Faculty
Oncology Division
Alphabetical list (active faculty):   
Lukas D. Wartman

Lukas D. Wartman, MD

Assistant Professor

Department of Medicine

Oncology Division

Stem Cell Biology

Clinical Interests

  • Leukemia

Research Interests

  • Leukemogenesis
  • Acute promeylocytic leukemia
  • Cancer genomics
  • Epigenetics

Contact

  • 314-362-9669 (office)
  • 314-362-9333 (fax)
  • Division of Oncology
    Campus Box 8007
    Washington University
    660 South Euclid Avenue
    St. Louis, MO 63110
  • Room 628 Southwest Tower (office)
  • Room 626 Southwest Tower (lab)

Peer-reviewed Manuscripts

  • Kdm6a Deficiency Restricted to Mouse Hematopoietic Cells Causes an Age- and Sex-Dependent Myelodysplastic Syndrome-Like Phenotype
    Tian L, Chavez M, Chang GS, Helton NM, Katerndahl CDS, Miller CA, Wartman LD
    PLoS One 2021 Nov 15;16(11):e0255706
  • Tumor Suppressor Function of Gata2 in Acute Promyelocytic Leukemia
    Katerndahl CDS, Rogers ORS, Day RB, Cai MA, Rooney TP, Helton NM, Hoock M, Ramakrishnan SM, Nonavinkere Srivatsan S, Wartman LD, Miller CA, Ley TJ
    Blood 2021 Sep 30;138(13):1148-1161
  • Impact of a 40-Gene Targeted Panel Test on Physician Decision Making for Patients With Acute Myeloid Leukemia
    Barnell EK, Newcomer KF, Skidmore ZL, Krysiak K, Anderson SR, Wartman LD, Oh ST, Welch JS, Stockerl-Goldstein KE, Vij R, Cashen AF, Pusic I, Westervelt P, Abboud CN, Ghobadi A, Uy GL, Schroeder MA, DiPersio JF, Politi MC, Spencer DH, Duncavage EJ, Ley TJ, Griffith M, Jacoby MA, Griffith OL
    JCO Precis Oncol 2021 Jan 14;5
  • Shared Cell of Origin in a Patient With Erdheim-Chester Disease and Acute Myeloid Leukemia
    Ghobadi A, Miller CA, Li T, O'Laughlin M, Lee YS, Ali M, Westervelt P, DiPersio JF, Wartman LD
    Haematologica 2019 Aug;104(8):e373-e375
  • Exome Analysis of Treatment-Related AML After APL Suggests Secondary Evolution
    Wang T, Jacoby MA, Duncavage EJ, Miller CA, Heath S, Rahme R, Fenaux P, Ades L, Renneville A, Cassinat B, Takeshita A, Asou N, Miyazaki Y, Kiyoi H, Ravandi F, Westervelt P, Wartman LD, Welch JS
    Br J Haematol 2019 Jun;185(5):984-987
  • Fifty Shades of GATA2 Mutation: A Case of Plasmablastic Lymphoma, Nontuberculous Mycobacterial Infection, and Myelodysplastic Syndrome
    Fakhri B, Cashen AF, Duncavage EJ, Watkins MP, Wartman LD, Bartlett NL
    Clin Lymphoma Myeloma Leuk 2019 Sep;19(9):e532-e535
  • Immune Escape of Relapsed AML Cells After Allogeneic Transplantation
    Christopher MJ, Petti AA, Rettig MP, Miller CA, Chendamarai E, Duncavage EJ, Klco JM, Helton NM, O'Laughlin M, Fronick CC, Fulton RS, Wilson RK, Wartman LD, Welch JS, Heath SE, Baty JD, Payton JE, Graubert TA, Link DC, Walter MJ, Westervelt P, Ley TJ, DiPersio JF
    N Engl J Med 2018 Dec 13;379(24):2330-2341
  • Mutation Clearance After Transplantation for Myelodysplastic Syndrome
    Duncavage EJ, Jacoby MA, Chang GS, Miller CA, Edwin N, Shao J, Elliott K, Robinson J, Abel H, Fulton RS, Fronick CC, O'Laughlin M, Heath SE, Brendel K, Saba R, Wartman LD, Christopher MJ, Pusic I, Welch JS, Uy GL, Link DC, DiPersio JF, Westervelt P, Ley TJ, Trinkaus K, Graubert TA, Walter MJ
    N Engl J Med 2018 Sep 13;379(11):1028-1041
