Oncology Division
Alphabetical list (active faculty):   
Gregory D. Longmore

Gregory D. Longmore, MD


Department of Medicine

Oncology Division

Molecular Oncology

Department of Cell Biology & Physiology

Research Interests

  • Epithelia morphogenesis
  • Cancer metastasis


  • 314-362-8834 (office)
  • BJCIH 7th floor ICCE Institute
    Campus Box 8069
    Washington University
    660 South Euclid Avenue
    St. Louis, MO 63110
  • Room 7627 BJC Institute of Health (office)
  • Room 7311 BJC Institute of Health (lab)

Peer-reviewed Publications

  • Bacteria in Tumors "Hit the Road" Together
    Longmore GD
    Cell 2022 Apr 14;185(8):1292-1294
  • Collagen Linearization Within Tumors
    Barcus CE, Longmore GD
    Cancer Res 2021 Nov 15;81(22):5611-5612
  • Tyrosine Kinase-Independent Actions of DDR2 in Tumor Cells and Cancer-Associated Fibroblasts Influence Tumor Invasion, Migration and Metastasis
    Barcus CE, Hwang PY, Morikis V, Brenot A, Pence P, Clarke M, Longmore GD
    J Cell Sci 2021 Oct 1;134(19):258431
  • STK39 Promotes Breast Cancer Invasion and Metastasis by Increasing SNAI1 Activity Upon Phosphorylation
    Qiu Z, Dong B, Guo W, Piotr R, Longmore G, Yang X, Yu Z, Deng J, Evers BM, Wu Y
    Theranostics 2021 Jun 11;11(16):7658-7670
  • Contextual Cues From Cancer Cells Govern Cancer-Associated Fibroblast Heterogeneity
    Bota-Rabassedas N, Banerjee P, Niu Y, Cao W, Luo J, Xi Y, Tan X, Sheng K, Ahn YH, Lee S, Parra ER, Rodriguez-Canales J, Albritton J, Weiger M, Liu X, Guo HF, Yu J, Rodriguez BL, Firestone JJA, Mino B, Creighton CJ, Solis LM, Villalobos P, Raso MG, Sazer DW, Gibbons DL, Russell WK, Longmore GD, Wistuba II, Wang J, Chapman HA, Miller JS, Zong C, Kurie JM
    Cell Rep 2021 Apr 20;35(3):109009
  • Micro-Strains in the Extracellular Matrix Induce Angiogenesis
    Sewell-Loftin MK, Katz JB, George SC, Longmore GD
    Lab Chip 2020 Aug 7;20(15):2776-2787
  • Guidelines and Definitions for Research on Epithelial-Mesenchymal Transition
    Yang J, Antin P, Berx G, Blanpain C, Brabletz T, Bronner M, Campbell K, Cano A, Casanova J, Christofori G, Dedhar S, Derynck R, Ford HL, Fuxe J, Garcia de Herreros A, Goodall GJ, Hadjantonakis AK, Huang RJY, Kalcheim C, Kalluri R, Kang Y, Khew-Goodall Y, Levine H, Liu J, Longmore GD, Mani SA, Massague J, Mayor R, McClay D, Mostov KE, Newgreen DF, Nieto MA, Puisieux A, Runyan R, Savagner P, Stanger B, Stemmler MP, Takahashi Y, Takeichi M, Theveneau E, Thiery JP, Thompson EW, Weinberg RA, Williams ED, Xing J, Zhou BP, Sheng G
    EMT International Association (TEMTIA)

    Nat Rev Mol Cell Biol 2020 Jun;21(6):341-352
  • DDR2 Controls Breast Tumor Stiffness and Metastasis by Regulating Integrin Mediated Mechanotransduction in CAFs
    Bayer SV, Grither WR, Brenot A, Hwang PY, Barcus CE, Ernst M, Pence P, Walter C, Pathak A, Longmore GD
    Elife 2019 May 30;8
  • Randomly Distributed K14(+) Breast Tumor Cells Polarize to the Leading Edge and Guide Collective Migration in Response to Chemical and Mechanical Environmental Cues
    Hwang PY, Brenot A, King AC, Longmore GD, George SC
    Cancer Res 2019 Apr 15;79(8):1899-1912
  • LATS1/2 Kinases Trigger Self-Renewal of Cancer Stem Cells in Aggressive Oral Cancer
    Nozaki M, Yabuta N, Fukuzawa M, Mukai S, Okamoto A, Sasakura T, Fukushima K, Naito Y, Longmore GD, Nojima H
    Oncotarget 2019 Feb 1;10(10):1014-1030
