Faculty
Oncology Division
Alphabetical list (active faculty):   
Xinming Su

Xinming Su, PhD

Assistant Professor

Department of Medicine

Oncology Division

Molecular Oncology

Research Interests

  • Mouse models of breast cancer bone metastasis
  • Bone remodeling and disseminated tumor cells in bone marrow
  • Myeloid cell function in the tumor microenvironment

Contact

  • 314-454-8973 (office)
  • 314-747-2797 (fax)
  • Division of Oncology
    Mail Stop 8056-0012-08
    Washington University
    660 South Euclid Avenue
    St. Louis, MO 63110
  • Room 805, McDonnell Medical Sciences Building (office)

Peer-reviewed Manuscripts

  • Breast Cancer-Derived GM-CSF Regulates Arginase 1 in Myeloid Cells to Promote an Immunosuppressive Microenvironment
    Su X, Xu Y, Fox GC, Xiang J, Kwakwa KA, Davis JL, Belle JI, Lee WC, Wong WH, Fontana F, Hernandez-Aya LF, Kobayashi T, Tomasson HM, Su J, Bakewell SJ, Stewart SA, Egbulefu C, Karmakar P, Meyer MA, Veis DJ, DeNardo DG, Lanza GM, Achilefu S, Weilbaecher KN
    J Clin Invest 2021 Oct 15;131(20):145296
  • Targeted Therapy to Beta3 Integrin Reduces Chemoresistance in Breast Cancer Bone Metastases
    Fox GC, Su X, Davis JL, Xu Y, Kwakwa KA, Ross MH, Fontana F, Xiang J, Esser AK, Cordell E, Pagliai K, Dang HX, Sivapackiam J, Stewart SA, Maher CA, Bakewell SJ, Fitzpatrick JAJ, Sharma V, Achilefu S, Veis DJ, Lanza GM, Weilbaecher KN
    Mol Cancer Ther 2021 Jun;20(6):1183-1198
  • N-Cadherin in Osteolineage Cells Modulates Stromal Support of Tumor Growth
    Fontana F, Xiang J, Su X, Tycksen E, Nassau R, Fox G, Leanza G, Weilbaecher K, Civitelli R
    J Bone Oncol 2021 Mar 23;28:100356
  • Hepatic Lipids Promote Liver Metastasis
    Li Y, Su X, Rohatgi N, Zhang Y, Brestoff JR, Shoghi KI, Xu Y, Semenkovich CF, Harris CA, Peterson LL, Weilbaecher KN, Teitelbaum SL, Zou W
    JCI Insight 2020 Sep 3;5(17)
  • Nanotherapy Delivery of c-MYC Inhibitor Targets Protumor Macrophages and Preserves Antitumor Macrophages in Breast Cancer
    Esser AK, Ross MH, Fontana F, Su X, Gabay A, Fox GC, Xu Y, Xiang J, Schmieder AH, Yang X, Cui G, Scott M, Achilefu S, Chauhan J, Fletcher S, Lanza GM, Weilbaecher KN
    Theranostics 2020 Jun 12;10(17):7510-7526
  • HTLV-1 Viral Oncogene HBZ Drives Bone Destruction in Adult T Cell Leukemia
    Xiang J, Rauch DA, Huey DD, Panfil AR, Cheng X, Esser AK, Su X, Harding JC, Xu Y, Fox GC, Fontana F, Kobayashi T, Su J, Sundaramoorthi H, Wong WH, Jia Y, Rosol TJ, Veis DJ, Green PL, Niewiesk S, Ratner L, Weilbaecher KN
    JCI Insight 2019 Oct 3;4(19)
  • CD4+ T Cells Induce Rejection of Urothelial Tumors After Immune Checkpoint Blockade
    Sato Y, Bolzenius JK, Eteleeb AM, Su X, Maher CA, Sehn JK, Arora VK
    JCI Insight 2018 Dec 6;3(23)
  • Inhibition of the Stromal P38MAPK/MK2 Pathway Limits Breast Cancer Metastases and Chemotherapy-Induced Bone Loss
    Murali B, Ren Q, Luo X, Faget DV, Wang C, Johnson RM, Gruosso T, Flanagan KC, Fu Y, Leahy K, Alspach E, Su X, Ross MH, Burnette B, Weilbaecher KN, Park M, Mbalaviele G, Monahan JB, Stewart SA
    Cancer Res 2018 Oct 1;78(19):5618-5630