  • Oral Cavity Squamous Cell Carcinoma Xenografts Retain Complex Genotypes and Intertumor Molecular Heterogeneity
    Campbell KM, Lin T, Zolkind P, Barnell EK, Skidmore ZL, Winkler AE, Law JH, Mardis ER, Wartman LD, Adkins DR, Chernock RD, Griffith M, Uppaluri R, Griffith OL
    Cell Rep 2018 Aug 21;24(8):2167-2178
  • A Case of Acute Myeloid Leukemia With Promyelocytic Features Characterized by Expression of a Novel RARG-CPSF6 Fusion
    Miller CA, Tricarico C, Skidmore ZL, Uy GL, Lee YS, Hassan A, O'Laughlin MD, Schmidt H, Tian L, Duncavage EJ, Griffith M, Griffith OL, Welch JS, Wartman LD
    Blood Adv 2018 Jun 12;2(11):1295-1299
  • Acute Graft-Versus-Host Disease Following Lung Transplantation in a Patient With a Novel TERT Mutation
    Brestoff JR, Vessoni AT, Brenner KA, Uy GL, DiPersio JF, Blinder M, Witt CA, Byers DE, Hachem RR, Truclock EP, Early DS, Anadkat MJ, Musiek A, Javidan-Nejad C, Balfe DM, Rosman IS, Liu C, Zhang L, Despotis GJ, Ruzinova MB, Sehn JK, Amarillo I, Heusel JW, Swat W, Kim BS, Wartman LD, Yusen RD, Batista LFZ
    Thorax 2018 May;73(5):489-492
  • The Future of Cancer Treatment Using Precision Oncogenomics
    Wartman LD
    Cold Spring Harb Mol Case Stud 2018 Apr 2;4(2)
  • Patterns of Infectious Complications in Acute Myeloid Leukemia and Myelodysplastic Syndromes Patients Treated With 10-Day Decitabine Regimen
    Ali AM, Weisel D, Gao F, Uy GL, Cashen AF, Jacoby MA, Wartman LD, Ghobadi A, Pusic I, Romee R, Fehniger TA, Stockerl-Goldstein KE, Vij R, Oh ST, Abboud CN, Schroeder MA, Westervelt P, DiPersio JF, Welch JS
    Cancer Med 2017 Dec;6(12):2814-2821
  • Bladder-Cancer-Associated Mutations in RXRA Activate Peroxisome Proliferator-Activated Receptors to Drive Urothelial Proliferation
    Halstead AM, Kapadia CD, Bolzenius J, Chu CE, Schriefer A, Wartman LD, Bowman GR, Arora VK
    Elife 2017 Nov 16;6
  • Mutational Landscape and Response Are Conserved in Peripheral Blood of AML and MDS Patients During Decitabine Therapy
    Duncavage EJ, Uy GL, Petti AA, Miller CA, Lee YS, Tandon B, Gao F, Fronick CC, O'Laughlin M, Fulton RS, Wilson RK, Jacoby MA, Cashen AF, Wartman LD, Walter MJ, Westervelt P, Link DC, DiPersio JF, Ley TJ, Welch JS
    Blood 2017 Mar 9;129(10):1397-1401
  • CpG Island Hypermethylation Mediated by DNMT3A Is a Consequence of AML Progression
    Spencer DH, Russler-Germain DA, Ketkar S, Helton NM, Lamprecht TL, Fulton RS, Fronick CC, O'Laughlin M, Heath SE, Shinawi M, Westervelt P, Payton JE, Wartman LD, Welch JS, Wilson RK, Walter MJ, Link DC, DiPersio JF, Ley TJ
    Cell 2017 Feb 23;168(5):801-816
  • CIViC Is a Community Knowledgebase for Expert Crowdsourcing the Clinical Interpretation of Variants in Cancer
    Griffith M, Spies NC, Krysiak K, McMichael JF, Coffman AC, Danos AM, Ainscough BJ, Ramirez CA, Rieke DT, Kujan L, Barnell EK, Wagner AH, Skidmore ZL, Wollam A, Liu CJ, Jones MR, Bilski RL, Lesurf R, Feng YY, Shah NM, Bonakdar M, Trani L, Matlock M, Ramu A, Campbell KM, Spies GC, Graubert AP, Gangavarapu K, Eldred JM, Larson DE, Walker JR, Good BM, Wu C, Su AI, Dienstmann R, Margolin AA, Tamborero D, Lopez-Bigas N, Jones SJ, Bose R, Spencer DH, Wartman LD, Wilson RK, Mardis ER, Griffith OL
    Nat Genet 2017 Jan 31;49(2):170-174
