Faculty
Hematology Division
Alphabetical list (active faculty):   
Philip W. Majerus

Philip W. Majerus, MD

July 10, 1936 - June 8, 2016

Professor (1966-2014)

Department of Medicine

Hematology Division

Department of Biochemistry & Molecular Biophysics

Original Articles

  • An aspirin a day
    Majerus PW
    Adv Biol Regul 2014 Jan;54C:231-241
  • The role of myotubularin-related phosphatases in the control of autophagy and programmed cell death
    Zou J, Majerus PW, Wilson DB, Schrade A, Chang SC, Wilson MP
    Adv Biol Regul 2012 Jan;52(1):282-289
  • Myotubularin-related protein (MTMR) 9 determines the enzymatic activity, substrate specificity, and role in autophagy of MTMR8
    Zou J, Zhang C, Marjanovic J, Kisseleva MV, Majerus PW, Wilson MP
    Proc Natl Acad Sci U S A 2012 Jun 12;109(24):9539-44
  • Regulation of inositol 1,3,4-trisphosphate 5/6-kinase (ITPK1) by reversible lysine acetylation
    Zhang C, Majerus PW, Wilson MP
    Proc Natl Acad Sci U S A 2012 Feb 14;109(7):2290-5
  • Inositol polyphosphate 4-phosphatase B as a regulator of bone mass in mice and humans
    Ferron M, Boudiffa M, Arsenault M, Rached M, Pata M, Giroux S, Elfassihi L, Kisseleva M, Majerus PW, Rousseau F, Vacher J
    Cell Metab 2011 Oct 5;14(4):466-77
  • The role of inositol polyphosphate 4-phosphatase 1 in platelet function using a weeble mouse model
    Marjanovic J, Wilson MP, Zhang C, Zou J, Nicholas P, Majerus PW
    Adv Enzyme Regul 2011;51(1):101-5
  • Wandering through the laboratory
    Majerus PW
    J Biol Chem 2011 Feb 18;286(7):4941-5
  • Expression of inositol 1,3,4-trisphosphate 5/6-kinase (ITPK1) and its role in neural tube defects
    Majerus PW, Wilson DB, Zhang C, Nicholas PJ, Wilson MP
    Adv Enzyme Regul 2010;50(1):365-72
  • Inositol polyphosphate 4-phosphatase II regulates PI3K/Akt signaling and is lost in human basal-like breast cancers
    Fedele CG, Ooms LM, Ho M, Vieusseux J, O'Toole SA, Millar EK, Lopez-Knowles E, Sriratana A, Gurung R, Baglietto L, Giles GG, Bailey CG, Rasko JE, Shields BJ, Price JT, Majerus PW, Sutherland RL, Tiganis T, McLean CA, Mitchell CA
    Proc Natl Acad Sci U S A 2010 Dec 21;107(51):22231-22236
  • INO-4995 therapeutic efficacy is enhanced with repeat dosing in cystic fibrosis knockout mice and human epithelia
    Traynor-Kaplan AE, Moody M, Nur M, Gabriel S, Majerus PW, Drumm ML, Langton-Webster B
    Am J Respir Cell Mol Biol 2010 Jan;42(1):105-12
  • Mutations in INPP5E, encoding inositol polyphosphate-5-phosphatase E, link phosphatidyl inositol signaling to the ciliopathies
    Bielas SL, Silhavy JL, Brancati F, Kisseleva MV, Al-Gazali L, Sztriha L, Bayoumi RA, Zaki MS, Abdel-Aleem A, Rosti RO, Kayserili H, Swistun D, Scott LC, Bertini E, Boltshauser E, Fazzi E, Travaglini L, Field SJ, Gayral S, Jacoby M, Schurmans S, Dallapiccola B, Majerus PW, Valente EM, Gleeson JG
    Nat Genet 2009 Sep;41(9):1032-6
  • Neural tube defects in mice with reduced levels of inositol 1,3,4-trisphosphate 5/6-kinase
    Wilson MP, Hugge C, Bielinska M, Nicholas P, Majerus PW, Wilson DB
    Proc Natl Acad Sci U S A 2009 Jun 16;106(24):9831-5
  • Regulation of PI(3)K/Akt signalling and cellular transformation by inositol polyphosphate 4-phosphatase-1
    Ivetac I, Gurung R, Hakim S, Horan KA, Sheffield DA, Binge LC, Majerus PW, Tiganis T, Mitchell CA
    EMBO Rep 2009 May;10(5):487-93
  • Phosphoinositide phosphatases and disease
    Majerus PW, York JD
    J Lipid Res 2009 Apr;50 Suppl:S249-54
  • MTMR9 increases MTMR6 enzyme activity, stability, and role in apoptosis
    Zou J, Chang SC, Marjanovic J, Majerus PW
    J Biol Chem 2009 Jan 23;284(4):2064-71
  • The role of inositol signaling in the control of apoptosis
    Majerus PW, Zou J, Marjanovic J, Kisseleva MV, Wilson MP
    Adv Enzyme Regul 2008;48:10-7
  • Type I phosphatidylinositol-4,5-bisphosphate 4-phosphatase regulates stress-induced apoptosis
    Zou J, Marjanovic J, Kisseleva MV, Wilson M, Majerus PW
    Proc Natl Acad Sci U S A 2007 Oct 23;104(43):16834-9
  • A discrete signaling function for an inositol pyrophosphate
    Majerus PW
    Sci STKE 2007 Dec 11;2007(416):pe72
  • Inositol polyphosphate multikinase regulates inositol 1,4,5,6-tetrakisphosphate
    Chang SC, Majerus PW
    Biochem Biophys Res Commun 2006 Jan 6;339(1):209-16
  • The identification and characterization of two phosphatidylinositol-4,5-bisphosphate 4-phosphatases
    Ungewickell A, Hugge C, Kisseleva M, Chang SC, Zou J, Feng Y, Galyov EE, Wilson M, Majerus PW
    Proc Natl Acad Sci U S A 2005 Dec 27;102(52):18854-9
  • Increased levels of inositol hexakisphosphate (InsP6) protect HEK293 cells from tumor necrosis factor (alpha)- and Fas-induced apoptosis
    Verbsky J, Majerus PW
    J Biol Chem 2005 Aug 12;280(32):29263-8
  • Disruption of the mouse inositol 1,3,4,5,6-pentakisphosphate 2-kinase gene, associated lethality, and tissue distribution of 2-kinase expression
    Verbsky J, Lavine K, Majerus PW
    Proc Natl Acad Sci U S A 2005 Jun 14;102(24):8448-53
  • Specificity determinants in inositol polyphosphate synthesis: crystal structure of inositol 1,3,4-trisphosphate 5/6-kinase
    Miller GJ, Wilson MP, Majerus PW, Hurley JH
    Mol Cell 2005 Apr 15;18(2):201-12
  • The type Ialpha inositol polyphosphate 4-phosphatase generates and terminates phosphoinositide 3-kinase signals on endosomes and the plasma membrane
    Ivetac I, Munday AD, Kisseleva MV, Zhang XM, Luff S, Tiganis T, Whisstock JC, Rowe T, Majerus PW, Mitchell CA
    Mol Biol Cell 2005 May;16(5):2218-33
  • Blood coagulation and anticoagulant, thrombolytic, and antiplatelet drugs
    Majerus PW, Tollefsen DM
    In: "Goodman & Gilman's The Pharmacological Basis of Therapeutics, 11th Edition" (Brunton LL, Lazo JS, Parker KL, eds.), McGraw-Hill, New York, pp. 1467-1488 (2006)
  • The pathway for the production of inositol hexakisphosphate in human cells
    Verbsky JW, Chang SC, Wilson MP, Mochizuki Y, Majerus PW
    J Biol Chem 2005 Jan 21;280(3):1911-20
  • Blasts from the past
    Insel PA, Kornfeld S, Majerus PW, Marks AR, Marks PA, Relman AS, Scharschmidt BF, Stossel TP, Varki AP, Weiss SJ, Wilson JD
    J Clin Invest 2004 Oct;114(8):1017-33
  • The inositol polyphosphate 5-phosphatase Ocrl associates with endosomes that are partially coated with clathrin
    Ungewickell A, Ward ME, Ungewickell E, Majerus PW
    Proc Natl Acad Sci U S A 2004 Sep 14;101(37):13501-6
  • The mRNA export factor human Gle1 interacts with the nuclear pore complex protein Nup155
    Rayala HJ, Kendirgi F, Barry DM, Majerus PW, Wente SR
    Mol Cell Proteomics 2004 Feb;3(2):145-55
  • Inositol 1,3,4-trisphosphate 5/6-kinase inhibits tumor necrosis factor-induced apoptosis
    Sun Y, Mochizuki Y, Majerus PW
    J Biol Chem 2003 Oct 31;278(44):43645-53
  • Characterization of myotubularin-related protein 7 and its binding partner, myotubularin-related protein 9
