Faculty
Oncology Division
Alphabetical list (active faculty):   
Russell K. Pachynski

Russell K. Pachynski, MD

Associate Professor

Department of Medicine

Oncology Division

Molecular Oncology

Clinical Interests

  • Prostate cancer
  • Genitourinary cancers

Research Interests

  • Tumor immunology
  • Leukocyte trafficking
  • Immunotherapy

Contact

  • 314-362-5677 (office)
  • 314-362-7086 (fax)
  • Division of Oncology
    Mail Stop 8069-0012-05
    Washington University
    660 South Euclid Avenue
    St. Louis, MO 63110
  • Room 554B, McDonnell Medical Sciences Building (office)
  • Room 554, McDonnell Medical Sciences Building (lab)

Original Articles

  • Nivolumab Plus Docetaxel in Patients With Chemotherapy-Naive Metastatic Castration-Resistant Prostate Cancer: Results From the Phase II CheckMate 9KD Trial
    Fizazi K, Gonzalez Mella P, Castellano D, Minatta JN, Rezazadeh Kalebasty A, Shaffer D, Vazquez Limon JC, Sanchez Lopez HM, Armstrong AJ, Horvath L, Bastos DA, Amin NP, Li J, Unsal-Kacmaz K, Retz M, Saad F, Petrylak DP, Pachynski RK
    Eur J Cancer 2021 Nov 18; [Epub ahead of print]
  • IL-7 Expands Lymphocyte Populations and Enhances Immune Responses to Sipuleucel-T in Patients With Metastatic Castration-Resistant Prostate Cancer (MCRPC)
    Pachynski RK, Morishima C, Szmulewitz R, Harshman L, Appleman L, Monk P, Bitting RL, Kucuk O, Millard F, Seigne JD, Fling SP, Maecker HT, Duault C, Ramchurren N, Hess B, D'Amico L, Lacroix A, Kaiser JC, Morre M, Gregoire A, Cheever M, Yu EY, Fong L
    J Immunother Cancer 2021 Aug;9(8):002903
  • Blind Image Restoration Enhances Digital Autoradiographic Imaging of Radiopharmaceutical Tissue Distribution
    Lu P, Benabdallah N, Jiang W, Simons BW, Zhang H, Hobbs RF, Ulmert D, Baumann B, Pachynski RK, Jha AK, Thorek DL
    J Nucl Med 2021 Aug 12; [Epub ahead of print]
  • A Prospective Multicenter Evaluation of Initial Treatment Choice in Metastatic Renal Cell Carcinoma Prior to the Immunotherapy Era: The MaRCC Registry Experience
    Costello BA, Bhavsar NA, Zakharia Y, Pal SK, Vaishampayan U, Jim H, Fishman MN, Molina AM, Kyriakopoulos CE, Tsao CK, Appleman LJ, Gartrell BA, Hussain A, Stadler WM, Agarwal N, Pachynski RK, Hutson TE, Hammers HJ, Ryan CW, Mardekian J, Borham A, George DJ, Harrison MR
    Clin Genitourin Cancer 2021 Jul 10; [Epub ahead of print]
  • Safety and Preliminary Immunogenicity of JNJ-64041809, a Live-Attenuated, Double-Deleted Listeria Monocytogenes-Based Immunotherapy, in Metastatic Castration-Resistant Prostate Cancer
    Drake CG, Pachynski RK, Subudhi SK, McNeel DG, Antonarakis ES, Bauer TM, Lauer P, Brockstedt D, Patricia D, Wade M, Zudaire E, Bandyopadhyay N, Parasrampuria DA, Girgis S, Mason GE, Knoblauch RE, Stone N, Infante JR, Gottardis MM, Fong L
    Prostate Cancer Prostatic Dis 2021 Jul 13; [Epub ahead of print]
  • Clinical Results and Biomarker Analyses of Axitinib and TRC105 Versus Axitinib Alone in Patients With Advanced or Metastatic Renal Cell Carcinoma (TRAXAR)
    Choueiri TK, Zakharia Y, Pal S, Kocsis J, Pachynski R, Poprach A, Nixon AB, Liu Y, Starr M, Lyu J, Owzar K, deShazo M, Lara P, Geczi L, Ho TH, Walsh M, Adams B, Robertson L, Darif M, Theuer C, Agarwal N
    Oncologist 2021 Jul;26(7):560-e1103
  • Active Surveillance of Metastatic Renal Cell Carcinoma: Results From a Prospective Observational Study (MaRCC)
    Harrison MR, Costello BA, Bhavsar NA, Vaishampayan U, Pal SK, Zakharia Y, Jim HSL, Fishman MN, Molina AM, Kyriakopoulos CE, Tsao CK, Appleman LJ, Gartrell BA, Hussain A, Stadler WM, Agarwal N, Pachynski RK, Hutson TE, Hammers HJ, Ryan CW, Inman BA, Mardekian J, Borham A, George DJ
    Cancer 2021 Jul 1;127(13):2204-2212
  • Diagnostic Performance of (18)F-DCFPyL-PET/CT in Men With Biochemically Recurrent Prostate Cancer: Results From the CONDOR Phase III, Multicenter Study
    Morris MJ, Rowe SP, Gorin MA, Saperstein L, Pouliot F, Josephson D, Wong JYC, Pantel AR, Cho SY, Gage KL, Piert M, Iagaru A, Pollard JH, Wong V, Jensen J, Lin T, Stambler N, Carroll PR, Siegel BA
    CONDOR Study Group (Investigators include: Pachynski RK)

