006 Sep;98(5):1646-56
  • Activation of Protein Kinase C in Sensory Neurons Accelerates Ca2+ Uptake Into the Endoplasmic Reticulum
    Usachev YM, Marsh AJ, Johanns TM, Lemke MM, Thayer SA
    J Neurosci 2006 Jan 4;26(1):311-8
  • Restricted STAT5 Activation Dictates Appropriate Thymic B Versus T Cell Lineage Commitment
    Goetz CA, Harmon IR, O'Neil JJ, Burchill MA, Johanns TM, Farrar MA
    J Immunol 2005 Jun 15;174(12):7753-63

Invited Publications and Book Chapters

  • Cancer Immunotherapy
    Iglesia MD, Johanns TM
    In: The Washington Manual of Oncology, 4th Edition (Morgensztern D, Ghobadi A, Govindan R, Editors), Wolters Kluwer, Philadelphia, 2022
  • BRAF-Targeted Therapy in the Treatment of BRAF-Mutant High-Grade Gliomas in Adults
    Johanns TM, Ansstas G, Dahiya S
    J Natl Compr Canc Netw 2018 Apr;16(4):451-454
  • Applied Cancer Immunogenomics: Leveraging Neoantigen Discovery in Glioblastoma
    Johanns TM, Dunn GP
    Cancer J 2017 Mar/Apr;23(2):125-130
  • Targeting Neoantigens in Glioblastoma: An Overview of Cancer Immunogenomics and Translational Implications
    Johanns TM, Bowman-Kirigin JA, Liu C, Dunn GP
    Neurosurgery 2017 Sep 1;64(CN_suppl_1):165-176
  • Cancers of the Central Nervous System
    Johanns TM, Campian JL, Ansstas G
    In: R Govindan & D Morgensztern (Eds.), DeVita, Hellman, Rosenberg's Cancer, Priniciples and Practice of Oncology: Review, Edition 4 2016: Lippincott Williams & Wilkins