    Mochizuki Y, Majerus PW
    Proc Natl Acad Sci U S A 2003 Aug 19;100(17):9768-73
  • Identification of myotubularin as the lipid phosphatase catalytic subunit associated with the 3-phosphatase adapter protein, 3-PAP
    Nandurkar HH, Layton M, Laporte J, Selan C, Corcoran L, Caldwell KK, Mochizuki Y, Majerus PW, Mitchell CA
    Proc Natl Acad Sci U S A 2003 Jul 22;100(15):8660-5
  • Inositol 1,3,4-trisphosphate 5/6-kinase associates with the COP9 signalosome by binding to CSN1
    Sun Y, Wilson MP, Majerus PW
    J Biol Chem 2002 Nov 29;277(48):45759-64
  • The human homolog of the rat inositol phosphate multikinase is an inositol 1,3,4,6-tetrakisphosphate 5-kinase
    Chang SC, Miller AL, Feng Y, Wente SR, Majerus PW
    J Biol Chem 2002 Nov 15;277(46):43836-43
  • The synthesis of inositol hexakisphosphate. Characterization of human inositol 1,3,4,5,6-pentakisphosphate 2-kinase
    Verbsky JW, Wilson MP, Kisseleva MV, Majerus PW, Wente SR
    J Biol Chem 2002 Aug 30;277(35):31857-62
  • Phosphoinositide-specific inositol polyphosphate 5-phosphatase IV inhibits Akt/protein kinase B phosphorylation and leads to apoptotic cell death
    Kisseleva MV, Cao L, Majerus PW
    J Biol Chem 2002 Feb 22;277(8):6266-72
  • Characterization of an adapter subunit to a phosphatidylinositol (3)P 3-phosphatase: identification of a myotubularin-related protein lacking catalytic activity
    Nandurkar HH, Caldwell KK, Whisstock JC, Layton MJ, Gaudet EA, Norris FA, Majerus PW, Mitchell CA
    Proc Natl Acad Sci U S A 2001 Aug 14;98(17):9499-504
  • Inositol 1,3,4-trisphosphate 5/6-kinase is a protein kinase that phosphorylates the transcription factors c-Jun and ATF-2
    Wilson MP, Sun Y, Cao L, Majerus PW
    J Biol Chem 2001 Nov 2;276(44):40998-1004
  • Overexpression of the inositol phosphatase SopB in human 293 cells stimulates cellular chloride influx and inhibits nuclear mRNA export
    Feng Y, Wente SR, Majerus PW
    Proc Natl Acad Sci U S A 2001 Jan 30;98(3):875-9
  • Inositol polyphosphate 4-phosphatase type I regulates cell growth downstream of transcription factor GATA-1
    Vyas P, Norris FA, Joseph R, Majerus PW, Orkin SH
    Proc Natl Acad Sci U S A 2000 Dec 5;97(25):13696-701
  • An Entamoeba histolytica inositol 1,3,4-trisphosphate 5/6-kinase has a novel 3-kinase activity
    Field J, Wilson MP, Mai Z, Majerus PW, Samuelson J
    Mol Biochem Parasitol 2000 Apr 30;108(1):119-23
  • The isolation and characterization of a cDNA encoding phospholipid-specific inositol polyphosphate 5-phosphatase
    Kisseleva MV, Wilson MP, Majerus PW
    J Biol Chem 2000 Jun 30;275(26):20110-6
  • The activation loop of phosphatidylinositol phosphate kinases determines signaling specificity
    Kunz J, Wilson MP, Kisseleva M, Hurley JH, Majerus PW, Anderson RA
    Mol Cell 2000 Jan;5(1):1-11
  • Increased levels of plasma lysosomal enzymes in patients with Lowe syndrome
    Ungewickell AJ, Majerus PW
    Proc Natl Acad Sci U S A 1999 Nov 9;96(23):13342-4
  • The inositol polyphosphate 4-phosphatase forms a complex with phosphatidylinositol 3-kinase in human platelet cytosol
    Munday AD, Norris FA, Caldwell KK, Brown S, Majerus PW, Mitchell CA
    Proc Natl Acad Sci U S A 1999 Mar 30;96(7):3640-5
  • The role of phosphatases in inositol signaling reactions
    Majerus PW, Kisseleva MV, Norris FA
    J Biol Chem 1999 Apr 16;274(16):10669-72
  • Multiple forms of the SH2-containing inositol phosphatase, SHIP, are generated by C-terminal truncation
    Damen JE, Liu L, Ware MD, Ermolaeva M, Majerus PW, Krystal G
    Blood 1998 Aug 15;92(4):1199-205
  • SopB, a protein required for virulence of Salmonella dublin, is an inositol phosphate phosphatase [see comments]
    Norris FA, Wilson MP, Wallis TS, Galyov EE, Majerus PW
    Proc Natl Acad Sci U S A 1998 Nov 24;95(24):14057-9
  • The protein tyrosine phosphatase SHP-1 regulates integrin-mediated adhesion of macrophages
    Roach TI, Slater SE, White LS, Zhang X, Majerus PW, Brown EJ, Thomas ML
    Curr Biol 1998 Sep 10;8(18):1035-8
  • Cell lines from kidney proximal tubules of a patient with Lowe syndrome lack OCRL inositol polyphosphate 5-phosphatase and accumulate phosphatidylinositol 4,5-bisphosphate
    Zhang X, Hartz PA, Philip E, Racusen LC, Majerus PW
    J Biol Chem 1998 Jan 16;273(3):1574-82
  • Phosphatidylinositol signalling reactions
    Zhang X, Majerus PW
    Semin Cell Dev Biol 1998 Apr;9(2):153-60
  • Prostaglandins: critical roles in pregnancy and colon cancer
    Majerus PW
    Curr Biol 1998 Jan 29;8(3):R87-9
  • The role of erythropoietin receptor tyrosine phosphorylation in erythropoietin-induced proliferation
    Damen JE, Liu L, Wakao H, Miyajima A, Rosten P, Jefferson AB, Majerus PW, Krosl J, Humphries RK, Krystal G
    Leukemia 1997 Apr;11 Suppl 3:423-5
  • The cDNA cloning and characterization of inositol polyphosphate 4-phosphatase type II. Evidence for conserved alternative splicing in the 4-phosphatase family
    Norris FA, Atkins RC, Majerus PW
    J Biol Chem 1997 Sep 19;272(38):23859-64
  • Phosphatidylinositol-4-phosphate 5-kinase isozymes catalyze the synthesis of 3-phosphate-containing phosphatidylinositol signaling molecules
    Zhang X, Loijens JC, Boronenkov IV, Parker GJ, Norris FA, Chen J, Thum O, Prestwich GD, Majerus PW, Anderson RA
    J Biol Chem 1997 Jul 11;272(28):17756-61
  • Inositol polyphosphate 4-phosphatase is inactivated by calpain-mediated proteolysis in stimulated human platelets
    Norris FA, Atkins RC, Majerus PW
    J Biol Chem 1997 Apr 25;272(17):10987-9
  • Characterization of a cDNA encoding Arabidopsis thaliana inositol 1,3,4- trisphosphate 5/6-kinase
    Wilson MP, Majerus PW
    Biochem Biophys Res Commun 1997 Mar 27;232(3):678-81
  • Signaling inositol polyphosphate-5-phosphatase. Characterization of activity and effect of GRB2 association
    Jefferson AB, Auethavekiat V, Pot DA, Williams LT, Majerus PW
    J Biol Chem 1997 Feb 28;272(9):5983-8
  • Phosphorylation of platelet pleckstrin activates inositol polyphosphate 5-phosphatase I
    Auethavekiat V, Abrams CS, Majerus PW
    J Biol Chem 1997 Jan 17;272(3):1786-90
  • A novel phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase associates with the interleukin-3 receptor
    Liu L, Jefferson AB, Zhang X, Norris FA, Majerus PW, Krystal G
    J Biol Chem 1996 Nov 22;271(47):29729-33
  • The inositol 5'-phosphatase SHIP binds to immunoreceptor signaling motifs and responds to high affinity IgE receptor aggregation
    Osborne MA, Zenner G, Lubinus M, Zhang X, Songyang Z, Cantley LC, Majerus P, Burn P, Kochan JP
    J Biol Chem 1996 Nov 15;271(46):29271-8
  • Inositols do it all
    Majerus PW
    Genes Dev 1996 May 1;10(9):1051-3
  • The effect of overexpression of the protein tyrosine phosphatase PTPMEG on cell growth and on colony formation in soft agar in COS-7 cells
    Gu M, Meng K, Majerus PW
