Faculty
Oncology Division
Alphabetical list (active faculty):   
Karolyn A. Oetjen

Karolyn A. Oetjen, MD, PhD

Instructor

Department of Medicine

Oncology Division

Stem Cell Biology

Clinical Interests

  • Myelodysplastic syndromes
  • Acute myeloid leukemia

Research Interests

  • Malignant clonal evolution

Contact

  • 314-362-8872 (office)
  • 314-362-1953 (fax)
  • Division of Oncology
    Mail Stop 8007-0057-07
    Washington University
    660 South Euclid Avenue
    St. Louis, MO 63110
  • Room 724 Southwest Tower (lab)

Peer-reviewed Manuscripts

  • Personalized Single-Cell Proteogenomics to Distinguish Acute Myeloid Leukemia From Non-Malignant Clonal Hematopoiesis
    Dillon LW, Ghannam J, Nosiri C, Gui G, Goswami M, Calvo KR, Lindblad KE, Oetjen KA, Wilkerson M, Soltis AR, Sukumar G, Dalgard CL, Thompson J, Valdez J, DeStefano CB, Lai C, Sciambi A, Durruthy-Durruthy R, Llanso A, Gulati S, Wang S, Ooi A, Dagur PK, McCoy JP, Burr P, Li Y, Hourigan CS
    Cancer Discov 2021 Jul;2(4):319-325
  • Predisposition to Hematologic Malignancies in Patients With Xeroderma Pigmentosum
    Oetjen KA*, Levoska MA*, Tamura D, Ito S, Douglas D, Khan SG, Calvo KR, Kraemer KH, DiGiovanna JJ (*contributed equally)
    Haematologica 2020 Apr;105(4):e144-e146
  • Persistence of Skewed X-Chromosome Inactivation in Pre-B Acute Lymphoblastic Leukemia of a Female ATRX Mutation Carrier
    Bradley CP, Chen C, Oetjen KA, Yan C, Panjwani R, Hauffe S, Calvo KR, Yuan C, Patel PA, Montgomery ND, Foster MC, Battiwalla M, Barrett AJ, Gibbons RJ, Ito S
    Blood Adv 2019 Sep 10;3(17):2627-2631
  • Mortality-Associated Immunological Abnormalities in Trichothiodystrophy: Correlation of Reduced Levels of Immunoglobulin And Neutrophils With Poor Patient Survival
    Randall G, Kraemer KH, Pugh J, Tamura D, DiGiovanna JJ, Khan SG, Oetjen KA
    Br J Haematol 2019 May;185(4):752-754
  • The Distribution of T-Cell Subsets and the Expression of Immune Checkpoint Receptors and Ligands in Patients With Newly Diagnosed and Relapsed Acute Myeloid Leukemia
    Williams P, Basu S, Garcia-Manero G, Hourigan CS, Oetjen KA, Cortes JE, Ravandi F, Jabbour EJ, Al-Hamal Z, Konopleva M, Ning J, Xiao L, Hidalgo Lopez J, Kornblau SM, Andreeff M, Flores W, Bueso-Ramos C, Blando J, Galera P, Calvo KR, Al-Atrash G, Allison JP, Kantarjian HM, Sharma P, Daver NG
    Cancer 2019 May 1;125(9):1470-1481
  • Human Bone Marrow Assessment by Single-Cell RNA Sequencing, Mass Cytometry, and Flow Cytometry
    Oetjen KA, Lindblad KE, Goswami M, Gui G, Dagur PK, Lai C, Dillon LW, McCoy JP, Hourigan CS
    JCI Insight 2018 Dec 6;3(23):124928
  • Successful Salvage Chemotherapy and Allogeneic Transplantation of an Acute Myeloid Leukemia Patient With Disseminated Fusarium Solani Infection
    Sheela S, Ito S, Strich JR, Manion M, Montemayor-Garcia C, Wang HW, Oetjen KA, West KA, Barrett AJ, Parta M, Gea-Banacloche J, Holland SM, Hourigan CS, Lai C
    Leuk Res Rep 2017 Jul 18;8:4-6
  • Phenotypic Differences Between Mice Deficient in XIAP and SAP, Two Factors Targeted in X-Linked Lymphoproliferative Syndrome (XLP)
    Rumble JM, Oetjen KA, Stein PL, Schwartzberg PL, Moore BB, Duckett CS
    Cell Immunol 2009;259(1):82-9
  • Cytoprotective Effects of IAPs Revealed by a Small Molecule Antagonist
    Galban S, Hwang C, Rumble JM, Oetjen KA, Wright CW, Boudreault A, Durkin J, Gillard JW, Jaquith JB, Morris SJ, Duckett CS
    Biochem J 2009 Feb 1;417(3):765-71
  • Two Distinct Signalling Cascades Target the NF-KappaB Regulatory Factor C-IAP1 for Degradation
    Csomos RA, Wright CW, Galban S, Oetjen KA, Duckett CS
    Biochem J 2009 Apr 28;420(1):83-91
  • X-Linked Inhibitor of Apoptosis Deficiency in the TRAMP Mouse Prostate Cancer Model
    Hwang C*, Oetjen KA*, Kosoff D, Wojno KJ, Albertelli MA, Dunn RL, Robins DM, Cooney KA, Duckett CS (*authors contributed equally)
    Cell Death Differ 2008 May;15(5):831-40
  • Influencing Receptor-Ligand Binding Mechanisms With Multivalent Ligand Architecture
    Gestwicki JE, Cairo CW, Strong LE, Oetjen KA, Kiessling LL
    J Am Chem Soc 2002 Dec 18;124(50):14922-33

Reviews and Book Chapters

  • Thrombocytopenia
    Oetjen KA, Dunbar CE
    In: The Bethesda Handbook of Clinical Hematology 4th Edition (Griffith G, Young NS, eds), Lippincott Williams & Wilkins, 2018
  • Immunological Effects of Hypomethylating Agents
    Lindblad KE, Goswami M, Hourigan CS, Oetjen KA
    Expert Rev Hematol 2017 Aug;10(8):745-752
  • Identifying the Trigger of C-IAPs: Structural and Functional Characterization of CARD-Mediated Modulation of Ubiquitin Ligase Activity
    Oetjen KA, Duckett CS
    Mol Cell 2011 Jun 10;42(5):553-4