Faculty
Oncology Division
Alphabetical list (active faculty):   
Brian A. Van Tine

Brian A. Van Tine, MD, PhD

Associate Professor

Department of Medicine

Oncology Division

Medical Oncology

Department of Pediatrics

Clinical Interests

  • Soft tissue and bone sarcomas

Research Interests

  • Human-in-mouse sarcoma models
  • Amino acid deprivation therapies
  • Metabolic deficiencies in sarcoma

Contact

  • 314-747-3096 (office)
  • 314-362-7086 (fax)
  • Division of Oncology
    Mail Stop 8076-0041-03
    Washington University
    660 South Euclid Avenue
    St. Louis, MO 63110
  • Room 3302, Couch Biomedical Research Building (office)

Original Articles

  • Nab-Sirolimus for Patients With Malignant Perivascular Epithelioid Cell Tumors
    Wagner AJ, Ravi V, Riedel RF, Ganjoo K, Van Tine BA, Chugh R, Cranmer L, Gordon EM, Hornick JL, Du H, Grigorian B, Schmid AN, Hou S, Harris K, Kwiatkowski DJ, Desai NP, Dickson MA
    J Clin Oncol 2021 Nov 20;39(33):3660-3670
  • Common Pitfalls in Ewing Sarcoma and Desmoplastic Small Round Cell Tumor Diagnosis Seen in a Study of 115 Cases
    Trikalinos NA, Chrisinger JSA, Van Tine BA
    Med Sci (Basel) 2021 Oct 15;9(4):9040062
  • A Phase I Study of the Combination of Pexidartinib and Sirolimus to Target Tumor-Associated Macrophages in Unresectable Sarcoma and Malignant Peripheral Nerve Sheath Tumors
    Manji GA, Van Tine BA, Lee SM, Raufi AG, Pellicciotta I, Hirbe AC, Pradhan J, Chen A, Rabadan R, Schwartz GK
    Clin Cancer Res 2021 Oct 15;27(20):5519-5527
  • Phase II Study of Dacarbazine Given With Modern Prophylactic Anti-Emetics and Growth Factor Support to Patients With Metastatic, Resistant Soft Tissue, and Bone Sarcoma
    Van Tine BA, Weiss MC, Hirbe AC, Oppelt PJ, Abaricia S, Trinkaus K, Luo J, Berry S, Ruff T, Callahan C, Toensikoetter J, Ley J, Siegel MJ, Dehdashti F, Siegel BA, Adkins DR
    Rare Tumors 2021 Oct 8;13:20363613211052498
  • Comprehensive Characterization of 536 Patient-Derived Xenograft Models Prioritizes Candidates For Targeted Treatment
    Sun H, Cao S, Mashl RJ, Mo CK, Zaccaria S, Wendl MC, Davies SR, Bailey MH, Primeau TM, Hoog J, Mudd JL, Dean DA 2nd, Patidar R, Chen L, Wyczalkowski MA, Jayasinghe RG, Rodrigues FM, Terekhanova NV, Li Y, Lim KH, Wang-Gillam A, Van Tine BA, Ma CX, Aft R, Fuh KC, Schwarz JK, Zevallos JP, Puram SV, DiPersio JF, Davis-Dusenbery B, Ellis MJ, Lewis MT, Davies MA, Herlyn M, Fang B, Roth JA, Welm AL, Welm BE, Meric-Bernstam F, Chen F, Fields RC, Li S, Govindan R, Doroshow JH, Moscow JA, Evrard YA, Chuang JH, Raphael BJ, Ding L
    NCI PDXNET Consortium (Contributors include: Van Tine BA)

    Nat Commun 2021 Aug 24;12(1):5086
  • Phase II Study of Pazopanib With Oral Topotecan in Patients With Metastatic and Non-Resectable Soft Tissue and Bone Sarcomas
    Schulte B, Mohindra N, Milhem M, Attia S, Robinson S, Monga V, Hirbe AC, Oppelt P, Charlson J, Helenowski I, Abbinanti S, Cehic R, Okuno S, Van Tine BA, Agulnik M
    Br J Cancer 2021 Aug;125(4):528-533
  • An Open-Label Single-Arm Phase II Study of Regorafenib for the Treatment of Angiosarcoma
    Agulnik M, Schulte B, Robinson S, Hirbe AC, Kozak K, Chawla SP, Attia S, Rademaker A, Zhang H, Abbinanti S, Cehic R, Monga V, Milhem M, Okuno S, Van Tine BA
    Eur J Cancer 2021 Sep;154:201-208
  • Phase II Randomized Study of CMB305 and Atezolizumab Compared With Atezolizumab Alone in Soft-Tissue Sarcomas Expressing NY-ESO-1
    Chawla SP, Van Tine BA, Pollack SM, Ganjoo KN, Elias AD, Riedel RF, Attia S, Choy E, Okuno SH, Agulnik M, von Mehren M, Livingston MB, Keedy VL, Verschraegen CF, Philip T, Bohac GC, Yurasov S, Yakovich A, Lu H, Chen M, Maki RG
    J Clin Oncol 2021 Jul 14:JCO2003452; [Epub ahead of print]
  • Cardiac Safety of Trabectedin Monotherapy or in Combination With Pegylated Liposomal Doxorubicin in Patients With Sarcomas and Ovarian Cancer
    Jones RL, Herzog TJ, Patel SR, von Mehren M, Schuetze SM, Van Tine BA, Coleman RL, Knoblauch R, Triantos S, Hu P, Shalaby W, McGowan T, Monk BJ, Demetri GD
    Cancer Med 2021 Jun;10(11):3565-3574
  • Targeting One-Carbon Metabolism Requires mTOR Inhibition: A New Therapeutic Approach in Osteosarcoma
    Rathore R, Van Tine B
    Mol Cell Oncol 2021 Mar 25;8(3):1902250
  • Concurrent Paclitaxel and Radiation Therapy for the Treatment of Cutaneous Angiosarcoma
    Roy A, Gabani P, Davis EJ, Oppelt P, Merfeld E, Keedy VL, Zoberi I, Chrisinger JSA, Michalski JM, Van Tine B, Spraker MB
    Clin Transl Radiat Oncol 2021 Jan 28;27:114-120
  • Pathogenesis and Current Treatment of Osteosarcoma: Perspectives for Future Therapies
    Rathore R, Van Tine BA
    J Clin Med 2021 Mar 12;10(6)
  • Genomic and Neoantigen Evolution From Primary Tumor to First Metastases in Head and Neck Squamous Cell Carcinoma
    Schutt CR, Sun H, Pradham JS, Saenger Y, Ley J, Adkins D, Ingham M, Ding L, Van Tine BA
    Oncotarget 2021 Mar 16;12(6):534-548
  • Unmet Medical Needs and Future Perspectives for Leiomyosarcoma Patients-A Position Paper From the National LeioMyoSarcoma Foundation (NLMSF) and Sarcoma Patients EuroNet (SPAEN)
    Kasper B, Achee A, Schuster K, Wilson R, van Oortmerssen G, Gladdy RA, Hemming ML, Huang P, Ingham M, Jones RL, Pollack SM, Reinke D, Sanfilippo R, Schuetze SM, Somaiah N, Van Tine BA, Wilky B, Okuno S, Trent J
    Cancers (Basel) 2021 Feb 20;13(4)
  • Conservation of Copy Number Profiles During Engraftment and Passaging of Patient-Derived Cancer Xenografts
    Woo XY, Giordano J, Srivastava A, Zhao ZM, Lloyd MW, de Bruijn R, Suh YS, Patidar R, Chen L, Scherer S, Bailey MH, Yang CH, Cortes-Sanchez E, Xi Y, Wang J, Wickramasinghe J, Kossenkov AV, Rebecca VW, Sun H, Mashl RJ, Davies SR, Jeon R, Frech C, Randjelovic J, Rosains J, Galimi F, Bertotti A, Lafferty A, O'Farrell AC, Modave E, Lambrechts D, Ter Brugge P, Serra V, Marangoni E, El Botty R, Kim H, Kim JI, Yang HK, Lee C, Dean DA 2nd, Davis-Dusenbery B, Evrard YA, Doroshow JH, Welm AL, Welm BE, Lewis MT, Fang B, Roth JA, Meric-Bernstam F, Herlyn M, Davies MA, Ding L, Li S, Govindan R, Isella C, Moscow JA, Trusolino L, Byrne AT, Jonkers J, Bult CJ, Medico E, Chuang JH
    PDXNET Consortium (Contributors include: Van Tine BA)

