Faculty
Oncology Division
Alphabetical list (active faculty):   
Alessandro Vindigni

Alessandro Vindigni, PhD

Professor

Department of Medicine

Oncology Division

Molecular Oncology

Department of Pathology & Immunology

Research Interests

  • DNA replication and repair
  • Genome stability and tumorigenesis
  • DNA replication stress response
  • DNA damaging chemotherapy

Contact

  • 314-273-8612 (office)
  • 314-362-9221 (lab)
  • 314-362-7086 (fax)
  • Division of Oncology
    Campus Box 8125
    Washington University
    660 South Euclid Avenue
    St. Louis, MO 63110
  • Rooms 8844/8848 Clinical Sciences Research Building (lab)

Peer-reviewed Articles

  • Aberrant RNA Methylation Triggers Recruitment of an Alkylation Repair Complex
    Tsao N, Brickner JR, Rodell R, Ganguly A, Wood M, Oyeniran C, Ahmad T, Sun H, Bacolla A, Zhang L, Lukinovic V, Soll JM, Townley BA, Casanova AG, Tainer JA, He C, Vindigni A, Reynoird N, Mosammaparast N
    Mol Cell 2021 Oct 21;81(20):4228-4242
  • Lamin-A/C Recruits ssDNA Protective Proteins RPA and RAD51 to Stalled Replication Forks to Maintain Fork Stability
    Graziano S, Coll-Bonfill N, Teodoro-Castro B, Kuppa S, Jackson J, Shashkova E, Mahajan U, Vindigni A, Antony E, Gonzalo S
    J Biol Chem 2021 Oct 11:101301; [Epub ahead of print]
  • Temporally Distinct Post-Replicative Repair Mechanisms Fill PRIMPOL-Dependent ssDNA Gaps in Human Cells
    Tirman S, Quinet A, Wood M, Meroni A, Cybulla E, Jackson J, Pegoraro S, Simoneau A, Zou L, Vindigni A
    Mol Cell 2021 Oct 7;81(19):4026-4040
  • RADX Prevents Genome Instability by Confining Replication Fork Reversal to Stalled Forks
    Krishnamoorthy A, Jackson J, Mohamed T, Adolph M, Vindigni A, Cortez D
    Mol Cell 2021 Jul 15;81(14):3007-3017
  • Entinostat, a Selective HDAC1/2 Inhibitor, Potentiates the Effects of Olaparib in Homologous Recombination Proficient Ovarian Cancer
    Gupta VG, Hirst J, Petersen S, Roby KF, Kusch M, Zhou H, Clive ML, Jewell A, Pathak HB, Godwin AK, Wilson AJ, Crispens MA, Cybulla E, Vindigni A, Fuh KC, Khabele D
    Gynecol Oncol 2021 Jul;162(1):163-172
  • TDP-43 Dysfunction Results in R-Loop Accumulation and DNA Replication Defects
    Wood M, Quinet A, Lin YL, Davis AA, Pasero P, Ayala YM, Vindigni A
    J Cell Sci 2020 Oct 30;133(20)
  • TDP-43 Dysfunction Results in R-Loop Accumulation and DNA Replication Defects
    Wood M, Quinet A, Lin YL, Davis AA, Pasero P, Ayala YM, Vindigni A
    J Cell Sci 2020 Jan 1; [Epub ahead of print]
  • Telomere Erosion in Human Pluripotent Stem Cells Leads to ATR-Mediated Mitotic Catastrophe
    Vessoni AT, Zhang T, Quinet A, Jeong HC, Munroe M, Wood M, Tedone E, Vindigni A, Shay JW, Greenberg RA, Batista LFZ
    J Cell Biol 2021 Jun 7;220(6):e202011014
  • To Skip or Not to Skip: Choosing Repriming to Tolerate DNA Damage
    Quinet A, Tirman S, Cybulla E, Meroni A, Vindigni A
    Mol Cell 2021 Feb 18;81(4):649-658
  • CARM1 Regulates Replication Fork Speed and Stress Response by Stimulating PARP1
    Genois MM, Gagne JP, Yasuhara T, Jackson J, Saxena S, Langelier MF, Ahel I, Bedford MT, Pascal JM, Vindigni A, Poirier GG, Zou L