    Proc Natl Acad Sci U S A 1996 Nov 12;93(23):12980-5
  • Isolation of inositol 1,3,4-trisphosphate 5/6-kinase, cDNA cloning and expression of the recombinant enzyme
    Wilson MP, Majerus PW
    J Biol Chem 1996 May 17;271(20):11904-10
  • The properties of the protein tyrosine phosphatase PTPMEG
    Gu M, Majerus PW
    J Biol Chem 1996 Nov 1;271(44):27751-9
  • Mutation of the conserved domains of two inositol polyphosphate 5- phosphatases
    Jefferson AB, Majerus PW
    Biochemistry 1996 Jun 18;35(24):7890-4
  • The 145-kDa protein induced to associate with Shc by multiple cytokines is an inositol tetraphosphate and phosphatidylinositol 3,4,5- triphosphate 5-phosphatase
    Damen JE, Liu L, Rosten P, Humphries RK, Jefferson AB, Majerus PW, Krystal G
    Proc Natl Acad Sci U S A 1996 Feb 20;93(4):1689-93
  • Multiple forms of an inositol polyphosphate 5-phosphatase form signaling complexes with Shc and Grb2
    Kavanaugh WM, Pot DA, Chin SM, Deuter-Reinhard M, Jefferson AB, Norris FA, Masiarz FR, Cousens LS, Majerus PW, Williams LT
    Curr Biol 1996 Apr 1;6(4):438-45
  • The isolation and characterization of cDNA encoding human and rat brain inositol polyphosphate 4-phosphatase
    Norris FA, Auethavekiat V, Majerus PW
    J Biol Chem 1995 Jul 7;270(27):16128-33
  • The protein deficient in Lowe syndrome is a phosphatidylinositol-4,5- bisphosphate 5-phosphatase
    Zhang X, Jefferson AB, Auethavekiat V, Majerus PW
    Proc Natl Acad Sci U S A 1995 May 23;92(11):4853-6
  • Definition of a metal-dependent/Li(+)-inhibited phosphomonoesterase protein family based upon a conserved three-dimensional core structure
    York JD, Ponder JW, Majerus PW
    Proc Natl Acad Sci U S A 1995 May 23;92(11):5149-53
  • Properties of type II inositol polyphosphate 5-phosphatase
    Jefferson AB, Majerus PW
    J Biol Chem 1995 Apr 21;270(16):9370-7
  • Inositol hexakisphosphate binds to clathrin assembly protein 3 (AP- 3/AP180) and inhibits clathrin cage assembly in vitro
    Norris FA, Ungewickell E, Majerus PW
    J Biol Chem 1995 Jan 6;270(1):214-7
  • Crystal structure of inositol polyphosphate 1-phosphatase at 2.3-A resolution
    York JD, Ponder JW, Chen ZW, Mathews FS, Majerus PW
    Biochemistry 1994 Nov 15;33(45):13164-71
  • Inositol polyphosphate 1-phosphatase is present in the nucleus and inhibits DNA synthesis
    York JD, Saffitz JE, Majerus PW
    J Biol Chem 1994 Aug 5;269(31):19992-9
  • Human genetics. Bad blood by mutation
    Majerus PW
    Nature 1994 May 5;369(6475):14-5
  • Hydrolysis of phosphatidylinositol 3,4-bisphosphate by inositol polyphosphate 4-phosphatase isolated by affinity elution chromatography
    Norris FA, Majerus PW
    J Biol Chem 1994 Mar 25;269(12):8716-20
  • Nuclear phosphatidylinositols decrease during S-phase of the cell cycle in HeLa cells. [published erratum appears in J Biol Chem 1994 Dec 9;269(49):31322]
    York JD, Majerus PW
    J Biol Chem 1994 Mar 18;269(11):7847-50
  • Crystallization and initial X-ray crystallographic characterization of recombinant bovine inositol polyphosphate 1-phosphatase produced in Spodoptera frugiperda cells
    York JD, Chen ZW, Ponder JW, Chauhan AK, Mathews FS, Majerus PW
    J Mol Biol 1994 Feb 18;236(2):584-9
  • Platelets
    Majerus PW
    In: G. Stamatoyannopoulos, A.W. Nienhuis, P.W. Majerus and H. Varmus (Eds.), Molecular Basis of Blood Diseases, 2nd ed.  Philadelphia: W.B. Saunders Company (1994)
  • Cloning, heterologous expression, and chromosomal localization of human inositol polyphosphate 1-phosphatase
    York JD, Veile RA, Donis-Keller H, Majerus PW
    Proc Natl Acad Sci U S A 1993 Jun 15;90(12):5833-7
  • Inherited predisposition to thrombosis
    Miletich JP, Prescott SM, White R, Majerus PW, Bovill EG
    Cell 1993 Feb 26;72(4):477-80
  • Mammalian cells that express Bacillus cereus phosphatidylinositol-specific phospholipase C have increased levels of inositol cyclic 1:2-phosphate, inositol 1-phosphate, and inositol 2-phosphate
    Ross TS, Wang FP, Majerus PW
    J Biol Chem 1992 Oct 5;267(28):19919-23
  • Identification of a phosphodiesterase that converts inositol cyclic 1:2- phosphate to inositol 2-phosphate
    Ross TS, Majerus PW
    J Biol Chem 1992 Oct 5;267(28):19924-8
  • Cloning and expression of a cytosolic megakaryocyte protein-tyrosine- phosphatase with sequence homology to retinaldehyde-binding protein and yeast SEC14p
    Gu M, Warshawsky I, Majerus PW
    Proc Natl Acad Sci U S A 1992 Apr 1;89(7):2980-4
  • Inositol phosphate biochemistry
    Majerus PW
    Annu Rev Biochem 1992;61:225-50
  • The George M. Kober Lecture: molecular mechanisms of intracellular signal transduction
    Majerus PW
    Trans Assoc Am Physicians 1991;104:clxviii-clxxx
  • The v-sis oncogene product but not platelet-derived growth factor (PDGF) A homodimers activate PDGF alpha and beta receptors intracellularly and initiate cellular transformation
    Bejcek BE, Hoffman RM, Lipps D, Li DY, Mitchell CA, Majerus PW, Deuel TF
    J Biol Chem 1992 Feb 15;267(5):3289-93
  • Diverse proteins homologous to inositol monophosphatase
    Neuwald AF, York JD, Majerus PW
    FEBS Lett 1991 Dec 2;294(1-2):16-8
  • Formation of phosphatidylinositol 3-phosphate by isomerization from phosphatidylinositol 4-phosphate
    Walsh JP, Caldwell KK, Majerus PW
    Proc Natl Acad Sci U S A 1991 Oct 15;88(20):9184-7
  • Cloning and expression of human 75-kDa inositol polyphosphate-5-phosphatase
    Ross TS, Jefferson AB, Mitchell CA, Majerus PW
    J Biol Chem 1991 Oct 25;266(30):20283-9
  • Isolation and characterization of two 3-phosphatases that hydrolyze both phosphatidylinositol 3-phosphate and inositol 1,3-bisphosphate
    Caldwell KK, Lips DL, Bansal VS, Majerus PW
    J Biol Chem 1991 Sep 25;266(27):18378-86
  • Identification, cloning, and expression of a cytosolic megakaryocyte protein-tyrosine-phosphatase with sequence homology to cytoskeletal protein 4.1
    Gu MX, York JD, Warshawsky I, Majerus PW
    Proc Natl Acad Sci U S A 1991 Jul 1;88(13):5867-71
  • Pathway for the formation of D-3 phosphate containing inositol phospholipids in PDGF stimulated NIH 3T3 fibroblasts
    Cunningham TW, Majerus PW
    Biochem Biophys Res Commun 1991 Mar 15;175(2):568-76
  • Cyclic hydrolase-transfected 3T3 cells have low levels of inositol 1,2- cyclic phosphate and reach confluence at low density
    Ross TS, Whiteley B, Graham RA, Majerus PW
    J Biol Chem 1991 May 15;266(14):9086-92
  • Inositol-1,2-cyclic-phosphate 2-inositolphosphohydrolase. Substrate specificity and regulation of activity by phospholipids, metal ion chelators, and inositol 2-phosphate
    Ross TS, Majerus PW
    J Biol Chem 1991 Jan 15;266(2):851-6
  • Anticoagulant, thrombolytic and antiplatelet drugs
    Majerus PW, Broze GJ Jr, Miletich JP, Tollefsen DM
    The pharmacologic basis of theropeutics.  A. Gilman, ed., pp. 1311-1331.  New York: Pergamon Press (1990)
