Oncology Division
Alphabetical list (active faculty):   
Annabel Quinet

Annabel Quinet, PhD


Department of Medicine

Oncology Division

Molecular Oncology

Research Interests

  • DNA repair and replication stress
  • Genomic stability and tumorigenesis
  • DNA replication stress response to chemotherapy


  • 314-362-9221 (lab)
  • 314-747-2797 (fax)
  • Division of Oncology
    Mail Stop 8069-0020-08
    Washington University
    660 South Euclid Avenue
    St. Louis, MO 63110
  • Room 8848, Clinical Sciences Research Building (office)

Peer-reviewed Manuscripts

  • Temporally Distinct Post-Replicative Repair Mechanisms Fill PRIMPOL-Dependent ssDNA Gaps in Human Cells
    Tirman S, Quinet A, Wood M, Meroni A, Cybulla E, Jackson J, Pegoraro S, Simoneau A, Zou L, Vindigni A
    Mol Cell 2021 Oct 7;81(19):4026-4040
  • Telomere Erosion in Human Pluripotent Stem Cells Leads to ATR-Mediated Mitotic Catastrophe
    Vessoni AT, Zhang T, Quinet A, Jeong HC, Munroe M, Wood M, Tedone E, Vindigni A, Shay JW, Greenberg RA, Batista LFZ
    J Cell Biol 2021 Jun 7;220(6):e202011014
  • To Skip or Not to Skip: Choosing Repriming to Tolerate DNA Damage
    Quinet A, Tirman S, Cybulla E, Meroni A, Vindigni A
    Mol Cell 2021 Feb 18;81(4):649-658
  • PRIMPOL Ready, Set, Reprime!
    Tirman S, Cybulla E, Quinet A, Meroni A, Vindigni A
    Crit Rev Biochem Mol Biol 2021 Feb;56(1):17-30
  • TDP-43 Dysfunction Results in R-Loop Accumulation and DNA Replication Defects
    Wood M, Quinet A, Lin YL, Davis AA, Pasero P, Ayala YM, Vindigni A
    J Cell Sci 2020 Oct 30;133(20):244129
  • PRIMPOL-Mediated Adaptive Response Suppresses Replication Fork Reversal in BRCA-Deficient Cells
    Quinet A, Tirman S, Jackson J, Svikovic S, Lemacon D, Carvajal-Maldonado D, Gonzalez-Acosta D, Vessoni AT, Cybulla E, Wood M, Tavis S, Batista LFZ, Mendez J, Sale JE, Vindigni A
    Mol Cell 2020 Feb 6;77(3):461-474
  • XLF and H2AX Function in Series to Promote Replication Fork Stability
    Chen BR*, Quinet A*, Byrum AK, Jackson J, Berti M, Thangavel S, Bredemeyer AL, Hindi I, Mosammaparast N, Tyler JK, Vindigni A, Sleckman BP (*contributed equally)
    J Cell Biol 2019 Jul 1;218(7):2113-2123
  • Perturbing Cohesin Dynamics Drives MRE11 Nuclease-Dependent Replication Fork Slowing
    Carvajal-Maldonado D, Byrum AK, Jackson J, Wessel S, Lemacon D, Guitton-Sert L, Quinet A, Tirman S, Graziano S, Masson JY, Cortez D, Gonzalo S, Mosammaparast N, Vindigni A
    Nucleic Acids Res 2019 Feb 20;47(3):1294-1310
  • Filling Gaps in Translesion DNA Synthesis in Human Cells
    Quinet A*, Lerner LK*, Martins DJ, Menck CFM (*contributed equally)
    Mutat Res Genet Toxicol Environ Mutagen 2018 Dec;836(Pt B):127-142
  • DNA Repair Pathways and Cisplatin Resistance: An Intimate Relationship
    Rocha CRR, Silva MM, Quinet A, Cabral-Neto JB, Menck CFM
    Clinics (Sao Paulo) 2018 Sep 6;73(suppl 1):e478s
  • DUOX1 Silencing in Mammary Cell Alters the Response to Genotoxic Stress
    Fortunato RS, Gomes LR, Munford V, Pessoa CF, Quinet A, Hecht F, Kajitani GS, Milito CB, Carvalho DP, Menck CFM