    Mol Cell 2021 Feb 18;81(4):784-800e8
  • PRIMPOL Ready, Set, Reprime!
    Tirman S, Cybulla E, Quinet A, Meroni A, Vindigni A
    Crit Rev Biochem Mol Biol 2021 Feb;56(1):17-30
  • Homologous Recombination Deficiency Real-Time Clinical Assays, Ready or Not?
    Fuh K, Mullen M, Blachut B, Stover E, Konstantinopoulos P, Liu J, Matulonis U, Khabele D, Mosammaparast N, Vindigni A
    Gynecol Oncol 2020 Dec;159(3):877-886
  • ISG15 Fast-Tracks DNA Replication
    Meroni A, Vindigni A
    J Cell Biol 2020 Aug 3;219(8)
  • Inhibition of the Translesion Synthesis Polymerase REV1 Exploits Replication Gaps as a Cancer Vulnerability
    Nayak S, Calvo JA, Cong K, Peng M, Berthiaume E, Jackson J, Zaino AM, Vindigni A, Hadden MK, Cantor SB
    Sci Adv 2020 Jun 10;6(24):eaaz7808
  • The Multifunctional Protein PACS-1 Is Required for HDAC2- and HDAC3-Dependent Chromatin Maturation and Genomic Stability
    Mani C, Tripathi K, Luan S, Clark DW, Andrews JF, Vindigni A, Thomas G, Palle K
    Oncogene 2020 Mar;39(12):2583-2596
  • PRIMPOL-Mediated Adaptive Response Suppresses Replication Fork Reversal in BRCA-Deficient Cells
    Quinet A, Tirman S, Jackson J, Svikovic S, Lemacon D, Carvajal-Maldonado D, Gonzalez-Acosta D, Vessoni AT, Cybulla E, Wood M, Tavis S, Batista LFZ, Mendez J, Sale JE, Vindigni A
    Mol Cell 2020 Feb 6;77(3):461-474e9
  • XLF and H2AX Function in Series to Promote Replication Fork Stability
    Chen BR, Quinet A, Byrum AK, Jackson J, Berti M, Thangavel S, Bredemeyer AL, Hindi I, Mosammaparast N, Tyler JK, Vindigni A, Sleckman BP
    J Cell Biol 2019 Jul 1;218(7):2113-2123
  • Ca(2+)-Stimulated AMPK-Dependent Phosphorylation of Exo1 Protects Stressed Replication Forks From Aberrant Resection
    Li S, Lavagnino Z, Lemacon D, Kong L, Ustione A, Ng X, Zhang Y, Wang Y, Zheng B, Piwnica-Worms H, Vindigni A, Piston DW, You Z
    Mol Cell 2019 Jun 20;74(6):1123-1137e6
  • Mitotic Regulators TPX2 and Aurora A Protect DNA Forks During Replication Stress by Counteracting 53BP1 Function
    Byrum AK, Carvajal-Maldonado D, Mudge MC, Valle-Garcia D, Majid MC, Patel R, Sowa ME, Gygi SP, Harper JW, Shi Y, Vindigni A, Mosammaparast N
    J Cell Biol 2019 Feb 4;218(2):422-432
  • Perturbing Cohesin Dynamics Drives MRE11 Nuclease-Dependent Replication Fork Slowing
    Carvajal-Maldonado D, Byrum AK, Jackson J, Wessel S, Lemacon D, Guitton-Sert L, Quinet A, Tirman S, Graziano S, Masson JY, Cortez D, Gonzalo S, Mosammaparast N, Vindigni A
    Nucleic Acids Res 2019 Feb 20;47(3):1294-1310
  • A Cell-Intrinsic Interferon-Like Response Links Replication Stress to Cellular Aging Caused by Progerin
    Kreienkamp R, Graziano S, Coll-Bonfill N, Bedia-Diaz G, Cybulla E, Vindigni A, Dorsett D, Kubben N, Batista LFZ, Gonzalo S
    Cell Rep 2018 Feb 20;22(8):2006-2015
  • Break-Induced Replication Promotes Formation of Lethal Joint Molecules Dissolved by Srs2
    Elango R, Sheng Z, Jackson J, DeCata J, Ibrahim Y, Pham NT, Liang DH, Sakofsky CJ, Vindigni A, Lobachev KS, Ira G, Malkova A
    Nat Commun 2017 Nov 27;8(1):1790
  • A Ubiquitin-Dependent Signalling Axis Specific for ALKBH-Mediated DNA Dealkylation Repair
