Faculty
Oncology Division
Waqar.jpg

Saiama N. Waqar, MBBS, MSCI

Associate Professor
Department of Medicine
Oncology Division
Medical Oncology

Clinical Interests

  • Thoracic malignancies
  • New treatment approaches for patients with lung cancer

Contact

  • 314-362-5817 (office)
  • 314-362-3895 (fax)
  • 11th Floor Mid-Campus Center (office)
  • Division of Oncology
    Campus Box 8056
    Washington University Medical School
    660 South Euclid Avenue
    St. Louis, MO 63110

Peer-reviewed Publications

  • Phase II Trial of Carfilzomib Plus Irinotecan in Patients With Small-Cell Lung Cancer Who Have Progressed on Prior Platinum-Based Chemotherapy
    Arnold SM, Chansky K, Baggstrom MQ, Thompson MA, Sanborn RE, Villano JL, Waqar SN, Hamm J, Leggas M, Willis M, Rosales J, Crowley JJ
    Clin Lung Cancer 2020 Jan 27; [Epub ahead of print]
  • Circulating Tumor (Ct) DNA Analysis to Monitor Response and Resistance to Ensartinib in Patients (Pts) With ALK+ Non-Small Cell Lung Cancer (NSCLC)
    Horn L, Whisenant JG, Wakelee H, Reckamp KL, Qiao H, Du L, Hernandez J, Huang V, Waqar SN, Patel S, Sanborn RE, Shaffer T, Garg K, Holzhausen A, Harrow K, Liang C, Lim LP, Li M, Lovly CM
    Ann Oncol 2019 Apr;30 Suppl 2:ii48
  • Monitoring Therapeutic Response and Resistance: Analysis of Circulating Tumor DNA in Patients With ALK+ Lung Cancer
    Horn L, Whisenant JG, Wakelee H, Reckamp KL, Qiao H, Leal TA, Du L, Hernandez J, Huang V, Blumenschein GR, Waqar SN, Patel SP, Nieva J, Oxnard GR, Sanborn RE, Shaffer T, Garg K, Holzhausen A, Harrow K, Liang C, Lim LP, Li M, Lovly CM
    J Thorac Oncol 2019 Nov;14(11):1901-1911
  • Circulating Tumor DNA Profiling in Small-Cell Lung Cancer Identifies Potentially Targetable Alterations
    Devarakonda S, Sankararaman S, Herzog BH, Gold KA, Waqar SN, Ward JP, Raymond VM, Lanman RB, Chaudhuri AA, Owonikoko TK, Li BT, Poirier JT, Rudin CM, Govindan R, Morgensztern D
    Clin Cancer Res 2019 Oct 15;25(20):6119-6126
  • SWOG S1400C (NCT02154490)-A Phase II Study of Palbociclib for Previously Treated Cell Cycle Gene Alteration-Positive Patients With Stage IV Squamous Cell Lung Cancer (Lung-MAP Substudy)
    Edelman MJ, Redman MW, Albain KS, McGary EC, Rafique NM, Petro D, Waqar SN, Minichiello K, Miao J, Papadimitrakopoulou VA, Kelly K, Gandara DR, Herbst RS
    J Thorac Oncol 2019 Oct;14(10):1853-1859
  • RRx-001 Followed by Platinum Plus Etoposide in Patients With Previously Treated Small-Cell Lung Cancer
    Morgensztern D, Rose M, Waqar SN, Morris J, Ma PC, Reid T, Brzezniak CE, Zeman KG, Padmanabhan A, Hirth J, I Spira A, Trepel JB, Padda SK
    Br J Cancer 2019 Jul;121(3):211-217
  • A Phase I Trial of Sunitinib and Rapamycin in Patients With Advanced Non-Small Cell Lung Cancer
    Waqar SN, Gopalan PK, Williams K, Devarakonda S, Govindan R
    Chemotherapy 2013;59(1):8-13
  • Association Between Depth of Response and Survival in Patients With Advanced-Stage Non-Small Cell Lung Cancer Treated With First-Line Chemotherapy
    Morgensztern D, Ko A, O'Brien M, Ong TJ, Waqar SN, Socinski MA, Postmus PE, Bhore R