    Nat Genet 2021 Jan;53(1):86-99
  • Prospective Evaluation of Doxorubicin Cardiotoxicity in Patients With Advanced Soft-Tissue Sarcoma Treated in the ANNOUNCE Phase III Randomized Trial
    Jones RL, Wagner AJ, Kawai A, Tamura K, Shahir A, Van Tine BA, Martin-Broto J, Peterson PM, Wright J, Tap WD
    Clin Cancer Res 2021 Jul 15;27(14):3861-3866
  • Interim Analysis of the Phase II Study: Noninferiority Study of Doxorubicin With Upfront Dexrazoxane Plus Olaratumab for Advanced or Metastatic Soft-Tissue Sarcoma
    Van Tine BA, Hirbe AC, Oppelt P, Frith AE, Rathore R, Mitchell JD, Wan F, Berry S, Landeau M, Heberton GA, Gorcsan J 3rd, Huntjens PR, Soyama Y, Vader JM, Alvarez-Cardona JA, Zhang KW, Lenihan DJ, Krone RJ
    Clin Cancer Res 2021 Jul 15;27(14):3854-3860
  • Metabolic Compensation Activates Pro-Survival mTORC1 Signaling Upon 3-Phosphoglycerate Dehydrogenase Inhibition in Osteosarcoma
    Rathore R, Caldwell KE, Schutt C, Brashears CB, Prudner BC, Ehrhardt WR, Leung CH, Lin H, Daw NC, Beird HC, Giles A, Wang WL, Lazar AJ, Chrisinger JSA, Livingston JA, Van Tine BA
    Cell Rep 2021 Jan 26;34(4):108678
  • Intracellular Arginine-Dependent Translation Sensor Reveals the Dynamics of Arginine Starvation Response and Resistance in ASS1-Negative Cells
    Rogers LC, Zhou J, Baker A, Schutt CR, Panda PK, Van Tine BA
    Cancer Metab 2021 Jan 21;9(1):4
  • Circulating Tumor Cells and Biomarker Modulation With Olaratumab Monotherapy Followed by Olaratumab Plus Doxorubicin: Phase Ib Study in Patients With Soft-Tissue Sarcoma
    Martin-Broto J, Pousa AL, Brohl AS, Van Tine BA, Powers B, Stacchiotti S, Blay JY, Hu JS, Oakley GJ 3rd, Wang H, Szpurka AM, Levy DE, Mo G, Ceccarelli M, Jones RL
    Mol Cancer Ther 2021 Jan;20(1):132-141
  • Real-World Outcomes of Patients With Locally Advanced or Metastatic Epithelioid Sarcoma
    Gounder MM, Merriam P, Ratan R, Patel SR, Chugh R, Villalobos VM, Thornton M, Van Tine BA, Abdelhamid AH, Whalen J, Yang J, Rajarethinam A, Duh MS, Bobbili PJ, Huynh L, Totev TI, Lax AK, Agarwal S, Demetri GD
    Cancer 2021 Apr 15;127(8):1311-1317
  • A Randomized, Open-Label, Phase 2, Multicenter Trial of Gemcitabine With Pazopanib or Gemcitabine With Docetaxel in Patients With Advanced Soft-Tissue Sarcoma
    Somaiah N, Van Tine BA, Wahlquist AE, Milhem MM, Hill EG, Garrett-Mayer E, Armeson KE, Schuetze SM, Meyer CF, Reuben DY, Elias AD, Read WL, Chawla SP, Kraft AS
    Cancer 2021 Mar 15;127(6):894-904
  • A Phase I Trial of Temsirolimus and Erlotinib in Patients With Refractory Solid Tumors
    Park H, Williams K, Trikalinos NA, Larson S, Tan B, Waqar S, Suresh R, Morgensztern D, Van Tine BA, Govindan R, Luo J, Lockhart AC, Wang-Gillam A
    Cancer Chemother Pharmacol 2021 Mar;87(3):337-347
  • Tazemetostat in Advanced Epithelioid Sarcoma With Loss of INI1/SMARCB1: An International, Open-Label, Phase 2 Basket Study
    Gounder M, Schoffski P, Jones RL, Agulnik M, Cote GM, Villalobos VM, Attia S, Chugh R, Chen TW, Jahan T, Loggers ET, Gupta A, Italiano A, Demetri GD, Ratan R, Davis LE, Mir O, Dileo P, Van Tine BA, Pressey JG, Lingaraj T, Rajarethinam A, Sierra L, Agarwal S, Stacchiotti S
    Lancet Oncol 2020 Nov;21(11):1423-1432
  • PHGDH as a Mechanism for Resistance in Metabolically-Driven Cancers
    Rathore R, Schutt CR, Van Tine BA
    Cancer Drug Resist 2020;3:762-774
  • A Phase II Study of Pazopanib as Front-Line Therapy in Patients With Non-Resectable or Metastatic Soft-Tissue Sarcomas Who Are Not Candidates for Chemotherapy
    Hirbe AC, Eulo V, Moon CI, Luo J, Myles S, Seetharam M, Toeniskoetter J, Kershner T, Haarberg S, Agulnik M, Monga V, Milhem M, Parkes A, Robinson S, Okuno S, Attia S, Van Tine BA
    Eur J Cancer 2020 Sep;137:1-9
  • Atypical Fibroxanthoma: A Malignant Tumor of the Skin and Soft Tissue
    Rosenfeld D, Alam M, Van Tine B, Council ML
    J Am Acad Dermatol 2020 Dec;83(6):e429-e430
  • A Retrospective Analysis of the Efficacy of Immunotherapy in Metastatic Soft-Tissue Sarcomas
    Monga V, Skubitz KM, Maliske S, Mott SL, Dietz H, Hirbe AC, Van Tine BA, Oppelt P, Okuno S, Robinson S, O'Connor M, Seetharam M, Attia S, Charlson J, Agulnik M, Milhem M
    Cancers (Basel) 2020 Jul 11;12(7)
  • Facts and Hopes in Immunotherapy of Soft-Tissue Sarcomas
    Martin-Broto J, Moura DS, Van Tine BA
    Clin Cancer Res 2020 Nov 15;26(22):5801-5808
  • Multi-Institutional Analysis of Stereotactic Body Radiotherapy for Sarcoma Pulmonary Metastases: High Rates of Local Control With Favorable Toxicity
    Baumann BC, Bernstein KA, DeLaney TF, Simone CB 2nd, Kolker JD, Choy E, Levin WP, Weber KL, Muniappan A, Berman AT, Staddon A, Hartner L, Van Tine B, Hirbe A, Glatstein E, Hahn SM, Nagda SN, Chen YL
    J Surg Oncol 2020 Oct;122(5):877-883
  • Clinical Outcomes of Patients With Advanced Synovial Sarcoma or Myxoid/Round Cell Liposarcoma Treated at Major Cancer Centers in the United States
    Pollack SM, Somaiah N, Araujo DM, Druta M, Van Tine BA, Burgess MA, Chawla SP, Seetharam M, Okuno SH, Bohac C, Chen M, Yurasov S, Attia S
    Cancer Med 2020 Jul;9(13):4593-4602
  • Subgroup Analysis of Older Patients Treated Within the Randomized Phase 3 Doxorubicin Versus Doxorubicin Plus Evofosfamide (SARC021) Trial
    Younger E, Ballman K, Lu Y, Papai Z, Van Tine BA, Attia S, Schoffski P, Reinke D, Tap WD, Jones RL
    J Geriatr Oncol 2020 Apr;11(3):463-469
  • Effect of Doxorubicin Plus Olaratumab Vs Doxorubicin Plus Placebo on Survival in Patients With Advanced Soft Tissue Sarcomas: The ANNOUNCE Randomized Clinical Trial
    Tap WD, Wagner AJ, Schoffski P, Martin-Broto J, Krarup-Hansen A, Ganjoo KN, Yen CC, Abdul Razak AR, Spira A, Kawai A, Le Cesne A, Van Tine BA, Naito Y, Park SH, Fedenko A, Papai Z, Soldatenkova V, Shahir A, Mo G, Wright J, Jones RL
    ANNOUNCE Investigators