    Brickner JR, Soll JM, Lombardi PM, Vagbo CB, Mudge MC, Oyeniran C, Rabe R, Jackson J, Sullender ME, Blazosky E, Byrum AK, Zhao Y, Corbett MA, Gecz J, Field M, Vindigni A, Slupphaug G, Wolberger C, Mosammaparast N
    Nature 2017 Nov 16;551(7680):389-393
  • MRE11 and EXO1 Nucleases Degrade Reversed Forks and Elicit MUS81-Dependent Fork Rescue in BRCA2-Deficient Cells
    Lemacon D, Jackson J, Quinet A, Brickner JR, Li S, Yazinski S, You Z, Ira G, Zou L, Mosammaparast N, Vindigni A
    Nat Commun 2017 Oct 16;8(1):860
  • Human Ribonuclease H1 Resolves R-Loops and Thereby Enables Progression of the DNA Replication Fork
    Parajuli S, Teasley DC, Murali B, Jackson J, Vindigni A, Stewart SA
    J Biol Chem 2017 Sep 15;292(37):15216-15224
  • The Architectural Chromatin Factor High Mobility Group A1 Enhances DNA Ligase IV Activity Influencing DNA Repair
    Pellarin I, Arnoldo L, Costantini S, Pegoraro S, Ros G, Penzo C, Triolo G, Demarchi F, Sgarra R, Vindigni A, Manfioletti G
    PLoS One 2016 Oct 10;11(10):e0164258
  • Topoisomerase IIbeta Mediates the Resistance of Glioblastoma Stem Cells to Replication Stress-Inducing Drugs
    Kenig S, Faoro V, Bourkoula E, Podergajs N, Ius T, Vindigni M, Skrap M, Lah T, Cesselli D, Storici P, Vindigni A
    Cancer Cell Int 2016 Jul 26;16:58
  • Kinase-Dead ATM Protein Is Highly Oncogenic and Can Be Preferentially Targeted by Topo-Isomerase I Inhibitors
    Yamamoto K, Wang J, Sprinzen L, Xu J, Haddock CJ, Li C, Lee BJ, Loredan DG, Jiang W, Vindigni A, Wang D, Rabadan R, Zha S
    Elife 2016 Jun 15;5
  • Structural and Biochemical Characterization of an RNA/DNA Binding Motif in the N-Terminal Domain of RecQ4 Helicases
    Marino F, Mojumdar A, Zucchelli C, Bhardwaj A, Buratti E, Vindigni A, Musco G, Onesti S
    Sci Rep 2016 Feb 18;6:21501
  • Fourier Transform Infrared Microspectroscopy Reveals Biochemical Changes Associated With Glioma Stem Cell Differentiation
    Kenig S, Bedolla DE, Birarda G, Faoro V, Mitri E, Vindigni A, Storici P, Vaccari L
    Biophys Chem 2015 Dec;207:90-6
  • Human RECQ1 Helicase-Driven DNA Unwinding, Annealing, and Branch Migration: Insights From DNA Complex Structures
    Pike AC, Gomathinayagam S, Swuec P, Berti M, Zhang Y, Schnecke C, Marino F, von Delft F, Renault L, Costa A, Gileadi O, Vindigni A
    Proc Natl Acad Sci U S A 2015 Apr 7;112(14):4286-91
  • Rad51-Mediated Replication Fork Reversal Is a Global Response to Genotoxic Treatments in Human Cells
    Zellweger R, Dalcher D, Mutreja K, Berti M, Schmid JA, Herrador R, Vindigni A, Lopes M
    J Cell Biol 2015 Mar 2;208(5):563-79
  • DNA2 Drives Processing and Restart of Reversed Replication Forks in Human Cells
    Thangavel S, Berti M, Levikova M, Pinto C, Gomathinayagam S, Vujanovic M, Zellweger R, Moore H, Lee EH, Hendrickson EA, Cejka P, Stewart S, Lopes M, Vindigni A
    J Cell Biol 2015 Mar 2;208(5):545-62
  • Identification of RECQ1-Regulated Transcriptome Uncovers a Role of RECQ1 in Regulation of Cancer Cell Migration and Invasion
    Li XL, Lu X, Parvathaneni S, Bilke S, Zhang H, Thangavel S, Vindigni A, Hara T, Zhu Y, Meltzer PS, Lal A, Sharma S
    Cell Cycle 2014;13(15):2431-45
