Faculty
Oncology Division
Alphabetical list (active faculty):   
Charles K. Kaufman

Charles K. Kaufman, MD, PhD

Assistant Professor

Department of Medicine

Oncology Division

Molecular Oncology

Department of Developmental Biology

Clinical Interests

  • Melanoma

Research Interests

  • Cancer initiation
  • Epigenetics
  • Developmental biology

Contact

  • 314-273-1330 (office)
  • 314-273-1331 (lab)
  • 314-747-2797 (fax)
  • Division of Oncology
    Mail Stop 8056-0012-05
    Washington University
    660 South Euclid Avenue
    St. Louis, MO 63110
  • Room 558 McDonnell Medical Sciences Building (office)

Peer-reviewed Manuscripts

  • Transcriptional Profile and Chromatin Accessibility in Zebrafish Melanocytes and Melanoma Tumors
    Kramer ET, Godoy PM, Kaufman CK
    G3 (Bethesda) 2021 Nov 15; [Epub ahead of print]
  • Epigenetic Dynamics Shaping Melanophore and Iridophore Cell Fate in Zebrafish
    Jang HS, Chen Y, Ge J, Wilkening AN, Hou Y, Lee HJ, Choi YR, Lowdon RF, Xing X, Li D, Kaufman CK, Johnson SL, Wang T
    Genome Biol 2021 Oct 4;22(1):282
  • Synergistic Melanoma Cell Death Mediated by Inhibition of Both MCL1 and BCL2 in High-Risk Tumors Driven by NF1/PTEN Loss
    He S, Zimmerman MW, Layden HM, Berezovskaya A, Etchin J, Martel MW, Thurston G, Jing CB, van Rooijen E, Kaufman CK, Rodig SJ, Zon LI, Patton EE, Mansour MR, Look AT
    Oncogene 2021 Sep;40(38):5718-5729
  • Functional in Vivo Characterization of Sox10 Enhancers in Neural Crest and Melanoma Development
    Cunningham RL, Kramer ET, DeGeorgia SK, Godoy PM, Zarov AP, Seneviratne S, Grigura V, Kaufman CK
    Commun Biol 2021 Jun 7;4(1):695
  • Isotope Tracing in Adult Zebrafish Reveals Alanine Cycling Between Melanoma and Liver
    Naser FJ, Jackstadt MM, Fowle-Grider R, Spalding JL, Cho K, Stancliffe E, Doonan SR, Kramer ET, Yao L, Krasnick B, Ding L, Fields RC, Kaufman CK, Shriver LP, Johnson SL, Patti GJ
    Cell Metab 2021 Jul 6;33(7):1493-1504
  • SATB2 Induction of a Neural Crest Mesenchyme-Like Program Drives Melanoma Invasion and Drug Resistance
    Fazio M, van Rooijen E, Dang M, van de Hoek G, Ablain J, Mito JK, Yang S, Thomas A, Michael J, Fabo T, Modhurima R, Pessina P, Kaufman CK, Zhou Y, White RM, Zon LI
    Elife 2021 Feb 2;10
  • Melanoma Models for the Next Generation of Therapies
    Patton EE, Mueller KL, Adams DJ, Anandasabapathy N, Aplin AE, Bertolotto C, Bosenberg M, Ceol CJ, Burd CE, Chi P, Herlyn M, Holmen SL, Karreth FA, Kaufman CK, Khan S, Kobold S, Leucci E, Levy C, Lombard DB, Lund AW, Marie KL, Marine JC, Marais R, McMahon M, Robles-Espinoza CD, Ronai ZA, Samuels Y, Soengas MS, Villanueva J, Weeraratna AT, White RM, Yeh I, Zhu J, Zon LI, Hurlbert MS, Merlino G
    Cancer Cell 2021 May 10;39(5):610-631
  • Difference in Biophysical Properties of Cancer-Initiating Cells in Melanoma Mutated Zebrafish
    Makarova N, Kalaparthi V, Wang A, Williams C, Dokukin ME, Kaufman CK, Zon L, Sokolov I
    J Mech Behav Biomed Mater 2020 Jul;107:103746
  • A Hox-TALE Regulatory Circuit for Neural Crest Patterning Is Conserved Across Vertebrates
    Parker HJ, De Kumar B, Green SA, Prummel KD, Hess C, Kaufman CK, Mosimann C, Wiedemann LM, Bronner ME, Krumlauf R
    Nat Commun 2019 Mar 13;10(1):1189
  • Feeding Amount Significantly Alters Overt Tumor Onset Rate in a Zebrafish Melanoma Model
    Grigura V, Barbier M, Zarov AP, Kaufman CK
    Biol Open 2018 Jan 23;7(1)
  • A Chemical Screen in Zebrafish Embryonic Cells Establishes That Akt Activation Is Required for Neural Crest Development
    Ciarlo C, Kaufman CK, Kinikoglu B, Michael J, Yang S, D Amato C, Blokzijl-Franke S, den Hertog J, Schlaeger TM, Zhou Y, Liao E, Zon LI
    Elife 2017 Aug 23;6
  • Efficient Transduction of Zebrafish Melanoma Cell Lines and Embryos Using Lentiviral Vectors