  • Perfusion-Based Fluorescence Imaging Method Delineates Diverse Organs and Identifies Multifocal Tumors Using Generic Near-Infrared Molecular Probes
    Miller J, Wang ST, Orukari I, Prior J, Sudlow G, Su X, Liang K, Tang R, Hillman EMC, Weilbaecher KN, Culver JP, Berezin MY, Achilefu S
    J Biophotonics 2018 Apr;11(4):e201700232
  • Breast and Pancreatic Cancer Interrupt IRF8-Dependent Dendritic Cell Development to Overcome Immune Surveillance
    Meyer MA, Baer JM, Knolhoff BL, Nywening TM, Panni RZ, Su X, Weilbaecher KN, Hawkins WG, Ma C, Fields RC, Linehan DC, Challen GA, Faccio R, Aft RL, DeNardo DG
    Nat Commun 2018 Mar 28;9(1):1250
  • Radionuclides Transform Chemotherapeutics Into Phototherapeutics for Precise Treatment of Disseminated Cancer
    Kotagiri N, Cooper ML, Rettig M, Egbulefu C, Prior J, Cui G, Karmakar P, Zhou M, Yang X, Sudlow G, Marsala L, Chanswangphuwana C, Lu L, Habimana-Griffin L, Shokeen M, Su X, Weilbaecher K, Tomasson M, Lanza G, DiPersio JF, Achilefu S
    Nat Commun 2018 Jan 18;9(1):275
  • Bone-Induced Expression of Integrin Beta3 Enables Targeted Nanotherapy of Breast Cancer Metastases
    Ross MH, Esser AK, Fox GC, Schmieder AH, Yang X, Hu G, Pan D, Su X, Xu Y, Novack DV, Walsh T, Colditz GA, Lukaszewicz GH, Cordell E, Novack J, Fitzpatrick JAJ, Waning DL, Mohammad KS, Guise TA, Lanza GM, Weilbaecher KN
    Cancer Res 2017 Nov 15;77(22):6299-6312
  • HTLV-1 Viral Oncogene HBZ Induces Osteolytic Bone Disease in Transgenic Mice
    Esser AK, Rauch DA, Xiang J, Harding JC, Kohart NA, Ross MH, Su X, Wu K, Huey D, Xu Y, Vij K, Green PL, Rosol TJ, Niewiesk S, Ratner L, Weilbaecher KN
    Oncotarget 2017 Aug 27;8(41):69250-69263
  • Evaluating Acetate Metabolism for Imaging and Targeting in Multiple Myeloma
    Fontana F, Ge X, Su X, Hathi D, Xiang J, Cenci S, Civitelli R, Shoghi KI, Akers WJ, D'avignon A, Weilbaecher KN, Shokeen M
    Clin Cancer Res 2017 Jan 15;23(2):416-429
  • Novel ERalpha Positive Breast Cancer Model With Estrogen Independent Growth in the Bone Microenvironment
    Capietto AH, Chan SR, Ricci B, Allen JA, Su X, Novack DV, Schreiber RD, Faccio R
    Oncotarget 2016 Aug 2;7(31):49751-49764
  • Antagonizing Integrin Beta3 Increases Immunosuppression in Cancer
    Su X, Esser AK, Amend SR, Xiang J, Xu Y, Ross MH, Fox GC, Kobayashi T, Steri V, Roomp K, Fontana F, Hurchla MA, Knolhoff BL, Meyer MA, Morgan EA, Tomasson JC, Novack JS, Zou W, Faccio R, Novack DV, Robinson SD, Teitelbaum SL, DeNardo DG, Schneider JG, Weilbaecher KN
    Cancer Res 2016 Jun 15;76(12):3484-95
  • Dickkopf-Related Protein 1 (Dkk1) Regulates the Accumulation and Function of Myeloid Derived Suppressor Cells in Cancer
    D'Amico L, Mahajan S, Capietto AH, Yang Z, Zamani A, Ricci B, Bumpass DB, Meyer M, Su X, Wang-Gillam A, Weilbaecher K, Stewart SA, DeNardo DG, Faccio R
    J Exp Med 2016 May 2;213(5):827-40
  • Stromal-Initiated Changes in the Bone Promote Metastatic Niche Development
    Luo X, Fu Y, Loza AJ, Murali B, Leahy KM, Ruhland MK, Gang M, Su X, Zamani A, Shi Y, Lavine KJ, Ornitz DM, Weilbaecher KN, Long F, Novack DV, Faccio R, Longmore GD, Stewart SA
    Cell Rep 2016 Jan 5;14(1):82-92