    Clin Cancer Res 2021 Jul 1;27(13):3674-3682
  • Videos of Sipuleucel-T Programmed T Cells Lysing Cells That Express Prostate Cancer Target Antigens
    Kibel AS, Inman BA, Pachynski RK, Vu T, Sheikh NA, Petrylak DP
    J Natl Cancer Inst 2021 Feb 25; [Epub ahead of print]
  • Single-Cell Spatial Proteomic Revelations on the Multiparametric MRI Heterogeneity of Clinically Significant Prostate Cancer
    Pachynski RK, Kim EH, Miheecheva N, Kotlov N, Ramachandran A, Postovalova E, Galkin I, Svekolkin V, Lyu Y, Zou Q, Cao D, Gaut J, Ippolito JE, Bagaev A, Bruttan M, Gancharova O, Nomie K, Tsiper M, Andriole GL, Ataullakhanov R, Hsieh JJ
    Clin Cancer Res 2021 Jun 15;27(12):3478-3490
  • Immunotherapy and Immunotherapy Combinations in Metastatic Castration-Resistant Prostate Cancer
    Bansal D, Reimers MA, Knoche EM, Pachynski RK
    Cancers (Basel) 2021 Jan 18;13(2)
  • Management of Muscle-Invasive Bladder Cancer During a Pandemic: Impact of Treatment Delay on Survival Outcomes for Patients Treated With Definitive Concurrent Chemoradiotherapy
    Fischer-Valuck BW, Michalski JM, Harton JG, Birtle A, Christodouleas JP, Efstathiou JA, Arora VK, Kim EH, Knoche EM, Pachynski RK, Picus J, Rao YJ, Reimers M, Roth BJ, Sargos P, Smith ZL, Zaghloul MS, Gay HA, Patel SA, Baumann BC
    Clin Genitourin Cancer 2021 Feb;19(1):41-46
  • Nivolumab Plus Ipilimumab for Metastatic Castration-Resistant Prostate Cancer: Preliminary Analysis of Patients in the CheckMate 650 Trial
    Sharma P, Pachynski RK, Narayan V, Flechon A, Gravis G, Galsky MD, Mahammedi H, Patnaik A, Subudhi SK, Ciprotti M, Simsek B, Saci A, Hu Y, Han GC, Fizazi K
    Cancer Cell 2020 Oct 12;38(4):489-499
  • A "Tail" of Immunotherapy in Metastatic Prostate Cancer
    Pachynski RK
    Eur Urol 2020 Dec;78(6):831-833
  • Radiation and Checkpoint Inhibitor Immunotherapy Lead to Long Term Disease Control in a Metastatic RCC Patient With Brain Metastases
    Levitin M, Ofori J, Shin WJ, Huang J, Daly M, Cao D, Pachynski R
    Front Oncol 2020 Sep 23;10:566070
  • Chemerin Reactivates PTEN and Suppresses PD-L1 in Tumor Cells Via Modulation of a Novel CMKLR1-Mediated Signaling Cascade
    Rennier K, Shin WJ, Krug E, Virdi G, Pachynski RK
    Clin Cancer Res 2020 Sep 15;26(18):5019-5035
  • Cell-Free DNA Alterations in the AR Enhancer and Locus Predict Resistance to AR-Directed Therapy in Patients With Metastatic Prostate Cancer
    Dang HX, Chauhan PS, Ellis H, Feng W, Harris PK, Smith G, Qiao M, Dienstbach K, Beck R, Atkocius A, Qaium F, Luo J, Michalski JM, Picus J, Pachynski RK, Maher CA, Chaudhuri AA
    JCO Precis Oncol 2020;4:680-713
  • Immunotherapy in Metastatic Castration-Resistant Prostate Cancer: Past and Future Strategies for Optimization
    Reimers MA, Slane KE, Pachynski RK
    Curr Urol Rep 2019 Sep 3;20(10):64
  • How Else Can We Approach Prostate Cancer Biomarker Discovery?