    JAMA 2020 Apr 7;323(13):1266-1276
  • Targeting Refractory Sarcomas and Malignant Peripheral Nerve Sheath Tumors in a Phase I/II Study of Sirolimus in Combination With Ganetespib (SARC023)
    Kim A, Lu Y, Okuno SH, Reinke D, Maertens O, Perentesis J, Basu M, Wolters PL, De Raedt T, Chawla S, Chugh R, Van Tine BA, O'Sullivan G, Chen A, Cichowski K, Widemann BC
    Sarcoma 2020 Jan 30;2020:5784876
  • The Angiosarcoma Project: Enabling Genomic and Clinical Discoveries in a Rare Cancer Through Patient-Partnered Research
    Painter CA, Jain E, Tomson BN, Dunphy M, Stoddard RE, Thomas BS, Damon AL, Shah S, Kim D, Gomez Tejeda Zanudo J, Hornick JL, Chen YL, Merriam P, Raut CP, Demetri GD, Van Tine BA, Lander ES, Golub TR, Wagle N
    Nat Med 2020 Feb;26(2):181-187
  • Correlative Analyses of the SARC028 Trial Reveal an Association Between Sarcoma-Associated Immune Infiltrate and Response to Pembrolizumab
    Keung EZ, Burgess M, Salazar R, Parra ER, Rodrigues-Canales J, Bolejack V, Van Tine BA, Schuetze SM, Attia S, Riedel RF, Hu J, Okuno SH, Priebat DA, Movva S, Davis LE, Reed DR, Reuben A, Roland CL, Reinke D, Lazar AJ, Wang WL, Wargo JA, Tawbi HA
    Clin Cancer Res 2020 Mar 15;26(6):1258-1266
  • Pharmacokinetics of Doxorubicin Following Concomitant Intravenous Administration of Olaratumab (IMC-3G3) to Patients With Advanced Soft Tissue Sarcoma
    Villalobos VM, Mo G, Agulnik M, Pollack SM, Rushing DA, Singh A, Van Tine BA, McNaughton R, Decker RL, Zhang W, Shahir A, Cronier DM
    Cancer Med 2020 Feb;9(3):882-893
  • Whole Exome Sequencing Reveals the Maintained Polyclonal Nature From Primary to Metastatic Malignant Peripheral Nerve Sheath Tumor in Two Patients With NF1
    Godec A, Jayasinghe R, Chrisinger JSA, Prudner B, Ball T, Wang Y, Srihari D, Kaushal M, Dietz H, Zhang X, Pekmezci M, Dahiya S, Tao Y, Luo J, Van Tine BA, Ding L, Gutmann DH, Hirbe AC
    Neurooncol Adv 2019 Sep 10;2(Suppl 1):i75-i84
  • Systems Level Profiling of Arginine Starvation Reveals MYC and ERK Adaptive Metabolic Reprogramming
    Brashears CB, Barlin M, Ehrhardt WR, Rathore R, Schultze M, Tzeng SC, Van Tine BA, Held JM
    Cell Death Dis 2020 Aug 20;11(8):662
  • Hepatic Epithelioid Hemangioendothelioma Associated With Acute Disseminated Encephalomyelitis by a Possible Paraneoplastic Process
    Aktas A, Probst D, Van Tine B, Marlow K
    Rare Tumors 2020 Nov 25;12:2036361320977012
  • Cisplatin Exposure Causes c-MYC-Dependent Resistance to CDK4/6 Inhibition in HPV-Negative Head and Neck Squamous Cell Carcinoma
    Robinson AM, Rathore R, Redlich NJ, Adkins DR, VanArsdale T, Van Tine BA, Michel LS
    Cell Death Dis 2019 Nov 14;10(11):867
  • Systemic and Local Immunity Following Adoptive Transfer of NY-ESO-1 SPEAR T Cells in Synovial Sarcoma
    Ramachandran I, Lowther DE, Dryer-Minnerly R, Wang R, Fayngerts S, Nunez D, Betts G, Bath N, Tipping AJ, Melchiori L, Navenot JM, Glod J, Mackall CL, D'Angelo SP, Araujo DM, Chow WA, Demetri GD, Druta M, Van Tine BA, Grupp SA, Abdul Razak AR, Wilky B, Iyengar M, Trivedi T, Winkle EV, Chagin K, Amado R, Binder GK, Basu S
    J Immunother Cancer 2019 Oct 24;7(1):276
  • Palbociclib and Cetuximab in Platinum-Resistant and in Cetuximab-Resistant Human Papillomavirus-Unrelated Head and Neck Cancer: A Multicentre, Multigroup, Phase 2 Trial
    Adkins DR, Ley J, Neupane P, Worden F, Sacco AG, Palka KT, Grilley-Olson JE, Maggiore R, Salama NN, Trinkaus K, Van Tine BA, Steuer CE, Saba NF, Oppelt PJ
    Lancet Oncol 2019 Sep;20(9):1295-1305
  • Incidence and Management of Olaratumab Infusion-Related Reactions
    Van Tine BA, Govindarajan R, Attia S, Somaiah N, Barker SS, Shahir A, Barrett E, Lee P, Wacheck V, Ramage SC, Tap WD
    J Oncol Pract 2019 Nov;15(11):e925-e933
  • Management of Localized Extremity and Retroperitoneal Soft Tissue Sarcoma
    Abaricia S, Van Tine BA
    Curr Probl Cancer 2019 Aug;43(4):273-282
  • Systemic Interferon-Gamma Increases MHC Class I Expression and T-Cell Infiltration in Cold Tumors: Results of a Phase 0 Clinical Trial
    Zhang S, Kohli K, Black RG, Yao L, Spadinger SM, He Q, Pillarisetty VG, Cranmer LD, Van Tine BA, Yee C, Pierce RH, Riddell SR, Jones RL, Pollack SM
    Cancer Immunol Res 2019 Aug;7(8):1237-1243
  • Arginine Starvation and Docetaxel Induce c-MYC-Driven HENT1 Surface Expression to Overcome Gemcitabine Resistance in ASS1-Negative Tumors
    Prudner BC, Rathore R, Robinson AM, Godec A, Chang SF, Hawkins WG, Hirbe AC, Van Tine BA
    Clin Cancer Res 2019 Aug 15;25(16):5122-5134
  • A Phase 1 and Randomized Controlled Phase 2 Trial of the Safety and Efficacy of the Combination of Gemcitabine and Docetaxel With Ontuxizumab (MORAb-004) in Metastatic Soft-Tissue Sarcomas
    Jones RL, Chawla SP, Attia S, Schoffski P, Gelderblom H, Chmielowski B, Le Cesne A, Van Tine BA, Trent JC, Patel S, Wagner AJ, Chugh R, Heyburn JW, Weil SC, Wang W, Viele K, Maki RG
    Cancer 2019 Jul 15;125(14):2445-2454
  • How We Use Pazopanib in Treating Soft-Tissue Sarcoma: Experience at Our Multidisciplinary Sarcoma Centers
    Van Tine BA, Trent JC
    Curr Med Res Opin 2019 Apr;35(4):623-629
  • A Phase II Clinical Study of 13-Deoxy, 5-Iminodoxorubicin (GPX-150) With Metastatic and Unresectable Soft Tissue Sarcoma
    Van Tine BA, Agulnik M, Olson RD, Walsh GM, Klausner A, Frank NE, Talley TT, Milhem MM
    Cancer Med 2019 Jun;8(6):2994-3003
  • The Metastatic Spine Disease Multidisciplinary Working Group Algorithms
    Wallace AN, Robinson CG, Meyer J, Tran ND, Gangi A, Callstrom MR, Chao ST, Van Tine BA, Morris JM, Bruel BM, Long J, Timmerman RD, Buchowski JM, Jennings JW
    Oncologist 2019 Mar;24(3):424 [published erratum]
  • Clinical Outcomes and Prognostic Features of Angiosarcoma: Significance of Prior Radiation Therapy
    Merfeld E, Gabani P, Spraker MB, Zoberi I, Kim H, Van Tine B, Chrisinger J, Michalski JM
    Clin Oncol (R Coll Radiol) 2019 Apr;31(4):232-241
  • Sorafenib for Advanced and Refractory Desmoid Tumors
    Gounder MM, Mahoney MR, Van Tine BA, Ravi V, Attia S, Deshpande HA, Gupta AA, Milhem MM, Conry RM, Movva S, Pishvaian MJ, Riedel RF, Sabagh T, Tap WD, Horvat N, Basch E, Schwartz LH, Maki RG, Agaram NP, Lefkowitz RA, Mazaheri Y, Yamashita R, Wright JJ, Dueck AC, Schwartz GK
    N Engl J Med 2018 Dec 20;379(25):2417-2428
  • Systemic Anti-Cancer Therapy in Synovial Sarcoma: A Systematic Review
    Riedel RF, Jones RL, Italiano A, Bohac C, Thompson JC, Mueller K, Khan Z, Pollack SM, Van Tine BA
    Cancers (Basel) 2018 Nov 1;10(11)
  • Efficacy and Tolerability of Trabectedin in Elderly Patients With Sarcoma: Subgroup Analysis From a Phase III, Randomized Controlled Study of Trabectedin or Dacarbazine in Patients With Advanced Liposarcoma or Leiomyosarcoma
    Jones RL, Demetri GD, Schuetze SM, Milhem M, Elias A, Van Tine BA, Hamm J, McCarthy S, Wang G, Parekh T, Knoblauch R, Hensley ML, Maki RG, Patel S, von Mehren M
    Ann Oncol 2018 Sep 1;29(9):1995-2002
  • Long-Term Effects of Crizotinib in ALK-Positive Tumors (Excluding NSCLC): A Phase 1b Open-Label Study
    Gambacorti-Passerini C, Orlov S, Zhang L, Braiteh F, Huang H, Esaki T, Horibe K, Ahn JS, Beck JT, Edenfield WJ, Shi Y, Taylor M, Tamura K, Van Tine BA, Wu SJ, Paolini J, Selaru P, Kim TM
    Am J Hematol 2018 May;93(5):607-614
  • Driver Fusions and Their Implications in the Development and Treatment of Human Cancers
    Gao Q, Liang WW, Foltz SM, Mutharasu G, Jayasinghe RG, Cao S, Liao WW, Reynolds SM, Wyczalkowski MA, Yao L, Yu L, Sun SQ, Chen K, Lazar AJ, Fields RC, Wendl MC, Van Tine BA, Vij R, Chen F, Nykter M, Shmulevich I, Ding L
    Fusion Analysis Working Group (Contributors include: Van Tine Tine B)