  • The phosphatidylinositol pathway of platelets and vascular cells
    Majerus PW, Bansal VS, Lips DL, Ross TA, Mitchell CA, Caldwell KK, Cunningham TW
    Ann N Y Acad Sci 1991;614:44-50
  • Isolation and heterologous expression of a cDNA encoding bovine inositol polyphosphate 1-phosphatase
    York JD, Majerus PW
    Proc Natl Acad Sci U S A 1990 Dec;87(24):9548-52
  • Thrombin-stimulated immunoprecipitation of phosphatidylinositol 3-kinase from human platelets
    Mitchell CA, Jefferson AB, Bejeck BE, Brugge JS, Deuel TF, Majerus PW
    Proc Natl Acad Sci U S A 1990 Dec;87(23):9396-400
  • Recent insights in phosphatidylinositol signaling
    Majerus PW, Ross TS, Cunningham TW, Caldwell KK, Jefferson AB, Bansal VS
    Cell 1990 Nov 2;63(3):459-65
  • Phosphatidylinositol-derived precursors and signals
    Bansal VS, Majerus PW
    Annu Rev Cell Biol 1990;6:41-67
  • Identity of inositol 1,2-cyclic phosphate 2-phosphohydrolase with lipocortin III
    Ross TS, Tait JF, Majerus PW
    Science 1990 May 4;248(4955):605-7
  • Pathway for the formation of D-3 phosphate containing inositol phospholipids in intact human platelets
    Cunningham TW, Lips DL, Bansal VS, Caldwell KK, Mitchell CA, Majerus PW
    J Biol Chem 1990 Dec 15;265(35):21676-83
  • The isolation and characterization of inositol polyphosphate 4-phosphatase
    Bansal VS, Caldwell KK, Majerus PW
    J Biol Chem 1990 Jan 25;265(3):1806-11
  • Structure and function of thrombomodulin: a natural anticoagulant
    Dittman WA, Majerus PW
    Blood 1990 Jan 15;75(2):329-36
  • Phosphatidylinositol phospholipase C
    Deckmyn H, Whiteley BJ, Majerus PW
    In: L. Birnbaumer and R. Iyengar (eds.), G-Proteins.  Academic Press, 429-452 (1990)
  • Inherited disorders of platelets
    McEver RP, Majerus PW
    In: R. Scriver, A.L. Beaudet, W.S. Sly, and D. Valle (eds.), The Metabolic Basis of Inherited Disease, 6th edition.  New York: McGraw Hill  (1989)
  • The discovery of a 3-phosphomonoesterase that hydrolyzes phosphatidylinositol 3-phosphate in NIH 3T3 cells
    Lips DL, Majerus PW
    J Biol Chem 1989 Nov 25;264(33):19911-5
  • Transcription of thrombomodulin mRNA in mouse hemangioma cells is increased by cycloheximide and thrombin
    Dittman WA, Kumada T, Majerus PW
    Proc Natl Acad Sci U S A 1989 Sep;86(18):7179-82
  • Phosphatidylinositol 3-phosphate is present in normal and transformed fibroblasts and is resistant to hydrolysis by bovine brain phospholipase C II
    Lips DL, Majerus PW, Gorga FR, Young AT, Benjamin TL
    J Biol Chem 1989 May 25;264(15):8759-63
  • Identification and isolation of a 75-kDa inositol polyphosphate-5-phosphatase from human platelets
    Mitchell CA, Connolly TM, Majerus PW
    J Biol Chem 1989 May 25;264(15):8873-7
  • Sequence of a cDNA for mouse thrombomodulin and comparison of the predicted mouse and human amino acid sequences
    Dittman WA, Majerus PW
    Nucleic Acids Res 1989 Jan 25;17(2):802
  • [Distribution of thrombomodulin in human tissues and characterization of thrombomodulin in plasma]
    Ishii H, Nakano M, Tsubouchi J, Kazama M, Majerus PW
    Nippon Ketsueki Gakkai Zasshi 1988 Nov;51(7):1228-33
  • The structure and function of mouse thrombomodulin. Phorbol myristate acetate stimulates degradation and synthesis of thrombomodulin without affecting mRNA levels in hemangioma cells
    Dittman WA, Kumada T, Sadler JE, Majerus PW
    J Biol Chem 1988 Oct 25;263(30):15815-22
  • Properties of inositol polyphosphate 1-phosphatase
    Inhorn RC, Majerus PW
    J Biol Chem 1988 Oct 5;263(28):14559-65
  • Inositol phosphates: synthesis and degradation
    Majerus PW, Connolly TM, Bansal VS, Inhorn RC, Ross TS, Lips DL
    J Biol Chem 1988 Mar 5;263(7):3051-4
  • A role for thrombomodulin in the pathogenesis of thrombin-induced thromboembolism in mice
    Kumada T, Dittman WA, Majerus PW
    Blood 1988 Mar;71(3):728-33
  • Isolation of 1-monomethylphosphoinositol 4,5-bisphosphate [a product of methanolysis of inositol 1,2-(cyclic)-4,5-trisphosphate] from Swiss mouse 3T3 cells
    Lips DL, Bross TE, Majerus PW
    Proc Natl Acad Sci U S A 1988 Jan;85(1):88-92
  • The metabolism of inositol phosphates
    Majerus PW, Connolly TM, Bansal VS, Inhorn RC, Deckmyn H
    Cellular and Molecular Aspects of Inflammation, pp. 445-459.  Philadelphia: Smith Kline and French Laboratories Research Symposium (1988)
  • Inositol polyphosphate 1-phosphatase from calf brain. Purification and inhibition by Li+, Ca2+, and Mn2+
    Inhorn RC, Majerus PW
    J Biol Chem 1987 Nov 25;262(33):15946-52
  • Thrombomodulin as a marker for vascular tumors. Comparative study with factor VIII and Ulex europaeus I lectin
    Yonezawa S, Maruyama I, Sakae K, Igata A, Majerus PW, Sato E
    Am J Clin Pathol 1987 Oct;88(4):405-11
  • Human thrombomodulin: complete cDNA sequence and chromosome localization of the gene
    Wen DZ, Dittman WA, Ye RD, Deaven LL, Majerus PW, Sadler JE
    Biochemistry 1987 Jul 14;26(14):4350-7
  • The metabolism of inositol 1,3,4-trisphosphate to inositol 1,3-bisphosphate
    Bansal VS, Inhorn RC, Majerus PW
    J Biol Chem 1987 Jul 15;262(20):9444-7
  • Platelets: Disorders and role in hemostasis
    Majerus PW
    In: P. Leder, PW Majerus, A.W. Nienhuis, G. Stamatoyannopoulos (eds.), Molecular Basis of Blood Diseases, pp. 689-721.  Philadelphia: W.B. Saunders Company (1987)
  • Eicosadiynoic acid: a non-toxic inhibitor of multiple enzymatic steps in the production of icosanoids from arachidonic acid
    Laposata M, Kaiser SL, Reich EL, Majerus PW
    Prostaglandins 1987 Apr;33(4):603-15
  • Pathway for inositol 1,3,4-trisphosphate and 1,4-bisphosphate metabolism
    Inhorn RC, Bansal VS, Majerus PW
    Proc Natl Acad Sci U S A 1987 Apr;84(8):2170-4
  • Synthesis of inositol 1,2-(cyclic)-4,5-trisphosphate
    Auchus RJ, Kaiser SL, Majerus PW
    Proc Natl Acad Sci U S A 1987 Mar;84(5):1206-9
  • Measurement of icosanoid precursor uptake and release by intact cells
    Laposata M, Majerus PW
    Methods Enzymol 1987;141:350-5
  • Phosphoinositide turnover provides a link in stimulus-response coupling
    Majerus PW, Wilson DB, Connolly TM, Bross TE, Neufeld EJ
    In: R. Bradshaw & S. Prentis (eds.), Oncogenes and Growth Factors, pp. 269-274.  Cambridge, U.K.: Elsevier Publications (1987)
  • The metabolism of tris- and tetraphosphates of inositol by 5-phosphomonoesterase and 3-kinase enzymes
    Connolly TM, Bansal VS, Bross TE, Irvine RF, Majerus PW
    J Biol Chem 1987 Feb 15;262(5):2146-9
  • Protein C inhibits endocytosis of thrombin-thrombomodulin complexes in A549 lung cancer cells and human umbilical vein endothelial cells
    Maruyama I, Majerus PW
    Blood 1987 May;69(5):1481-4
  • Phosphoinositide metabolism in human platelets
    Wilson DB, Connolly TM, Ross TS, Ishii H, Bross TE, Deckmyn H, Brass LF, Majerus PW