    Cancer 2019 Jul 15;125(14):2394-2399
  • Recurrent WNT Pathway Alterations Are Frequent in Relapsed Small Cell Lung Cancer
    Wagner AH, Devarakonda S, Skidmore ZL, Krysiak K, Ramu A, Trani L, Kunisaki J, Masood A, Waqar SN, Spies NC, Morgensztern D, Waligorski J, Ponce J, Fulton RS, Maggi LB Jr, Weber JD, Watson MA, O'Conor CJ, Ritter JH, Olsen RR, Cheng H, Mukhopadhyay A, Can I, Cessna MH, Oliver TG, Mardis ER, Wilson RK, Griffith M, Griffith OL, Govindan R
    Nat Commun 2018 Sep 17;9(1):3787
  • Randomized, Double-Blind, Phase II Study of Temozolomide in Combination With Either Veliparib or Placebo in Patients With Relapsed-Sensitive or Refractory Small-Cell Lung Cancer
    Pietanza MC, Waqar SN, Krug LM, Dowlati A, Hann CL, Chiappori A, Owonikoko TK, Woo KM, Cardnell RJ, Fujimoto J, Long L, Diao L, Wang J, Bensman Y, Hurtado B, de Groot P, Sulman EP, Wistuba II, Chen A, Fleisher M, Heymach JV, Kris MG, Rudin CM, Byers LA
    J Clin Oncol 2018 Aug 10;36(23):2386-2394
  • A Placebo-Controlled Phase II Study of Ruxolitinib in Combination With Pemetrexed and Cisplatin for First-Line Treatment of Patients With Advanced Nonsquamous Non-Small-Cell Lung Cancer and Systemic Inflammation
    Giaccone G, Sanborn RE, Waqar SN, Martinez-Marti A, Ponce S, Zhen H, Kennealey G, Erickson-Viitanen S, Schaefer E
    Clin Lung Cancer 2018 Sep;19(5):e567-e574
  • Clinical Utility of Cell-Free DNA for the Detection of ALK Fusions and Genomic Mechanisms of ALK Inhibitor Resistance in Non-Small Cell Lung Cancer
    McCoach CE, Blakely CM, Banks KC, Levy B, Chue BM, Raymond VM, Le AT, Lee CE, Diaz J, Waqar SN, Purcell WT, Aisner DL, Davies KD, Lanman RB, Shaw AT, Doebele RC
    Clin Cancer Res 2018 Jun 15;24(12):2758-2770
  • Ensartinib (X-396) in ALK-Positive Non-Small Cell Lung Cancer: Results From a First-In-Human Phase I/II, Multicenter Study
    Horn L, Infante JR, Reckamp KL, Blumenschein GR, Leal TA, Waqar SN, Gitlitz BJ, Sanborn RE, Whisenant JG, Du L, Neal JW, Gockerman JP, Dukart G, Harrow K, Liang C, Gibbons JJ, Holzhausen A, Lovly CM, Wakelee HA
    Clin Cancer Res 2018 Jun 15;24(12):2771-2779
  • Non-Small-Cell Lung Cancer With Brain Metastasis at Presentation
    Waqar SN, Samson PP, Robinson CG, Bradley J, Devarakonda S, Du L, Govindan R, Gao F, Puri V, Morgensztern D
    Clin Lung Cancer 2018 Jul;19(4):e373-e379
  • Early Mortality in Patients Undergoing Adjuvant Chemotherapy for Non-Small Cell Lung Cancer
    Morgensztern D, Samson PS, Waqar SN, Devarakonda S, Robinson CG, Govindan R, Puri V
    J Thorac Oncol 2018 Apr;13(4):543-549
  • The Impact of Smoking and TP53 Mutations in Lung Adenocarcinoma Patients With Targetable Mutations-The Lung Cancer Mutation Consortium (LCMC2)
    Aisner DL, Sholl LM, Berry LD, Rossi MR, Chen H, Fujimoto J, Moreira AL, Ramalingam SS, Villaruz LC, Otterson GA, Haura E, Politi K, Glisson B, Cetnar J, Garon EB, Schiller J, Waqar SN, Sequist LV, Brahmer J, Shyr Y, Kugler K, Wistuba II, Johnson BE, Minna JD, Kris MG, Bunn PA, Kwiatkowski DJ
    LCMC2 investigators