    Drake RR, Angel PM, Wu J, Pachynski RK, Ippolito JE
    Expert Rev Mol Diagn 2020 Feb;20(2):123-125
  • Chemerin Suppresses Breast Cancer Growth by Recruiting Immune Effector Cells Into the Tumor Microenvironment
    Pachynski RK, Wang P, Salazar N, Zheng Y, Nease L, Rosalez J, Leong WI, Virdi G, Rennier K, Shin WJ, Nguyen V, Butcher EC, Zabel BA
    Front Immunol 2019 May 8;10:983
  • Magnetic Resonance Image Guided Stereotactic Body Radiation Therapy to the Primary Renal Mass in Metastatic Renal Cell Carcinoma
    Rudra S, Fischer-Valuck B, Pachynski R, Daly M, Green O
    Adv Radiat Oncol 2019 Apr 13;4(4):566-570
  • Effectiveness of Postoperative Radiotherapy After Radical Cystectomy for Locally Advanced Bladder Cancer
    Fischer-Valuck BW, Michalski JM, Mitra N, Christodouleas JP, DeWees TA, Kim E, Smith ZL, Andriole GL, Arora VK, Bullock A, Carmona R, Figenshau RS, Grubb RL, Guzzo TJ, Knoche EM, Malkowicz SB, Mamtani R, Pachynski RK, Roth BJ, Zaghloul MS, Gay HA, Baumann BC
    Cancer Med 2019 Jul;8(8):3698-3709
  • Cabozantinib in Advanced Non-Clear-Cell Renal Cell Carcinoma: A Multicentre, Retrospective, Cohort Study
    Martinez Chanza N, Xie W, Asim Bilen M, Dzimitrowicz H, Burkart J, Geynisman DM, Balakrishnan A, Bowman IA, Jain R, Stadler W, Zakharia Y, Narayan V, Beuselinck B, McKay RR, Tripathi A, Pachynski R, Hahn AW, Hsu J, Shah SA, Lam ET, Rose TL, Mega AE, Vogelzang N, Harrison MR, Mortazavi A, Plimack ER, Vaishampayan U, Hammers H, George S, Haas N, Agarwal N, Pal SK, Srinivas S, Carneiro BA, Heng DYC, Bosse D, Choueiri TK, Harshman LC
    Lancet Oncol 2019 Apr;20(4):581-590
  • A Propensity Analysis Comparing Definitive Chemo-Radiotherapy for Muscle-Invasive Squamous Cell Carcinoma of the Bladder Vs. Urothelial Carcinoma of the Bladder Using the National Cancer Database
    Fischer-Valuck BW, Michalski JM, Contreras JA, Brenneman R, Christodouleas JP, Abraham CD, Kim EH, Arora VK, Bullock AD, Carmona R, Figenshau RS, Grubb R 3rd, Knoche EM, Pachynski RK, Picus J, Roth BJ, Sargos P, Andriole GL, Gay HA, Baumann BC
    Clin Transl Radiat Oncol 2018 Dec 12;15:38-41
  • Mechanisms and Functions of Chemerin in Cancer: Potential Roles in Therapeutic Intervention
    Shin WJ, Zabel BA, Pachynski RK
    Front Immunol 2018 Nov 30;9:2772
  • Chemerin Modulation of Tumor Growth: Potential Clinical Applications in Cancer
    Shin WJ, Pachynski RK
    Discov Med 2018 Aug;26(141):31-37
  • Contemporary Management of the Newly Diagnosed Prostate Cancer Patient With Metastatic Disease at Presentation
    Xu L, Pachynski RK
    Curr Urol Rep 2018 Aug 13;19(10):79
  • Apalutamide Treatment and Metastasis-Free Survival in Prostate Cancer
    Smith MR, Saad F, Chowdhury S, Oudard S, Hadaschik BA, Graff JN, Olmos D, Mainwaring PN, Lee JY, Uemura H, Lopez-Gitlitz A, Trudel GC, Espina BM, Shu Y, Park YC, Rackoff WR, Yu MK, Small EJ (Contributors include: Pachynski R)
    SPARTAN Investigators