    Adv Prostaglandin Thromboxane Leukot Res 1987;17A:558-62
  • Complex interaction between factor Va-light chain and thrombomodulin in the regulation of protein C activation
    Salem HH, Esmon NL, Esmon CT, Majerus PW
    Ann N Y Acad Sci 1986;485:221-7
  • The metabolism of phosphoinositide-derived messenger molecules
    Majerus PW, Connolly TM, Deckmyn H, Ross TS, Bross TE, Ishii H, Bansal VS, Wilson DB
    Science 1986 Dec 19;234(4783):1519-26
  • Guanine nucleotides stimulate soluble phosphoinositide-specific phospholipase C in the absence of membranes
    Deckmyn H, Tu SM, Majerus PW
    J Biol Chem 1986 Dec 15;261(35):16553-8
  • Protein kinase C phosphorylates human platelet inositol trisphosphate 5'-phosphomonoesterase, increasing the phosphatase activity
    Connolly TM, Lawing WJ Jr, Majerus PW
    Cell 1986 Sep 12;46(6):951-8
  • Inositol cyclic triphosphate [inositol 1,2-(cyclic)-4,5-triphosphate] is formed upon thrombin stimulation of human platelets
    Ishii H, Connolly TM, Bross TE, Majerus PW
    Proc Natl Acad Sci U S A 1986 Sep;83(17):6397-401
  • Isolation of D-myo-inositol 1:2-cyclic phosphate 2-inositolphosphohydrolase from human placenta
    Ross TS, Majerus PW
    J Biol Chem 1986 Aug 25;261(24):11119-23
  • Thrombomodulin, an endothelial anticoagulant protein, is absent from the human brain
    Ishii H, Salem HH, Bell CE, Laposata EA, Majerus PW
    Blood 1986 Feb;67(2):362-5
  • Isolation and characterization of the inositol cyclic phosphate products of phosphoinositide cleavage by phospholipase C. Metabolism in cell-free extracts
    Connolly TM, Wilson DB, Bross TE, Majerus PW
    J Biol Chem 1986 Jan 5;261(1):122-6
  • The production of phosphoinositide-derived messenger molecules
    Majerus PW
    Harvey Lect 1986-87;82:145-55
  • The role of phosphoinositides in cell physiology
    Majerus PW, Connolly TM, Ross TS, Ishii H, Deckmyn H
    Symp Fundam Cancer Res 1986;39:157-63
  • Thrombomodulin is present in human plasma and urine
    Ishii H, Majerus PW
    J Clin Invest 1985 Dec;76(6):2178-81
  • The turnover of thrombin-thrombomodulin complex in cultured human umbilical vein endothelial cells and A549 lung cancer cells. Endocytosis and degradation of thrombin
    Maruyama I, Majerus PW
    J Biol Chem 1985 Dec 15;260(29):15432-8
  • Isolation and characterization of the inositol cyclic phosphate products of polyphosphoinositide cleavage by phospholipase C. Physiological effects in permeabilized platelets and Limulus photoreceptor cells
    Wilson DB, Connolly TM, Bross TE, Majerus PW, Sherman WR, Tyler AN, Rubin LJ, Brown JE
    J Biol Chem 1985 Nov 5;260(25):13496-501
  • Arachidonoyl-CoA synthetase. Separation from nonspecific acyl-CoA synthetase and distribution in various cells and tissues
    Laposata M, Reich EL, Majerus PW
    J Biol Chem 1985 Sep 15;260(20):11016-20
  • The 5-hydroxyl of myo-inositol is essential for uptake into HSDM1C1 mouse fibrosarcoma cells
    Auchus RJ, Wilson DB, Covey DF, Majerus PW
    Biochem Biophys Res Commun 1985 Aug 15;130(3):1139-46
  • Uptake and subcellular distribution of [3H]arachidonic acid in murine fibrosarcoma cells measured by electron microscope autoradiography
    Neufeld EJ, Majerus PW, Krueger CM, Saffitz JE
    J Cell Biol 1985 Aug;101(2):573-81
  • Phosphoinositide turnover provides a link in stimulus-response coupling
    Majerus PW, Wilson DB, Connolly TM, Bross TE, Neufeld EJ
    Trends Biochem Sci 1985;10:168-171
  • Pathways of phosphoinositide metabolism in human platelets
    Majerus PW, Wilson DB, Connolly TM, Bross TE, Neufeld EJ
    Adv Prostaglandin Thromboxane Leukot Res 1985;15:109-12
  • Inositol cyclic phosphates are produced by cleavage of phosphatidylphosphoinositols (polyphosphoinositides) with purified sheep seminal vesicle phospholipase C enzymes
    Wilson DB, Bross TE, Sherman WR, Berger RA, Majerus PW
    Proc Natl Acad Sci U S A 1985 Jun;82(12):4013-7
  • Isolation of a phosphomonoesterase from human platelets that specifically hydrolyzes the 5-phosphate of inositol 1,4,5-trisphosphate
    Connolly TM, Bross TE, Majerus PW
    J Biol Chem 1985 Jul 5;260(13):7868-74
  • Thrombomodulin is found on endothelium of arteries, veins, capillaries, and lymphatics, and on syncytiotrophoblast of human placenta
    Maruyama I, Bell CE, Majerus PW
    J Cell Biol 1985 Aug;101(2):363-71
  • Phosphoinositide interconversion in thrombin-stimulated human platelets
    Wilson DB, Neufeld EJ, Majerus PW
    J Biol Chem 1985 Jan 25;260(2):1046-51
  • Human thrombomodulin is not an efficient inhibitor of the procoagulant activity of thrombin
    Maruyama I, Salem HH, Ishii H, Majerus PW
    J Clin Invest 1985 Mar;75(3):987-91
  • Mechanisms for eicosanoid precursor uptake and release by a tissue culture cell line
    Majerus PW, Neufeld EJ, Laposata M
    In: J.E. Bleasdale, Eichberg, J., and G. Hauser (eds.), Inositol and Phosphoinositides: Metabolism and Regulation, pp. 443-457.  Clifton, NJ: Humana Press (1985)
  • Production of phosphoinositide-derived messengers
    Majerus PW, Neufeld EJ, Wilson DB
    Cell 1984 Jul;37(3):701-3
  • Hydrolysis of polyphosphoinositides by purified sheep seminal vesicle phospholipase C enzymes
    Wilson DB, Bross TE, Hofmann SL, Majerus PW
    J Biol Chem 1984 Oct 10;259(19):11718-24
  • Isolation and characterization of thrombomodulin from human placenta
    Salem HH, Maruyama I, Ishii H, Majerus PW
    J Biol Chem 1984 Oct 10;259(19):12246-51
  • Coagulation factor Va binds to human umbilical vein endothelial cells and accelerates protein C activation
    Maruyama I, Salem HH, Majerus PW
    J Clin Invest 1984 Jul;74(1):224-30
  • Effects of thrombomodulin and coagulation Factor Va-light chain on protein C activation in vitro
    Salem HH, Esmon NL, Esmon CT, Majerus PW
    J Clin Invest 1984 Apr;73(4):968-72
  • Fatty acid structural requirements for activity of arachidonoyl-CoA synthetase
    Neufeld EJ, Sprecher H, Evans RW, Majerus PW
    J Lipid Res 1984 Mar;25(3):288-93
  • A mutant HSDM1C1 fibrosarcoma line selected for defective eicosanoid precursor uptake lacks arachidonate-specific acyl-CoA synthetase
    Neufeld EJ, Bross TE, Majerus PW
    J Biol Chem 1984 Feb 10;259(3):1986-92
  • Biosynthesis of coagulation Factor V by a human hepatocellular carcinoma cell line
    Wilson DB, Salem HH, Mruk JS, Maruyama I, Majerus PW
    J Clin Invest 1984 Mar;73(3):654-8
  • Arachidonate metabolism in vascular disorders
    Majerus PW
    J Clin Invest 1983 Nov;72(5):1521-5
  • RHC 80267 does not inhibit the diglyceride lipase pathway in intact platelets
    Bross TE, Prescott SM, Majerus PW
    Biochem Biophys Res Commun 1983 Oct 14;116(1):68-74
  • Antithrombotic therapy: Current achievements and future directions
    Majerus PW
    Drug Therapy 1983;13:51-52
  • The light chain of factor Va contains the activity of factor Va that accelerates protein C activation by thrombin