    Oxid Med Cell Longev 2018 Apr 19;2018:3570526
  • Replication Fork Reversal: Players and Guardians
    Quinet A, Lemacon D, Vindigni A
    Mol Cell 2017 Dec 7;68(5):830-833
  • MRE11 and EXO1 Nucleases Degrade Reversed Forks and Elicit MUS81-Dependent Fork Rescue in BRCA2-Deficient Cells
    Lemacon D, Jackson J, Quinet A, Brickner JR, Li S, Yazinski S, You Z, Ira G, Zou L, Mosammaparast N, Vindigni A
    Nat Commun 2017 Oct 16;8(1):860
  • Biomass Burning in the Amazon Region Causes DNA Damage and Cell Death in Human Lung Cells
    de Oliveira Alves N, Vessoni AT, Quinet A, Fortunato RS, Kajitani GS, Peixoto MS, Hacon SS, Artaxo P, Saldiva P, Menck CFM, Batistuzzo de Medeiros SR
    Sci Rep 2017 Sep 7;7(1):10937
  • Predominant Role of DNA Polymerase Eta and p53-Dependent Translesion Synthesis in the Survival of Ultraviolet-Irradiated Human Cells
    Lerner LK, Francisco G, Soltys DT, Rocha CR, Quinet A, Vessoni AT, Castro LP, David TI, Bustos SO, Strauss BE, Gottifredi V, Stary A, Sarasin A, Chammas R, Menck CF
    Nucleic Acids Res 2017 Feb 17;45(3):1270-1280
  • NRF2 and Glutathione Are Key Resistance Mediators to Temozolomide in Glioma and Melanoma Cells
    Rocha CR, Kajitani GS, Quinet A, Fortunato RS, Menck CF
    Oncotarget 2016 Jul 26;7(30):48081-48092
  • Translesion Synthesis Mechanisms Depend on the Nature of DNA Damage in UV-Irradiated Human Cells
    Quinet A, Martins DJ, Vessoni AT, Biard D, Sarasin A, Stary A, Menck CF
    Nucleic Acids Res 2016 Jul 8;44(12):5717-31
  • Cockayne Syndrome-Derived Neurons Display Reduced Synapse Density and Altered Neural Network Synchrony
    Vessoni AT, Herai RH, Karpiak JV, Leal AM, Trujillo CA, Quinet A, Agnez Lima LF, Menck CF, Muotri AR
    Hum Mol Genet 2016 Apr 1;25(7):1271-80
  • Chloroquine-Induced Glioma Cells Death Is Associated With Mitochondrial Membrane Potential Loss, but Not Oxidative Stress
    Vessoni AT, Quinet A, de Andrade-Lima LC, Martins DJ, Garcia CC, Rocha CR, Vieira DB, Menck CF
    Free Radic Biol Med 2016 Jan;90:91-100
  • Gap-Filling and Bypass at the Replication Fork Are Both Active Mechanisms for Tolerance of Low-Dose Ultraviolet-Induced DNA Damage in the Human Genome
    Quinet A, Vessoni AT, Rocha CR, Gottifredi V, Biard D, Sarasin A, Menck CF, Stary A
    DNA Repair (Amst) 2014 Feb;14:27-38
  • Glutathione Depletion Sensitizes Cisplatin- and Temozolomide-Resistant Glioma Cells in Vitro and in Vivo
    Rocha CR, Garcia CC, Vieira DB, Quinet A, de Andrade-Lima LC, Munford V, Belizario JE, Menck CF
    Cell Death Dis 2014 Oct 30;5:e1505
  • The Relative Roles of DNA Damage Induced by UVA Irradiation in Human Cells
    Cortat B, Garcia CC, Quinet A, Schuch AP, de Lima-Bessa KM, Menck CF
    Photochem Photobiol Sci 2013 Aug;12(8):1483-95
  • Both XPA and DNA Polymerase Eta Are Necessary for the Repair of Doxorubicin-Induced DNA Lesions
    Moraes MC, de Andrade AQ, Carvalho H, Guecheva T, Agnoletto MH, Henriques JA, Sarasin A, Stary A, Saffi J, Menck CF
    Cancer Lett 2012 Jan 1;314(1):108-18

Invited Publications