  • Bioinformatic Analysis of RecQ4 Helicases Reveals the Presence of a RQC Domain and a Zn Knuckle
    Marino F, Vindigni A, Onesti S
    Biophys Chem 2013 Jul-Aug;177-178:34-9
  • Human RECQ1 Promotes Restart of Replication Forks Reversed by DNA Topoisomerase I Inhibition
    Berti M, Ray Chaudhuri A, Thangavel S, Gomathinayagam S, Kenig S, Vujanovic M, Odreman F, Glatter T, Graziano S, Mendoza-Maldonado R, Marino F, Lucic B, Biasin V, Gstaiger M, Aebersold R, Sidorova JM, Monnat RJ Jr, Lopes M, Vindigni A
    Nat Struct Mol Biol 2013 Mar;20(3):347-54
  • Discovery of ML216, a Small Molecule Inhibitor of Bloom (BLM) Helicase
    Rosenthal AS, Dexheimer TS, Nguyen G, Gileadi O, Vindigni A, Simeonov A, Jadhav A, Hickson I, Maloney DJ
    Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010-2011 Apr 15 [updated 2013 Feb 28]
  • In Vitro Enzyme Comparative Kinetics: Unwinding of Surface-Bound DNA Nanostructures by RecQ and RecQ1
    Parisse P, Vindigni A, Scoles G, Casalis L
    J Phys Chem Lett 2012 Dec 6;3(23):3532-7
  • The Alpha2 Helix in the DNA Ligase IV BRCT-1 Domain Is Required for Targeted Degradation of Ligase IV During Adenovirus Infection
    Gilson T, Greer AE, Vindigni A, Ketner G, Hanakahi LA
    Virology 2012 Jul 5;428(2):128-35
  • Proteomic Analysis of Gastric Cancer and Immunoblot Validation of Potential Biomarkers
    Kocevar N, Odreman F, Vindigni A, Grazio SF, Komel R
    World J Gastroenterol 2012 Mar 21;18(11):1216-28
  • The Human RECQ1 Helicase Is Highly Expressed in Glioblastoma and Plays an Important Role in Tumor Cell Proliferation
    Mendoza-Maldonado R, Faoro V, Bajpai S, Berti M, Odreman F, Vindigni M, Ius T, Ghasemian A, Bonin S, Skrap M, Stanta G, Vindigni A
    Mol Cancer 2011 Jul 13;10:83
  • A Prominent Beta-Hairpin Structure in the Winged-Helix Domain of RECQ1 Is Required for DNA Unwinding and Oligomer Formation
    Lucic B, Zhang Y, King O, Mendoza-Maldonado R, Berti M, Niesen FH, Burgess-Brown NA, Pike AC, Cooper CD, Gileadi O, Vindigni A
    Nucleic Acids Res 2011 Mar;39(5):1703-17
  • Rif1 Provides a New DNA-Binding Interface for the Bloom Syndrome Complex to Maintain Normal Replication
    Xu D, Muniandy P, Leo E, Yin J, Thangavel S, Shen X, Ii M, Agama K, Guo R, Fox D 3rd, Meetei AR, Wilson L, Nguyen H, Weng NP, Brill SJ, Li L, Vindigni A, Pommier Y, Seidman M, Wang W
    EMBO J 2010 Sep 15;29(18):3140-55
  • Human RECQ1 and RECQ4 Helicases Play Distinct Roles in DNA Replication Initiation
    Thangavel S, Mendoza-Maldonado R, Tissino E, Sidorova JM, Yin J, Wang W, Monnat RJ Jr, Falaschi A, Vindigni A
    Mol Cell Biol 2010 Mar;30(6):1382-96
  • An ATM- and ATR-Dependent Checkpoint Inactivates Spindle Assembly by Targeting CEP63
    Smith E, Dejsuphong D, Balestrini A, Hampel M, Lenz C, Takeda S, Vindigni A, Costanzo V
    Nat Cell Biol 2009 Mar;11(3):278-85
  • Structure of the Human RECQ1 Helicase Reveals a Putative Strand-Separation Pin
    Pike AC, Shrestha B, Popuri V, Burgess-Brown N, Muzzolini L, Costantini S, Vindigni A, Gileadi O
    Proc Natl Acad Sci U S A 2009 Jan 27;106(4):1039-44