    Salem HH, Broze GJ, Miletich JP, Majerus PW
    J Biol Chem 1983 Jul 25;258(14):8531-4
  • High affinity esterification of eicosanoid precursor fatty acids by platelets
    Neufeld EJ, Wilson DB, Sprecher H, Majerus PW
    J Clin Invest 1983 Jul;72(1):214-20
  • Human coagulation factor Va is a cofactor for the activation of protein C
    Salem HH, Broze GJ, Miletich JP, Majerus PW
    Proc Natl Acad Sci U S A 1983 Mar;80(6):1584-8
  • Arachidonate release and phosphatidic acid turnover in stimulated human platelets
    Neufeld EJ, Majerus PW
    J Biol Chem 1983 Feb 25;258(4):2461-7
  • Characterization of 1,2-diacylglycerol hydrolysis in human platelets. Demonstration of an arachidonoyl-monoacylglycerol intermediate
    Prescott SM, Majerus PW
    J Biol Chem 1983 Jan 25;258(2):764-9
  • Uptake and release of arachidonate by platelets
    Majerus PW, Prescott SM, Hofmann SL, Neufeld EJ, Wilson DB
    Adv Prostaglandin Thromboxane Leukot Res 1983;11:45-52
  • Drugs for the prevention of cardiovascular disease
    Prescott SM, Majerus PW
    In: Kaplan (ed.), Preventive Cardiology, pp. 147-160.  Philadelphia: W.B. Saunders (1983)
  • Development and characterization of a tissue culture cell line with essential fatty acid deficiency
    Laposata M, Prescott SM, Bross TE, Majerus PW
    Proc Natl Acad Sci U S A 1982 Dec;79(24):7654-8
  • Modulation of phosphatidylinositol-specific phospholipase C activity by phospholipid interactions, diglycerides, and calcium ions
    Hofmann SL, Majerus PW
    J Biol Chem 1982 Dec 10;257(23):14359-64
  • Activation of coagulation factor V by a platelet protease
    Kane WH, Mruk JS, Majerus PW
    J Clin Invest 1982 Nov;70(5):1092-100
  • Fraud in medical research. Presidential address delivered before the 74th annual meeting of the American Society for Clinical Investigation, Washington, DC, 8 May 1982
    Majerus PW
    J Clin Invest 1982 Jul;70(1):213-7
  • Identification and properties of two distinct phosphatidylinositol- specific phospholipase C enzymes from sheep seminal vesicular glands
    Hofmann SL, Majerus PW
    J Biol Chem 1982 Jun 10;257(11):6461-9
  • Discovery of an arachidonoyl coenzyme A synthetase in human platelets
    Wilson DB, Prescott SM, Majerus PW
    J Biol Chem 1982 Apr 10;257(7):3510-5
  • The effects of mepacrine and p-bromophenacyl bromide on arachidonic acid release in human platelets
    Hofmann SL, Prescott SM, Majerus PW
    Arch Biochem Biophys 1982 Apr 15;215(1):237-44
  • Characterization and assay of diacylglycerol lipase from human platelets
    Majerus PW, Prescott SM
    Methods Enzymol 1982;86:11-7
  • Platelet and vascular effects of aspirin
    Prescott SM, Majerus PW
    Primary Cardiology 1982;8:58-65
  • Isolation and structural characterization of the polypeptide subunits of membrane glycoprotein IIb-IIIa from human platelets
    McEver RP, Baenziger JU, Majerus PW
    Blood 1982 Jan;59(1):80-5
  • Inherited disorders of platelets
    McEver RP, Majerus PW
    In: Stanbury (ed.), Metabolic Basis of Inherited Disease, 5th edition, pp. 1561-1572.  New York: McGraw-Hill(1982)
  • The interaction of human coagulation factor Va with platelets
    Kane WH, Majerus PW
    J Biol Chem 1982 Apr 10;257(7):3963-9
  • Purification of human coagulation factors II, IX and X using sulfated dextran beads
    Miletich JP, Broze GJ, Majerus PW
    Methods Enzymol 1981;80:221-228
  • Human factor VII
    Broze GJ, Majerus PW
    Methods Enzymol 1981;80:228-237
  • Purification and characterization of human coagulation factor V
    Kane WH, Majerus PW
    J Biol Chem 1981 Jan 25;256(2):1002-7
  • The fatty acid composition of phosphatidylinositol from thrombin-stimulated human platelets
    Prescott SM, Majerus PW
    J Biol Chem 1981 Jan 25;256(2):579-82
  • Isolation and quantitation of the platelet membrane glycoprotein deficient in thrombasthenia using a monoclonal hybridoma antibody
    McEver RP, Baenziger NL, Majerus PW
    J Clin Invest 1980 Dec;66(6):1311-8
  • Prevention of thrombosis by inhibition of prostaglandin synthesis
    Majerus PW, Stanford N
    In: P. Ramwell (ed.), Prostaglandin Synthetase Inhibitors, pp. 209-219.  New York: A.R. Liss, Inc. (1980)
  • Bradykinin-stimulated release of arachidonate from phosphatidyl inositol in mouse fibrosarcoma cells
    Bell RL, Baenziger NL, Majerus PW
    Prostaglandins 1980 Aug;20(2):269-74
  • The synthesis of sulfated dextran beads for isolation of human plasma coagulation factors II, IX, and X
    Miletich JP, Broze GJ Jr, Majerus PW
    Anal Biochem 1980 Jul 1;105(2):304-10
  • Thrombin-induced hydrolysis of phosphatidylinositol in human platelets
    Bell RL, Majerus PW
    J Biol Chem 1980 Mar 10;255(5):1790-2
  • Purification and properties of human coagulation factor VII
    Broze GJ Jr, Majerus PW
    J Biol Chem 1980 Feb 25;255(4):1242-7
  • Factor Va-dependent binding of factor Xa to human platelets
    Kane WH, Lindhout MJ, Jackson CM, Majerus PW
    J Biol Chem 1980 Feb 10;255(3):1170-4
  • Prostacyclin production in cultured human vascular endothelial cells, smooth muscle cells, and skin fibrobalsts
    Baenziger NL, Becherer PR, Dillender M, Majerus PW
    In: Mann and Taylor (eds.), The Regulation of coagulation, pp. 479-485.  New York: Elsevier North Holland, Inc. (1980)
  • Diglyceride lipase: A pathway for arachidonate release from human platelets
    Majerus PW, Bell RL, Stanford N, Kennerly DA
    In: Mann and Taylor (eds.), The Regulation of Coagulation, pp. 461-470.  New York: Elsevier North Holland, Inc. (1980)
  • The formation of thrombin on the platelet surface
    Majerus PW, Miletich JP, Kane WH, Hofmann SL, Stanford N, Jackson CM
    In: Mann and Taylor (eds.) The Regulation of Coagulation, pp. 215-224.  New York: Elsevier North Holland, Inc. (1980)
  • Enzymatic properties of activated factor X from the gamma-carboxyglutamic acid containing domain has been removed
    Morita T, Kane WH, Majerus PW, Jackson CM
    In: Mann and Taylor (eds.), The Regulation of Coagulation, pp. 187-188.  New York: Elsevier North Holland, Inc. (1980)
  • Diglyceride lipase: a pathway for arachidonate release from human platelets
    Bell RL, Stanford N, Kennerly DA, Majerus PW
    Adv Prostaglandin Thromboxane Res 1980;6:219-24
  • Plasma antithrombins and thrombin binding to platelets in plasma
    Rotoli B, Majerus PW
    Haematologica 1979 Oct;64(5):537-51
  • Deficiency of factor Xa-factor Va binding sites on the platelets of a patient with a bleeding disorder
    Miletich JP, Kane WH, Hofmann SL, Stanford N, Majerus PW
    Blood 1979 Nov;54(5):1015-22
  • Prevention of thrombosis in patients on hemodialysis by low-dose aspirin
    Harter HR, Burch JW, Majerus PW, Stanford N, Delmez JA, Anderson CB, Weerts CA
    N Engl J Med 1979 Sep 13;301(11):577-9