    Cell Rep 2018 Apr 3;23(1):227-238e3
  • Nivolumab With or Without Ipilimumab Treatment for Metastatic Sarcoma (Alliance A091401): Two Open-Label, Non-Comparative, Randomised, Phase 2 Trials
    D'Angelo SP, Mahoney MR, Van Tine BA, Atkins J, Milhem MM, Jahagirdar BN, Antonescu CR, Horvath E, Tap WD, Schwartz GK, Streicher H
    Lancet Oncol 2018 Mar;19(3):416-426
  • Amino Acid Uptake Measured by [(18)F]AFETP Increases in Response to Arginine Starvation in ASS1-Deficient Sarcomas
    Prudner BC, Sun F, Kremer JC, Xu J, Huang C, Sai KKS, Morgan Z, Leeds H, McConathy J, Van Tine BA
    Theranostics 2018 Mar 7;8(8):2107-2116
  • A Phase II Study of Tumor Ablation in Patients With Metastatic Sarcoma Stable on Chemotherapy
    Hirbe AC, Jennings J, Saad N, Giardina JD, Tao Y, Luo J, Berry S, Toeniskoetter J, Van Tine BA
    Oncologist 2018 Jul;23(7):760-e76
  • Synovial Sarcoma: Current Concepts and Future Perspectives
    Stacchiotti S, Van Tine BA
    J Clin Oncol 2018 Jan 10;36(2):180-187
  • Anti-Trop2 Blockade Enhances the Therapeutic Efficacy of ErbB3 Inhibition in Head and Neck Squamous Cell Carcinoma
    Redlich N, Robinson AM, Nickel KP, Stein AP, Wheeler DL, Adkins DR, Uppaluri R, Kimple RJ, Van Tine BA, Michel LS
    Cell Death Dis 2018 Jan 5;9(1):5
  • Intensity Modulated Radiation Therapy and Surgery for Management of Retroperitoneal Sarcomas: A Single-Institution Experience
    Cosper PF, Olsen J, DeWees T, Van Tine BA, Hawkins W, Michalski J, Zoberi I
    Radiat Oncol 2017 Dec 8;12(1):198
  • Pembrolizumab in Advanced Soft-Tissue Sarcoma and Bone Sarcoma (SARC028): A Multicentre, Two-Cohort, Single-Arm, Open-Label, Phase 2 Trial
    Tawbi HA, Burgess M, Bolejack V, Van Tine BA, Schuetze SM, Hu J, D'Angelo S, Attia S, Riedel RF, Priebat DA, Movva S, Davis LE, Okuno SH, Reed DR, Crowley J, Butterfield LH, Salazar R, Rodriguez-Canales J, Lazar AJ, Wistuba II, Baker LH, Maki RG, Reinke D, Patel S
    Lancet Oncol 2017 Nov;18(11):1493-1501
  • Activity of Eribulin in Patients With Advanced Liposarcoma Demonstrated in a Subgroup Analysis From a Randomized Phase III Study of Eribulin Versus Dacarbazine
    Demetri GD, Schoffski P, Grignani G, Blay JY, Maki RG, Van Tine BA, Alcindor T, Jones RL, D'Adamo DR, Guo M, Chawla S
    J Clin Oncol 2017 Oct 20;35(30):3433-3439
  • Doxorubicin Plus Evofosfamide Versus Doxorubicin Alone in Locally Advanced, Unresectable or Metastatic Soft-Tissue Sarcoma (TH CR-406/SARC021): An International, Multicentre, Open-Label, Randomised Phase 3 Trial
    Tap WD, Papai Z, Van Tine BA, Attia S, Ganjoo KN, Jones RL, Schuetze S, Reed D, Chawla SP, Riedel RF, Krarup-Hansen A, Toulmonde M, Ray-Coquard I, Hohenberger P, Grignani G, Cranmer LD, Okuno S, Agulnik M, Read W, Ryan CW, Alcindor T, Del Muro XFG, Budd GT, Tawbi H, Pearce T, Kroll S, Reinke DK, Schoffski P
    Lancet Oncol 2017 Aug;18(8):1089-1103
  • Breast Tumors Educate the Proteome of Stromal Tissue in an Individualized but Coordinated Manner
    Wang X, Mooradian AD, Erdmann-Gilmore P, Zhang Q, Viner R, Davies SR, Huang KL, Bomgarden R, Van Tine BA, Shao J, Ding L, Li S, Ellis MJ, Rogers JC, Townsend RR, Fenyo D, Held JM
    Sci Signal 2017 Aug 8;10(491)
  • Melorheostosis: Exome Sequencing of an Associated Dermatosis Implicates Postzygotic Mosaicism of Mutated KRAS
    Whyte MP, Griffith M, Trani L, Mumm S, Gottesman GS, McAlister WH, Krysiak K, Lesurf R, Skidmore ZL, Campbell KM, Rosman IS, Bayliss S, Bijanki VN, Nenninger A, Van Tine BA, Griffith OL, Mardis ER
    Bone 2017 Aug;101:145-155
  • Gastrointestinal Stromal Tumors (GISTs): Point Mutations Matter in Management, a Review
    Oppelt PJ, Hirbe AC, Van Tine BA
    J Gastrointest Oncol 2017 Jun;8(3):466-473
  • Neoadjuvant Ifosfamide and Epirubicin in the Treatment of Malignant Peripheral Nerve Sheath Tumors
    Hirbe AC, Cosper PF, Dahiya S, Van Tine BA
    Sarcoma 2017;2017:3761292
  • Therapeutic Arginine Starvation in ASS1-Deficient Cancers Inhibits the Warburg Effect
    Kremer JC, Van Tine BA
    Mol Cell Oncol 2017 Mar 1;4(3):e1295131
  • Arginine Deprivation Inhibits the Warburg Effect and Upregulates Glutamine Anaplerosis and Serine Biosynthesis in ASS1-Deficient Cancers
    Kremer JC, Prudner BC, Lange SE, Bean GR, Schultze MB, Brashears CB, Radyk MD, Redlich N, Tzeng SC, Kami K, Shelton L, Li A, Morgan Z, Bomalaski JS, Tsukamoto T, McConathy J, Michel LS, Held JM, Van Tine BA
    Cell Rep 2017 Jan 24;18(4):991-1004
  • A Phase II Study of Tivozanib in Patients With Metastatic and Nonresectable Soft-Tissue Sarcomas
    Agulnik M, Costa RLB, Milhem M, Rademaker AW, Prunder BC, Daniels D, Rhodes BT, Humphreys C, Abbinanti S, Nye L, Cehic R, Polish A, Vintilescu C, McFarland T, Skubitz K, Robinson S, Okuno S, Van Tine BA
    Ann Oncol 2017 Jan 1;28(1):121-127