  • A Proteomic Approach for Evaluating the Cell Response to a Novel Histone Deacetylase Inhibitor in Colon Cancer Cells
    Milli A, Cecconi D, Campostrini N, Timperio AM, Zolla L, Righetti SC, Zunino F, Perego P, Benedetti V, Gatti L, Odreman F, Vindigni A, Righetti PG
    Biochim Biophys Acta 2008 Nov;1784(11):1702-10
  • Werner Protein Cooperates With the XRCC4-DNA Ligase IV Complex in End-Processing
    Kusumoto R, Dawut L, Marchetti C, Wan Lee J, Vindigni A, Ramsden D, Bohr VA
    Biochemistry 2008 Jul 15;47(28):7548-56
  • The Human RecQ Helicases, BLM and RECQ1, Display Distinct DNA Substrate Specificities
    Popuri V, Bachrati CZ, Muzzolini L, Mosedale G, Costantini S, Giacomini E, Hickson ID, Vindigni A
    J Biol Chem 2008 Jun 27;283(26):17766-76
  • DNA Repair Is Limiting for Haematopoietic Stem Cells During Ageing
    Nijnik A, Woodbine L, Marchetti C, Dawson S, Lambe T, Liu C, Rodrigues NP, Crockford TL, Cabuy E, Vindigni A, Enver T, Bell JI, Slijepcevic P, Goodnow CC, Jeggo PA, Cornall RJ
    Nature 2007 Jun 7;447(7145):686-90
  • Interaction of the Ku Heterodimer With the DNA Ligase IV/Xrcc4 Complex and Its Regulation by DNA-PK
    Costantini S, Woodbine L, Andreoli L, Jeggo PA, Vindigni A
    DNA Repair (Amst) 2007 Jun 1;6(6):712-22
  • Different Quaternary Structures of Human RECQ1 Are Associated With Its Dual Enzymatic Activity
    Muzzolini L, Beuron F, Patwardhan A, Popuri V, Cui S, Niccolini B, Rappas M, Freemont PS, Vindigni A
    PLoS Biol 2007 Feb;5(2):e20
  • A Topological Mechanism for TRF2-Enhanced Strand Invasion
    Amiard S, Doudeau M, Pinte S, Poulet A, Lenain C, Faivre-Moskalenko C, Angelov D, Hug N, Vindigni A, Bouvet P, Paoletti J, Gilson E, Giraud-Panis MJ
    Nat Struct Mol Biol 2007 Feb;14(2):147-54
  • Identification of a Novel Motif in DNA Ligases Exemplified by DNA Ligase IV
    Marchetti C, Walker SA, Odreman F, Vindigni A, Doherty AJ, Jeggo P
    DNA Repair (Amst) 2006 Jul 13;5(7):788-98
  • Proteomic Studies on the White Matter of Human Brain
    Pozzi Mucelli S, Odreman F, Gonzales ML, Gerardi E, Stanta G, Vindigni A
    J Chromatogr B Analyt Technol Biomed Life Sci 2006 Mar 20;833(1):80-90
  • Analysis of Polymorphic Sites in the Promoter of the Nitric Oxide Synthase 2 Gene
    Coia V, Juliger S, Mordmuller B, Kreidenweis A, Stroh AL, Ortega C, Vindigni A, Dengjel J, Lukyanov DV, Destro-Bisol G, Fedorov A, Podgornaya OI, Kun JF
    Biochem Biophys Res Commun 2005 Oct 7;335(4):1123-31
  • The HRDC Domain of BLM Is Required for the Dissolution of Double Holliday Junctions
    Wu L, Chan KL, Ralf C, Bernstein DA, Garcia PL, Bohr VA, Vindigni A, Janscak P, Keck JL, Hickson ID
    EMBO J 2005 Jul 20;24(14):2679-87
  • Biochemical Analysis of the DNA Unwinding and Strand Annealing Activities Catalyzed by Human RECQ1
    Sharma S, Sommers JA, Choudhary S, Faulkner JK, Cui S, Andreoli L, Muzzolini L, Vindigni A, Brosh RM Jr
    J Biol Chem 2005 Jul 29;280(30):28072-84
  • RECQ1 Helicase Interacts With Human Mismatch Repair Factors That Regulate Genetic Recombination
    Doherty KM, Sharma S, Uzdilla LA, Wilson TM, Cui S, Vindigni A, Brosh RM Jr
    J Biol Chem 2005 Jul 29;280(30):28085-94