    Clin Cancer Res 2018 Mar 1;24(5):1038-1047
  • Percutaneous Image-Guided Ablation in the Treatment of Osseous Metastases From Non-Small Cell Lung Cancer
    Ma Y, Wallace AN, Waqar SN, Morgensztern D, Madaelil TP, Tomasian A, Jennings JW
    Cardiovasc Intervent Radiol 2018 May;41(5):726-733
  • Immunogenicity of Influenza Vaccination in Patients With Cancer
    Waqar SN, Boehmer L, Morgensztern D, Wang-Gillam A, Sorscher S, Lawrence S, Gao F, Guebert K, Williams K, Govindan R
    Am J Clin Oncol 2018 Mar;41(3):248-253
  • Brain Metastases at Presentation in Patients With Non-Small Cell Lung Cancer
    Waqar SN, Waqar SH, Trinkaus K, Gadea CA, Robinson CG, Bradley J, Watson MA, Puri V, Govindan R, Morgensztern D
    Am J Clin Oncol 2018 Jan;41(1):36-40
  • Alectinib Versus Crizotinib in Untreated ALK-Positive Non-Small-Cell Lung Cancer
    Peters S, Camidge DR, Shaw AT, Gadgeel S, Ahn JS, Kim DW, Ou SI, Perol M, Dziadziuszko R, Rosell R, Zeaiter A, Mitry E, Golding S, Balas B, Noe J, Morcos PN, Mok T
    ALEX Trial Investigators (Contributors include: Waqar S)