  • Inhibition of Tumor-Microenvironment Interaction and Tumor Invasion by Small-Molecule Allosteric Inhibitor of DDR2 Extracellular Domain
    Grither WR, Longmore GD
    Proc Natl Acad Sci U S A 2018 Aug 14;115(33):E7786-E7794
  • TWIST1 Induces Expression of Discoidin Domain Receptor 2 to Promote Ovarian Cancer Metastasis
    Grither WR, Divine LM, Meller EH, Wilke DJ, Desai RA, Loza AJ, Zhao P, Lohrey A, Longmore GD, Fuh KC
    Oncogene 2018 Mar;37(13):1714-1729
  • SNAIL1 Action in Tumor Cells Influences Macrophage Polarization and Metastasis in Breast Cancer Through Altered GM-CSF Secretion
    Brenot A, Knolhoff BL, DeNardo DG, Longmore GD
    Oncogenesis 2018 Mar 29;7(3):32
  • Cancer-Associated Fibroblasts Support Vascular Growth Through Mechanical Force
    Sewell-Loftin MK, Bayer SVH, Crist E, Hughes T, Joison SM, Longmore GD, George SC
    Sci Rep 2017 Oct 3;7(1):12574
  • Upholding a Role for EMT in Breast Cancer Metastasis
    Ye X, Brabletz T, Kang Y, Longmore GD, Nieto MA, Stanger BZ, Yang J, Weinberg RA
    Nature 2017 Jul 5;547(7661):E1-E3
  • Action of SNAIL1 in Cardiac Myofibroblasts Is Important for Cardiac Fibrosis Following Hypoxic Injury
    Biswas H, Longmore GD
    PLoS One 2016 Oct 5;11(10):e0162636
  • Cell Density and Actomyosin Contractility Control the Organization of Migrating Collectives Within an Epithelium
    Loza AJ, Koride S, Schimizzi GV, Li B, Sun SX, Longmore GD
    Mol Biol Cell 2016 Nov 7;27(22):3459-3470
  • Dachsous1b Cadherin Regulates Actin and Microtubule Cytoskeleton During Early Zebrafish Embryogenesis
    Li-Villarreal N, Forbes MM, Loza AJ, Chen J, Ma T, Helde K, Moens CB, Shin J, Sawada A, Hindes AE, Dubrulle J, Schier AF, Longmore GD, Marlow FL, Solnica-Krezel L
    Development 2016 May 15;143(10):1832
  • Disruption of the Cdc42/Par6/APKC or Dlg/Scrib/Lgl Polarity Complex Promotes Epithelial Proliferation Via Overlapping Mechanisms
    Schimizzi GV, Maher MT, Loza AJ, Longmore GD
    PLoS One 2016 Jul 25;11(7):e0159881
  • AJUBA LIM Proteins Limit Hippo Activity in Proliferating Cells by Sequestering the Hippo Core Kinase Complex in the Cytosol
    Jagannathan R, Schimizzi GV, Zhang K, Loza AJ, Yabuta N, Nojima H, Longmore GD
    Mol Cell Biol 2016 Sep 26;36(20):2526-42
  • Stromal Senescence Establishes an Immunosuppressive Microenvironment That Drives Tumorigenesis
    Ruhland MK, Loza AJ, Capietto AH, Luo X, Knolhoff BL, Flanagan KC, Belt BA, Alspach E, Leahy K, Luo J, Schaffer A, Edwards JR, Longmore G, Faccio R, DeNardo DG, Stewart SA
    Nat Commun 2016 Jun 8;7:11762
  • Mechanical Signals Regulate and Activate SNAIL1 Protein to Control the Fibrogenic Response of Cancer-Associated Fibroblasts
    Zhang K, Grither WR, Van Hove S, Biswas H, Ponik SM, Eliceiri KW, Keely PJ, Longmore GD
    J Cell Sci 2016 May 15;129(10):1989-2002
  • The Action of Discoidin Domain Receptor 2 in Basal Tumor Cells and Stromal Cancer-Associated Fibroblasts Is Critical for Breast Cancer Metastasis
    Corsa CA, Brenot A, Grither WR, Van Hove S, Loza AJ, Zhang K, Ponik SM, Liu Y, DeNardo DG, Eliceiri KW, Keely PJ, Longmore GD
    Cell Rep 2016 Jun 14;15(11):2510-2523
  • Stromal-Initiated Changes in the Bone Promote Metastatic Niche Development
    Luo X, Fu Y, Loza AJ, Murali B, Leahy KM, Ruhland MK, Gang M, Su X, Zamani A, Shi Y, Lavine KJ, Ornitz DM, Weilbaecher KN, Long F, Novack DV, Faccio R, Longmore GD, Stewart SA
    Cell Rep 2016 Jan 5;14(1):82-92
