Julie O'Neal, PhD

Department of Medicine
Oncology Division
Stem Cell Biology

Research Interests

  • CAR-T therapy for multiple myeloma
  • Novel therapeutics for multiple myeloma
  • Genomics and biology of multiple myeloma


  • 314-362-9335 (tel)
  • 314-362-9333 (fax)
  • Room 626P, Southwest Tower (office)
  • Washington University School of Medicine
    Division of Oncology
    Campus Box 8007
    660 South Euclid Avenue
    St. Louis, MO 63110

Peer-reviewed Manuscripts

  • An "Off-The-Shelf" Fratricide-Resistant CAR-T for the Treatment of T Cell Hematologic Malignancies
    Cooper ML, Choi J, Staser K, Ritchey JK, Devenport JM, Eckardt K, Rettig MP, Wang B, Eissenberg LG, Ghobadi A, Gehrs LN, Prior JL, Achilefu S, Miller CA, Fronick CC, O'Neal J, Gao F, Weinstock DM, Gutierrez A, Fulton RS, DiPersio JF
    Leukemia 2018 Sep;32(9):1970-1983
  • A Multiple Myeloma-Specific Capture Sequencing Platform Discovers Novel Translocations and Frequent, Risk-Associated Point Mutations in IGLL5
    White BS, Lanc I, O'Neal J, Gupta H, Fulton RS, Schmidt H, Fronick C, Belter EA Jr, Fiala M, King J, Ahmann GJ, DeRome M, Mardis ER, Vij R, DiPersio JF, Levy J, Auclair D, Tomasson MH
    Blood Cancer J 2018 Mar 21;8(3):35
  • Inhibition of 6-Phosphofructo-2-Kinase (PFKFB3) Suppresses Glucose Metabolism and the Growth of HER2+ Breast Cancer
    O'Neal J, Clem A, Reynolds L, Dougherty S, Imbert-Fernandez Y, Telang S, Chesney J, Clem BF
    Breast Cancer Res Treat 2016 Nov;160(1):29-40
  • Collaborative Control of Cell Cycle Progression by the RNA Exonuclease Dis3 and Ras Is Conserved Across Species
    Snee MJ, Wilson WC, Zhu Y, Chen SY, Wilson BA, Kseib C, O'Neal J, Mahajan N, Tomasson MH, Arur S, Skeath JB
    Genetics 2016 Jun;203(2):749-62
  • Deletion of Rb1 Induces Both Hyperproliferation and Cell Death in Murine Germinal Center B Cells
    He Z*, O'Neal J*, Wilson WC, Mahajan N, Luo J, Wang Y, Su MY, Lu L, Skeath JB, Bhattacharya D, Tomasson MH (*Co-first authors)
    Exp Hematol 2016 Mar;44(3):161-5e4
  • Clinical Development of Cancer Therapeutics That Target Metabolism
    Clem BF, O'Neal J, Klarer AC, Telang S, Chesney J
    QJM 2016 Jun;109(6):367-72
  • Whole Genome Sequence of Multiple Myeloma-Prone C57BL/KaLwRij Mouse Strain Suggests the Origin of Disease Involves Multiple Cell Types
    Amend SR, Wilson WC, Chu L, Lu L, Liu P, Serie D, Su X, Xu Y, Wang D, Gramolini A, Wen XY, O'Neal J, Hurchla M, Vachon CM, Colditz G, Vij R, Weilbaecher KN, Tomasson MH
    PLoS One 2015 May 28;10(5):e0127828
  • Glucose Availability and Glycolytic Metabolism Dictate Glycosphingolipid Levels
    Stathem M, Marimuthu S, O'Neal J, Rathmell JC, Chesney JA, Beverly LJ, Siskind LJ
    J Cell Biochem 2015 Jan;116(1):67-80
  • Estradiol Stimulates Glucose Metabolism Via 6-Phosphofructo-2-Kinase (PFKFB3)
    Imbert-Fernandez Y, Clem BF, O'Neal J, Kerr DA, Spaulding R, Lanceta L, Clem AL, Telang S, Chesney J
    J Biol Chem 2014 Mar 28;289(13):9440-8
  • Inhibition of 6-Phosphofructo-2-Kinase (PFKFB3) Induces Autophagy as a Survival Mechanism
    Klarer AC, O'Neal J, Imbert-Fernandez Y, Clem A, Ellis SR, Clark J, Clem B, Chesney J, Telang S
    Cancer Metab 2014 Jan 23;2(1):2
  • Targeting 6-Phosphofructo-2-Kinase (PFKFB3) as a Therapeutic Strategy Against Cancer
    Clem BF, O'Neal J, Tapolsky G, Clem AL, Imbert-Fernandez Y, Kerr DA 2nd, Klarer AC, Redman R, Miller DM, Trent JO, Telang S, Chesney J
    Mol Cancer Ther 2013 Aug;12(8):1461-70
  • Targeting Metabolic Enzymes in Cancer - Clinical Trials Update
    O’Neal J, Chesney J
    Current Enzyme Inhibition 2013;9(2):152-60
  • The Function of the Conserved Regulatory Element Within the Second Intron of the Mammalian Csf1r Locus
    Sauter KA, Bouhlel MA, O'Neal J, Sester DP, Tagoh H, Ingram RM, Pridans C, Bonifer C, Hume DA
    PLoS One 2013;8(1):e54935
  • Neurobeachin (NBEA) Is a Target of Recurrent Interstitial Deletions at 13q13 in Patients With MGUS and Multiple Myeloma
    O'Neal J, Gao F, Hassan A, Monahan R, Barrios S, Kilimann MW, Lee I, Chng WJ, Vij R, Tomasson MH
    Exp Hematol 2009 Feb;37(2):234-44
  • RelB Is the NF-KappaB Subunit Downstream of NIK Responsible for Osteoclast Differentiation
    Vaira S, Johnson T, Hirbe AC, Alhawagri M, Anwisye I, Sammut B, O'Neal J, Zou W, Weilbaecher KN, Faccio R, Novack DV
    Proc Natl Acad Sci U S A 2008 Mar 11;105(10):3897-902
  • Myeloproliferative Disease Induced by TEL-PDGFRB Displays Dynamic Range Sensitivity to Stat5 Gene Dosage
    Cain JA, Xiang Z, O'Neal J, Kreisel F, Colson A, Luo H, Hennighausen L, Tomasson MH
    Blood 2007 May 1;109(9):3906-14
  • c-MYC Rapidly Induces Acute Myeloid Leukemia in Mice Without Evidence of Lymphoma-Associated Antiapoptotic Mutations
    Luo H, Li Q, O'Neal J, Kreisel F, Le Beau MM, Tomasson MH
    Blood 2005 Oct 1;106(7):2452-61
  • An Activated Receptor Tyrosine Kinase, TEL/PDGFbetaR, Cooperates With AML1/ETO to Induce Acute Myeloid Leukemia in Mice
    Grisolano JL, O'Neal J, Cain J, Tomasson MH
    Proc Natl Acad Sci U S A 2003 Aug 5;100(16):9506-11
  • OCP1, an F-Box Protein, Co-Localizes With OCP2/SKP1 in the Cochlear Epithelial Gap Junction Region
    Henzl MT, O'Neal J, Killick R, Thalmann I, Thalmann R
    Hear Res 2001 Jul;157(1-2):100-11