  • A Metabolic Synthetic Lethal Strategy With Arginine Deprivation and Chloroquine Leads to Cell Death in ASS1-Deficient Sarcomas
    Bean GR, Kremer JC, Prudner BC, Schenone AD, Yao JC, Schultze MB, Chen DY, Tanas MR, Adkins DR, Bomalaski J, Rubin BP, Michel LS, Van Tine BA
    Cell Death Dis 2016 Oct 13;7(10):e2406
  • Olaratumab and Doxorubicin Versus Doxorubicin Alone for Treatment of Soft-Tissue Sarcoma: An Open-Label Phase 1b and Randomised Phase 2 Trial
    Tap WD, Jones RL, Van Tine BA, Chmielowski B, Elias AD, Adkins D, Agulnik M, Cooney MM, Livingston MB, Pennock G, Hameed MR, Shah GD, Qin A, Shahir A, Cronier DM, Ilaria R Jr, Conti I, Cosaert J, Schwartz GK
    Lancet 2016 Jul 30;388(10043):488-97
  • Phase II Study of MLN8237 (Alisertib) in Advanced/Metastatic Sarcoma
    Dickson MA, Mahoney MR, Tap WD, D'Angelo SP, Keohan ML, Van Tine BA, Agulnik M, Horvath LE, Nair JS, Schwartz GK
    Ann Oncol 2016 Oct;27(10):1855-60
  • PICASSO III: A Phase III, Placebo-Controlled Study of Doxorubicin With or Without Palifosfamide in Patients With Metastatic Soft Tissue Sarcoma
    Ryan CW, Merimsky O, Agulnik M, Blay JY, Schuetze SM, Van Tine BA, Jones RL, Elias AD, Choy E, Alcindor T, Keedy VL, Reed DR, Taub RN, Italiano A, Garcia Del Muro X, Judson IR, Buck JY, Lebel F, Lewis JJ, Maki RG, Schoffski P
    J Clin Oncol 2016 Nov 10;34(32):3898-3905
  • Conjugation to the Sigma-2 Ligand SV119 Overcomes Uptake Blockade and Converts Dm-Erastin Into a Potent Pancreatic Cancer Therapeutic
    Ohman KA, Hashim YM, Vangveravong S, Nywening TM, Cullinan DR, Goedegebuure SP, Liu J, Van Tine BA, Tiriac H, Tuveson DA, DeNardo DG, Spitzer D, Mach RH, Hawkins WG
    Oncotarget 2016 Jun 7;7(23):33529-41
  • Development of 89Zr-Ontuxizumab for in Vivo TEM-1/Endosialin PET Applications
    Lange SE, Zheleznyak A, Studer M, O'Shannessy DJ, Lapi SE, Van Tine BA
    Oncotarget 2016 Mar 15;7(11):13082-13092
  • Improved Clinical Trial Enrollments for Uterine Leiomyosarcoma Patients After Gynecologic Oncology Partnership With a Sarcoma Center
    Lange SE, Liu J, Adkins DR, Powell MA, Van Tine BA, Mutch DG
    Gynecol Oncol 2016 Feb;140(2):307-312
  • Efficacy and Safety of Trabectedin or Dacarbazine for Metastatic Liposarcoma or Leiomyosarcoma After Failure of Conventional Chemotherapy: Results of a Phase III Randomized Multicenter Clinical Trial
    Demetri GD, von Mehren M, Jones RL, Hensley ML, Schuetze SM, Staddon A, Milhem M, Elias A, Ganjoo K, Tawbi H, Van Tine BA, Spira A, Dean A, Khokhar NZ, Park YC, Knoblauch RE, Parekh TV, Maki RG, Patel SR
    J Clin Oncol 2016 Mar 10;34(8):786-93
  • A Phase Ib/II Study of Gemcitabine and Docetaxel in Combination With Pazopanib for the Neoadjuvant Treatment of Soft Tissue Sarcomas
    Munhoz RR, D'Angelo SP, Gounder MM, Keohan ML, Chi P, Carvajal RD, Singer S, Crago AM, Landa J, Healey JH, Qin LX, Hameed M, Ezeoke MO, Singh AS, Agulnik M, Chmielowski B, Luke JJ, Van Tine BA, Schwartz GK, Tap WD, Dickson MA
    Oncologist 2015 Nov;20(11):1245-6
  • The Metastatic Spine Disease Multidisciplinary Working Group Algorithms
    Wallace AN, Robinson CG, Meyer J, Tran ND, Gangi A, Callstrom MR, Chao ST, Van Tine BA, Morris JM, Bruel BM, Long J, Timmerman RD, Buchowski JM, Jennings JW
    Oncologist 2015 Oct;20(10):1205-15
  • Multi-Platform Profiling of Over 2000 Sarcomas: Identification of Biomarkers and Novel Therapeutic Targets
    Movva S, Wen W, Chen W, Millis SZ, Gatalica Z, Reddy S, von Mehren M, Van Tine BA
    Oncotarget 2015 May 20;6(14):12234-47
  • Alliance A091103 a Phase II Study of the Angiopoietin 1 and 2 Peptibody Trebananib for the Treatment of Angiosarcoma
    D' Angelo SP, Mahoney MR, Van Tine BA, Adkins DR, Perdekamp MT, Condy MM, Luke JJ, Hartley EW, Antonescu CR, Tap WD, Schwartz GK
    Cancer Chemother Pharmacol 2015 Mar;75(3):629-38
  • Using Molecular Profiling Diagnostics to Identify Predictive Biomarkers in Metastatic Cancer
    Van Tine BA
    MLO Med Lab Obs 2014 Sep;46(9):18, 20-1
  • Taspase1 Cleaves MLL1 to Activate Cyclin E for HER2/Neu Breast Tumorigenesis
    Dong Y, Van Tine BA*, Oyama T, Wang PI, Cheng EH, Hsieh JJ (*co-first author)
    Cell Res 2014 Nov;24(11):1354-66
  • Loss of Trop2 Causes ErbB3 Activation Through a Neuregulin-1-Dependent Mechanism in the Mesenchymal Subtype of HNSCC
    Zhang K, Jones L, Lim S, Maher CA, Adkins D, Lewis J, Kimple RJ, Fertig EJ, Chung CH, Van Tine BA, Ellis MJ, Herrlich A, Michel LS
    Oncotarget 2014 Oct 15;5(19):9281-94
  • Phase II Study of the Safety and Antitumor Activity of the Hypoxia-Activated Prodrug TH-302 in Combination With Doxorubicin in Patients With Advanced Soft Tissue Sarcoma
    Chawla SP, Cranmer LD, Van Tine BA, Reed DR, Okuno SH, Butrynski JE, Adkins DR, Hendifar AE, Kroll S, Ganjoo KN
    J Clin Oncol 2014 Oct 10;32(29):3299-306
  • Current Management and Molecular Targets of Synovial Sarcoma
