Faculty
Hematology Division
Alphabetical list (active faculty):   
Kristen M. Sanfilippo

Kristen M. Sanfilippo, MD, MPHS

Assistant Professor

Department of Medicine

Hematology Division

Clinical Interests

  • Venous thromboembolism
  • Cancer associated thrombosis
  • Arterial thromboembolism
  • Anticoagulation
  • Antiphospholipid antibody syndrome
  • Pregnancy associated thrombosis
  • Thrombophilia
  • Hypercoagulable diseases

Research Interests

  • Venous thromboembolism
  • Risk prediction, venous thromboembolism in multiple myeloma
  • Cancer associated thrombosis
  • Hypercoagulability in liver disease
  • Risk prediction, anticoagulant associated bleeding

Contact

  • 314-362-0164 (office)
  • 314-362-8813 (fax)
  • Hematology Division
    Campus Box 8125
    Washington University
    660 South Euclid Avenue
    St. Louis, MO 63110
  • Suite 1101 Wohl Hospital (office)

Research

Venous Thromboembolism in Multiple Myeloma

The overall goal of this project is to assess the impact of venous thromboembolism on patients with multiple myeloma as well as complete preliminary work to allow development of a clinical risk prediction model for venous thromboembolism in multiple myeloma. Thus far, I have developed a clinical tool to detect venous thromboembolism within administrative databases. Current use of ICD-9 codes to detect venous thromboembolism with databases yields poor accuracy with a positive predictive value averaging at 72%. Through development of a unique algorithm, I have improved accuracy to 91% thus allowing for reliable identification of venous thromboembolism. Given an accurate way of detecting VTE has been established, I am currently working on assessing the impact of venous thromboembolism on survival in multiple myeloma. Preliminary assessments show a 46% increase in mortality at 2 years in patients with multiple myeloma and venous thromboembolism versus those with multiple myeloma alone.