Oncology Division
Alphabetical list (active faculty):   
Jieya Shao

Jieya Shao, PhD

Assistant Professor

Department of Medicine

Oncology Division

Molecular Oncology

Research Interests

  • Mechanistic study of novel anticancer targets
  • DNA damage response
  • Chemotherapy resistance
  • Endocrine therapy resistance


  • 314-362-8695 (office)
  • 314-747-9310 (lab)
  • 314-747-9320 (fax)
  • Division of Oncology
    Campus Box 8076
    Washington University
    660 South Euclid Avenue
    St. Louis, MO 63110
  • Room 3308, Couch Biomedical Research Building (office)

Peer-reviewed Manuscripts

  • Phospho-Ser(784)-VCP Drives Resistance of Pancreatic Ductal Adenocarcinoma to Genotoxic Chemotherapies and Predicts the Chemo-Sensitizing Effect of VCP Inhibitor
    Wang F, Vij K, Li L, Dodhiawala P, Lim KH, Shao J
    Cancers (Basel) 2021 Oct 11;13(20):13205076
  • Ser(71) Phosphorylation Inhibits Actin-Binding of Profilin-1 and Its Apoptosis-Sensitizing Activity
    Wang F, Zhu C, Cai S, Boudreau A, Kim SJ, Bissell M, Shao J
    Front Cell Dev Biol 2021 Jun 21;9:692269
  • Cancer-Associated Exportin-6 Upregulation Inhibits the Transcriptionally Repressive and Anticancer Effects of Nuclear Profilin-1
    Zhu C, Kim SJ, Mooradian A, Wang F, Li Z, Holohan S, Collins PL, Wang K, Guo Z, Hoog J, Ma CX, Oltz EM, Held JM, Shao J
    Cell Rep 2021 Feb 16;34(7):108749
  • Ser(784) Phosphorylation: A Clinically Relevant Enhancer of VCP Function in the DNA Damage Response
    Shao J
    Mol Cell Oncol 2020 Aug 12;7(5):1796179
  • Phospho-Ser(784)-VCP Is Required for DNA Damage Response and Is Associated With Poor Prognosis of Chemotherapy-Treated Breast Cancer
    Zhu C, Rogers A, Asleh K, Won J, Gao D, Leung S, Li S, Vij KR, Zhu J, Held JM, You Z, Nielsen TO, Shao J
    Cell Rep 2020 Jun 9;31(10):107745
  • TYK2 Promotes Malignant Peripheral Nerve Sheath Tumor Progression Through Inhibition of Cell Death
    Qin W, Godec A, Zhang X, Zhu C, Shao J, Tao Y, Bu X, Hirbe AC
    Cancer Med 2019 Sep;8(11):5232-5241
  • Functional Annotation of ESR1 Gene Fusions in Estrogen Receptor-Positive Breast Cancer
    Lei JT*, Shao J*, Zhang J*, Iglesia M*, Chan DW, Cao J, Anurag M, Singh P, He X, Kosaka Y, Matsunuma R, Crowder R, Hoog J, Phommaly C, Goncalves R, Ramalho S, Peres RMR, Punturi N, Schmidt C, Bartram A, Jou E, Devarakonda V, Holloway KR, Lai WV, Hampton O, Rogers A, Tobias E, Parikh PA, Davies SR, Li S, Ma CX, Suman VJ, Hunt KK, Watson MA, Hoadley KA, Thompson EA, Chen X, Kavuri SM, Creighton CJ, Maher CA, Perou CM, Haricharan S, Ellis MJ (*Equal authorships)
    Cell Rep 2018 Aug 7;24(6):1434-1444e7
  • Proteomic Profiling Identifies Key Coactivators Utilized by Mutant ERalpha Proteins as Potential New Therapeutic Targets
    Gates LA, Gu G, Chen Y, Rohira AD, Lei JT, Hamilton RA, Yu Y, Lonard DM, Wang J, Wang SP, Edwards DG, Lavere PF, Shao J, Yi P, Jain A, Jung SY, Malovannaya A, Li S, Shao J, Roeder RG, Ellis MJ, Qin J, Fuqua SAW, O'Malley BW, Foulds CE
    Oncogene 2018 Aug;37(33):4581-4598
  • Breast Tumors Educate the Proteome of Stromal Tissue in an Individualized but Coordinated Manner
    Wang X, Mooradian AD, Erdmann-Gilmore P, Zhang Q, Viner R, Davies SR, Huang KL, Bomgarden R, Van Tine BA, Shao J, Ding L, Li S, Ellis MJ, Rogers JC, Townsend RR, Fenyo D, Held JM
    Sci Signal 2017 Aug 8;10(491)
  • Efficacy of SERD/SERM Hybrid-CDK4/6 Inhibitor Combinations in Models of Endocrine Therapy-Resistant Breast Cancer
    Wardell SE, Ellis MJ, Alley HM, Eisele K, VanArsdale T, Dann SG, Arndt KT, Primeau T, Griffin E, Shao J, Crowder R, Lai JP, Norris JD, McDonnell DP, Li S
    Clin Cancer Res 2015 Nov 15;21(22):5121-30
  • Subcellular Localization and Ser-137 Phosphorylation Regulate Tumor-Suppressive Activity of Profilin-1
    Diamond MI, Cai S, Boudreau A, Carey CJ Jr, Lyle N, Pappu RV, Swamidass SJ, Bissell M, Piwnica-Worms H, Shao J* (*Corresponding author)
    J Biol Chem 2015 Apr 3;290(14):9075-86