    N Engl J Med 2017 Aug 31;377(9):829-838
  • A Phase 2, Open-Label, Multi-Center Study of Amuvatinib in Combination With Platinum Etoposide Chemotherapy in Platinum-Refractory Small Cell Lung Cancer Patients
    Byers LA, Horn L, Ghandi J, Kloecker G, Owonikoko T, Waqar SN, Krzakowski M, Cardnell RJ, Fujimoto J, Taverna P, Azab M, Camidge DR
    Oncotarget 2017 Aug 3;8(46):81441-81454
  • Treatment Advances in Small Cell Lung Cancer (SCLC)
    Waqar SN, Morgensztern D
    Pharmacol Ther 2017 Dec;180:16-23
  • Systemic Treatment of Brain Metastases
    Waqar SN, Morgensztern D, Govindan R
    Hematol Oncol Clin North Am 2017 Feb;31(1):157-176
  • Precision Medicine in Lung Cancer: The Battle Continues
    Waqar SN, Morgensztern D
    J Thorac Dis 2016 Nov;8(11):2991-2993
  • Immune Checkpoint Inhibition in Patients With Brain Metastases
    Johanns T, Waqar SN, Morgensztern D
    Ann Transl Med 2016 Oct;4(Suppl 1):S9
  • Role for Adjuvant Chemotherapy in Patients With Resected Small Cell Lung Cancer
    Du L, Waqar SN, Morgensztern D
    J Thorac Dis 2016 Aug;8(8):1891-2
  • Multimodality Therapy for NSCLC
    Du L, Waqar SN, Morgensztern D
    Cancer Treat Res 2016;170:151-63
  • Clinician Perspectives on Current Issues in Lung Cancer Drug Development
    Waqar SN, Bonomi PD, Govindan R, Hirsch FR, Riely GJ, Papadimitrakopoulou V, Kazandjian D, Khozin S, Larkins E, Dickson DJ, Malik S, Horn L, Ferris A, Shaw AT, Janne PA, Mok TS, Herbst R, Keegan P, Pazdur R, Blumenthal GM
    J Thorac Oncol 2016 Sep;11(9):1387-96
  • Adjuvant Chemotherapy for Patients With T2N0M0 NSCLC
    Morgensztern D, Du L, Waqar SN, Patel A, Samson P, Devarakonda S, Gao F, Robinson CG, Bradley J, Baggstrom M, Masood A, Govindan R, Puri V
    J Thorac Oncol 2016 Oct;11(10):1729-35
  • Patterns of Care in Hilar Node-Positive (N1) Non-Small Cell Lung Cancer: A Missed Treatment Opportunity?
    Bott MJ, Patel AP, Verma V, Crabtree TD, Morgensztern D, Robinson CG, Colditz GA, Waqar S, Kreisel D, Krupnick AS, Patterson GA, Broderick S, Meyers BF, Puri V
    J Thorac Cardiovasc Surg 2016 Jun;151(6):1549-1558e2
  • Delayed Nausea and Vomiting From Carboplatin Doublet Chemotherapy
    Waqar SN, Mann J, Baggstrom MQ, Waqar MA, Chitneni P, Williams K, Gao F, Morgensztern D, Govindan R
    Acta Oncol 2016 Jun;55(6):700-4
  • A Phase I Trial of Temsirolimus and Pemetrexed in Patients With Advanced Non-Small Cell Lung Cancer
    Waqar SN, Baggstrom MQ, Morgensztern D, Williams K, Rigden C, Govindan R
    Chemotherapy 2016;61(3):144-7
  • The Role of Surgical Resection in Stage IIIa Non-Small Cell Lung Cancer: A Decision and Cost-Effectiveness Analysis
    Samson P, Patel A, Robinson CG, Morgensztern D, Chang SH, Colditz GA, Waqar S, Crabtree TD, Krupnick AS, Kreisel D, Patterson GA, Meyers BF, Puri V
    Ann Thorac Surg 2015 Dec;100(6):2026-2032
  • Multidisciplinary Treatment for Stage IIIa Non-Small Cell Lung Cancer: Does Institution Type Matter?
    Samson P, Patel A, Crabtree TD, Morgensztern D, Robinson CG, Colditz GA, Waqar S, Kreisel D, Krupnick AS, Patterson GA, Broderick S, Meyers BF, Puri V
    Ann Thorac Surg 2015 Nov;100(5):1773-9
  • Immunotherapy for Non-Small Cell Lung Cancer: Are We on the Cusp of a New Era?
    Waqar SN, Morgensztern D
    Expert Rev Clin Immunol 2015 Aug;11(8):871-873
  • Role for Surgical Resection in the Multidisciplinary Treatment of Stage IIIB Non-Small Cell Lung Cancer
    Bott MJ, Patel AP, Crabtree TD, Morgensztern D, Robinson CG, Colditz GA, Waqar S, Kreisel D, Krupnicka AS, Patterson GA, Broderick S, Meyers BF, Puri V
    Ann Thorac Surg 2015 Jun;99(6):1921-1928
  • MET Mutation Associated With Responsiveness to Crizotinib
    Waqar SN, Morgensztern D, Sehn J
    J Thorac Oncol 2015 May;10(5):e29-31
  • Postoperative Radiotherapy for Pathologic N2 Non-Small-Cell Lung Cancer Treated With Adjuvant Chemotherapy: A Review of the National Cancer Data Base