  • Diglyceride lipase: a pathway for arachidonate release from human platelets
    Bell RL, Kennerly DA, Stanford N, Majerus PW
    Proc Natl Acad Sci U S A 1979 Jul;76(7):3238-41
  • The role of prostaglandins in platelet function
    Burch JW, Majerus PW
    Semin Hematol 1979 Jul;16(3):196-207
  • Thrombin generation during hemostasis
    Shuman MA, Majerus PW, Tollefsen DM
    Proceedings of First Florence Conference on Hemostasis and Thrombosis.  Academic Press, pp. 91-101 (1979)
  • Characterization of prostacyclin synthesis in cultured human arterial smooth muscle cells, venous endothelial cells and skin fibroblasts
    Baenziger NL, Becherer PR, Majerus PW
    Cell 1979 Apr;16(4):967-74
  • The mechanism of action of antiplatelet drugs
    Baenziger NL, Majerus PW
    In: J.H. Joist and L.A. Sherman (eds.) Venous and Arterial Thrombosis. Pathogenesis, Diagnosis, Prevention, and Treatment.  New York: Grune and Stratton, pp. 327-338 (1979)
  • The relation of conductivity to the binding of thrombin to human platelets
    Rotoli B, Miletich JP, Majerus PW
    Thromb Res 1978 Dec;13(6):1103-9
  • Sensitivity of fatty acid cyclooxygenase from human aorta to acetylation by aspirin
    Burch JW, Baenziger NL, Stanford N, Majerus PW
    Proc Natl Acad Sci U S A 1978 Oct;75(10):5181-4
  • Patients with congenital factor V deficiency have decreased factor Xa binding sites on their platelets
    Miletich JP, Majerus DW, Majerus PW
    J Clin Invest 1978 Oct;62(4):824-31
  • Properties of the factor Xa binding site on human platelets
    Miletich JP, Jackson CM, Majerus PW
    J Biol Chem 1978 Oct 10;253(19):6908-16
  • Bleeding disorders secondary to platelet abnormalities
    Majerus PW
    In: H.F. Conn (ed.).  Philadelphia: W.B. Saunders, pp. 288-290 (1978)
  • Inhibition of platelet prostaglandin synthetase by oral aspirin
    Burch JW, Stanford N, Majerus PW
    J Clin Invest 1978 Feb;61(2):314-9
  • Relationships between platelets and coagulation factors in hemostasis
    Majerus PW, Miletich JP
    Annu Rev Med 1978;29:41-9
  • Interaction of coagulation factor Xa with human platelets
    Miletich JP, Jackson CM, Majerus PW
    Proc Natl Acad Sci U S A 1977 Sep;74(9):4033-6
  • Acetylation of prostaglandin synthetase by aspirin. Purification and properties of the acetylated protein from sheep vesicular gland
    Roth GJ, Stanford N, Jacobs JW, Majerus PW
    Biochemistry 1977 Sep 20;16(19):4244-8
  • Cultured human skin fibroblasts and arterial cells produce a labile platelet-inhibitory prostaglandin
    Baenziger NL, Dillender MJ, Majerus PW
    Biochem Biophys Res Commun 1977 Sep 9;78(1):294-301
  • Comparative effects of aspirin and diflunisal on prostaglandin synthetase from human platelets and sheep seminal vesicles
    Majerus PW, Stanford N
    Br J Clin Pharmacol 1977 Feb;4 Suppl 1:15S-18S
  • Lack of covalent modification of prostaglandin synthetase (cyclo- oxygenase) by indomethacin
    Stanford N, Roth GJ, Shen TY, Majerus PW
    Prostaglandins 1977 Apr;13(4):669-75
  • Cyclic adenosine 3',5'-monophosphate inhibits the availability of arachidonate to prostaglandin synthetase in human platelet suspensions
    Minkes M, Stanford N, Chi MM, Roth GJ, Raz A, Needleman P, Majerus PW
    J Clin Invest 1977 Mar;59(3):449-54
  • Acetylation of prostaglandin synthetase by aspirin
    Roth GJ, Majerus PW
    In: M. Silver (ed.) Prostaglandins in Hematology, Spectrum Publications, pp. 345-360 (1977)
  • The measurement of thrombin in clotting blood by radioimmunoassay
    Shuman MA, Majerus PW
    J Clin Invest 1976 Nov;58(5):1249-58
  • The interaction of platelets with thrombin
    Majerus PW, Tollefsen DM, Shuman MA
    In: J.L. Gordon (ed.) Platelets in Biology and Pathology.  ASP Biological Press, pp. 241-260 (1976)
  • Evidence for a single class of thrombin-binding sites of human platelets
    Tollefsen DM, Majerus PW
    Biochemistry 1976 May 18;15(10):2144-9
  • Editorial: Why aspirin?
    Majerus PW
    Circulation 1976 Sep;54(3):357-9
  • Aspirin as a quantitative acetylating reagent for the fatty acid oxygenase that forms prostaglandins
    Rome LH, Lands WE, Roth GJ, Majerus PW
    Prostaglandins 1976 Jan;11(1):23-30
  • The binding of human and bovine thrombin to human platelets
    Shuman MA, Tollefsen DM, Majerus PW
    Blood 1976 Jan;47(1):43-54
  • Binding of the products of prothrombin activation to human platelets
    Tollefsen DM, Jackson CM, Majerus PW
    J Clin Invest 1975 Jul;56(1):241-5
  • The perturbation of thrombin binding to human platelets by anions
    Shuman MA, Majerus PW
    J Clin Invest 1975 Oct;56(4):945-50
  • Acetylation of prostaglandin synthase by aspirin
    Roth GJ, Stanford N, Majerus PW
    Proc Natl Acad Sci U S A 1975 Aug;72(8):3073-6
  • Thrombin-induced protein phosphorylation in human platelets
    Lyons RM, Stanford N, Majerus PW
    J Clin Invest 1975 Oct;56(4):924-36
  • The mechanism of the effect of aspirin on human platelets. I. Acetylation of a particulate fraction protein
    Roth GJ, Majerus PW
    J Clin Invest 1975 Sep;56(3):624-32
  • Gamma heavy chain disease: rapid, sustained response to cyclophosphamide and prednisone
    Lyons RM, Chaplin H, Tillack TW, Majerus PW
    Blood 1975 Jul;46(1):1-9
  • Inhibition of human platelet aggregation by monovalent antifibrinogen antibody fragments
    Tollefsen DM, Majerus PW
    J Clin Invest 1975 Jun;55(6):1259-68
  • Isolation of human platelets and platelet surface membranes
    Baenziger NL, Majerus PW
    Methods Enzymol 1974;31(Pt A):149-55
  • Use of vitamin B 12 in affinity chromatography
    Allen RH, Burger RL, Mehlman CS, Majerus PW
    Methods Enzymol 1974;34:305-14
  • Erythrocyte glutathione synthesis in the neonate
    Minnich V, Smith ME, Rajanasathit C, Majerus PW
    Biol Neonate 1974;24(1):128-33
  • The binding of thrombin to the surface of human platelets
    Tollefsen DM, Feagler JR, Majerus PW
    J Biol Chem 1974 Apr 25;249(8):2646-51
  • The effects of thrombin on phytohemagglutinin receptor sites in human platelets
    Feagler JR, Tillack TW, Chaplin DD, Majerus PW
    J Cell Biol 1974 Mar;60(3):541-53
  • Induction of the platelet release reaction by phytohemagglutinin
    Tollefsen DM, Feagler JR, Majerus PW
    J Clin Invest 1974 Jan;53(1):211-8
  • The regulation of fatty acid synthesis in human skin fibroblasts. Inhibition of fatty acid synthesis by free fatty acids
    Jacobs RA, Majerus PW
    J Biol Chem 1973 Dec 25;248(24):8392-401
  • The regulation of fatty acid biosynthesis in human skin fibroblasts
    Jacobs RA, Sly WS, Majerus PW
    J Biol Chem 1973 Feb 25;248(4):1268-76
  • Association of androgenic-anabolic steroid therapy with development of hepatocellular carcinoma
    Johnson FL, Lerner KG, Siegel M, Feagler JR, Majerus PW, Hartmann JR, Thomas ED
    Lancet 1972 Dec 16;2(7790):1273-6
