Faculty
Oncology Division
Alphabetical list (active faculty):   
Jeffrey P. Ward

Jeffrey P. Ward, MD, PhD

Assistant Professor

Department of Medicine

Oncology Division

Medical Oncology

Clinical Interests

  • Thoracic malignancies

Research Interests

  • Tumor Immunology
  • Neoantigens
  • Immunotherapy

Contact

  • 314-747-7409 (office)
  • 314-362-7086 (fax)
  • Division of Oncology
    Mail Stop 8056-0021-09
    Washington University
    660 South Euclid Avenue
    St. Louis, MO 63110
  • 9934 Wohl Clinic (office)
  • 9934 Wohl Clinic (lab)

Research

The clinical development and successful introduction into practice of immune checkpoint inhibitors that reinvigorate a patient's own immune cells to target tumors have revolutionized the treatment paradigm for those with lung cancer. However, the fact remains that many patients will not benefit from current cancer immunotherapies, and a better understanding of the interactions between lymphocytes, tumor cells, and the cells that make up the tumor microenvironment will be required to move towards the next generation of therapeutics.

My research focuses on the identification of tumor specific mutant antigens recognized by the immune system as foreign that serve as the target of a T-cell response against tumors. We take advantage of cancer genomics and bioinformatics techniques to detect tumor-specific mutations that accumulate during transformation and use this information to predict which mutations are potentially antigenic. We then use these predictions to validate those that elicit T-cell responses. In preclinical models, personalized vaccines targeting neoantigens trigger potent anti-tumor immune responses leading to rejection of established tumors, providing proof of principle that a similar strategy may prove successful for patients.

Clinically, I focus on the care of patients with thoracic malignancies, with a special emphasis on clinical and translational trials of novel immunotherapies.