  • Three-Dimensional Matrix Fiber Alignment Modulates Cell Migration and MT1-MMP Utility by Spatially and Temporally Directing Protrusions
    Fraley SI, Wu PH, He L, Feng Y, Krisnamurthy R, Longmore GD, Wirtz D
    Sci Rep 2015 Oct 1;5:14580
  • Dachsous1b Cadherin Regulates Actin and Microtubule Cytoskeleton During Early Zebrafish Embryogenesis
    Li-Villarreal N, Forbes MM, Loza AJ, Chen J, Ma T, Helde K, Moens CB, Shin J, Sawada A, Hindes AE, Dubrulle J, Schier AF, Longmore GD, Marlow FL, Solnica-Krezel L
    Development 2015 Aug 1;142(15):2704-18
  • Ajuba Proteins
    Schimizzi GV, Longmore GD
    Curr Biol 2015 Jun 1;25(11):R445-6
  • Transient SNAIL1 Expression Is Necessary for Metastatic Competence in Breast Cancer
    Tran HD, Luitel K, Kim M, Zhang K, Longmore GD, Tran DD
    Cancer Res 2014 Nov 1;74(21):6330-40
  • Rho1 Regulates Adherens Junction Remodeling by Promoting Recycling Endosome Formation Through Activation of Myosin II
    Yashiro H, Loza AJ, Skeath JB, Longmore GD
    Mol Biol Cell 2014 Oct 1;25(19):2956-69
  • Nuclear Ubiquitination by FBXL5 Modulates Snail1 DNA Binding and Stability
    Vinas-Castells R, Frias A, Robles-Lanuza E, Zhang K, Longmore GD, Garcia de Herreros A, Diaz VM
    Nucleic Acids Res 2014 Jan;42(2):1079-94
  • Beta-Catenin Serves as a Clutch Between Low and High Intercellular E-Cadherin Bond Strengths
    Bajpai S, Feng Y, Wirtz D, Longmore GD
    Biophys J 2013 Nov 19;105(10):2289-300
  • The Arp2/3 Complex Mediates Multigeneration Dendritic Protrusions for Efficient 3-Dimensional Cancer Cell Migration
    Giri A, Bajpai S, Trenton N, Jayatilaka H, Longmore GD, Wirtz D
    FASEB J 2013 Oct;27(10):4089-99
  • The Collagen Receptor Discoidin Domain Receptor 2 Stabilizes SNAIL1 to Facilitate Breast Cancer Metastasis
    Zhang K, Corsa CA, Ponik SM, Prior JL, Piwnica-Worms D, Eliceiri KW, Keely PJ, Longmore GD
    Nat Cell Biol 2013 Jun;15(6):677-87
  • Alpha-Actinin1 and 4 Tyrosine Phosphorylation Is Critical for Stress Fiber Establishment, Maintenance and Focal Adhesion Maturation
    Feng Y, Ngu H, Alford SK, Ward M, Yin F, Longmore GD
    Exp Cell Res 2013 May 1;319(8):1124-35
  • The LINC-Anchored Actin Cap Connects the Extracellular Milieu to the Nucleus for Ultrafast Mechanotransduction
    Chambliss AB, Khatau SB, Erdenberger N, Robinson DK, Hodzic D, Longmore GD, Wirtz D
    Sci Rep 2013;3:1087
  • Actin Cap Associated Focal Adhesions and Their Distinct Role in Cellular Mechanosensing
    Kim DH, Khatau SB, Feng Y, Walcott S, Sun SX, Longmore GD, Wirtz D
    Sci Rep 2012;2:555
  • Mismatch in Mechanical and Adhesive Properties Induces Pulsating Cancer Cell Migration in Epithelial Monolayer
    Lee MH, Wu PH, Staunton JR, Ros R, Longmore GD, Wirtz D
    Biophys J 2012 Jun 20;102(12):2731-41
  • Dimensional and Temporal Controls of Three-Dimensional Cell Migration by Zyxin and Binding Partners
    Fraley SI, Feng Y, Giri A, Longmore GD, Wirtz D
    Nat Commun 2012 Mar 6;3:719
  • The LIMD1 Protein Bridges an Association Between the Prolyl Hydroxylases and VHL to Repress HIF-1 Activity
    Foxler DE, Bridge KS, James V, Webb TM, Mee M, Wong SC, Feng Y, Constantin-Teodosiu D, Petursdottir TE, Bjornsson J, Ingvarsson S, Ratcliffe PJ, Longmore GD, Sharp TV
    Nat Cell Biol 2012 Jan 29;14(2):201-8
  • Ajuba Is Required for Rac Activation and Maintenance of E-Cadherin Adhesion
    Nola S, Daigaku R, Smolarczyk K, Carstens M, Martin-Martin B, Longmore G, Bailly M, Braga VM