  • TP53 and Decitabine in Acute Myeloid Leukemia and Myelodysplastic Syndromes
    Welch JS, Petti AA, Miller CA, Fronick CC, O'Laughlin M, Fulton RS, Wilson RK, Baty JD, Duncavage EJ, Tandon B, Lee YS, Wartman LD, Uy GL, Ghobadi A, Tomasson MH, Pusic I, Romee R, Fehniger TA, Stockerl-Goldstein KE, Vij R, Oh ST, Abboud CN, Cashen AF, Schroeder MA, Jacoby MA, Heath SE, Luber K, Janke MR, Hantel A, Khan N, Sukhanova MJ, Knoebel RW, Stock W, Graubert TA, Walter MJ, Westervelt P, Link DC, DiPersio JF, Ley TJ
    N Engl J Med 2016 Nov 24;375(21):2023-2036
  • A Genomic Analysis of Philadelphia Chromosome-Negative AML Arising in Patients With CML
    Krysiak K, Christopher MJ, Skidmore ZL, Demeter RT, Magrini V, Kunisaki J, O'Laughlin M, Duncavage EJ, Miller CA, Ozenberger BA, Griffith M, Wartman LD, Griffith OL
    Blood Cancer J 2016 Apr 8;6:e413
  • A Common Founding Clone With TP53 and PTEN Mutations Gives Rise to a Concurrent Germ Cell Tumor and Acute Megakaryoblastic Leukemia
    Lu C, Riedell P, Miller CA, Hagemann IS, Westervelt P, Ozenberger BA, O'Laughlin M, Magrini V, Demeter RT, Duncavage EJ, Griffith M, Griffith OL, Wartman LD
    Cold Spring Harb Mol Case Stud 2016 Jan;2(1):a000687
  • A Phase I Study of Carfilzomib for Relapsed or Refractory Acute Myeloid and Acute Lymphoblastic Leukemia
    Wartman LD, Fiala MA, Fletcher T, Hawkins ER, Cashen A, DiPersio JF, Jacoby MA, Stockerl-Goldstein KE, Pusic I, Uy GL, Westervelt P, Vij R
    Leuk Lymphoma 2016 Mar;57(3):728-730
  • Association Between Mutation Clearance After Induction Therapy and Outcomes in Acute Myeloid Leukemia
    Klco JM, Miller CA, Griffith M, Petti A, Spencer DH, Ketkar-Kulkarni S, Wartman LD, Christopher M, Lamprecht TL, Helton NM, Duncavage EJ, Payton JE, Baty J, Heath SE, Griffith OL, Shen D, Hundal J, Chang GS, Fulton R, O'Laughlin M, Fronick C, Magrini V, Demeter RT, Larson DE, Kulkarni S, Ozenberger BA, Welch JS, Walter MJ, Graubert TA, Westervelt P, Radich JP, Link DC, Mardis ER, DiPersio JF, Wilson RK, Ley TJ
    JAMA 2015 Aug 25;314(8):811-822
  • Genomic and Epigenomic Landscapes of Adult De Novo Acute Myeloid Leukemia
    Ley TJ, Miller C, Ding L, Raphael BJ, Mungall AJ, Robertson A, Hoadley K, Triche TJ Jr, Laird PW, Baty JD, Fulton LL, Fulton R, Heath SE, Kalicki-Veizer J, Kandoth C, Klco JM, Koboldt DC, Kanchi KL, Kulkarni S, Lamprecht TL, Larson DE, Lin L, Lu C, McLellan MD, McMichael JF, Payton J, Schmidt H, Spencer DH, Tomasson MH, Wallis JW, Wartman LD, Watson MA, Welch J, Wendl MC, Ally A, Balasundaram M, Birol I, Butterfield Y, Chiu R, Chu A, Chuah E, Chun HJ, Corbett R, Dhalla N, Guin R, He A, Hirst C, Hirst M, Holt RA, Jones S, Karsan A, Lee D, Li HI, Marra MA, Mayo M, Moore RA, Mungall K, Parker J, Pleasance E, Plettner P, Schein J, Stoll D, Swanson L, Tam A, Thiessen N, Varhol R, Wye N, Zhao Y, Gabriel S, Getz G, Sougnez C, Zou L, Leiserson MD, Vandin F, Wu HT, Applebaum F, Baylin SB, Akbani R, Broom BM, Chen K, Motter TC, Nguyen K, Weinstein JN, Zhang N, Ferguson ML, Adams C, Black A, Bowen J, Gastier-Foster J, Grossman T, Lichtenberg T, Wise L, Davidsen T, Demchok JA, Shaw KR, Sheth M, Sofia HJ, Yang L, Downing JR, Eley G, Alonso S, Ayala B, Baboud J, Backus M, Barletta SP, Berton DL, Chu AL, Girshik S, Jensen MA, Kahn A, Kothiyal P, Nicholls MC, Pihl TD, Pot DA, Raman R, Sanbhadti RN, Snyder EE, Srinivasan D, Walton J, Wan Y, Wang Z, Issa JP, Le Beau M, Carroll M, Kantarjian H, Kornblau S, Bootwalla MS, Lai PH, Shen H, Van Den Berg DJ, Weisenberger DJ, Link DC, Walter MJ, Ozenberger BA, Mardis ER, Westervelt P, Graubert TA, DiPersio JF, Wilson RK