  • Proteomic Studies on Low- and High-Grade Human Brain Astrocytomas
    Odreman F, Vindigni M, Gonzales ML, Niccolini B, Candiano G, Zanotti B, Skrap M, Pizzolitto S, Stanta G, Vindigni A
    J Proteome Res 2005 May-Jun;4(3):698-708
  • Novel Target Genes of PsrA Transcriptional Regulator of Pseudomonas Aeruginosa
    Kojic M, Jovcic B, Vindigni A, Odreman F, Venturi V
    FEMS Microbiol Lett 2005 May 15;246(2):175-81
  • Fluorescence Anisotropy Studies on the Ku-DNA Interaction: Anion and Cation Effects
    Arosio D, Costantini S, Kong Y, Vindigni A
    J Biol Chem 2004 Oct 8;279(41):42826-35
  • Analysis of the Unwinding Activity of the Dimeric RECQ1 Helicase in the Presence of Human Replication Protein A
    Cui S, Arosio D, Doherty KM, Brosh RM Jr, Falaschi A, Vindigni A
    Nucleic Acids Res 2004 Apr 19;32(7):2158-70
  • In Vitro Protein-DNA Interactions at the Human Lamin B2 Replication Origin
    Stefanovic D, Stanojcic S, Vindigni A, Ochem A, Falaschi A
    J Biol Chem 2003 Oct 31;278(44):42737-43
  • Cell Cycle-Dependent Phosphorylation of Human DNA Ligase I at the Cyclin-Dependent Kinase Sites
    Ferrari G, Rossi R, Arosio D, Vindigni A, Biamonti G, Montecucco A
    J Biol Chem 2003 Sep 26;278(39):37761-7
  • Localization of Proteins Bound to a Replication Origin of Human DNA Along the Cell Cycle
    Abdurashidova G, Danailov MB, Ochem A, Triolo G, Djeliova V, Radulescu S, Vindigni A, Riva S, Falaschi A
    EMBO J 2003 Aug 15;22(16):4294-303
  • A Thermostable Alpha-Arabinofuranosidase From Xylanolytic Bacillus Pumilus: Purification and Characterisation
    Degrassi G, Vindigni A, Venturi V
    J Biotechnol 2003 Feb 27;101(1):69-79
  • Characterization of the DNA-Unwinding Activity of Human RECQ1, a Helicase Specifically Stimulated by Human Replication Protein A
    Cui S, Klima R, Ochem A, Arosio D, Falaschi A, Vindigni A
    J Biol Chem 2003 Jan 17;278(3):1424-32
  • DNA Unwinding Step-Size of E. Coli RecBCD Helicase Determined From Single Turnover Chemical Quenched-Flow Kinetic Studies
    Lucius AL, Vindigni A, Gregorian R, Ali JA, Taylor AF, Smith GR, Lohman TM
    J Mol Biol 2002 Nov 29;324(3):409-28
  • Studies on the Mode of Ku Interaction With DNA
    Arosio D, Cui S, Ortega C, Chovanec M, Di Marco S, Baldini G, Falaschi A, Vindigni A
    J Biol Chem 2002 Mar 22;277(12):9741-8
  • N(omega)-Arginine Dimethylation Modulates the Interaction Between a Gly/Arg-Rich Peptide From Human Nucleolin and Nucleic Acids
    Raman B, Guarnaccia C, Nadassy K, Zakhariev S, Pintar A, Zanuttin F, Frigyes D, Acatrinei C, Vindigni A, Pongor G, Pongor S
    Nucleic Acids Res 2001 Aug 15;29(16):3377-84
  • Platelet Glycoprotein Ib Alpha Binds to Thrombin Anion-Binding Exosite II Inducing Allosteric Changes in the Activity of Thrombin
    Li CQ, Vindigni A, Sadler JE, Wardell MR
    J Biol Chem 2001 Mar 2;276(9):6161-8
  • Identification of Human DNA Helicase V With the Far Upstream Element-Binding Protein
    Vindigni A, Ochem A, Triolo G, Falaschi A
    Nucleic Acids Res 2001 Mar 1;29(5):1061-7
  • Role of Residue Y99 in Tissue Plasminogen Activator
    Vindigni A, Winfield M, Ayala YM, Di Cera E
    Protein Sci 2000 Mar;9(3):619-22