    J Cell Biol 2011 Nov 28;195(5):855-71
  • Temporal and Spatial Cooperation of Snail1 and Twist1 During Epithelial-Mesenchymal Transition Predicts for Human Breast Cancer Recurrence
    Tran DD, Corsa CA, Biswas H, Aft RL, Longmore GD
    Mol Cancer Res 2011 Dec;9(12):1644-57
  • Lats2 Kinase Potentiates Snail1 Activity by Promoting Nuclear Retention Upon Phosphorylation
    Zhang K, Rodriguez-Aznar E, Yabuta N, Owen RJ, Mingot JM, Nojima H, Nieto MA, Longmore GD
    EMBO J 2011 Sep 27;31(1):29-43
  • Reply: Reducing Background Fluorescence Reveals Adhesions in 3D Matrices
    Fraley SI, Feng Y, Wirtz D, Longmore GD
    Nat Cell Biol 2011 Jan;13(1):5-7
  • A Multifunctional Lentiviral-Based Gene Knockdown With Concurrent Rescue That Controls for Off-Target Effects of RNAi
    Feng Y, Nie L, Thakur MD, Su Q, Chi Z, Zhao Y, Longmore GD
    Genomics Proteomics Bioinformatics 2010 Dec;8(4):238-45
  • Context-Dependent Compensatory Proliferation in Epithelial Homeostasis and Tumorigenesis
    Warner SJ, Longmore GD
    Cell Cycle 2010 Oct;9(20):4037-8
  • LIM-Domain Proteins, LIMD1, Ajuba, and WTIP Are Required for MicroRNA-Mediated Gene Silencing
    James V, Zhang Y, Foxler DE, de Moor CH, Kong YW, Webb TM, Self TJ, Feng Y, Lagos D, Chu CY, Rana TM, Morley SJ, Longmore GD, Bushell M, Sharp TV
    Proc Natl Acad Sci U S A 2010 Jul 13;107(28):12499-504
  • A Distinctive Role for Focal Adhesion Proteins in Three-Dimensional Cell Motility
    Fraley SI, Feng Y, Krishnamurthy R, Kim DH, Celedon A, Longmore GD, Wirtz D
    Nat Cell Biol 2010 Jun;12(6):598-604
  • The Cdc42/Par6/APKC Polarity Complex Regulates Apoptosis-Induced Compensatory Proliferation in Epithelia
    Warner SJ, Yashiro H, Longmore GD
    Curr Biol 2010 Apr 27;20(8):677-86
  • Prediction of Sphingosine 1-Phosphate-Stimulated Endothelial Cell Migration Rates Using Biochemical Measurements
    Alford SK, Wang Y, Feng Y, Longmore GD, Elbert DL
    Ann Biomed Eng 2010 Aug;38(8):2775-90
  • Ajuba LIM Proteins Are Negative Regulators of the Hippo Signaling Pathway
    Das Thakur M, Feng Y, Jagannathan R, Seppa MJ, Skeath JB, Longmore GD
    Curr Biol 2010 Apr 13;20(7):657-62
  • LIM Protein Ajuba Functions as a Nuclear Receptor Corepressor and Negatively Regulates Retinoic Acid Signaling
    Hou Z, Peng H, White DE, Negorev DG, Maul GG, Feng Y, Longmore GD, Waxman S, Zelent A, Rauscher FJ 3rd
    Proc Natl Acad Sci U S A 2010 Feb 16;107(7):2938-43
  • Effect of Focal Adhesion Proteins on Endothelial Cell Adhesion, Motility and Orientation Response to Cyclic Strain
    Ngu H, Feng Y, Lu L, Oswald SJ, Longmore GD, Yin FC
    Ann Biomed Eng 2010 Jan;38(1):208-22
  • Cdc42 Antagonizes Rho1 Activity at Adherens Junctions to Limit Epithelial Cell Apical Tension
    Warner SJ, Longmore GD
    J Cell Biol 2009 Oct 5;187(1):119-33
  • Erythroid-Stimulating Agents in Cancer Therapy: Potential Dangers and Biologic Mechanisms
    Hadland BK, Longmore GD
    J Clin Oncol 2009 Sep 1;27(25):4217-26
  • Distinct Functions for Rho1 in Maintaining Adherens Junctions and Apical Tension in Remodeling Epithelia
    Warner SJ, Longmore GD
    J Cell Biol 2009 Jun 15;185(6):1111-25
  • Loss of Alpha-Catenin Decreases the Strength of Single E-Cadherin Bonds Between Human Cancer Cells
    Bajpai S, Feng Y, Krishnamurthy R, Longmore GD, Wirtz D
    J Biol Chem 2009 Jul 3;284(27):18252-9