  • Dual-Therapy With AlphavBeta3-Targeted Sn2 Lipase-Labile Fumagillin-Prodrug Nanoparticles and Zoledronic Acid in the Vx2 Rabbit Tumor Model
    Esser AK, Schmieder AH, Ross MH, Xiang J, Su X, Cui G, Zhang H, Yang X, Allen JS, Williams T, Wickline SA, Pan D, Lanza GM, Weilbaecher KN
    Nanomedicine 2016 Jan;12(1):201-11
  • CXCR4 Protein Epitope Mimetic Antagonist POL5551 Disrupts Metastasis and Enhances Chemotherapy Effect in Triple-Negative Breast Cancer
    Xiang J, Hurchla MA, Fontana F, Su X, Amend SR, Esser AK, Douglas GJ, Mudalagiriyappa C, Luker KE, Pluard T, Ademuyiwa FO, Romagnoli B, Tuffin G, Chevalier E, Luker GD, Bauer M, Zimmermann J, Aft RL, Dembowsky K, Weilbaecher KN
    Mol Cancer Ther 2015 Nov;14(11):2473-85
  • Whole Genome Sequence of Multiple Myeloma-Prone C57BL/KaLwRij Mouse Strain Suggests the Origin of Disease Involves Multiple Cell Types
    Amend SR, Wilson WC, Chu L, Lu L, Liu P, Serie D, Su X, Xu Y, Wang D, Gramolini A, Wen XY, O'Neal J, Hurchla M, Vachon CM, Colditz G, Vij R, Weilbaecher KN, Tomasson MH
    PLoS One 2015 May 28;10(5):e0127828
  • Antagonism of Inhibitor of Apoptosis Proteins Increases Bone Metastasis Via Unexpected Osteoclast Activation
    Yang C, Davis JL, Zeng R, Vora P, Su X, Collins LI, Vangveravong S, Mach RH, Piwnica-Worms D, Weilbaecher KN, Faccio R, Novack DV
    Cancer Discov 2013 Feb;3(2):212-23
  • The ADP Receptor P2RY12 Regulates Osteoclast Function and Pathologic Bone Remodeling
    Su X, Floyd DH, Hughes A, Xiang J, Schneider JG, Uluckan O, Heller E, Deng H, Zou W, Craft CS, Wu K, Hirbe AC, Grabowska D, Eagleton MC, Townsley S, Collins L, Piwnica-Worms D, Steinberg TH, Novack DV, Conley PB, Hurchla MA, Rogers M, Weilbaecher KN
    J Clin Invest 2012 Oct;122(10):3579-92
  • Hedgehog Signaling Inhibition Blocks Growth of Resistant Tumors Through Effects on Tumor Microenvironment
    Heller E, Hurchla MA, Xiang J, Su X, Chen S, Schneider J, Joeng KS, Vidal M, Goldberg L, Deng H, Hornick MC, Prior JL, Piwnica-Worms D, Long F, Cagan R, Weilbaecher KN
    Cancer Res 2012 Feb 15;72(4):897-907
  • Human Tumor-Infiltrating Th17 Cells Have the Capacity to Differentiate Into IFN-Gamma+ and FOXP3+ T Cells With Potent Suppressive Function
    Ye J, Su X, Hsueh EC, Zhang Y, Koenig JM, Hoft DF, Peng G
    Eur J Immunol 2011 Apr;41(4):936-51
  • Tumor Microenvironments Direct the Recruitment and Expansion of Human Th17 Cells
    Su X, Ye J, Hsueh EC, Zhang Y, Hoft DF, Peng G
    J Immunol 2010 Feb 1;184(3):1630-41
  • EGF-Recruited JunD/C-Fos Complexes Activate CD2AP Gene Promoter and Suppress Apoptosis in Renal Tubular Epithelial Cells
    Lu C, Ren W, Su XM, Chen JQ, Wu SH, Zhou GP
    Gene 2009 Mar 15;433(1-2):56-64
  • Functional Characterization of the Regulatory Region of Human CD2-Associated Protein Promoter in HEK 293 Cells
    Su XM, Ren W, Lu C, Chen JQ, Wu SH, Chen RH, Zhou GP
    Am J Nephrol 2009;29(3):203-12
  • CREB and Sp1 Regulate the Human CD2AP Gene Promoter Activity in Renal Tubular Epithelial Cells
    Lu C, Ren W, Su XM, Chen JQ, Wu SH, Guo XR, Huang SM, Chen LH, Zhou GP
    Arch Biochem Biophys 2008 Jun 1;474(1):143-9