  • Isolation of vitamin B12-binding proteins using affinity chromatography. 3. Purification and properties of human plasma transcobalamin II
    Allen RH, Majerus PW
    J Biol Chem 1972 Dec 10;247(23):7709-17
  • Isolation of vitamin B12-binding proteins using affinity chromatography. II. Purification and properties of a human granulocyte vitamine B12-binding protein
    Allen RH, Majerus PW
    J Biol Chem 1972 Dec 10;247(23):7702-8
  • Isolation of vitamin B12-binding proteins using affinity chromatography. I. Preparation and properties of vitamin B12-sepharose
    Allen RH, Majerus PW
    J Biol Chem 1972 Dec 10;247(23):7695-701
  • The binding of phytohemagglutinins to human platelet plasma membranes
    Majerus PW, Brodie GN
    J Biol Chem 1972 Jul 10;247(13):4253-7
  • Isolation and properties of a thrombin-sensitive protein of human platelets
    Baenziger NL, Brodie GN, Majerus PW
    J Biol Chem 1972 May 10;247(9):2723-31
  • The effects of thrombin on adenyl cyclase activity and a membrane protein from human platelets
    Brodie GN, Baenziger NL, Chase LR, Majerus PW
    J Clin Invest 1972 Jan;51(1):81-8
  • Bleeding disorders secondary to platelet abnormalities
    Majerus PW
    In: H.F. Conn (ed.) Current Therapy, pp. 260-262.  Philadelphia: W.B. Saunders (1972)
  • Glutathione synthesis in human erythrocytes. II. Purification and properties of the enzymes of glutathione biosynthesis
    Majerus PW, Brauner MJ, Smith MB, Minnich V
    J Clin Invest 1971 Aug;50(8):1637-43
  • An unusual type of spiculated erythrocyte in metastatic liver disease and hemolytic anemia. Report of a case
    Keller JW, Majerus PW, Finke EH
    Ann Intern Med 1971 May;74(5):732-7
  • A thrombin-sensitive protein of human platelet membranes
    Baenziger NL, Brodie GN, Majerus PW
    Proc Natl Acad Sci U S A 1971 Jan;68(1):240-3
  • Lipid metabolism in human platelets
    Majerus PW, Baenziger NL, Brodie GN
    Ser Haematol 1971;4(1):59-74
  • Glutathione biosynthesis in human erythrocytes. I. Identification of the enzymes of glutathione synthesis in hemolysates
    Minnich V, Smith MB, Brauner MJ, Majerus PW
    J Clin Invest 1971 Mar;50(3):507-13
  • Glutathione synthetase deficiency as a cause of hereditary hemolytic disease
    Mohler DN, Majerus PW, Minnich V, Hess CE, Garrick MD
    N Engl J Med 1970 Dec 3;283(23):1253-7
  • Acetyl coenzyme A carboxylase. The effects of biotin deficiency on enzyme in rat liver and adipose tissue
    Jacobs R, Kilburn E, Majerus PW
    J Biol Chem 1970 Dec 10;245(23):6462-7
  • Acetyl coenzyme A carboxylase. The roles of synthesis and degradation in regulation of enzyme levels in rat liver
    Majerus PW, Kilburn E
    J Biol Chem 1969 Nov 25;244(22):6254-62
  • Lipid metabolism in human platelets. II. De novo phospholipid synthesis and the effect of thrombin on the pattern of synthesis
    Lewis N, Majerus PW
    J Clin Invest 1969 Nov;48(11):2114-23
  • Lipid metabolism in human platelets. I. Evidence for a complete fatty acid synthesizing system
    Majerus PW, Smith MB, Clamon GH
    J Clin Invest 1969 Jan;48(1):156-64
  • Beta-ketoacyl acyl carrier protein reductase
    Vagelos PR, Alberts AW, Majerus PW
    Methods Enzymol 1969;14:60-63
  • Beta-hydroxyacyl ACP dehydrase from Escherichia coli
    Majerus PW, Alberts AW, Vagelos PR
    Methods Enzymol 1969;14:64-66
  • Beta-ketoacyl acyl carrier protein synthetase
    Alberts AW, Majerus PW, Vagelos PR
    Methods Enzymol 1969;14:57-60
  • Acetyl CoA-acyl carrier protein transacylase
    Alberts AW, Majerus PW, Vagelos PR
    Methods Enzymol 1969;14:53-56
  • Malonyl CoA-acyl carrier protein transacylase
    Alberts AW, Majerus PW, Vagelos PR
    Methods Enzymol 1969;14:50-53
  • Acyl carrier protein from Escherichia coli
    Majerus PW, Alberts AW, Vagelos PR
    Methods Enzymol 1969;14:43-49
  • Mechanism of saturated fatty acid biosynthesis in Escherichia coli
    Vagelos PR, Jacobs RH, Smith MB, Majerus PW
    Methods Enzymol 1969;14:39-43
  • The regulation of fatty acid biosynthesis in rat hepatomas
    Majerus PW, Jacobs R, Smith MB, Morris HP
    J Biol Chem 1968 Jul 10;243(13):3588-95
  • Acyl carrier proteIn: effects of acetylation and tryptic hydrolysis on function in fatty acid synthesis
    Majerus PW
    Science 1968 Jan 26;159(813):428-30
  • The preparation of the acyl carrier protein from Escherichia coli
    Majerus PW, Alberts AW, Vagelos PR
    Biochemical Preparations, Vol. 12, 56-65 (1968)
  • Fatty acid biosynthesis in human leukocytes
    Majerus PW, Lastra R
    J Clin Invest 1967 Oct;46(10):1596-602
  • Acyl carrier protein. Structural requirements for function in fatty acid biosynthesis
    Majerus PW
    J Biol Chem 1967 May 25;242(10):2325-32
  • Fatty acid biosynthesis and the role of the acyl carrier protein
    Majerus PW, Vagelos PR
    Adv Lipid Res 1967;5:1-33
  • Structure and function of the acyl carrier protein
    Vagelos PR, Majerus PW, Alberts AW, Larrabee AR, Ailhaud GP
    Fed Proc 1966 Sep-Oct;25(5):1485-94
  • The biosynthesis of beta-hydroxy-beta-methylglutaryl coenzyme A in yeast. V. The role of acyl carrier protein
    Rudney H, Stewart PR, Majerus PW, Vagelos PR
    J Biol Chem 1966 Mar 10;241(5):1226-8
  • The mechanism of fatty acid biosynthesis and the involvement of an acyl carrier protein
    Vagelos PR, Alberts AW, Majerus PW
    Ann N Y Acad Sci 1965 Oct 8;131(1):177-88
  • Acyl carrier protein. VII. The primary structure of the substrate- binding site
    Majerus PW, Alberts AW, Vagelos PR
    J Biol Chem 1965 Dec;240(12):4723-6
  • Acyl carrier protein. VI. Purification and properties of beta-ketoacyl carrier protein synthetase
    Alberts AW, Majerus PW, Vagelos PR
    Biochemistry 1965;4:2265-2274
  • Acyl carrier protein. IV. The identification of 4'-phosphopantetheine as the prosthetic group of the acyl carrier protein
    Majerus PW, Alberts AW, Vagelos PR
    Proc Natl Acad Sci U S A 1965 Feb;53:410-7
  • Acyl carrier protein.  III. An enoyl-hydrase specific for acyl carrier protein thioesters
    Majerus PW, Alberts AW, Vagelos PR
    J Biol Chem 1965 Feb;240:618-21
  • Acyl carrier protein. II. Intermediary reactions of fatty acid synthesis
    Alberts AW, Majerus PW, Talamo B, Vagelos PR
    Biochemistry 1964 Oct;3:1563-71
  • The acyl carrier protein of fatty acid synthesis. I. Purification, physical properties and substrate binding site
    Majerus PW, Alberts AW, Vagelos PR
    Proc Natl Acad Sci U S A 1964 Jun;51:1231-8
  • Psychologic factors and psychiatric disease in hyperemesis gravidarum: A followup study of 69 vomiters and 66 controls
    Majerus PW, Guze SB, Delong WB, Robins E
    Am J Psychiatry 1960 Nov;117:421-8
  • Association of clinical psychiatric disease with hyperemesis gravidarum. A three-and-a-half-year follow-up study of 48 patients and 45 controls
    Guze SB, Delong WB, Majerus PW, Robins E
    N Engl J Med 1959 Dec 31;261:1363-8