  • P38delta Mitogen-Activated Protein Kinase Is Essential for Skin Tumor Development in Mice
    Schindler EM, Hindes A, Gribben EL, Burns CJ, Yin Y, Lin MH, Owen RJ, Longmore GD, Kissling GE, Arthur JS, Efimova T
    Cancer Res 2009 Jun 1;69(11):4648-55
  • Ajuba Functions as a Histone Deacetylase-Dependent Co-Repressor for Autoregulation of the Growth Factor-Independent-1 Transcription Factor
    Montoya-Durango DE, Velu CS, Kazanjian A, Rojas ME, Jay CM, Longmore GD, Grimes HL
    J Biol Chem 2008 Nov 14;283(46):32056-65
  • {alpha}-Catenin Mediates Initial E-Cadherin-Dependent Cell-Cell Recognition and Subsequent Bond Strengthening
    Bajpai S, Correia J, Feng Y, Figueiredo J, Sun SX, Longmore GD, Suriano G, Wirtz D
    Proc Natl Acad Sci U S A 2008 Nov 25;105(47):18331-6
  • The Chromosome 3p21.3-Encoded Gene, LIMD1, Is a Critical Tumor Suppressor Involved in Human Lung Cancer Development
    Sharp TV, Al-Attar A, Foxler DE, Ding L, de A Vallim TQ, Zhang Y, Nijmeh HS, Webb TM, Nicholson AG, Zhang Q, Kraja A, Spendlove I, Osborne J, Mardis E, Longmore GD
    Proc Natl Acad Sci U S A 2008 Dec 16;105(50):19932-7
  • The LIM Protein LIMD1 Influences Osteoblast Differentiation and Function
    Luderer HF, Bai S, Longmore GD
    Exp Cell Res 2008 Sep 10;314(15):2884-94
  • Differential Subcellular Localisation of the Tumour Suppressor Protein LIMD1 in Breast Cancer Correlates With Patient Survival
    Spendlove I, Al-Attar A, Watherstone O, Webb TM, Ellis IO, Longmore GD, Sharp TV
    Int J Cancer 2008 Nov 15;123(10):2247-53
  • CD46-Induced Immunomodulatory CD4+ T Cells Express the Adhesion Molecule and Chemokine Receptor Pattern of Intestinal T Cells
    Alford SK, Longmore GD, Stenson WF, Kemper C
    J Immunol 2008 Aug 15;181(4):2544-55
  • Phospholipase Cgamma2 Modulates Integrin Signaling in the Osteoclast by Affecting the Localization and Activation of Src Kinase
    Epple H, Cremasco V, Zhang K, Mao D, Longmore GD, Faccio R
    Mol Cell Biol 2008 Jun;28(11):3610-22
  • The LIM Protein AJUBA Recruits Protein Arginine Methyltransferase 5 to Mediate SNAIL-Dependent Transcriptional Repression
    Hou Z, Peng H, Ayyanathan K, Yan KP, Langer EM, Longmore GD, Rauscher FJ 3rd
    Mol Cell Biol 2008 May;28(10):3198-207
  • Ajuba LIM Proteins Are Snail/Slug Corepressors Required for Neural Crest Development in Xenopus
    Langer EM, Feng Y, Zhaoyuan H, Rauscher FJ 3rd, Kroll KL, Longmore GD
    Dev Cell 2008 Mar;14(3):424-36
  • Actin Stress Fiber Pre-Extension in Human Aortic Endothelial Cells
    Lu L, Feng Y, Hucker WJ, Oswald SJ, Longmore GD, Yin FC
    Cell Motil Cytoskeleton 2008 Apr;65(4):281-94
  • Endothelial Cell Migration on RGD-Peptide-Containing PEG Hydrogels in the Presence of Sphingosine 1-Phosphate
    Wacker BK, Alford SK, Scott EA, Das Thakur M, Longmore GD, Elbert DL
    Biophys J 2008 Jan 1;94(1):273-85
  • Phosphatidylinositol 3-Kinase Activation Is Required to Form the NKG2D Immunological Synapse
    Giurisato E, Cella M, Takai T, Kurosaki T, Feng Y, Longmore GD, Colonna M, Shaw AS
    Mol Cell Biol 2007 Dec;27(24):8583-99
  • The Ajuba LIM Domain Protein Is a Corepressor for SNAG Domain Mediated Repression and Participates in Nucleocytoplasmic Shuttling
    Ayyanathan K, Peng H, Hou Z, Fredericks WJ, Goyal RK, Langer EM, Longmore GD, Rauscher FJ 3rd
    Cancer Res 2007 Oct 1;67(19):9097-106
  • Do Cancer Cells Express Functional Erythropoietin Receptors?