    Lange SES, Kremer JC, Schenone AD, Schultze, MB, Van Tine BA
    Austin J Canc Clin Res 2014;1(2):9
  • Masitinib in Advanced Gastrointestinal Stromal Tumor (GIST) After Failure of Imatinib: A Randomized Controlled Open-Label Trial
    Adenis A, Blay JY, Bui-Nguyen B, Bouche O, Bertucci F, Isambert N, Bompas E, Chaigneau L, Domont J, Ray-Coquard I, Blesius A, Van Tine BA, Bulusu VR, Dubreuil P, Mansfield CD, Acin Y, Moussy A, Hermine O, Le Cesne A
    Ann Oncol 2014 Sep;25(9):1762-9
  • Prospective Biomarkers for Chemotherapy Selection in Sarcoma
    Schenone AD, Van Tine BA
    ESUN 2014;11(4)
  • Risk-Stratified Patients With Resectable Soft Tissue Sarcoma Benefit From Epirubicin-Based Adjuvant Chemotherapy
    Schenone AD, Luo J, Montgomery L, Morgensztern D, Adkins DR, Van Tine BA
    Cancer Med 2014 Jun;3(3):603-12
  • Gastrointestinal Stromal Tumors, Version 2.2014
    von Mehren M, Randall RL, Benjamin RS, Boles S, Bui MM, Casper ES, Conrad EU 3rd, DeLaney TF, Ganjoo KN, George S, Gonzalez RJ, Heslin MJ, Kane JM 3rd, Mayerson J, McGarry SV, Meyer C, O'Donnell RJ, Pappo AS, Paz IB, Pfeifer JD, Riedel RF, Schuetze S, Schupak KD, Schwartz HS, Van Tine BA, Wayne JD, Bergman MA, Sundar H
    J Natl Compr Canc Netw 2014 Jun;12(6):853-62
  • Soft Tissue Sarcoma, Version 2.2014
    von Mehren M, Randall RL, Benjamin RS, Boles S, Bui MM, Casper ES, Conrad EU 3rd, Delaney TF, Ganjoo KN, George S, Gonzalez RJ, Heslin MJ, Kane JM 3rd, Mayerson J, McGarry SV, Meyer C, O'Donnell RJ, Pappo AS, Paz IB, Pfeifer JD, Riedel RF, Schuetze S, Schupak KD, Schwartz HS, Van Tine BA, Wayne JD, Bergman MA, Sundar H
    J Natl Compr Canc Netw 2014 Apr;12(4):473-83
  • BRAFV600E Mutation in Sporadic and Neurofibromatosis Type 1-Related Malignant Peripheral Nerve Sheath Tumors
    Hirbe AC, Pekmezci M, Dahiya S, Apicelli AJ, Van Tine BA, Perry A, Gutmann DH
    Neuro Oncol 2014 Mar;16(3):466-7
  • Novel Treatment Targets in Sarcoma: More Than Just the GIST
    Shoushtari AN, Van Tine BA, Schwartz GK
    Am Soc Clin Oncol Educ Book 2014:e488-95
  • Novel Pathways and Molecular Targets for the Treatment of Sarcoma
    Frith AE, Hirbe AC, Van Tine BA
    Curr Oncol Rep 2013 Aug;15(4):378-85
  • Cixutumumab and Temsirolimus for Patients With Bone and Soft-Tissue Sarcoma: A Multicentre, Open-Label, Phase 2 Trial
    Schwartz GK, Tap WD, Qin LX, Livingston MB, Undevia SD, Chmielowski B, Agulnik M, Schuetze SM, Reed DR, Okuno SH, Ludwig JA, Keedy V, Rietschel P, Kraft AS, Adkins D, Van Tine BA, Brockstein B, Yim V, Bitas C, Abdullah A, Antonescu CR, Condy M, Dickson MA, Vasudeva SD, Ho AL, Doyle LA, Chen HX, Maki RG
    Lancet Oncol 2013 Apr;14(4):371-82
  • Soft Tissue Sarcoma, Version 2.2012: Featured Updates to the NCCN Guidelines
    von Mehren M, Benjamin RS, Bui MM, Casper ES, Conrad EU 3rd, DeLaney TF, Ganjoo KN, George S, Gonzalez R, Heslin MJ, Kane JM 3rd, Mayerson J, McGarry SV, Meyer C, O'Donnell RJ, Paz B, Pfeifer JD, Pollock RE, Randall RL, Riedel RF, Schuetze S, Schupak KD, Schwartz HS, Shankar S, Van Tine BA, Wayne J, Sundar H, McMillian NR
    J Natl Compr Canc Netw 2012 Aug;10(8):951-60
  • Whole-Genome Analysis Informs Breast Cancer Response to Aromatase Inhibition
    Ellis MJ, Ding L, Shen D, Luo J, Suman VJ, Wallis JW, Van Tine BA, Hoog J, Goiffon RJ, Goldstein TC, Ng S, Lin L, Crowder R, Snider J, Ballman K, Weber J, Chen K, Koboldt DC, Kandoth C, Schierding WS, McMichael JF, Miller CA, Lu C, Harris CC, McLellan MD, Wendl MC, DeSchryver K, Allred DC, Esserman L, Unzeitig G, Margenthaler J, Babiera GV, Marcom PK, Guenther JM, Leitch M, Hunt K, Olson J, Tao Y, Maher CA, Fulton LL, Fulton RS, Harrison M, Oberkfell B, Du F, Demeter R, Vickery TL, Elhammali A, Piwnica-Worms H, McDonald S, Watson M, Dooling DJ, Ota D, Chang LW, Bose R, Ley TJ, Piwnica-Worms D, Stuart JM, Wilson RK, Mardis ER
    Nature 2012 Jun 10;486(7403):353-60
  • A Pharmacologic Inhibitor of the Protease Taspase1 Effectively Inhibits Breast and Brain Tumor Growth
    Chen DY, Lee Y, Van Tine BA*, Searleman AC, Westergard TD, Liu H, Tu HC, Takeda S, Dong Y, Piwnica-Worms DR, Oh KJ, Korsmeyer SJ, Hermone A, Gussio R, Shoemaker RH, Cheng EH, Hsieh JJ (*co-first author)
    Cancer Res 2012 Feb 1;72(3):736-746
  • ER and PI3K Independently Modulate Endocrine Resistance in ER Positive Breast Cancer
    Van Tine BA, Crowder RJ, Ellis MJ
    Cancer Discov 2011 Sep;1(4):287-288
  • Understanding the Estrogen Receptor-Positive Breast Cancer Genome: Not Even the End of the Beginning
    Van Tine BA, Ellis MJ
    J Natl Cancer Inst 2011 Apr 6;103(7):526-7
  • Taspase1 Functions as a Non-Oncogene Addiction Protease That Coordinates Cancer Cell Proliferation and Apoptosis
    Chen DY, Liu H, Takeda S, Tu HC, Sasagawa S, Van Tine BA, Lu D, Cheng EH, Hsieh JJ
    Cancer Res 2010 Jul 1;70(13):5358-67