    Robinson CG, Patel AP, Bradley JD, DeWees T, Waqar SN, Morgensztern D, Baggstrom MQ, Govindan R, Bell JM, Guthrie TJ, Colditz GA, Crabtree TD, Kreisel D, Krupnick AS, Patterson GA, Meyers BF, Puri V
    J Clin Oncol 2015 Mar 10;33(8):870-6
  • Clinical Next-Generation Sequencing in Patients With Non-Small Cell Lung Cancer
    Hagemann IS, Devarakonda S, Lockwood CM, Spencer DH, Guebert K, Bredemeyer AJ, Al-Kateb H, Nguyen TT, Duncavage EJ, Cottrell CE, Kulkarni S, Nagarajan R, Seibert K, Baggstrom M, Waqar SN, Pfeifer JD, Morgensztern D, Govindan R
    Cancer 2015 Feb 15;121(4):631-9
  • A Phase I Study of Temsirolimus and Thoracic Radiation in Non-Small-Cell Lung Cancer
    Waqar SN, Robinson C, Bradley J, Goodgame B, Rooney M, Williams K, Gao F, Govindan R
    Clin Lung Cancer 2014 Mar;15(2):119-23
  • Prognostic Impact of Malignant Pleural Effusion at Presentation in Patients With Metastatic Non-Small-Cell Lung Cancer
    Morgensztern D, Waqar S, Subramanian J, Trinkaus K, Govindan R
    J Thorac Oncol 2012 Oct;7(10):1485-9
  • Prognostic Significance of Tumor Size in Patients With Stage III Non-Small-Cell Lung Cancer: A Surveillance, Epidemiology, and End Results (SEER) Survey From 1998 to 2003
    Morgensztern D, Waqar S, Subramanian J, Gao F, Trinkaus K, Govindan R
    J Thorac Oncol 2012 Oct;7(10):1479-84
  • A Roundup of Articles Published in Recent Months
    Subramanian J, Waqar S, Morgensztern D, Govindan R
    J Thorac Oncol 2012 Mar;7(3):626-8
  • Recent Advances in Lung Cancer: Summary of Presentations From the 47th Annual Meeting of the American Society of Clinical Oncology (ASCO) 2011
    Subramanian J, Waqar SN, Morgensztern D, Govindan R
    J Thorac Oncol 2012 Jan;7(1):260-5
  • Targeted Therapy in Lung Cancer: Lessons Learned From Past Experiences
    Subramanian J, Waqar SN, Govindan R
    J Thorac Oncol 2011 Nov;6(11 Suppl 4):S1786-8
  • Summary of Presentations From the 46th Annual Meeting of the American Society of Clinical Oncology (2010): Focus on Supportive Care Issues Related to Lung Cancer
    Boehmer L, Waqar S, Butler S, Sezhiyan A, Govindan R
    J Thorac Oncol 2011 Mar;6(3):645-9
  • Barriers to Enrollment in Non-Small Cell Lung Cancer Therapeutic Clinical Trials
    Baggstrom MQ, Waqar SN, Sezhiyan AK, Gilstrap E, Gao F, Morgensztern D, Govindan R
    J Thorac Oncol 2011 Jan;6(1):98-102
  • Influenza Vaccination in Patients With Cancer: An Overview
    Boehmer LM, Waqar SN, Govindan R
    Oncology (Williston Park) 2010 Nov 15;24(12):1167-70
  • Improving Survival for Stage IV Non-Small Cell Lung Cancer: A Surveillance, Epidemiology, and End Results Survey From 1990 to 2005
    Morgensztern D, Waqar S, Subramanian J, Gao F, Govindan R
    J Thorac Oncol 2009 Dec;4(12):1524-9
  • Does Malaria During Pregnancy Affect the Newborn?
    Yakoob MY, Zakaria A, Waqar SN, Zafar S, Wahla AS, Zaidi SK, Sarwari AR, Qureshi RN, Siddiqui AR
    J Pak Med Assoc 2005 Dec;55(12):543-6
  • Myocardial Ischaemia and Reperfusion Injury: Reactive Oxygen Species and the Role of Neutrophil
    Saeed SA, Waqar MA, Zubairi AJ, Bhurgri H, Khan A, Gowani SA, Waqar SN, Choudhary MI, Jalil S, Zaidi AH, Ara I
    J Coll Physicians Surg Pak 2005 Aug;15(8):507-14
  • Synergistic Interaction of Epinephrine and Calcium Ionophore in Platelet Aggregation
    Butt IF, Saeed SA, Waqar SN, Aslam M
    J Ayub Med Coll Abbottabad 2005 Apr-Jun;17(2):1-5
  • Cystic Breast Lymphangioma
    Waqar SN, Khan H, Mekan SF, Kayani N, Raja AJ
    J Pak Med Assoc 2004 Oct;54(10):531-3
  • Banti's Syndrome: Case Report and Review of Literature
    Waqar SN, Jindani S, Baig NS, Waqar MA, Ismail FW, Tariq M
    J Pak Med Assoc 2004 Feb;54(2):99-101
  • Intestinal Parasitic Infections in Children From Northern Pakistan
    Waqar SN, Hussain H, Khan R, Khwaja A, Majid H, Malik S, Nadeem T, Beg A
    Infectious Diseases Journal of Pakistan 2003;12(3):73-77
  • An Enzymatic Method for the Detection of Human Serum Albumin
    Javed MU, Waqar SN
    Exp Mol Med 2001 Jun 30;33(2):103-5