  • Endocrine-Therapy-Resistant ESR1 Variants Revealed by Genomic Characterization of Breast-Cancer-Derived Xenografts
    Li S, Shen D, Shao J, Crowder R, Liu W, Prat A, He X, Liu S, Hoog J, Lu C, Ding L, Griffith OL, Miller C, Larson D, Fulton RS, Harrison M, Mooney T, McMichael JF, Luo J, Tao Y, Goncalves R, Schlosberg C, Hiken JF, Saied L, Sanchez C, Giuntoli T, Bumb C, Cooper C, Kitchens RT, Lin A, Phommaly C, Davies SR, Zhang J, Kavuri MS, McEachern D, Dong YY, Ma C, Pluard T, Naughton M, Bose R, Suresh R, McDowell R, Michel L, Aft R, Gillanders W, DeSchryver K, Wilson RK, Wang S, Mills GB, Gonzalez-Angulo A, Edwards JR, Maher C, Perou CM, Mardis ER, Ellis MJ
    Cell Rep 2013 Sep 26;4(6):1116-30
  • Prion-Like Nuclear Aggregation of TDP-43 During Heat Shock Is Regulated by HSP40/70 Chaperones
    Udan-Johns M, Bengoechea R, Bell S, Shao J, Diamond MI, True HL, Weihl CC, Baloh RH
    Hum Mol Genet 2014 Jan 1;23(1):157-70
  • Protein Phosphatase 1 Dephosphorylates Profilin-1 at Ser-137
    Shao J*, Diamond MI (*Corresponding author)
    PLoS One 2012;7(3):e32802
  • Interaction With Polyglutamine Aggregates Reveals a Q/N-Rich Domain in TDP-43
    Fuentealba RA, Udan M, Bell S, Wegorzewska I, Shao J, Diamond MI, Weihl CC, Baloh RH
    J Biol Chem 2010 Aug 20;285(34):26304-14
  • F-Actin Binding Regions on the Androgen Receptor and Huntingtin Increase Aggregation and Alter Aggregate Characteristics
    Angeli S, Shao J, Diamond MI
    PLoS One 2010 Feb 4;5(2):e9053
  • Phosphorylation of Profilin by ROCK1 Regulates Polyglutamine Aggregation
    Shao J, Welch WJ, Diprospero NA, Diamond MI
    Mol Cell Biol 2008 Sep;28(17):5196-208
  • A Common Motif Targets Huntingtin and the Androgen Receptor to the Proteasome
    Chandra S*, Shao J*, Li JX, Li M, Longo FM, Diamond MI (*Equal authorships)
    J Biol Chem 2008 Aug 29;283(35):23950-5
  • ROCK and PRK-2 Mediate the Inhibitory Effect of Y-27632 on Polyglutamine Aggregation
    Shao J, Welch WJ, Diamond MI
    FEBS Lett 2008 May 28;582(12):1637-42
  • Evidence for Chaperone Heterocomplexes Containing Both Hsp90 and VCP
    Prince T, Shao J, Matts RL, Hartson SD
    Biochem Biophys Res Commun 2005 Jun 17;331(4):1331-7
  • A Rapid Cellular FRET Assay of Polyglutamine Aggregation Identifies a Novel Inhibitor
    Pollitt SK, Pallos J, Shao J, Desai UA, Ma AA, Thompson LM, Marsh JL, Diamond MI
    Neuron 2003 Nov 13;40(4):685-94
  • Functional Dissection of Cdc37: Characterization of Domain Structure and Amino Acid Residues Critical for Protein Kinase Binding
    Shao J, Irwin A, Hartson SD, Matts RL
    Biochemistry 2003 Nov 4;42(43):12577-88
  • High Affinity Binding of Hsp90 Is Triggered by Multiple Discrete Segments of Its Kinase Clients
    Scroggins BT, Prince T, Shao J, Uma S, Huang W, Guo Y, Yun BG, Hedman K, Matts RL, Hartson SD
    Biochemistry 2003 Nov 4;42(43):12550-61
  • Phosphorylation of Serine 13 Is Required for the Proper Function of the Hsp90 Co-Chaperone, Cdc37
    Shao J, Prince T, Hartson SD, Matts RL
    J Biol Chem 2003 Oct 3;278(40):38117-20
  • Evidence That Protein Phosphatase 5 Functions to Negatively Modulate the Maturation of the Hsp90-Dependent Heme-Regulated EIF2alpha Kinase
    Shao J, Hartson SD, Matts RL
    Biochemistry 2002 May 28;41(21):6770-9
  • Hsp90 Regulates P50(Cdc37) Function During the Biogenesis of the Activeconformation of the Heme-Regulated EIF2 Alpha Kinase
    Shao J, Grammatikakis N, Scroggins BT, Uma S, Huang W, Chen JJ, Hartson SD, Matts RL
    J Biol Chem 2001 Jan 5;276(1):206-14
  • P50(Cdc37) Is a Nonexclusive Hsp90 Cohort Which Participates Intimately in Hsp90-Mediated Folding of Immature Kinase Molecules
    Hartson SD, Irwin AD, Shao J, Scroggins BT, Volk L, Huang W, Matts RL
    Biochemistry 2000 Jun 27;39(25):7631-44
  • P50(Cdc37) Can Buffer the Temperature-Sensitive Properties of a Mutant of Hck
    Scholz G, Hartson SD, Cartledge K, Hall N, Shao J, Dunn AR, Matts RL
    Mol Cell Biol 2000 Sep;20(18):6984-95

Invited Publications