  • Human Breast Fibroblasts Inhibit Growth of the MCF10AT Xenograft Model of Proliferative Breast Disease
    Sadlonova A, Mukherjee S, Bowe DB, Gault SR, Dumas NA, Van Tine BA, Frolova N, Page GP, Welch DR, Novak L, Frost AR
    Am J Pathol 2007 Mar;170(3):1064-76
  • Disrupting the Enzyme Complex Regulating O-GlcNAcylation Blocks Signaling and Development
    Whisenhunt TR, Yang X, Bowe DB, Paterson AJ, Van Tine BA, Kudlow JE
    Glycobiology 2006 Jun;16(6):551-63
  • Dynamic Localization of the Human Papillomavirus Type 11 Origin Binding Protein E2 Through Mitosis While in Association With the Spindle Apparatus
    Dao LD, Duffy A, Van Tine BA, Wu SY, Chiang CM, Broker TR, Chow LT
    J Virol 2006 May;80(10):4792-800
  • Clonal Selection for Transcriptionally Active Viral Oncogenes During Progression to Cancer
    Van Tine BA, Kappes JC, Banerjee NS, Knops J, Lai L, Steenbergen RD, Meijer CL, Snijders PJ, Chatis P, Broker TR, Moen PT Jr, Chow LT
    J Virol 2004 Oct;78(20):11172-86
  • Human Papillomavirus (HPV) Origin-Binding Protein Associates With Mitotic Spindles to Enable Viral DNA Partitioning
    Van Tine BA, Dao LD, Wu SY, Sonbuchner TM, Lin BY, Zou N, Chiang CM, Broker TR, Chow LT
    Proc Natl Acad Sci U S A 2004 Mar 23;101(12):4030-5
  • Identification of Exogenous Forms of Human-Tropic Porcine Endogenous Retrovirus in Miniature Swine
    Wood JC, Quinn G, Suling KM, Oldmixon BA, Van Tine BA, Cina R, Arn S, Huang CA, Scobie L, Onions DE, Sachs DH, Schuurman HJ, Fishman JA, Patience C
    J Virol 2004 Mar;78(5):2494-501
  • mRNA Splicing Regulates Human Papillomavirus Type 11 E1 Protein Production and DNA Replication
    Deng W, Jin G, Lin BY, Van Tine BA, Broker TR, Chow LT
    J Virol 2003 Oct;77(19):10213-26
  • Assignment of N-Acetyl-D-Glucosaminidase (Mgea5) to Rat Chromosome 1q5 by Tyramide Fluorescence in Situ Hybridization (T-FISH): Synteny Between Rat, Mouse and Human With Insulin Degradation Enzyme (IDE)
    Van Tine BA, Patterson AJ, Kudlow JE
    Cytogenet Genome Res 2003;103(1-2):202B
  • Differential Expression and Biodistribution of Cytokeratin 18 and Desmoplakins in Non-Small Cell Lung Carcinoma Subtypes
    Young GD, Winokur TS, Cerfolio RJ, Van Tine BA, Chow LT, Okoh V, Garver RI Jr
    Lung Cancer 2002 May;36(2):133-41
  • Functional Analysis of the Simian Immunodeficiency Virus Vpx Protein: Identification of Packaging Determinants and a Novel Nuclear Targeting Domain
    Mahalingam S, Van Tine B, Santiago ML, Gao F, Shaw GM, Hahn BH
    J Virol 2001 Jan;75(1):362-74
  • Cell Cycle-Regulated Phosphorylation of P220(NPAT) by Cyclin E/Cdk2 in Cajal Bodies Promotes Histone Gene Transcription
    Ma T, Van Tine BA*, Wei Y, Garrett MD, Nelson D, Adams PD, Wang J, Qin J, Chow LT, Harper JW (*co-first author)
    Genes Dev 2000 Sep 15;14(18):2298-313
  • Mother-To-Infant Transmission of the Human Immunodeficiency Virus During Primary Infection
    Van Tine BA, Shaw GM, Aldrovandi G
    N Engl J Med 1999 Nov 11;341(20):1548
  • Concordant Induction of Cyclin E and P21cip1 in Differentiated Keratinocytes by the Human Papillomavirus E7 Protein Inhibits Cellular and Viral DNA Synthesis
    Jian Y, Van Tine BA, Chien WM, Shaw GM, Broker TR, Chow LT
    Cell Growth Differ 1999 Feb;10(2):101-11
  • Human Papillomavirus DNA Replication Compartments in a Transient DNA Replication System
    Swindle CS, Zou N, Van Tine BA, Shaw GM, Engler JA, Chow LT
    J Virol 1999 Feb;73(2):1001-9
  • Assignment of Human MFNG, Manic Fringe Drosophila Homolog, to 22q13.1 Using Tyramide Fluorescence in Situ Hybridization (T-FISH)
    Van Tine BA, Knops J, Shaw GM, May WA
    Cytogenet Cell Genet 1999;87(1-2):132-3
  • Characterization of CFTR Expression and Chloride Channel Activity in Human Endothelia
    Tousson A, Van Tine BA, Naren AP, Shaw GM, Schwiebert LM
    Am J Physiol 1998 Dec;275(6 Pt 1):C1555-64
  • Localization of HuC (ELAVL3) to Chromosome 19p13.2 by Fluorescence in Situ Hybridization Utilizing a Novel Tyramide Labeling Technique
    Van Tine BA, Knops JF, Butler A, Deloukas P, Shaw GM, King PH
    Genomics 1998 Nov 1;53(3):296-9
  • Pure Glucagon Antagonists: Biological Activities and cAMP Accumulation Using Phosphodiesterase Inhibitors
    Azizeh BY, Van Tine BA, Trivedi D, Hruby VJ
    Peptides 1997;18(5):633-41
  • Low Level Cyclic Adenosine 3',5'-Monophosphate Accumulation Analysis of [Des-His1, Des- Phe6, Glu9] Glucagon-NH2 Identifies Glucagon Antagonists From Weak Partial Agonists/Antagonists
    Van Tine BA, Azizeh BY, Trivedi D, Phelps JR, Houslay MD, Johnson DG, Hruby VJ
    Endocrinology 1996 Aug;137(8):3316-22
  • [DesHis1, DesPhe6, Glu9] Glucagon Amide: A Newly Designed "Pure Glucagon Antagonist"
    Azizeh BY, Van Tine BA, Sturm NS, Hutzler, AM, David C, Trivedi D, Hruby VJ
    Bioorganic and Medicinal Chemistry Letters 1995;5:1849-52