  • Incorporation of Noncoded Amino Acids Into the N-Terminal Domain 1-47 of Hirudin Yields a Highly Potent and Selective Thrombin Inhibitor
    De Filippis V, Russo I, Vindigni A, Di Cera E, Salmaso S, Fontana A
    Protein Sci 1999 Oct;8(10):2213-7
  • Synthesis and Characterization of More Potent Analogues of Hirudin Fragment 1-47 Containing Non-Natural Amino Acids
    De Filippis V, Quarzago D, Vindigni A, Di Cera E, Fontana A
    Biochemistry 1998 Sep 29;37(39):13507-15
  • Role of P225 and the C136-C201 Disulfide Bond in Tissue Plasminogen Activator
    Vindigni A, Di Cera E
    Protein Sci 1998 Aug;7(8):1728-37
  • Site-Specific Dissection of Substrate Recognition by Thrombin
    Vindigni A, Dang QD, Di Cera E
    Nat Biotechnol 1997 Sep;15(9):891-5
  • Prevention of Vascular and Neural Dysfunction in Diabetic Rats by C-Peptide
    Ido Y, Vindigni A, Chang K, Stramm L, Chance R, Heath WF, DiMarchi RD, Di Cera E, Williamson JR
    Science 1997 Jul 25;277(5325):563-6
  • Energetics of Thrombin-Thrombomodulin Interaction
    Vindigni A, White CE, Komives EA, Di Cera E
    Biochemistry 1997 Jun 3;36(22):6674-81
  • Release of Fibrinopeptides by the Slow and Fast Forms of Thrombin
    Vindigni A, Di Cera E
    Biochemistry 1996 Apr 9;35(14):4417-26
  • Identification of Residues Linked to the Slow-->Fast Transition of Thrombin
    Guinto ER, Vindigni A, Ayala YM, Dang QD, Di Cera E
    Proc Natl Acad Sci U S A 1995 Nov 21;92(24):11185-9
  • Thermodynamic Investigation of Hirudin Binding to the Slow and Fast Forms of Thrombin: Evidence for Folding Transitions in the Inhibitor and Protease Coupled to Binding
    Ayala YM, Vindigni A, Nayal M, Spolar RS, Record MT Jr, Di Cera E
    J Mol Biol 1995 Nov 10;253(5):787-98
  • The Na+ Binding Site of Thrombin
    Di Cera E, Guinto ER, Vindigni A, Dang QD, Ayala YM, Wuyi M, Tulinsky A
    J Biol Chem 1995 Sep 22;270(38):22089-92
  • Core Domain of Hirudin From the Leech Hirudinaria Manillensis: Chemical Synthesis, Purification, and Characterization of a Trp3 Analog of Fragment 1-47
    De Filippis V, Vindigni A, Altichieri L, Fontana A
    Biochemistry 1995 Jul 25;34(29):9552-64
  • An Allosteric Switch Controls the Procoagulant and Anticoagulant Activities of Thrombin
    Dang OD, Vindigni A, Di Cera E
    Proc Natl Acad Sci U S A 1995 Jun 20;92(13):5977-81
  • Probing the Structure of Hirudin From Hirudinaria Manillensis by Limited Proteolysis. Isolation, Characterization and Thrombin-Inhibitory Properties of N-Terminal Fragments
    Vindigni A, De Filippis V, Zanotti G, Visco C, Orsini G, Fontana A
    Eur J Biochem 1994 Dec 1;226(2):323-33

Review Articles

Book Chapters

  • Energetic Dissection of Specificity in Serine Proteases
    Di Cera E, Vindigni A, Banerjee D
    In: Thermodymamics and Structure Based Drug Design (Ladbury J, Connelly PR, eds), Landes Co., London, UK, 1997
  • The Core Domain of Hirudin From the Leech Hirudinaria Manillensis. Chemical Modification of a Tryptophan-Containing Synthetic Peptide Analog
    De Antoni F, De Filippis V, Altichieri L, Vindigni A, Polverino de Laureto P, Fontana A
    Adv Exp Med Biol 1996;398:627-33