    Longmore GD
    N Engl J Med 2007 Jun 14;356(24):2447
  • The LIM Protein, Limd1, Regulates AP-1 Activation Through an Interaction With Traf6 to Influence Osteoclast Development
    Feng Y, Zhao H, Luderer HF, Epple H, Faccio R, Ross FP, Teitelbaum SL, Longmore GD
    J Biol Chem 2007 Jan 5;282(1):39-48
  • A Unique Role for Stat5 in Recovery From Acute Anemia
    Longmore GD
    J Clin Invest 2006 Mar;116(3):626-8
  • Effects of Recombinant Hematopoietins on Blood-Loss Anemia in Mice
    Jones KB, Anderson DW, Longmore GD
    Iowa Orthop J 2005;25:129-34
  • The LIM Protein Ajuba Influences Interleukin-1-Induced NF-KappaB Activation by Affecting the Assembly and Activity of the Protein Kinase Czeta/P62/TRAF6 Signaling Complex
    Feng Y, Longmore GD
    Mol Cell Biol 2005 May;25(10):4010-22
  • The LIM Protein Ajuba Regulates Phosphatidylinositol 4,5-Bisphosphate Levels in Migrating Cells Through an Interaction With and Activation of PIPKI Alpha
    Kisseleva M, Feng Y, Ward M, Song C, Anderson RA, Longmore GD
    Mol Cell Biol 2005 May;25(10):3956-66
  • The LIM Protein Ajuba Influences P130Cas Localization and Rac1 Activity During Cell Migration
    Pratt SJ, Epple H, Ward M, Feng Y, Braga VM, Longmore GD
    J Cell Biol 2005 Feb 28;168(5):813-24
  • A Requirement for Notch1 Distinguishes 2 Phases of Definitive Hematopoiesis During Development
    Hadland BK, Huppert SS, Kanungo J, Xue Y, Jiang R, Gridley T, Conlon RA, Cheng AM, Kopan R, Longmore GD
    Blood 2004 Nov 15;104(10):3097-105
  • Differential Regulation of Apoptotic Genes by Rb in Human Versus Mouse Cells
    Young AP, Longmore GD
    Oncogene 2004 Apr 8;23(15):2587-99
  • Differences in Stability of Repressor Complexes at Promoters Underlie Distinct Roles for Rb Family Members
    Young AP, Longmore GD
    Oncogene 2004 Jan 22;23(3):814-23
  • Ras Protects Rb Family Null Fibroblasts From Cell Death: A Role for AP-1
    Young AP, Longmore GD
    J Biol Chem 2004 Mar 19;279(12):10931-8
  • Mechanisms of Transcriptional Regulation by Rb-E2F Segregate by Biological Pathway
    Young AP, Nagarajan R, Longmore GD
    Oncogene 2003 Oct 16;22(46):7209-17
  • The LIM Protein Ajuba Is Recruited to Cadherin-Dependent Cell Junctions Through an Association With Alpha-Catenin
    Marie H, Pratt SJ, Betson M, Epple H, Kittler JT, Meek L, Moss SJ, Troyanovsky S, Attwell D, Longmore GD, Braga VM
    J Biol Chem 2003 Jan 10;278(2):1220-8
  • The Amino Terminus of the Glial Glutamate Transporter GLT-1 Interacts With the LIM Protein Ajuba
    Marie H, Billups D, Bedford FK, Dumoulin A, Goyal RK, Longmore GD, Moss SJ, Attwell D
    Mol Cell Neurosci 2002 Feb;19(2):152-64
  • Oncogene Cooperativity in Friend Erythroleukemia: Erythropoietin Receptor Activation by the Env Gene of SFFV Leads to Transcriptional Upregulation of PU.1, Independent of SFFV Proviral Insertion
    Afrikanova I, Yeh E, Bartos D, Watowich SS, Longmore GD
    Oncogene 2002 Feb 14;21(8):1272-84
  • Gamma -Secretase Inhibitors Repress Thymocyte Development
    Hadland BK, Manley NR, Su D, Longmore GD, Moore CL, Wolfe MS, Schroeter EH, Kopan R
    Proc Natl Acad Sci U S A 2001 Jun 19;98(13):7487-91
  • Erythropoietin Receptors That Signal Through Stat5 or Stat3 Support Fetal Liver and Adult Erythropoiesis: Lack of Specificity of Stat Signals During Red Blood Cell Development
    Watowich SS, Mikami A, Busche RA, Xie X, Pharr PN, Longmore GD
    J Interferon Cytokine Res 2000 Dec;20(12):1065-70
  • Residual Erythroid Progenitors in W/W Mice Respond to Erythropoietin in the Absence of Steel Factor Signals
    Pharr PN, Hofbauer A, Worthington RE, Longmore GD
    Int J Hematol 2000 Aug;72(2):178-85
  • Ajuba, a Cytosolic LIM Protein, Shuttles Into the Nucleus and Affects Embryonal Cell Proliferation and Fate Decisions
    Kanungo J, Pratt SJ, Marie H, Longmore GD
    Mol Biol Cell 2000 Oct;11(10):3299-313