    N Engl J Med 2013 May 30;368(22):2059-74
  • Notch Signaling in Acute Promyelocytic Leukemia
    Grieselhuber NR, Klco JM, Verdoni AM, Lamprecht T, Sarkaria SM, Wartman LD, Ley TJ
    Leukemia 2013 Jul;27(7):1548-57
  • Expression and Function of PML-RARA in the Hematopoietic Progenitor Cells of Ctsg-PML-RARA Mice
    Wartman LD, Welch JS, Uy GL, Klco JM, Lamprecht T, Varghese N, Nagarajan R, Ley TJ
    PLoS One 2012;7(10):e46529
  • The Origin and Evolution of Mutations in Acute Myeloid Leukemia
    Welch JS, Ley TJ, Link DC, Miller CA, Larson DE, Koboldt DC, Wartman LD, Lamprecht TL, Liu F, Xia J, Kandoth C, Fulton RS, McLellan MD, Dooling DJ, Wallis JW, Chen K, Harris CC, Schmidt HK, Kalicki-Veizer JM, Lu C, Zhang Q, Lin L, O'Laughlin MD, McMichael JF, Delehaunty KD, Fulton LA, Magrini VJ, McGrath SD, Demeter RT, Vickery TL, Hundal J, Cook LL, Swift GW, Reed JP, Alldredge PA, Wylie TN, Walker JR, Watson MA, Heath SE, Shannon WD, Varghese N, Nagarajan R, Payton JE, Baty JD, Kulkarni S, Klco JM, Tomasson MH, Westervelt P, Walter MJ, Graubert TA, DiPersio JF, Ding L, Mardis ER, Wilson RK
    Cell 2012 Jul 20;150(2):264-78
  • Sequencing a Mouse Acute Promyelocytic Leukemia Genome Reveals Genetic Events Relevant for Disease Progression
    Wartman LD, Larson DE, Xiang Z, Ding L, Chen K, Lin L, Cahan P, Klco JM, Welch JS, Li C, Payton JE, Uy GL, Varghese N, Ries RE, Hoock M, Koboldt DC, McLellan MD, Schmidt H, Fulton RS, Abbott RM, Cook L, McGrath SD, Fan X, Dukes AF, Vickery T, Kalicki J, Lamprecht TL, Graubert TA, Tomasson MH, Mardis ER, Wilson RK, Ley TJ
    J Clin Invest 2011 Apr;121(4):1445-55
  • Identification of Acidic Dileucine Signals in LRP9 That Interact With Both GGAs and AP-1/AP-2
    Doray B, Knisely JM, Wartman L, Bu G, Kornfeld S
    Traffic 2008 Sep;9(9):1551-62
  • Differential Regulation of the Expression of Na(+)/H(+) Exchanger Isoform NHE3 by PKC-Alpha in Caco-2 Cells
    Alrefai WA, Scaglione-Sewell B, Tyagi S, Wartman L, Brasitus TA, Ramaswamy K, Dudeja PK
    Am J Physiol Cell Physiol 2001 Nov;281(5):C1551-8
  • Molecular Characterization and Chromosomal Localization of a Third Alpha-Class Hypoxia Inducible Factor Subunit, HIF3alpha
    Gu YZ, Moran SM, Hogenesch JB, Wartman L, Bradfield CA
    Gene Expr 1998;7(3):205-13

Book Chapters

  • Genomics
    Wartman LD, Mardis ER
    In: Williams Hematology, 9/E. McGraw-Hill, 2015
  • Oncologic Emergencies
    Wartman LD
    In: The Washington Manual Hematology and Oncology Subspecialty Consult (Cashen A, Wildes T, eds), Philadelphia: Lippincott Williams & Wilkins, 2008: 308-322
  • Cancer of Unknown Primary
    Wartman LD
    In: The Washington Manual Hematology and Oncology Subspecialty Consult (Cashen A, Wildes T, eds), Philadelphia: Lippincott Williams & Wilkins, 2008: 349-354

Editorials