Books and Chapters

  • Sarcoma
    Van Tine BA, Hirbe AC
    In: DeVita, Hellman, and Rosenberg's Cancer: Principles & Practice of Oncology Review, 5th Edition (Morgensztern D, Govindan R, Devarakonda S, Trikalinos NA, Editors), Wolters Kluwer, Philadelphia, 2022
  • Sarcoma
    Van Tine BA
    In: The Washington Manual of Oncology, 4th Edition (Morgensztern D, Ghobadi A, Govindan R, Editors), Wolters Kluwer, Philadelphia, 2022
  • Sarcomas of Soft Tissue
    Van Tine BA
    In: Abeloff’s Clinical Oncology (6th ed.) ebook: 1655, 2019
  • Retroperitoneum
    Xu-Welliver M, Miller ED, Mayerson JL, Van Tine BA, Buchsbaum JC
    In: Perez and Brady’s Principles and Practice of Radiation Oncology, Lippincott Williams & Wilkins, Philadelphia, PA, 2018
  • The Washington Manual Hematology and Oncology Subspecialty Consult, Fourth Edition
    Cashen AF, Van Tine BA, Editors
    Lippincott Williams and Wilkins, St. Louis, 2016
  • Sarcoma
    Van Tine BA
    In: The Washington Manual Hematology and Oncology Subspecialty Consult, Fourth Edition (Cashen AF, Van Tine BA, Eds), Lippincott Williams and Wilkins, St. Louis, 2016
  • Sarcomas
    Adkins DR, Van Tine BA, Rachocki TB
    In: DeVita, Hellman, and Rosenberg's Cancer: Principles and Practice of Oncology Review (Govindan R, Ed), Lippincott Williams and Wilkins, St. Louis, pp 365-74, 2012
  • Supportive Care in Oncology
    Van Tine BA
    In: The Washington Manual Hematology and Oncology Subspecialty Consult, Third Edition (Cashen AF, Van Tine BA, Eds), Lippincott Williams and Wilkins, St. Louis, pp 414-30, 2012
  • Sarcoma
    Van Tine BA
    In: The Washington Manual Hematology and Oncology Subspecialty Consult, Third Edition (Cashen AF, Van Tine BA, Eds), Lippincott Williams and Wilkins, St. Louis, pp 291-302, 2012
  • The Washington Manual Hematology and Oncology Subspecialty Consult, Third Edition
    Cashen AF, Van Tine BA, Editors
    Lippincott Williams and Wilkins, St. Louis, 2011
  • Supportive Care in Oncology
    Van Tine BA
    In: The Washington Manual Hematology and Oncology Subspecialty Consult, Second Edition (Cashen AF, Wildes TM, Eds), Lippincott Williams and Wilkins, St. Louis, pp 255-69, 2008
  • Simultaneous in Situ Detection of RNA, DNA, and Protein Using Tyramide-Coupled Immunofluorescence
    Van Tine BA, Broker TR, Chow LT
    Methods Mol Biol 2005;292:215-30
  • In Situ Analysis of the Transcriptional Activity of Integrated Viral DNA Using Tyramide-FISH
    Van Tine BA, Knops J, Broker TR, Chow LT, Moen PT Jr
    Dev Biol (Basel) 2001;106:381-5