  • Cytokine Signaling Through Stat3 Activates Integrins, Promotes Adhesion, and Induces Growth Arrest in the Myeloid Cell Line 32D
    Wooten DK, Xie X, Bartos D, Busche RA, Longmore GD, Watowich SS
    J Biol Chem 2000 Aug 25;275(34):26566-75
  • Activation of the Erythropoietin Receptor Is Not Required for Internalization of Bound Erythropoietin
    Beckman DL, Lin LL, Quinones ME, Longmore GD
    Blood 1999 Oct 15;94(8):2667-75
  • Abnormalities of Cytokine Receptor Signalling Contributing to Diseases of Red Blood Cell Production
    Goyal RK, Longmore GD
    Ann Med 1999 Jun;31(3):208-16
  • Genetic Evidence for an Additional Factor Required for Erythropoietin-Induced Signal Transduction
    Gaffen SL, Lai SY, Longmore GD, Liu KD, Goldsmith MA
    Blood 1999 Jul 1;94(1):74-86
  • Ajuba, a Novel LIM Protein, Interacts With Grb2, Augments Mitogen-Activated Protein Kinase Activity in Fibroblasts, and Promotes Meiotic Maturation of Xenopus Oocytes in a Grb2- And Ras-Dependent Manner
    Goyal RK, Lin P, Kanungo J, Payne AS, Muslin AJ, Longmore GD
    Mol Cell Biol 1999 Jun;19(6):4379-89
  • Oligomerization and Scaffolding Functions of the Erythropoietin Receptor Cytoplasmic Tail
    Watowich SS, Liu KD, Xie X, Lai SY, Mikami A, Longmore GD, Goldsmith MA
    J Biol Chem 1999 Feb 26;274(9):5415-21
  • Absence of Cytokine Receptor-Dependent Specificity in Red Blood Cell Differentiation in Vivo
    Goldsmith MA, Mikami A, You Y, Liu KD, Thomas L, Pharr P, Longmore GD
    Proc Natl Acad Sci U S A 1998 Jun 9;95(12):7006-11
  • Regulation of Cell Growth by IL-2: Role of STAT5 in Protection From Apoptosis but Not in Cell Cycle Progression
    Zamorano J, Wang HY, Wang R, Shi Y, Longmore GD, Keegan AD
    J Immunol 1998 Apr 1;160(7):3502-12
  • Redundant and Selective Roles for Erythropoietin Receptor Tyrosines in Erythropoiesis in Vivo
    Longmore GD, You Y, Molden J, Liu KD, Mikami A, Lai SY, Pharr P, Goldsmith MA
    Blood 1998 Feb 1;91(3):870-8
  • Cell Surface Organization of the Erythropoietin Receptor Complex Differs Depending on Its Mode of Activation
    Tarr K, Watowich SS, Longmore GD
    J Biol Chem 1997 Apr 4;272(14):9099-107
  • The Molecular Role of the Common Gamma C Subunit in Signal Transduction Reveals Functional Asymmetry Within Multimeric Cytokine Receptor Complexes
    Lai SY, Xu W, Gaffen SL, Liu KD, Longmore GD, Greene WC, Goldsmith MA
    Proc Natl Acad Sci U S A 1996 Jan 9;93(1):231-5
  • Growth Signal Transduction by the Human Interleukin-2 Receptor Requires Cytoplasmic Tyrosines of the Beta Chain and Non-Tyrosine Residues of the Gamma C Chain
    Goldsmith MA, Lai SY, Xu W, Amaral MC, Kuczek ES, Parent LJ, Mills GB, Tarr KL, Longmore GD, Greene WC
    J Biol Chem 1995 Sep 15;270(37):21729-37
  • Lineage-Restricted Recruitment of Immature Hematopoietic Progenitor Cells in Response to Epo After Normal Hematopoietic Cell Transfection With EpoR
    McArthur GA, Longmore GD, Klingler K, Johnson GR
    Exp Hematol 1995 Jul;23(7):645-54
  • The Conserved Box 1 Motif of Cytokine Receptors Is Required for Association With JAK Kinases
    Tanner JW, Chen W, Young RL, Longmore GD, Shaw AS
    J Biol Chem 1995 Mar 24;270(12):6523-30
  • Expression of an Activated Erythropoietin or a Colony-Stimulating Factor 1 Receptor by Pluripotent Progenitors Enhances Colony Formation but Does Not Induce Differentiation
    Pharr PN, Ogawa M, Hofbauer A, Longmore GD
    Proc Natl Acad Sci U S A 1994 Aug 2;91(16):7482-6
  • A Constitutively Activated Erythropoietin Receptor Stimulates Proliferation and Contributes to Transformation of Multipotent, Committed Nonerythroid and Erythroid Progenitor Cells
    Longmore GD, Pharr PN, Lodish HF
    Mol Cell Biol 1994 Apr;14(4):2266-77
  • The Erythropoietin Receptor: Its Role in Hematopoiesis and Myeloproliferative Diseases
    Longmore GD, Watowich SS, Hilton DJ, Lodish HF
    J Cell Biol 1993 Dec;123(6 Pt 1):1305-8