    N Engl J Med 2018 Apr 12;378(15):1408-1418
  • Treatment of Advanced Prostate Cancer
    Thomas TS, Pachynski RK
    Mo Med 2018 Mar-Apr;115(2):156-161
  • Role of Antigen Spread and Distinctive Characteristics of Immunotherapy in Cancer Treatment
    Gulley JL, Madan RA, Pachynski R, Mulders P, Sheikh NA, Trager J, Drake CG
    J Natl Cancer Inst 2017 Apr 1;109(4)
  • Holbrook Kohrt: In Memoriam (1977-2016)
    Houot R, Pachynski R, Czerwinski DK, Goldstein MJ, Sagiv-Barfi I, Brody J, Muller AM, Marabelle A
    Clin Cancer Res 2016 Jul 15;22(14):3695-6
  • Phase II Study of Pazopanib and Paclitaxel in Patients With Refractory Urothelial Cancer
    Narayanan S, Lam A, Vaishampayan U, Harshman L, Fan A, Pachynski R, Poushnejad S, Haas D, Li S, Srinivas S
    Clin Genitourin Cancer 2016 Oct;14(5):432-437
  • Leukocyte Trafficking: Can We Bring the Fight to the Tumor?
    Pachynski R, Nazha J, Kohrt H
    Discov Med 2016 Mar;21(115):205-212
  • Evaluation of Tumor-Infiltrating Leukocyte Subsets in a Subcutaneous Tumor Model
    Pachynski RK, Scholz A, Monnier J, Butcher EC, Zabel BA
    J Vis Exp 2015 Apr 13;(98)
  • The Chemoattractant Chemerin Suppresses Melanoma by Recruiting Natural Killer Cell Antitumor Defenses
    Pachynski RK, Zabel BA, Kohrt HE, Tejeda NM, Monnier J, Swanson CD, Holzer AK, Gentles AJ, Sperinde GV, Edalati A, Hadeiba HA, Alizadeh AA, Butcher EC
    J Exp Med 2012 Jul 30;209(8):1427-35
  • Plasmacytoid Dendritic Cells Transport Peripheral Antigens to the Thymus to Promote Central Tolerance
    Hadeiba H, Lahl K, Edalati A, Oderup C, Habtezion A, Pachynski R, Nguyen L, Ghodsi A, Adler S, Butcher EC
    Immunity 2012 Mar 23;36(3):438-50
  • Extranodal Dissemination of Non-Hodgkin Lymphoma Requires CD47 and Is Inhibited by Anti-CD47 Antibody Therapy
    Chao MP, Tang C, Pachynski RK, Chin R, Majeti R, Weissman IL
    Blood 2011 Nov 3;118(18):4890-901
  • CD137 Stimulation Enhances the Antilymphoma Activity of Anti-CD20 Antibodies
    Kohrt HE, Houot R, Goldstein MJ, Weiskopf K, Alizadeh AA, Brody J, Muller A, Pachynski R, Czerwinski D, Coutre S, Chao MP, Chen L, Tedder TF, Levy R
    Blood 2011 Feb 24;117(8):2423-32
  • Redirecting Migration of T Cells to Chemokine Secreted From Tumors by Genetic Modification With CXCR2
    Kershaw MH, Wang G, Westwood JA, Pachynski RK, Tiffany HL, Marincola FM, Wang E, Young HA, Murphy PM, Hwu P
    Hum Gene Ther 2002 Nov 1;13(16):1971-80
  • Secondary Lymphoid-Tissue Chemokine (SLC) Stimulates Integrin Alpha 4 Beta 7-Mediated Adhesion of Lymphocytes to Mucosal Addressin Cell Adhesion Molecule-1 (MAdCAM-1) Under Flow
    Pachynski RK, Wu SW, Gunn MD, Erle DJ
    J Immunol 1998 Jul 15;161(2):952-6
  • Presentation of Integrins on Leukocyte Microvilli: A Role for the Extracellular Domain in Determining Membrane Localization
    Abitorabi MA, Pachynski RK, Ferrando RE, Tidswell M, Erle DJ
    J Cell Biol 1997 Oct 20;139(2):563-71
  • Structure-Function Analysis of the Integrin Beta 7 Subunit: Identification of Domains Involved in Adhesion to MAdCAM-1
    Tidswell M, Pachynski R, Wu SW, Qiu SQ, Dunham E, Cochran N, Briskin MJ, Kilshaw PJ, Lazarovits AI, Andrew DP, Butcher EC, Yednock TA, Erle DJ
    J Immunol 1997 Aug 1;159(3):1497-505

Book Chapters

  • Genitourinary Cancer
    Pachynski RK
    In: DeVita, Hellman, and Rosenberg's Cancer: Principles & Practice of Oncology Review, 5th Edition (Morgensztern D, Govindan R, Devarakonda S, Trikalinos NA, Editors), Wolters Kluwer, Philadelphia, 2022
  • Prostate Cancer
    Pachynski RK
    In: The Washington Manual of Oncology, 4th Edition (Morgensztern D, Ghobadi A, Govindan R, Editors), Wolters Kluwer, Philadelphia, 2022
  • Prostate, Bladder, and Kidney Cancer
    Pachynski RK
    In: DeVita, Hellman, and Rosenberg's Cancer, Principles & Practice of Oncology Review (Govindan R, Morgensztern D, eds). Chapter 20. Lippincott Williams & Wilkins, 2016
  • NK Cell Responses in Immunotherapy: Novel Targets and Applications
    Pachynski RK, Kohrt HE
    In: Novel Immunotherapeutic Approaches to the Treatment of Cancer: Drug Development and Clinical Application (Rennert P, ed). Chapter VII. Springer, 2016