    Fazio M, Avagyan S, van Rooijen E, Mannherz W, Kaufman CK, Lobbardi R, Langenau DM, Zon LI
    Zebrafish 2017 Aug;14(4):379-382
  • Tumor Diversity and Evolution Revealed Through RADseq
    Perry EB, Makohon-Moore A, Zheng C, Kaufman CK, Cai J, Iacobuzio-Donahue CA, White RM
    Oncotarget 2017 Jun 27;8(26):41792-41805
  • Evolution of the Hypoxia-Sensitive Cells Involved in Amniote Respiratory Reflexes
    Hockman D, Burns AJ, Schlosser G, Gates KP, Jevans B, Mongera A, Fisher S, Unlu G, Knapik EW, Kaufman CK, Mosimann C, Zon LI, Lancman JJ, Dong PDS, Lickert H, Tucker AS, Baker CVH
    Elife 2017 Apr 7;6
  • A Zebrafish Melanoma Model Reveals Emergence of Neural Crest Identity During Melanoma Initiation
    Kaufman CK, Mosimann C, Fan ZP, Yang S, Thomas AJ, Ablain J, Tan JL, Fogley RD, van Rooijen E, Hagedorn EJ, Ciarlo C, White RM, Matos DA, Puller AC, Santoriello C, Liao EC, Young RA, Zon LI
    Science 2016 Jan 29;351(6272):aad2197
  • A Quantitative System for Studying Metastasis Using Transparent Zebrafish
    Heilmann S, Ratnakumar K, Langdon EM, Kansler ER, Kim IS, Campbell NR, Perry EB, McMahon AJ, Kaufman CK, van Rooijen E, Lee W, Iacobuzio-Donahue CA, Hynes RO, Zon LI, Xavier JB, White RM
    Cancer Res 2015 Oct 15;75(20):4272-82
  • Neural Crest Development and Craniofacial Morphogenesis Is Coordinated by Nitric Oxide and Histone Acetylation
    Kong Y, Grimaldi M, Curtin E, Dougherty M, Kaufman C, White RM, Zon LI, Liao EC
    Chem Biol 2014 Apr 24;21(4):488-501
  • The Genetic Heterogeneity and Mutational Burden of Engineered Melanomas in Zebrafish Models
    Yen J, White RM, Wedge DC, Van Loo P, de Ridder J, Capper A, Richardson J, Jones D, Raine K, Watson IR, Wu CJ, Cheng J, Martincorena I, Nik-Zainal S, Mudie L, Moreau Y, Marshall J, Ramakrishna M, Tarpey P, Shlien A, Whitmore I, Gamble S, Latimer C, Langdon E, Kaufman C, Dovey M, Taylor A, Menzies A, McLaren S, O'Meara S, Butler A, Teague J, Lister J, Chin L, Campbell P, Adams DJ, Zon LI, Patton EE, Stemple DL, Futreal PA
    Genome Biol 2013;14(10):R113
  • Small Molecule Screening in Zebrafish: Swimming in Potential Drug Therapies
    Tamplin OJ, White RM, Jing L, Kaufman CK, Lacadie SA, Li P, Taylor AM, Zon LI
    Wiley Interdiscip Rev Dev Biol 2012 May-Jun;1(3):459-68
  • DHODH Modulates Transcriptional Elongation in the Neural Crest and Melanoma
    White RM, Cech J, Ratanasirintrawoot S, Lin CY, Rahl PB, Burke CJ, Langdon E, Tomlinson ML, Mosher J, Kaufman C, Chen F, Long HK, Kramer M, Datta S, Neuberg D, Granter S, Young RA, Morrison S, Wheeler GN, Zon LI
    Nature 2011 Mar 24;471(7339):518-22
  • Ubiquitous Transgene Expression and Cre-Based Recombination Driven by the Ubiquitin Promoter in Zebrafish
    Mosimann C, Kaufman CK, Li P, Pugach EK, Tamplin OJ, Zon LI
    Development 2011 Jan;138(1):169-77
  • Chemical Genetic Screening in the Zebrafish Embryo
    Kaufman CK*, White RM*, Zon L (* Authors contributed equally)
    Nat Protoc 2009;4(10):1422-32
  • GATA-3: An Unexpected Regulator of Cell Lineage Determination in Skin
    Kaufman CK, Zhou P, Pasolli HA, Rendl M, Bolotin D, Lim KC, Dai X, Alegre ML, Fuchs E
    Genes Dev 2003 Sep 1;17(17):2108-22
  • Dissection of a Complex Enhancer Element: Maintenance of Keratinocyte Specificity but Loss of Differentiation Specificity
    Kaufman CK*, Sinha S*, Bolotin D, Fan J, Fuchs E (* Authors contributed equally)
    Mol Cell Biol 2002 Jun;22(12):4293-308
  • It's Got You Covered. NF-KappaB in the Epidermis
    Kaufman CK, Fuchs E
    J Cell Biol 2000 May 29;149(5):999-1004
  • Characterization of the Rhodobacter Capsulatus Housekeeping RNA Polymerase. In Vitro Transcription of Photosynthesis and Other Genes
    Cullen PJ*, Kaufman CK*, Bowman WC, Kranz RG (* Authors contributed equally)
    J Biol Chem 1997 Oct 24;272(43):27266-73

Invited Publications