  • Both Megakaryocytopoiesis and Erythropoiesis Are Induced in Mice Infected With a Retrovirus Expressing an Oncogenic Erythropoietin Receptor
    Longmore GD, Pharr P, Neumann D, Lodish HF
    Blood 1993 Oct 15;82(8):2386-95
  • Activation of the Erythropoietin Receptor and Leukemia Induction in Mice
    Longmore G, Watowich S, Pharr P, Neumann D, Lodish H
    Leukemia 1993 Aug;7 Suppl 2:S113-6
  • Erythropoietin Receptor Mutations and Olympic Glory
    Longmore GD
    Nat Genet 1993 Jun;4(2):108-10
  • Structure, Function, and Activation of the Erythropoietin Receptor
    Youssoufian H, Longmore G, Neumann D, Yoshimura A, Lodish HF
    Blood 1993 May 1;81(9):2223-36
  • Expression of a Constitutively Active Erythropoietin Receptor in Primary Hematopoietic Progenitors Abrogates Erythropoietin Dependence and Enhances Erythroid Colony-Forming Unit, Erythroid Burst-Forming Unit, and Granulocyte/Macrophage Progenitor Growth
    Pharr PN, Hankins D, Hofbauer A, Lodish HF, Longmore GD
    Proc Natl Acad Sci U S A 1993 Feb 1;90(3):938-42
  • Mutations in the Trp-Ser-X-Trp-Ser Motif of the Erythropoietin Receptor Abolish Processing, Ligand Binding, and Activation of the Receptor
    Yoshimura A, Zimmers T, Neumann D, Longmore G, Yoshimura Y, Lodish HF
    J Biol Chem 1992 Jun 5;267(16):11619-25
  • Homodimerization and Constitutive Activation of the Erythropoietin Receptor
    Watowich SS, Yoshimura A, Longmore GD, Hilton DJ, Yoshimura Y, Lodish HF
    Proc Natl Acad Sci U S A 1992 Mar 15;89(6):2140-4
  • The Erythropoietin Receptor: Dimerization, Activation, and Tumorigenesis
    Lodish HF, Hilton D, Longmore G, Watowich SS, Yoshimura A
    Cold Spring Harb Symp Quant Biol 1992;57:95-106
  • Mutation in Murine Erythropoietin Receptor Induces Erythropoietin-Independent Erythroid Proliferation in Vitro, Polycythemia in Vivo
    Longmore GD, Pharr P, Lodish HF
    Leukemia 1992;6 Suppl 3:130S-134S
  • A Simple Method for Hemoglobin Measurement in Cell Culture System
    Baliga BS, Isoyama K, Longmore G, Yang YM, Shah AK, Mankad VN
    Blood Cells 1992;18(2):187-93; discussion 194-5
  • An Activating Mutation in the Murine Erythropoietin Receptor Induces Erythroleukemia in Mice: A Cytokine Receptor Superfamily Oncogene
    Longmore GD, Lodish HF
    Cell 1991 Dec 20;67(6):1089-102
  • Point Mutation in the Exoplasmic Domain of the Erythropoietin Receptor Resulting in Hormone-Independent Activation and Tumorigenicity
    Yoshimura A, Longmore G, Lodish HF
    Nature 1990 Dec 13;348(6302):647-9
  • Bone Marrow Transplantation for Myelodysplasia and Secondary Acute Nonlymphoblastic Leukemia
    Longmore G, Guinan EC, Weinstein HJ, Gelber RD, Rappeport JM, Antin JH
    J Clin Oncol 1990 Oct;8(10):1707-14
  • Glycosylation of the T-Cell Antigen-Specific Receptor and Its Potential Role in Lectin-Mediated Cytotoxicity
    Hubbard SC, Kranz DM, Longmore GD, Sitkovsky MV, Eisen HN
    Proc Natl Acad Sci U S A 1986 Mar;83(6):1852-6
  • Product-Identification and Substrate-Specificity Studies of the GDP-L-Fucose:2-Acetamido-2-Deoxy-Beta-D-Glucoside (FUC Goes to Asn-Linked GlcNAc) 6-Alpha-L-Fucosyltransferase in a Golgi-Rich Fraction From Porcine Liver
    Longmore GD, Schachter H
    Carbohydr Res 1982 Mar 1;100:365-92
  • Mucin Synthesis. II. Substrate Specificity and Product Identification Studies on Canine Submaxillary Gland UDP-GlcNAc:Gal Beta 1-3GalNAc(GlcNAc Leads to GalNAc) Beta 6-N-Acetylglucosaminyltransferase
    Williams D, Longmore G, Matta KL, Schachter H
    J Biol Chem 1980 Dec 10;255(23):11253-61
  • Control of Glycoprotein Synthesis. the Purification by Preparative High Voltage Paper Electrophoresis in Borate of Glycopeptides Containing High Mannose and Complex Oligosaccharide Chains Linked to Asparagine
    Narasimhan S, Harpaz N, Longmore G, Carver JP, Grey AA, Schachter H
    J Biol Chem 1980 May 25;255(10):4876-84